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Mutations in multiple oncogenes including KRAS, CTNNB1, PIK3CA and FGFR2 have been identified in endometrial cancer. The aim of this study was to provide insight into the clinicopathological features associated with patterns of mutation in these genes, a necessary step in planning targeted therapies for endometrial cancer. 466 endometrioid endometrial tumors were tested for mutations in FGFR2, KRAS, CTNNB1, and PIK3CA. The relationships between mutation status, tumor microsatellite instability (MSI) and clinicopathological features including overall survival (OS) and disease-free survival (DFS) were evaluated using Kaplan-Meier survival analysis and Cox proportional hazard models. Mutations were identified in FGFR2 (48/466); KRAS (87/464); CTNNB1 (88/454) and PIK3CA (104/464). KRAS and FGFR2 mutations were significantly more common, and CTNNB1 mutations less common, in MSI positive tumors. KRAS and FGFR2 occurred in a near mutually exclusive pattern (p = 0.05) and, surprisingly, mutations in KRAS and CTNNB1 also occurred in a near mutually exclusive pattern (p = 0.0002). Multivariate analysis revealed that mutation in KRAS and FGFR2 showed a trend (p = 0.06) towards longer and shorter DFS, respectively. In the 386 patients with early stage disease (stage I and II), FGFR2 mutation was significantly associated with shorter DFS (HR = 3.24; 95% confidence interval, CI, 1.35-7.77; p = 0.008) and OS (HR = 2.00; 95% CI 1.09-3.65; p = 0.025) and KRAS was associated with longer DFS (HR = 0.23; 95% CI 0.05-0.97; p = 0.045). In conclusion, although KRAS and FGFR2 mutations share similar activation of the MAPK pathway, our data suggest very different roles in tumor biology. This has implications for the implementation of anti-FGFR or anti-MEK biologic therapies.

(Marketwired - Dec. 21, 2016) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE:NHK) is pleased to report final drill results from its summer 2016 program on the Colomac Gold Project, Northwest Territories (\"NWT\") (Figure 1 - Table 1 and 2). The Company has now released results on 8,400 metres (34 holes) of drilling that successfully delineated recently discovered high-grade gold Zone 1.5 (September 13, 2016; October 12, 2016,), highlighted by 52.07 metres (\"m\") of 7.72 grams per tonne (\"g/t\") gold (uncut), and 72.65 m of 5.58 g/t gold (uncut - Figure 2), and tested other potential high-grade prospects including Zone 2.5 (November 24, 2016) highlighted by 57.00 m (37.00 m true width) of 1.47 g/t gold, including 13.50 m of 2.82 g/t gold; and Zone 1.0 highlighted by 55.95 m (40.00 m true width) of 1.09 g/t gold, including 9.00 m of 2.36 g/t gold. \"Consistent positive results strengthen our belief that Colomac will continue to deliver numerous opportunities for expansion of known high-grade zones, and overall resource growth,\" said Dr. [Michael J. Byron, Ph.D.], President and CEO. \"Current drilling has effectively extended Zone 3.0 northward towards less defined Zone 2.5, emphasizing the zone's untapped potential for resource expansion and high-grade zone development laterally and to depth. Goldcrest hole G16-10 confirms continuity to depth of a previously reported gold zone, while G16-07 has intersected yet another zone of broad, potentially high-grade, gold mineralization of underexplored extensions. We are particularly excited to resume drilling at Zone 1.5, trace it to depth and test for the potential coalescence of high-grade Zones 2.0 and 1.5, a priority target area, that if proven, would become the deposits largest zone and host significant ounces of higher grade mineralization,\" added Dr. Byron. Nighthawk is a Canadian-based exploration company focused on acquiring and developing gold mineral properties in the Northwest Territories. Including the mineral claims and leases of the Colomac Gold Project, Nighthawk's Indin Lake Gold Property comprises a total land package of 222,203 acres in the Indin Lake Greenstone Belt, located approximately 200 kilometres north of Yellowknife, Northwest Territories and includes an Inferred Mineral Resource estimate, prepared in accordance with National Instrument 43-101 (\"NI 43-101\"), of 39.815 million tonnes with an average grade of 1.64 g/t gold for 2.101 million ounces gold using a cut-off grade of 0.6 g/t gold. Nighthawk also holds a 100% interest in the property known as the Superior Project, which covers 39,015 acres approximately 85 kilometres north of Sault Ste. Marie, Ontario.

(Marketwired - Dec. 21, 2016) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE:NHK) is pleased to report final drill results from its summer 2016 program on the Colomac Gold Project, Northwest Territories (\"NWT\") (Figure 1 - Table 1 and 2). The Company has now released results on 8,400 metres (34 holes) of drilling that successfully delineated recently discovered high-grade gold Zone 1.5 (September 13, 2016; October 12, 2016,), highlighted by 52.07 metres (\"m\") of 7.72 grams per tonne (\"g/t\") gold (uncut), and 72.65 m of 5.58 g/t gold (uncut - Figure 2), and tested other potential high-grade prospects including Zone 2.5 (November 24, 2016) highlighted by 57.00 m (37.00 m true width) of 1.47 g/t gold, including 13.50 m of 2.82 g/t gold; and Zone 1.0 highlighted by 55.95 m (40.00 m true width) of 1.09 g/t gold, including 9.00 m of 2.36 g/t gold. \"Consistent positive results strengthen our belief that Colomac will continue to deliver numerous opportunities for expansion of known high-grade zones, and overall resource growth,\" said Dr. [Michael J. Byron, Ph.D.], President and CEO. \"Current drilling has effectively extended Zone 3.0 northward towards less defined Zone 2.5, emphasizing the zone's untapped potential for resource expansion and high-grade zone development laterally and to depth. Goldcrest hole G16-10 confirms continuity to depth of a previously reported gold zone, while G16-07 has intersected yet another zone of broad, potentially high-grade, gold mineralization of underexplored extensions. We are particularly excited to resume drilling at Zone 1.5, trace it to depth and test for the potential coalescence of high-grade Zones 2.0 and 1.5, a priority target area, that if proven, would become the deposits largest zone and host significant ounces of higher grade mineralization,\" added Dr. Byron.

(Marketwired - November 24, 2016) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE: NHK) is pleased to announce the latest results from its 2016 drill program on its Indin Lake Gold Property in the Northwest Territories (\"NWT\") (Figure 1 | Table 1 and 2). Nighthawk previously reported on the discovery and delineation of high-grade gold Zone 1.5 (September 13, 2016; October 12, 2016), highlighted by intersections of 52.07 metres (\"m\") of 7.72 grams per tonne (\"g/t\") gold (uncut), and 72.65 m of 5.58 g/t gold (uncut), including 17.80 m of 17.72 g/t gold (uncut | Figure 2). The Company is now broadening its exploration targeting and drill testing other potential high-grade prospects along the seven kilometre Colomac sill and parallel Goldcrest sill 400 m to the west. Results are presented for Zones 1.0 and 2.5, two new Colomac high-grade gold zone candidates, as well as near surface resource expansion targets at Zone 3.5 and Goldcrest (Figure 1). From drill start-up (July 5, 2016 news release) to program conclusion in late September, 34 drillholes (8,400 m) were completed. Results from 12 of those holes (2,852 m) are presented in Tables 1 and 2 below. \"The current results strengthen our long held belief that Colomac offers immense opportunities for discovery of new zones, the expansion of known zones, and for continued success in unearthing additional high-grade domains,\" said Dr. [Michael J. Byron, Ph.D.], President and CEO. \"In particular, the latest Zone 2.5 results not only reinforce our position that high-grade gold zones exist that were previously overlooked, but also speaks to the vast near-surface resource expansion potential at Colomac. In addition, our continued positive Zone 1.0 drill results reaffirm its capacity to host higher grade mineralization similar to Zone 1.5, effectively opening up a previously untested and under-explored two kilometre section of the sill. We remain convinced that we are on the right track to continue to unlock Colomac's high grade opportunities. These distinct zones are a new reality and as such will positively impact resource growth, and as we continue to advance Colomac's evolving high-grade nature, we in turn escalate the significance and value of our many satellite deposits and prospects within our regional land package,\" added Dr. Byron. Holes C16-07 and C16-07B tested a potential higher grade gold target located between Zone 2.5 and Zone 2.0 (Figure 1), that also corresponds to an untested gap in mineralization. C16-07 intersected a broad area of mineralization, returning 44.00 m (33.00 m true width) of 1.29 g/t gold that included 29.50 m (22.00 m true width) of 1.69 g/t gold, and including 16.80 m of 1.92 g/t gold. Hole C16-07B, drilled from the same setup but at a steeper angle, intersected better values (Figure 3) including 57.00 m (37.00 m true width) of 1.47 g/t gold, including 34.65 m of 1.88 g/t gold, and 13.50 m of 2.82 g/t gold. These reported true widths are consistent with widths of known high-grade zones such as Zone 1.5; however additional drilling is required to test for the existence of a discrete higher grade core. Given that Colomac high-grade zones may be upwards of 125 m in strike length, tighter spaced drilling is being considered as holes C16-07 and C16-07B may lie lateral to higher-grade shoots. Detailed geological models are currently being updated to help define future drilling in the area.

(Marketwired - Oct. 12, 2016) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE:NHK) today announced that recent drilling has defined the near surface boundaries and dimensions of Zone 1.5, and accordingly, supports the existence of constrained high-grade domains within the Colomac mineralized system. Nighthawk previously reported results from step-out drilling at this newly discovered zone (see September 13, 2016 news release) where C16-03 intersected 52.07 metres (40 metres true width) of 7.72 g/t gold, including 25.47 metres of 14.25 g/t gold, and including 12.35 metres of 9.58 g/t gold. Today's results show that the zone continues uninterrupted down plunge and supports its continuity of mineralization to depth, as C16-03B cut 72.65 metres (50 metres true width) of 5.58 g/t gold, including 17.80 metres of 17.72 g/t gold, 100 metres below the C16-03 intersection (Figures 1, 2, 3 / Table 1). \"We've always considered the existence of distinct higher-grade domains as a very real opportunity at Colomac, although previous to this drilling they had yet to be constrained,\" said Dr. [Michael J. Byron, Ph.D.], President and CEO. \"In our June 20, 2012 news release the similarities between Colomac and Kalgoorlie, one of the world's largest Archean gold camps, was first discussed. The Western Australian analogue and Colomac are hosted by a fractionated mafic intrusion where gold is concentrated within its more silica-rich upper portions. Kalgoorlie hosts higher grade gold zones, but at Colomac the existence of similar zones had never been documented. Realizing that opportunity, we targeted Zone 1.5 based on the Kalgoorlie model, and that approach resulted in the discovery of the high-grade gold zone in 2014, in effect endorsing the analogue and our exploration strategies based on it. Discoveries of this size and continuity have radically changed our understanding of Colomac, as higher grade zones represent an exciting new resource expansion opportunity,\" commented Dr. Michael Byron. Four of the eight holes announced today were drilled at Zone 1.5 to help constrain its near-surface dimensions (Figure 1). C16-03B was collared from the same setup as previously reported C16-03 (see September 13, 2016 news release), but drilled at a steeper angle to test the zone 100 metres below the C16-03 intersection. The hole intersected 72.65 metres (50 metres true width) of 5.58 g/t gold (uncut), including 17.80 metres of 17.72 g/t gold (uncut), confirming the zone's consistency in grade and width to depth (Figure 3). Three holes (C15-06, C16-03, C16-03B) have now been drilled on this section, 25 metres north of the initial discovery hole C14-06, and collectively show great consistency in the nature of the zone's mineralization and overall continuity to depth (Figure 4).

Hole C16-03 was drilled 75 metres north of C16-01 on the same section as C15-06 (Figure 1), a 2015 hole that extended the zone northward by intersecting 31.20 metres of 3.89 g/t gold, including 22.50 metres of 5.03 g/t gold, and including 5.75 metres of 10.43 g/t gold (see October 26, 2015 news release). C16-03 was laid out to test the upward projection of mineralization cut by C15-06. At 100 metres vertical depth and 65 metres above the C15-06 intersection, C16-03 intersected 52.07 metres of 7.72 g/t gold, including 25.47 metres of 14.25 g/t gold, and including 12.35 metres of 9.58 g/t gold (Figure 4). As one of the best holes ever reported at Colomac, C16-03 also illustrates the zone's strong internal continuity as high-grade mineralization has now been traced to over 200 metres vertical depth on this section.

(Marketwired - Sept. 13, 2016) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE:NHK) is pleased to announce initial results from its ongoing 2016 drill program on its Indin Lake Gold Property in the Northwest Territories (\"NWT\") (Figure 1 / Table 1). In July 2016, the Company launched a 10,000 metre program (see July 5, 2016 news release) to advance delineation of the recently discovered high-grade gold mineralization at Zone 1.5 and to resume exploration for additional higher-grade domains, with the objective of expanding our current resource. Two drills are actively testing priority targets at both the Colomac and Goldcrest deposits. Results from 5 drillholes at Colomac Zone 1.5 are presented below. Results announced today are from five holes laid out to better define Zone 1.5 dimensions and to test for continuity along strike and to depth. Drillholes C16-01 and 01B were collared 25 metres south of C15-05 and 05B (Figure 1), two holes drilled in 2015 as step-outs from the initial 2014 discovery hole C14-06. Both holes intersected significant mineralization over widths typical of Zone 1.5 mineralization indicating that the zone extends southward as C16-01 returned 4.14 g/t gold over 31.45 metres, and C16-01B 39.60 metres of 2.38 g/t gold (Figure 3). Holes C16-02 and 02B were step-out holes 25 metres south of C16-01 and 01B. Although mineralization was intersected by both holes, it was weaker and over narrower widths, suggesting the high-grade portion of Zone 1.5 was not intersected, and that the southern boundary of this north plunging mineralized shoot may lie between the sections drilled by C16-01 and C16-02. Hole C16-03 was drilled 75 metres north of C16-01 on the same section as C15-06 (Figure 1), a 2015 hole that extended the zone northward by intersecting 31.20 metres of 3.89 g/t gold, including 22.50 metres of 5.03 g/t gold, and including 5.75 metres of 10.43 g/t gold (see October 26, 2015 news release). C16-03 was laid out to test the upward projection of mineralization cut by C15-06. At 100 metres vertical depth and 65 metres above the C15-06 intersection, C16-03 intersected 52.07 metres of 7.72 g/t gold, including 25.47 metres of 14.25 g/t gold, and including 12.35 metres of 9.58 g/t gold (Figure 4). As one of the best holes ever reported at Colomac, C16-03 also illustrates the zone's strong internal continuity as high-grade mineralization has now been traced to over 200 metres vertical depth on this section.

Nighthawk Gold Corp. (\"Nighthawk\") (TSX VENTURE:NHK) is pleased to announce the initiation of its 2016 drill program at the Colomac Gold Project's Colomac and Goldcrest deposits, located within its 100% owned Indin Lake Gold Property in the Northwest Territories. Two drill rigs will be utilized for this 10,000 metre (\"m\") program expected to be completed by late September. Drilling will continue to expand recently discovered high-grade gold mineralization at Colomac, and follow-up on the 2014 drilling results at Goldcrest, the sister intrusion to Colomac located 400 metres west. Nighthawk President and CEO, Dr. [Michael J. Byron, Ph.D.], commented, \"We are extremely encouraged with the success of our previous exploration programs in advancing the Colomac Gold Project. This success is probably best demonstrated by the new high-grade discovery at Zone 1.5, and the realization that the intrusion can host higher grade domains. Given Colomac's relatively underexplored state, we believe there is strong potential for substantial growth beyond the current resource estimate of 2.101 million ounces gold at 1.64 grams per tonne. Nighthawk's significantly low discovery cost of $8 per ounce, with 97.6% of its holes intersecting gold mineralization, speaks to the scale of opportunity at hand.\" Nighthawk is a Canadian-based exploration company focused on acquiring and developing gold mineral properties in the Northwest Territories. Including the mineral claims and leases of the Colomac Gold Project, Nighthawk's Indin Lake Gold Property comprises a total land package of 222,203 acres in the Indin Lake Greenstone Belt, located approximately 200 kilometres north of Yellowknife, Northwest Territories and includes an Inferred Mineral Resource estimate, prepared in accordance with National Instrument 43-101 (\"NI 43-101\"), of 39.815 million tonnes with an average grade of 1.64 g/t gold for 2.101 million ounces gold using a cut-off grade of 0.6 g/t gold. Nighthawk also holds a 100% interest in the property known as the Superior Project, which covers 39,015 acres approximately 85 kilometres north of Sault Ste. Marie, Ontario.

(Marketwired - Nov. 6, 2015) - Nighthawk Gold Corp. (\"Nighthawk\" or the \"Company\") (TSX VENTURE:NHK) announces that Dr. Michael Byron, the Company's Chief Geologist, has been appointed President and Chief Executive Officer. Concurrently, David Wiley has resigned as President and Chief Executive Officer and as a member of the Board of Directors of Nighthawk.

Dr. Byron is a highly respected geologist with more than 22 years of domestic and international experience including research, field work and senior management experience in gold, base-metal, magmatic nickel-copper-platinum group elements, rare earth elements, diamond and gemstone exploration. He has experience in a variety of sectors including the mineral exploration industry, government and educational institutions. His Ph.D. involved in-depth studies of the mafic ultrapotassic volcanic rocks (kamafugites, lamproites, kimberlites) of the Upper Cretaceous Mata da Corda Formation, Minas Gerais, Brazil, a region with a long history of diamond exploration and alluvial diamond production, and one of the regions where Brazilian Diamonds is currently active.