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"Blood circulatory system"
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The circulatory story
Your hardworking heart started beating eight months before you were born and continues to beat about one hundred thousand times a day. \"By the time you're seventy years old, it will have beaten about 2.5 billion times.\" Find out the story behind each beat on a journey through the body's circulatory system.
Book
A patient-specific modelling method of blood circulatory system for the numerical simulation of enhanced external counterpulsation
Lumped parameter model (LPM) is a common numerical model for hemodynamic simulation of human’s blood circulatory system. The numerical simulation of enhanced external counterpulsation (EECP) is a typical biomechanical simulation process based on the LPM of blood circulatory system. In order to simulate patient-specific hemodynamic effects of EECP and develop best treatment strategy for each individual, this study developed an optimization algorithm to individualize LPM elements. Physiological data from 30 volunteers including approximate aortic pressure, cardiac output, ankle pressure and carotid artery flow were clinically collected as optimization objectives. A closed-loop LPM was established for the simulation of blood circulatory system. Aiming at clinical data, a sensitivity analysis for each element was conducted to identify the significant ones. We improved the traditional simulated annealing algorithm to iteratively optimize the sensitive elements. To verify the accuracy of the patient-specific model, 30 samples of simulated data were compared with clinical measurements. In addition, an EECP experiment was conducted on a volunteer to verify the applicability of the optimized model for the simulation of EECP. For these 30 samples, the optimization results show a slight difference between clinical data and simulated data. The average relative root mean square error is lower than 5%. For the subject of EECP experiment, the relative error of hemodynamic responses during EECP is lower than 10%. This slight error demonstrated a good state of optimization. The optimized modeling algorithm can effectively individualize the LPM for blood circulatory system, which is significant to the numerical simulation of patient-specific hemodynamics.
Journal Article
The science of the heart and circulatory system
Introduces the workings of the heart and circulatory system in the human body.
Book
MATHEMATICAL MODELS OF HUMAN RESPIRATORY AND BLOOD CIRCULATORY SYSTEMS
Aim. To analyze modern approaches to mathematical modeling of human respiratory and blood circulatory systems. Methods. Comprehensive review of scientific literature sources extracted from domestic and international resources databases. Results. Historical information and modern data concerning mathematical modeling of human functional respiratory and blood circulatory systems were summarized and analyzed in present ¬review; current trends in approaches to the construction of these models were revealed. Conclusions. Currently, two main approaches to the mathematical modeling of respiratory and blood circulatory systems exist. One of them is the construction of models of the mechanics of respiration and blood circulation. They are based on the models of mechanics of solid deformable body, thermomechanics, hydromechanics, and continuum mechanics. This approach uses complex mathematical apparatus, including Navier-Stokes equation, which makes it possible to obtain a number of theoretical results, but it is hardly usable for real problems solutions at present time. The second approach is based on the model of F. Grodins, who represented the process of breathing as a controlled dynamic system, described by ordinary differential equations, in which the process control is carried out according to the feedback principle. There is a significant number of modifications of this model, which made it possible to simulate various disturbing influences, such as physical activity, hypoxia and hyperemia, and to predict parameters characterizing functional respiratory system under these disturbing influences.
Journal Article
Why do I bleed?
\"Want to know how arteries carry oxygen-rich blood throughout our bodies and what blood type means? Fun illustrations and entertaining text help give kids a clear understanding of the blood and circulatory system\"-- Provided by publisher.
Book
Exposure to Agrochemicals and Cardiovascular Disease: A Review
Introduction: In the agricultural world there is a continuous loss of food, fiber and other commodities due to pests, disease and weeds before harvesting time. These losses had create lots of financial burden to the farm owners that might lead to shutting down of their daily business. Worldwide, there is an overall very high loss of agricultural products due to weeds growth alone. To counteract this problem most farmers resort to the use of agrochemicals to increase their production but compromising the health of their farmworkers. The purpose of the study will be to assess the relationship between the agrochemical particles and cardiovascular diseases among farmworkers. Method: Non-systematic review was used to collect data. The following database were use: Medline, EBSCO, and Science Direct to search for the existing journal articles. Results: This study addresses the relationship between agrochemicals particles and cardiovascular diseases in the farming industries using literature review. Discussion: Other researchers had already done an extensive research on the pathway of potential mechanisms linking the ultrafine particulate matter to cardiovascular diseases. The outcomes of those investigations were the clinical results of events that might lead to the development of myocardial infarction, congestive heart failure (CHF), stroke, arrhythmia and sudden death. Xenobiotic compounds that maybe implicated in the pathophysiology of human cardiovascular diseases, will be examined and included in this study. There is compelling evidence suggesting that toxic free radicals of pesticides play an important role in human health. Conclusion: There is a close relationship between agrochemicals particle and cardiovascular diseases.
Journal Article
Cardiovascular Physiology
This chapter reviews the anatomy and physiology of the cardiovascular system of mammals and describes or summarizes the general effects of anesthesia and anesthetic drugs when appropriate. A description of the structure, function, and physiology of the heart, blood and lymph vessels, and blood is followed by a review of hemorrheology, hemodynamics, local and neurohumoral control mechanisms, and the balance between oxygen delivery and oxygen consumption. A brief review of the circulatory system of exotic species is included for comparison and because of their increasing prevalence as pets. The peripheral lymphatic system is not anatomically part of the blood circulatory system and consists of a dense network of channels that function in conjunction with the circulatory system for the one‐way transport of interstitial fluid, proteins, lipids, and waste products back to the blood circulation, via the thoracic duct.
Book Chapter
Anatomy and Physiology
This chapter contains sections titled:
Learning Outcomes
Introduction
Overview of the Circulatory System
Arteries, Veins and Capillaries
Structure of Blood Vessels
The Nervous System
Location of Veins
Systemic Blood Flow
Integumentary System
Conclusion
References
Book Chapter
Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell?
Cancer cells that transit from primary tumours into the circulatory system are known as circulating tumour cells (CTCs). These cancer cells have unique phenotypic and genotypic characteristics which allow them to survive within the circulation, subsequently extravasate and metastasise. CTCs have emerged as a useful diagnostic tool using “liquid biopsies” to report on the metastatic potential of cancers. However, CTCs by their nature interact with components of the blood circulatory system on a constant basis, influencing both their physical and morphological characteristics as well as metastatic capabilities. These properties and the associated molecular profile may provide critical diagnostic and prognostic capabilities in the clinic. Platelets interact with CTCs within minutes of their dissemination and are crucial in the formation of the initial metastatic niche. Platelets and coagulation proteins also alter the fate of a CTC by influencing EMT, promoting pro-survival signalling and aiding in evading immune cell destruction. CTCs have the capacity to directly hijack immune cells and utilise them to aid in CTC metastatic seeding processes. The disruption of CTC clusters may also offer a strategy for the treatment of advance staged cancers. Therapeutic disruption of these heterotypical interactions as well as direct CTC targeting hold great promise, especially with the advent of new immunotherapies and personalised medicines. Understanding the molecular role that platelets, immune cells and the coagulation cascade play in CTC biology will allow us to identify and characterise the most clinically relevant CTCs from patients. This will subsequently advance the clinical utility of CTCs in cancer diagnosis/prognosis.
Journal Article