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Catastrophic health events are natural or man-made incidents that create casualties in numbers that overwhelm the response capabilities of healthcare systems. Proper response planning for such events requires community-based surge solutions such as the location of alternative care facilities and ways to improve coordination by considering triage and the movement of self-evacuees. In this paper, we construct a three-stage stochastic programming model to locate alternative care facilities and allocate casualties in response to catastrophic health events. Our model integrates casualty triage and the movement of self-evacuees in a systemic response framework that treats uncertainties involved in such large-scale events as probabilistically distributed scenarios. Solution times being instrumental to the practicality of the model, we propose an algorithm, based on Benders decomposition, to generate good solutions fast. We derive new valid inequalities, which we add to the Benders decomposition master problem to reduce the number of weak feasibility cuts generated. Because our algorithm can also be ineffective if the number of scenarios is large, we propose a two-stage approximation model that attempts to guess good third-stage solutions without third-stage decision variables and constraints. Our model, algorithm, and two-stage approximation are implemented in the case study of an earthquake situation in California based on the realistic ShakeOut Scenario data. The online appendix is available at https://doi.org/10.1287/trsc.2017.0777 .

In late June 2021 a heatwave of unprecedented magnitude impacted the Pacific Northwest region of Canada and the United States. Many locations broke all-time maximum temperature records by more than 5 °C, and the Canadian national temperature record was broken by 4.6 °C, with a new record temperature of 49.6 °C. Here, we provide a comprehensive summary of this event and its impacts. Upstream diabatic heating played a key role in the magnitude of this anomaly. Weather forecasts provided advanced notice of the event, while sub-seasonal forecasts showed an increased likelihood of a heat extreme with lead times of 10-20 days. The impacts of this event were catastrophic, including hundreds of attributable deaths across the Pacific Northwest, mass-mortalities of marine life, reduced crop and fruit yields, river flooding from rapid snow and glacier melt, and a substantial increase in wildfires—the latter contributing to landslides in the months following. These impacts provide examples we can learn from and a vivid depiction of how climate change can be so devastating. The 2021 unprecedented Pacific Northwest heatwave broke temperature records by extraordinary amounts. Impacts included hundreds of deaths, mass-mortalities of marine life, increased wildfires, reduced crop and fruit yields, and river flooding.

On 4 July 2013, three catastrophic debris flows occurred in the Hougou, Majingzi, and Xiongjia gullies in Shimian county and produced debris dams and river blockages, resulting in serious casualties and huge economic loss. Though debris flows have been identified prior to the catastrophic events, their magnitudes and destructive power were far beyond early recognition and hazard assessment. Our primary objective for this study was to explore the formation mechanism and typical characteristics and to summarize the lessons learned from these disastrous events in order to avoid the repeat of such disasters in the future. Based on field investigation and imagery interpretation of remote sensing carried out following the catastrophic events, four conclusions were drawn: (1) The catastrophic debris flows were initiated from surface-water runoff, and the triggering factor was attributed to the local intensive rainfall with an hourly intensity of more than 46.7 mm. (2) Entrainment was the most important sediment-supplying method for the debris flow occurrence, and the source materials transported by debris flows from the three gullies were estimated to be about 97 × 10 4  m 3 in volume altogether. (3) As surface-water runoff eroded and entrained hillslope and channel materials persistently, debris flows were characterized by intensive incision at upper or middle reaches and significant magnification effect in flow discharge and volume downstream. Corresponding peak discharge surveyed at the outlets of the Hougou, Majingzi, and Xiongjia gullies was estimated up to 751.0 m 3 /s, 870.1 m 3 /s, and 758.7 m 3 /s, respectively. (4) Debris flows that occurred from the three gullies all belonged to viscous ones and the bulk densities were calculated more than 1.80 g/cm 3 , indicating a huge carrying capacity and destructive impacting power. In addition, the lessons learned from the catastrophic events were summarized, including recognition and assessment on debris flow hazard and utilization of deposition fan. In this paper, prevention suggestions on debris flow prone valleys with high-vegetation coverage and low occurrence frequency were also put forward. The results of this study contribute to a better understanding on the initiation mechanism, dynamic characteristics, and disaster mitigation of debris flows initiated from intense rainfall and surface-water runoff in mountainous areas.

Dielectric elastomer actuators are electrically powered muscle mimetics that offer high actuation strain and high efficiency but are limited by failure caused by high electric fields and aging. Acome et al. used a liquid dielectric, rather than an elastomeric polymer, to solve a problem of catastrophic failure in dielectric elastomer actuators. The dielectric's liquid nature allowed it to self-heal—something that would not be possible with a solid dielectric. The approach allowed the authors to exploit electrostatic and hydraulic forces to achieve muscle-like contractions in a powerful but delicate gripper. Science , this issue p. 61 Electrohydraulic soft actuators enable robust and versatile movement in next-generation soft robotic devices. Existing soft actuators have persistent challenges that restrain the potential of soft robotics, highlighting a need for soft transducers that are powerful, high-speed, efficient, and robust. We describe a class of soft actuators, termed hydraulically amplified self-healing electrostatic (HASEL) actuators, which harness a mechanism that couples electrostatic and hydraulic forces to achieve a variety of actuation modes. We introduce prototypical designs of HASEL actuators and demonstrate their robust, muscle-like performance as well as their ability to repeatedly self-heal after dielectric breakdown—all using widely available materials and common fabrication techniques. A soft gripper handling delicate objects and a self-sensing artificial muscle powering a robotic arm illustrate the wide potential of HASEL actuators for next-generation soft robotic devices.

Solid electrolytes hold great promise for enabling the use of Li metal anodes. The main problem is that during cycling, Li can infiltrate along grain boundaries and cause short circuits, resulting in potentially catastrophic battery failure. At present, this phenomenon is not well understood. Here, through electron microscopy measurements on a representative system, Li 7 La 3 Zr 2 O 12 , we discover that Li infiltration in solid oxide electrolytes is strongly associated with local electronic band structure. About half of the Li 7 La 3 Zr 2 O 12 grain boundaries were found to have a reduced bandgap, around 1–3 eV, making them potential channels for leakage current. Instead of combining with electrons at the cathode, Li + ions are hence prematurely reduced by electrons at grain boundaries, forming local Li filaments. The eventual interconnection of these filaments results in a short circuit. Our discovery reveals that the grain-boundary electronic conductivity must be a primary concern for optimization in future solid-state battery design. Solid electrolytes are promising for enabling the use of Li metal anodes but Li infiltration along grain boundaries can lead to battery failure. Li infiltration in a model solid oxide electrolyte is now found to be strongly associated with local electronic band structure.

Socioeconomic challenges continue to mount for half a billion residents of central India because of a decline in the total rainfall and a concurrent rise in the magnitude and frequency of extreme rainfall events. Alongside a weakening monsoon circulation, the locally available moisture and the frequency of moisture-laden depressions from the Bay of Bengal have also declined. Here we show that despite these negative trends, there is a threefold increase in widespread extreme rain events over central India during 1950–2015. The rise in these events is due to an increasing variability of the low-level monsoon westerlies over the Arabian Sea, driving surges of moisture supply, leading to extreme rainfall episodes across the entire central subcontinent. The homogeneity of these severe weather events and their association with the ocean temperatures underscores the potential predictability of these events by two-to-three weeks, which offers hope in mitigating their catastrophic impact on life, agriculture and property. Against the backdrop of a declining monsoon, the number of extreme rain events is on the rise over central India. Here the authors identify a threefold increase in widespread extreme rains over the region during 1950–2015, driven by an increasing variability of the low-level westerlies over the Arabian Sea.

Severe droughts have caused widespread tree mortality across many forest biomes with profound effects on the function of ecosystems and carbon balance. Climate change is expected to intensify regional-scale droughts, focusing attention on the physiological basis of drought-induced tree mortality. Recent work has shown that catastrophic failure of the plant hydraulic system is a principal mechanism involved in extensive crown death and tree mortality during drought, but the multi-dimensional response of trees to desiccation is complex. Here we focus on the current understanding of tree hydraulic performance under drought, the identification of physiological thresholds that precipitate mortality and the mechanisms of recovery after drought. Building on this, we discuss the potential application of hydraulic thresholds to process-based models that predict mortality.

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale 1 – 3 . Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter 4 ; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation 5 , 6 ; analyses timings and patterns of tumour evolution 7 ; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity 8 , 9 ; and evaluates a range of more-specialized features of cancer genomes 8 , 10 – 18 . The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

The human tragedy caused by the earthquake doublet on 6 February 2023 in Turkey and Syria is difficult to comprehend. While earthquake scientists are trying to understand this seismic event, its catastrophic impact highlights heightened risk in the entire region.

Purpose In few prior empirical studies on supply chain resilience (SCRES), the focus has been on the developed world. Yet, organisations in developing countries constitute a significant part of global supply chains and have also experienced the disastrous effects of supply chain failures. The purpose of this paper is therefore to empirically investigate SCRES in a developing country context and to show that this also provides theoretical insights into the nature of what is meant by resilience. Design/methodology/approach Using a case study approach, a supply network of 20 manufacturing firms in Uganda is analysed based on a total of 45 interviews. Findings The perceived threats to SCRES in this context are mainly small-scale, chronic disruptive events rather than discrete, large-scale catastrophic events typically emphasised in the literature. The data reveal how threats of disruption, resilience strategies and outcomes are inter-related in complex, coupled and non-linear ways. These interrelationships are explained by the political, cultural and territorial embeddedness of the supply network in a developing country. Further, this embeddedness contributes to the phenomenon of supply chain risk migration, whereby an attempt to mitigate one threat produces another threat and/or shifts the threat to another point in the supply network. Practical implications Managers should be aware, for example, of potential risk migration from one threat to another when crafting strategies to build SCRES. Equally, the potential for risk migration across the supply network means managers should look at the supply chain holistically because actors along the chain are so interconnected. Originality/value The paper goes beyond the extant literature by highlighting how SCRES is not only about responding to specific, isolated threats but about the continuous management of risk migration. It demonstrates that resilience requires both an understanding of the interconnectedness of threats, strategies and outcomes and an understanding of the embeddedness of the supply network. Finally, this study’s focus on the context of a developing country reveals that resilience should be equally concerned both with smaller in scale, chronic disruptions and with occasional, large-scale catastrophic events.