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"Bones Juvenile literature."
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My bones
\"A boy named Jack who has just broken his leg teaches his younger sister Lissa all the things he learned about bones while at the doctor's office getting his cast\"-- Provided by publisher.
Book
A rare association of osteogenesis imperfecta and juvenile idiopathic arthritis: case reports and literature review
Background. Osteogenesis imperfecta (OI) is a genetic disorder of connective tissues caused by an abnormality in the synthesis or processing of type I collagen. The combination of OI and inflammatory arthritis is rare. Our literature review identified 5 cases of OI-related inflammatory arthritis, but only 2 of these cases have been reported in children. Case Report. We present 3 cases diagnosed with OI and juvenile idiopathic arthritis (JIA). Two were diagnosed with enthesitis-associated arthritis, and one was diagnosed with oligoarticular JIA with laboratory findings and a magnetic resonance imaging examination. Only one of the patients had a previously diagnosed OI. For the others, whole gene sequence analysis was performed, and a mutation in the collagen type I alpha 1 (COL1A1) gene was detected. Identifying and treating inflammatory arthritis in our patients with OI improved their joint pain. Conclusion. Musculoskeletal pain is a common issue in individuals with OI and JIA. Considering children with OI may also develop arthritis, early diagnosis, and accurate treatment may be crucial. Recognizing the rare association between JIA and OI is important, as investigating this relationship could help alleviate the disease burden. Thorough evaluation and prompt diagnosis of JIA in patients with OI can significantly reduce the impact of the disease.
Journal Article
Management of juvenile and aneurysmal bone cysts: a systematic literature review with meta-analysis
PurposeNumerous approaches to the management of juvenile and aneurysmal bone cysts (ABC) are described in the specialist literature together with discussion of the associated healing and recurrence rates. Since there is currently no evidence-based treatment standard for these conditions, the aim of this systematic literature review with meta-analysis was to examine the different management approaches, evaluate the corresponding clinical outcomes and, as appropriate, to formulate a valid treatment recommendation.MethodsA systematic search on OVID Medline® based on a pre-existing search strategy returned 1333 publications. Having defined inclusion and exclusion criteria and analysis of the relevant full texts, 167 publications were included in the descriptive analysis and 163 in the meta-analysis. For this purpose, different subgroups were created, based on the type of cyst and the therapeutic procedure. Those subgroups were then analysed in relation to their healing rates, the number of recurrences and complication rates.ResultsFor aneurysmal bone cysts, both surgical removal and Doxycycline injection lead to excellent outcomes (98% healing) and low recurrence rates (6% and 11% resp.). Curettage (91% healing), including its combination with autologous cancellous bone graft (96% healing), showed very good healing rates but higher recurrence rates (22% and 15%, resp.), which were however improved by preoperative selective arterial embolization. A critical view must be taken of radiotherapy (90% healing) and the injection of alcohol (92% healing) because of their high complication rates (0.43/cyst and 0.42/cyst, resp.). In the management of juvenile bone cysts, surgical interventions like curettage and cancellous bone graft (87% healing) are far superior to non-surgical approaches (51% healing), furthermore, the application of autologous cancellous bone graft reduced the recurrence rate (3% recurrence) compared to curettage alone (20% recurrence). In subgroup analysis, treatment by ESIN was found to produce excellent outcomes (100% healing), though the patient collectives were small.ConclusionSurgical procedures to treat aneurysmal bone cysts appear to be the method of choice whereby Doxycycline injection may be an alternative. A surgical approach should be preferred in the treatment of juvenile bone cysts.
Journal Article
Case reports with literature review of an aneurysmal bone cyst in the maxilla and mandible of two juvenile dogs
This report identifies two cases of juvenile dogs with an aneurysmal bone cyst (ABC). The first case describes an ABC in the left rostral mandible, and the second case describes an ABC in the right maxilla. ABCs are typically identified in juvenile or young animals and have been reported in a variety of species. An ABC results from the intraosseous expansion of soft or immature bone and is more appropriately identified as a pseudocyst due to the absence of an epithelial lining. An ABC is most likely believed to be caused by trauma, which contributes to the formation of an expansile, blood-filled lesion encased with immature, proliferative bone. The classic presentation is an osteolytic, cavitated lesion in the metaphysis region of long bones. Both diagnostic imaging and histopathology are required for the diagnosis of an ABC, with differential diagnoses being fibrosarcoma, osteolytic osteosarcoma, osteoblastic or giant cell tumor, the unilocular membrane-lined simple bone cyst, ameloblastoma, fibro-odontoma, and papillary squamous cell carcinoma. In human medicine, ABCs are found in the head and neck region in 2–12% of reported cases, with 60–70% of the cases occurring in the jaws. Aneurysmal bone cysts in the maxillofacial region of the dog are a rare finding in veterinary medicine and are currently without confirmed etiopathogenesis. The following case reports describe an ABC in the left rostral mandible of a 7-month-old dog treated with complete excision and an ABC in the right maxilla of a 12-week-old dog treated with incisional biopsy and curettage that showed resolution of right facial swelling before being lost to follow-up. These cases and literature review add to the paucity of veterinary literature regarding aneurysmal bone cysts in dogs and provide case descriptions and treatment recommendations for this rare juvenile lesion.
Journal Article
Bones : skeletons and how they work
A guide to human and animal skeletons which provides comparisons and outlines such facts as the number of bones in the human body and the ways that skeletal structures work.
Book
Intra- and Juxta-Articular Osteoid Osteoma Mimicking Arthritis: Case Series and Literature Review
Background: Intra- and juxta-articular osteoid osteomas are rare, representing less than 10% of all osteomas. Compared to the classic diaphyseal or metaphyseal site of long bones, they often have an atypical onset, a longest diagnostic delay, and frequent initial misdiagnoses, with pictures that can mimic inflammatory monoarthritis. We aimed to describe a case series, and to provide a literature review of this uncommon and misleading tumor location. Methods: We performed a retrospective analysis of patients referred to three pediatric rheumatology centers, with a final diagnosis of articular osteoid osteoma. A review of the literature was additionally conducted. Results: We included 10 patients with a mean age of 14 years. All patients with unusual sites (olecranon fossa, lumbar vertebra, distal phalanx of the toe, fibula) had a misdiagnosis, and cases with initial suspicion of monoarthritis had the longest diagnostic delay, up to 24 months. The literature review confirms the significant risk of misdiagnosis, and an average time from symptom onset to diagnosis ranging from 0.4 to 1.8 years. Conclusions: Articular osteoid osteoma may mimic arthritis, especially in adolescence. Knowledge of the atypical forms of presentation, and of the clinical and radiological pitfalls, reduces the risk of diagnostic error.
Journal Article
Book of bones : 10 record-breaking animals
\"Ten record-breaking animal bones are introduced through a series of superlatives set up as a guessing game with clues. Readers examine animals' skeletons and guess to whom they belong; the answers are revealed in vibrant, full-color scenic habitats, with easily understood -- and humorous -- explanations. This entertaining introduction to the connection between animal bones (anatomy) and behavior is playful, relatable, and includes touch-and-feel finishes that bring the bones to life!\"--Publisher's description.
Book
Phenotypic variability in a child with Felty’s syndrome: a case report
Background
Felty’s syndrome (FS) is characterized by the triad of rheumatoid arthritis (RA), splenomegaly and neutropenia. The arthritis is typically severe and virtually always associated with high-titer rheumatoid factor. The presence of persistent neutropenia is generally required to make the diagnosis. Most patients diagnosed with FS are aged 50–70 years and have had RA for more than 10 years. It is rarely seen in patients with juvenile idiopathic arthritis (JIA), with only five cases having been reported throughout the world.
Case presentation
The present study describes the case of a 14-year-old female with a seven-year history of polyarticular JIA, presenting with splenomegaly, hepatomegaly, cholestasis and thrombocytopenia. However, she occasionally developed neutropenia. Titers of rheumatoid factor and anti-CCP were persistently high, and the antinuclear antibody titer was 1:320, while the antibody results for anti-dsDNA and anti-Sm were negative. Serum levels of IgA, IgG, IgM and IgE were all persistently elevated, and the ratio of CD19
+
lymphocytes in the subgroups of lymphocytes was persistently high. The level of complements was normal. No STAT3 and STAT5B mutations were found by next-generation sequencing. The patient did not respond to methotrexate, prednisolone, hydroxychloroquine (HCQ), sulfasalazine and etanercept but was responsive to rituximab.
Conclusions
JIA, thrombocytopenia and splenomegaly are the most common and important features in six children with FS, while persistent neutropenia is not seen in all these patients. No complement deficiency has been found in children with FS so far. Manifestations of FS without neutropenia may be extremely rare. There are differences between adults and children in the clinical and laboratory features of FS.
Journal Article