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Thermochemical biorefineries for the production of chemicals and materials can play an important role in the bioeconomy. However, their economic viability is often questioned under the premise of the economy of scale. This paper presents a regional, modular biorefinery concept for the production of the platform chemicals hydroxymethylfurfural (HMF), furfural and phenols from the lignocellulosic perennial miscanthus, which can be cultivated on marginal and degraded areas. The paper focuses on the question of the minimum selling price of HMF and the optimal plant size for this purpose, using the region of Baden‐Württemberg, Germany, as an example. Based on small pilot plant results, a scalable process simulation was created via AspenPlus. This allows different scenarios and process combinations of this multi‐output biorefinery concept to be compared with each other. Using this, a minimum sales price for the main product HMF is calculated using methods of dynamic investment cost calculation according to the net present value method. Based on this, the plant capacity was scaled. The scenarios and sensitivity analyses show that, with an accuracy of ±15%, regional biorefineries could already offer platform chemicals at prices of 2.21–2.90 EUR/kg HMF at the current stage of development. This corresponds to three to four times the price of today's comparative fossil base chemicals and is thus a competitive option from the authors’ point of view. The local biomass and the heat prices were identified as the main influencing factors. As a result, the selection of the location will have a decisive influence on the economic viability of such concepts in the case of further development and optimization of the process in first demonstration plants. This paper presents a regional, modular biorefinery concept for the production of the platform chemicals hydroxymethylfurfural (HMF), furfural and phenols from the lignocellulosic perennial miscanthus, which can be cultivated on marginal and degraded areas. The paper focuses on the question of the minimum selling price of HMF and the optimal plant size for this purpose, using the region of Baden‐Württemberg, Germany, as an example. Based on small pilot plant results, a scalable process simulation was created via AspenPlus.

Regarding the limited resources for fossil fuels and increasing global energy demands, greenhouse gas emissions, and climate change, there is a need to find alternative energy sources that are sustainable, environmentally friendly, renewable, and economically viable. In the last several decades, interest in second-generation bioethanol production from non-food lignocellulosic biomass in the form of organic residues rapidly increased because of its abundance, renewability, and low cost. Bioethanol production fits into the strategy of a circular economy and zero waste plans, and using ethanol as an alternative fuel gives the world economy a chance to become independent of the petrochemical industry, providing energy security and environmental safety. However, the conversion of biomass into ethanol is a challenging and multi-stage process because of the variation in the biochemical composition of biomass and the recalcitrance of lignin, the aromatic component of lignocellulose. Therefore, the commercial production of cellulosic ethanol has not yet become well-received commercially, being hampered by high research and production costs, and substantial effort is needed to make it more widespread and profitable. This review summarises the state of the art in bioethanol production from lignocellulosic biomass, highlights the most challenging steps of the process, including pretreatment stages required to fragment biomass components and further enzymatic hydrolysis and fermentation, presents the most recent technological advances to overcome the challenges and high costs, and discusses future perspectives of second-generation biorefineries.

There is world-wide generation of food waste daily in significant amounts, leading to depletion of natural resources and deteriorating air quality. One-third of global food produced is wasted laterally with the food value chain. Carbon footprint is an efficient way of communicating the issues related to climate change and the necessity of changing behavior. Valorization or utilization of food wastes helps in resolving issues related to environment pollution. Reduction in the carbon footprint throughout the chain of food supply makes the whole process eco-friendly. Prevailing food waste disposal systems focus on their economic and environmental viability and are putting efforts into using food waste as a resource input to agriculture. Effective and advanced waste management systems are adopted to deal with massive waste production so as to fill the gap between the production and management of waste disposal. Food waste biorefineries are a sustainable, eco-friendly, and cost-effective approach for the production of platform chemicals, biofuels, and other bio-based materials. These materials not only provide sustainable resources for producing various chemicals and materials but have the potential to reduce this huge environmental burden significantly. In this regard, technological advancement has occurred in past few years that has proven suitable for tackling this problem.

Blue economy, the sustainable and effective use of ocean resources for economic growth, is a major challenge to coastal communities. Marine macroalgae are potentially sustainable feedstock for future food, materials, chemicals, and fuels. For seaweed biorefinery, the fractionation of the biomass to co-produce multiple products is crucial in the efficient valorization of the marine biomass. In this work, we developed a protocol for co-production of six different products from the green macroalga Ulva ohnoi using green extraction methods. A total of 90.31 ± 1.94% of the initial biomass was recovered in separated products. The fraction of the recovered products from initial dry weight biomass was 45.42 ± 1.91% salts, 3.67 ± 1.38% starch, 3.81 ± 1.26% lipids, 13.88 ± 0.40% ulvan, 14.83 ± 1.06% proteins, and 8.70 ± 1.87% cellulose. A potential revenue analyses, based on these experimental data and current market prices, suggests that total the revenue fluctuates between US$1.56 and US$3.93 kg−1 of dry biomass and depends on recovered products fraction in the seaweed biomass and products market value.

Microalgae are increasingly considered as sources of renewable feedstocks for industrial production, and microalgae production now focuses on the multiproduct microalgal biorefinery. However, such a biorefinery presents several bottlenecks that are mainly associated with downstream processes. This reduced downstream efficiency results from unsolved problems related to the culture strategy for the accumulation of different products – the protein versus lipid dilemma – and the dilute nature of the microalgal culture. We identify new trends and propose promising solutions for realizing microalgal biorefineries at industrial scale. New perspectives and challenges are identified in protein properties and in the integration and cooptimization of culture and downstream processes. The exploitation of a single microalgal product is unprofitable and generates undesirable waste, inspiring the biorefinery approach to microalgae production. Several thin culture systems are currently being proposed for intensifying the conversion of light into biomass. Downstream processing, and in particular the fractionation of microalgal components, remains the most expensive step limiting the practical implementation of microalgal biorefineries.

In the current global scenario, the world is under a serious dilemma due to the increasing human population, industrialization, and urbanization. The ever-increasing need for fuels and increasing nutritional problems have made a serious concern on the demand for nutrients and renewable and eco-friendly fuel sources. Currently, the use of fossil fuels is creating ecological and economic problems. Microalgae have been considered as a promising candidate for high-value metabolites and alternative renewable energy sources. Microalgae offer several advantages such as rapid growth rate, efficient land utilization, carbon dioxide sequestration, ability to cultivate in wastewater, and most importantly, they do not participate in the food crop versus energy crop dilemma or debate. An efficient microalgal biorefinery system for the production of lipids and subsequent byproduct for nutraceutical applications could well satisfy the need. But, the current microalgal cultivation systems for the production of lipids and nutraceuticals do not offer techno-economic feasibility together with energy and environmental sustainability. This review article has its main focus on the production of lipids and nutraceuticals from microalgae, covering the current strategies used for lipid production and the major high-value metabolites from microalgae and their nutraceutical importance. This review also provides insights on the future strategies for enhanced microalgal lipid production and subsequent utilization of microalgal biomass. Graphical abstract