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\"QUICK: Name the most powerful and complex supercomputer ever built. Give up? Here's a hint: It's housed in your head and it's the one thing that makes you YOU. Your brain is mission control for the rest of your body and steers you through life. Not bad for something the size of a softball that looks like a wrinkled grey sponge! In this fascinating, interactive book-- a companion to the National Geographic Channel hit show-- kids explore the parts of the brain and how it all works, brainy news nuggets from a neuroscientist, plus fun facts and crazy challenges\" -- provided by publisher.

In this provocative study, Michael R. Trimble, M.D., tackles the interrelationship between brain function, language, art—especially music and poetry—and religion. By examining the breakdown of language in several neuropsychiatric disorders, he identifies brain circuits that are involved with metaphor, poetry, music, and religious experiences. Drawing on this body of evidence, Trimble argues that religious experiences and beliefs are explicable biologically and relate to brain function, especially of the nondominant hemisphere. Inspired by the writings and reflections of his patients—many of whom have epilepsy, psychosis, or affective disorders—Trimble asks how the human species, so enamored of its own logic and critical facilities, has held from the dawn of civilization strong religious beliefs and a reverence for the arts. He explores topics such as the phenomena of hypergraphia and hyper-religiosity, how religious experiences and poetic expression are neurologically linked with our capacity to respond to music, and how neuropsychiatric disorders influence behaviors related to artistic expression and religiosity by disturbing brain function. With the sensitivity of a dedicated doctor and the curiosity of an accomplished scholar, Trimble offers an insightful analysis of how the study of people with paradigmatical neuropsychiatric conditions can be the cornerstone to unraveling some of the mysteries of the cerebral representations of our highest cultural experiences.

The authors offer research-based answers to an array of questions about how the brain works.

Abstract PurposeQuantitative SPECT-CT is a modality of growing importance with initial developments in post radionuclide therapy dosimetry, and more recent expansion into bone, cardiac and brain imaging together with the concept of theranostics more generally. The aim of this document is to provide guidelines for nuclear medicine departments setting up and developing their quantitative SPECT-CT service with guidance on protocols, harmonisation and clinical use cases.MethodsThese practice guidelines were written by members of the European Association of Nuclear Medicine Physics, Dosimetry, Oncology and Bone committees representing the current major stakeholders in Quantitative SPECT-CT. The guidelines have also been reviewed and approved by all EANM committees and have been endorsed by the European Association of Nuclear Medicine.ConclusionThe present practice guidelines will help practitioners, scientists and researchers perform high-quality quantitative SPECT-CT and will provide a framework for the continuing development of quantitative SPECT-CT as an established modality.

An introduction to the human brain uses quizzes, trivia, and puzzles to explore the different functions of the brain, how to improve brain power, and why each brain is unique.

The use of CT scanning is associated with a radiation risk to children. The younger the child, the higher the risk, with perhaps three times the risk of leukaemia or neurological malignancies in some cases. Over the last few decades, there has been an increase use of CT scanning in trauma, but the yield from CT scanning, in cases of blunt abdominal trauma and head injury is low with only 1%–2% of cases requiring an intervention. So choosing when to scan and when not to scan has been a major point of research and clinical focus over the last decade. A number of clinical prediction rules have been developed to try to answer this question such as the Canadian Assessment of Tomography for Childhood Head injury and the Children’s Head injury Algorithm for the prediction of Important Clinical Events. Holmes et al (Lancet Child Adolesc Health 2024;8:339–47) have externally validated the Pediatric Emergency Care Applied Research Network (PECARN) prediction rules in a prospective validation study, examining patients younger than 18 years from six emergency departments in USA over a 5-year period. This is a large study, which included 7542 children with blunt abdominal trauma and 19 999 children with minor head trauma with prospective clinical use of the appropriate PECARN prediction rules by the clinicians involved in initial management. Acute intervention was defined, for abdominal trauma, as intravenous fluid for ≥2 days for pancreatic or gastrointestinal injuries, blood transfusion, therapeutic laparotomy, angiographic embolisation or death from intra-abdominal injury. Acute intervention for traumatic head injury was defined as intubation for >24 hours (for the head injury) or hospital admission ≥2 nights for ongoing symptoms and CT-confirmed traumatic brain injury; neurosurgery, or death from traumatic brain injury. The intra-abdominal injury rule had a sensitivity of 100.0% (95% CI 98.0 to 100.0) and a negative predictive value (NPV) of 100.0% (95% CI 99.9 to 100.0). The traumatic brain injury rule for children younger than 2 years had a sensitivity of 100.0% (93.1 to 100.0; 42 of 42) an NPV of 100.0%; 99.9 to 100.0) and in children aged 2 years and older had a sensitivity of 98.8% (95.8 to 99.9; 168 of 170) and an NPV of 100.0% (99.9 to 100.0; 6015 of 6017). It is important to realise that these rules have been established to identify those children who do not need CT scanning. They are for use to exclude serious acute injury requiring intervention; they are not there to tell you who to scan. It is the absence of the 6–7 features in each rule, which helps the clinicians conclude that CT scan is not warranted. Many families expect a CT scan (or a skull X-ray) to be ordered in children who have had minor head trauma or minor blunt abdominal trauma and it is sometimes hard to persuade the parents that a scan (or skull X-ray) is not necessary. This paper is reassuring and certainly helps decision-making and reducing unnecessary radiation exposure.