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Long-term spaceflight induces multisystem stress, including cardiovascular deconditioning, skeletal muscle atrophy, immune suppression, and neuro-ocular syndromes. Current countermeasures reduce symptoms but cannot replicate the synergistic resilience needed for extended missions or critical illness. Hibernating animals, specifically brown bears (Ursus arctos), survive prolonged immobility, starvation, and bradycardia without resultant pathology. This review incorporates adaptations observed in bears and certain torpid species, including reversible insulin resistance, suppression of muscle atrophy genes MuRF1 and Atrogin-1, and maintenance of the heart despite seasonal production decline. The thirteen-lined ground squirrels (Ictidomys tridecemlineatus) maintain retinal structure and synaptic stability throughout torpor, avoiding neuro-ocular complications despite prolonged inactivity. Mechanisms span from RBM3-dependent synaptic maintenance, titin isoform remodeling under the control of RBM20, mTOR and FOXO pathway regulation, remodeled hydrogen sulfide metabolism, and microbiome-mediated nitrogen salvage. These adaptations are different from human adaptation to microgravity and disuse and offer translational candidates for synthetic torpor, probiotic engineering, neuroprotection, and protein-sparing therapy. Hibernators are not passive stress subjects; they perform coordinated anticipatory responses in multiple organs. Comparing these systems in large and small hibernators, we aim to uncover a biologically realistic path to human resilience. These findings guide a shift from reactive, pharmacological measures for preserving human health during space flight, intensive care, and extreme environments towards proactive, biologically initiated measures.

Beyond killing Black males, US law enforcement continues to treat Black boys/men as threats to be neutralized even when not armed or resisting. In this study I investigate 15 Black men’s narratives to provide a deeper understanding of Black male vilification and vulnerabilities in police encounters insofar as being targeted and searched. Using Afropessimism’s tenet of social death and Critical Race Methodology: Counterstorytelling this study answers, (a) how do Black men describe being targeted by US police officers, and (b) what experiences do Black males encounter with police officers’ searches? Findings elucidate how Black males face a dual death even when no threats exist, therefore having their freedom(s) infringed. Conclusions inform psychological reforms and discretionary search policies.

The crisis in the Middle East escalates. The family of AndrewBrown Jr. gets access to bodycam footage of his final moments.

New CDC guidance says, fully vaccinated people can go masklessoutdoors, attend small outdoor gatherings with unvaccinated people.CDC says keep masks on indoors in public places even if vaccinated.Fully vaccinated people can unmask outdoors if they are walking,running or biking alone or with members of their household. Censusshows U.S. population grew at the second-slowest pace in history.Census announces changes to U.S. House seat apportionment. New censusdata shifts power to Republican strongholds. 2020 census data showssouth, west seize more power as population grows GUESTS: Marq Claxton, Michael Brooks

News conference from the attorneys and the family of AndrewBrown Jr., who was shot and killed by police.

CNN has just obtained the death certificate of Andrew Brown,Jr. He's the black man shot and killed by sheriff's deputies in NorthCarolina. It says Brown died of a, quote, \"Penetrating gun shot woundto the head and died within minutes of being shot.\" The certificatecalls Brown's death a homicide, saying Brown was shot by others. Nowthis comes as calls for the police body-cam footage grow louder.Attorneys for the Brown family spoke just moments ago at a pressconference. Attorney Benjamin Crump, who's representing the familymakes announcement that the family would now be seeing the video at1:30 this afternoon.

GENETICS, Vol. 211, March 2019, Copyright © 2019 Cell cycle-regulated transcription of CENP-A by the MBF complex ensures optimal level of CENP-A for centromere formation, pp. 861-875 David Aristizabal-Corrales, Jinpu Yang, and Fei Li In most eukaryotes, the histone H3 variant CENP-A serves as the epigenetic mark for centromeres. Through a genetic screen, Aristizabal-Corrales, Yang, and Li identify the MBF complex as a key regulator of temporal control of CENP-A transcription in fission yeast, providing insight into the mechanism for regulating cell cycle-dependent CENP-A transcription. Establishment and maintenance of chromatin architecture are promoted independently of transcription by the histone chaperone FACT and H3-K56 acetylation in Saccharomyces cerevisiae, pp. 877-892 Laura L. McCullough, Trang H. Pham, Timothy J. Parnell, Zaily Connell, Mahesh B. Chandrasekharan, David J. Stillman, and Tim Formosa Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and Pham et al. explore how the histone:DNA contact at the entry/exit site of nucleosomes affects the functions of the histone chaperone FACT in the yeast Saccharomyces cerevisiae.

Body cam footage of Brown shooting shown publicly for firsttime. District attorney says, deputies won't be charged in Brown'sdeath. District attorney says, Brown's actions clearly endangeredofficers. Biden expresses support for a ceasefire in call withNetanyahu. Israeli Prime Minister Netanyahu says offensive operationswill continue as necessary. Hamas-run health ministry says 213 killedin Gaza, Israel reports 12 killed since last week GUESTS: William Moss

The Taliban denied any involvement in multiple explosions thathave rocked a school in the Afghan capital of Kabul which killed 30students and dozens more were injured. A 20-ton, five meters indiameter debris of a Chinese rocket is expected to enter the earth'satmosphere between 7:30 p.m. Eastern time tonight, and 3:30 a.m.Sunday morning. Restaurant owner Caroline Styne talks about the storyof her restaurant manager who had decided to move to Bend, Oregon withfamily as L.A. is so expensive. GUESTS: Chance Lynch, Harry Daniels, Caroline Styne, Peter Hepburn,Jayne Morgan

President is on the road to pitch his infrastructure, jobs andeducation plans. GOP Senator Romney booed while speaking at Utah GOPconvention. GOP Representative Cheney says, the 2020 presidentialelection was not stolen. Biden on road promoting $2 trillioninfrastructure plan and $1.8 trillion American Families Plan. Bidensays, time for corporations, wealthiest Americans to pay fair share oftaxes. Biden says, trickle-down economy has never worked.