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Androgynous pantsuits paired with sheer feminine knits, classic shapes in postmodern fabrics, the allure of attractive opposites.

The suburban lady is spring's saucy muse all scarf prints and pantsuits, polka dots and cocktail shakers.

For a no-muss, no-fuss getaway to the land of whitewashed houses and sapphire-blue seas, a suitcaseful of simple shapes in vivid colors is all you need. Vogue goes island-hopping with real-life couple Kirsty Hume and Donovan Leitch.

Observed longitudinal water-surface profiles are commonly used to calibrate river hydrodynamic models, relying on assumptions of lateral uniformity in water surface elevation and velocity distribution. While suitable for 1D models, this approach has limitations in regard to 2D model calibration. When 2D flow measurements are available, a more robust quantitative evaluation is necessary to assess model accuracy. This study introduces a novel methodology to improve 2D model calibration and evaluate performance. High-resolution bathymetric and hydrodynamic data collected with a multibeam echosounder (MBES) and acoustic Doppler current profiler (ADCP) were aligned to compare observed and simulated flow velocities at matching spatial locations. Statistical metrics, including relative mean absolute error and root-mean-square error, were employed to assess hydrodynamic modeling. The methodology was tested using MBES and ADCP measurements alongside TELEMAC-2D simulations of a dynamic neck cutoff on the White River, Arkansas, USA. This approach provides a 2D calibration process, enhancing model accuracy and informing parameter selection, such as channel boundary roughness and downstream boundary water surface elevation.

Background Head and neck cancer (HNC) belongs to a group of heterogeneous disease with distinct patterns of behavior and presentation. TNFRSF10B, a tumor suppressor gene mapped on chromosome 8. Mutation in candidate gene is responsible for the loss of chromosome p arm which is frequently observed in head and neck tumors. TNFRSF10B inhibits tumor formation through apoptosis but deregulation encourages metastasis, migration and invasion of tumor cell tissues. Results Structural modeling was performed by employing MODELLER (9v10). A suitable template [2ZB9] was retrieved from protein databank with query coverage and sequence identity of 84% and 30% respectively. Predicted Model evaluation form Rampage revealed 93.2% residues in favoured region, 5.7% in allowed region while only 1 residue is in outlier region. ERRAT and ProSA demonstrated 51.85% overall quality with a −1.08 Z-score of predicted model. Molecular Evolutionary Genetics Analysis (MEGA 5) tool was executed to infer an evolutionary history of TNFRSF10B candidate gene. Orthologs and paralogs [TNFRSF10A & TNFRSF10D] protein sequences of TNFRSF10B gene were retrieved for developed ancestral relationship. Topology of tree presenting TNFRSF10A gene considered as outgroup. Human and gorilla shared more than 90% similarities with conserved amino acid sequence. Virtual screening approach was appliedfor identification of novel inhibitors. Library (Mcule) was screened for novel inhibitors and utilized the scrutinized lead compounds for protein ligand docking. Screened lead compounds were further investigated for molecular docking studies. STRING server was employed to explore protein-protein interactions of TNFRSF10B target protein. TNFSF10 protein showed highest 0.999 confidence score and selected protein-protein docking by utilizing GRAMM-X server. In-silico docking results revealed I-58, S-90 and A-62 as most active interacting residues of TNFRSF10B receptor protein with R-130, S-156 and R-130 of TNFSF10B ligand protein. Conclusion Current research may provide a backbone for understanding structural and functional insights of TNFRSF10B protein. The designed novel inhibitors and predicted interactions might serve to inhibit the disease. Effective in-vitro potent ligands are required which will be helpful in future to design a drug to against Head and neck cancer disease. There is an urgent need for affective drug designing of head and neck cancer and computational tools for examining candidate genes more efficiently and accurately are required.

Necropsy on an adult male pilot whale stranded in Denmark in an area with heavy boat traffic revealed internal lesions in the head and neck region, while the exterior did not show any visible lesions. We found multiple fractured bones, muscle trauma and extensive hemorrhage including a fractured occipital bone with several fragments and bone pieces deeply embedded into the cerebrum of the brain. The brain was literally smashed while the third and partially fourth cervical vertebrae were almost pulverized surrounded by large amounts of blood and muscle contusion. The whale was likely killed due to a ship collision, and this particular case substantiates the value of always performing full necropsies including incisions in head and neck regions on all stranded whales—especially in areas with heavy boat traffic. This case demonstrates the importance of veterinarians performing full necropsies of whales to rule out other causes of death. Otherwise, ship collisions may be an overlooked issue having implications for population health.