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The concentration of dissolved oxygen in aquatic systems helps to regulate biodiversity(1,2), nutrient biogeochemistry(3), greenhouse gas emissions(4), and the quality of drinking water(5). The long-term declines in dissolved oxygen concentrations in coastal and ocean waters have been linked to climate warming and human activity(6,7), but little is known about the changes in dissolved oxygen concentrations in lakes. Although the solubility of dissolved oxygen decreases with increasing water temperatures, long-term lake trajectories are difficult to predict. Oxygen losses in warming lakes may be amplified by enhanced decomposition and stronger thermal stratification(8,9) or oxygen may increase as a result of enhanced primary production(10). Here we analyse a combined total of 45,148 dissolved oxygen and temperature profiles and calculate trends for 393 temperate lakes that span 1941 to 2017. We find that a decline in dissolved oxygen is widespread in surface and deep-water habitats. The decline in surface waters is primarily associated with reduced solubility under warmer water temperatures, although dissolved oxygen in surface waters increased in a subset of highly productive warming lakes, probably owing to increasing production of phytoplankton. By contrast, the decline in deep waters is associated with stronger thermal stratification and loss of water clarity, but not with changes in gas solubility. Our results suggest that climate change and declining water clarity have altered the physical and chemical environment of lakes. Declines in dissolved oxygen in freshwater are 2.75 to 9.3 times greater than observed in the world's oceans(6,7) and could threaten essential lake ecosystem services(2,3,5,11).

Scholarly and managerial interest in corporate sustainability has increased significantly in the past two decades. However, the field is increasingly criticized for failing to effectively contribute to sustainable development and for its limited impact on managerial practice. We argue that this criticism arises due to a fundamental ambiguity around the nature of corporate sustainability. To address the lack of concept clarity, we conduct a systematic literature review and identify 33 definitions of corporate sustainability. Adopting the Aristotelian perspective on definitions, one that promotes reducing concepts to their essential attributes, we discern four components of corporate sustainability. These components offer a conceptual space of inquiry that, while being parsimonious, offers nuanced understanding of the dimensions along which definitions of corporate sustainability differ. We discuss implications for research and practice and outline several recommendations for how advancements in construct clarity may lead to a better scholarly understanding of corporate sustainability.

Across the globe, recent work examining the state of freshwater resources paints an increasingly dire picture of degraded water quality. However, much of this work either focuses on a small subset of large waterbodies or uses in situ water quality datasets that contain biases in when and where sampling occurred. Using these unrepresentative samples limits our understanding of landscape level changes in aquatic systems. In lakes, overall water clarity provides a strong proxy for water quality because it responds to surrounding atmospheric and terrestrial processes. Here, we use satellite remote sensing of over 14 000 lakes to show that lake water clarity in the U.S. has increased by an average of 0.52 cm yr −1 since 1984. The largest increases occurred prior to 2000 in densely populated catchments and within smaller waterbodies. This is consistent with observed improvements in water quality in U.S. streams and lakes stemming from sweeping environmental reforms in the 1970s and 1980s that prioritized point-source pollution in largely urban areas. The comprehensive, long-term trends presented here emphasize the need for representative sampling of freshwater resources when examining macroscale trends and are consistent with the idea that extensive U.S. freshwater pollution abatement measures have been effective and enduring, at least for point-source pollution controls.

The forthcoming JAIS special issue on “Envisioning Digital Transformation” is predicated on the assumption that theoretical diversity would be a good thing for the IS field. But making sense of theoretical diversity requires either a common frame of reference or crystal clarity about concept definitions and the phenomena to which they point. In this editorial, we argue that the IS field still lacks the conceptual and empirical clarity needed to benefit from theoretical diversity about digital transformation. The digital transformation label has been applied to the evolution of technology, as well as to the evolution of organizations and society. It has been used to refer to change in entities or processes and to processes of change. It has been used to refer to particular technological artifacts and to particular kinds of data and processing power. This type of diversity risks obscuring the value of diverse theoretical formulations. Only through clear distinctions and precise labeling of older and new phenomena can the IS field fully benefit from new theories and theoretical elaborations about digital transformation.

Previous research has suggested that, among adolescents, clarity about one’s self-concept is closely related to subjective well-being. However, longitudinal studies are scarce, and whether a clear self-concept is the cause or effect of subjective well-being remains unclear. This study examined the dynamic longitudinal associations between self-concept clarity and subjective well-being at the between- and within-person levels over a one-year time span among adolescents (baseline Mage = 16.01 years; 57.0% girls) from China. The data were collected in three waves (each at a six-month interval), in which adolescents reported their self-concept clarity and well-being (i.e., positive and negative affect and personal satisfaction with life). Both Random Intercept Cross-Lagged Panel Models (RI-CLPMs) and Cross-Lagged Panel Models (CLPMs) were applied to examine the stability, cross-sectional relationships, and cross-lagged effects between adolescents’ self-concept clarity and subjective well-being over time. The CLPMs provided unique support for a reciprocal relations model of self-concept clarity and subjective well-being (including both cognitive and emotional well-being) across three time points, although the results of traditional CLPM might represent an unknown blend of between- and within-person effects. However, the RI-CLPM analyses provided tentative support only for cross-sectional correlations between self-concept clarity and well-being outcomes. Our findings advance the literature by elucidating longitudinal relationships between self-concept clarity and subjective well-being in collectivist cultural contexts using CLPM and RI-CLPM.

Background: Cladribine tablets 3.5 mg/kg cumulative over 2 years (CT3.5) had significant clinical/imaging effects in patients with clinically isolated syndrome (CIS; ORACLE-MS) or relapsing-remitting MS (RRMS; CLARITY and CLARITY Extension). This analysis compared the effect of cladribine tablets on the dynamics of immune cell reduction and reconstitution in ORACLE-MS, CLARITY, and CLARITY Extension during the first year of treatment (i.e. the first course of CT1.75) in patients randomized to CT3.5. Methods: Lymphocyte subtypes were analyzed using multiparameter flow cytometry. Changes in cell counts and relative proportions of lymphocytes were evaluated at weeks 5, 13, 24, and 48. Results: Across studies, consistent and comparable selective kinetics of immune cell populations occurred following the first treatment year with CT. A rapid reduction in CD16+/CD56+ cells (week 5 nadir), a more marked reduction in CD19+ B cells (week 13 nadir), and a less-pronounced effect on CD4+ (week 13 nadir) and CD8+ T cells (week 24 nadir) was shown. There was little effect on neutrophils or monocytes. Lymphocyte recovery began after treatment with CT3.5. Regarding relative proportions of naïve and memory T-cell subtypes in ORACLE-MS, the proportion of naïve-like naturally occurring T-regulatory cells (nTregs) decreased, and the proportion of memory-like nTregs increased, relative to total CD4+ T cells. Conclusions: CT3.5 has comparable effects on the immune systems of patients with CIS or RRMS. The pronounced reduction and recovery dynamics of CD19+ B cells and relative changes in the proportion of some immune cell subtypes may underlie the clinical effects of CT3.5.

ObjectiveDelayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel disease treated with infliximab have attenuated serological responses to a single dose of a SARS-CoV-2 vaccine.DesignAntibody responses and seroconversion rates in infliximab-treated patients (n=865) were compared with a cohort treated with vedolizumab (n=428), a gut-selective anti-integrin α4β7 monoclonal antibody. Our primary outcome was anti-SARS-CoV-2 spike (S) antibody concentrations, measured using the Elecsys anti-SARS-CoV-2 spike (S) antibody assay 3–10 weeks after vaccination, in patients without evidence of prior infection. Secondary outcomes were seroconversion rates (defined by a cut-off of 15 U/mL), and antibody responses following past infection or a second dose of the BNT162b2 vaccine.ResultsGeometric mean (SD) anti-SARS-CoV-2 antibody concentrations were lower in patients treated with infliximab than vedolizumab, following BNT162b2 (6.0 U/mL (5.9) vs 28.8 U/mL (5.4) p<0.0001) and ChAdOx1 nCoV-19 (4.7 U/mL (4.9)) vs 13.8 U/mL (5.9) p<0.0001) vaccines. In our multivariable models, antibody concentrations were lower in infliximab-treated compared with vedolizumab-treated patients who received the BNT162b2 (fold change (FC) 0.29 (95% CI 0.21 to 0.40), p<0.0001) and ChAdOx1 nCoV-19 (FC 0.39 (95% CI 0.30 to 0.51), p<0.0001) vaccines. In both models, age ≥60 years, immunomodulator use, Crohn’s disease and smoking were associated with lower, while non-white ethnicity was associated with higher, anti-SARS-CoV-2 antibody concentrations. Seroconversion rates after a single dose of either vaccine were higher in patients with prior SARS-CoV-2 infection and after two doses of BNT162b2 vaccine.ConclusionInfliximab is associated with attenuated immunogenicity to a single dose of the BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines. Vaccination after SARS-CoV-2 infection, or a second dose of vaccine, led to seroconversion in most patients. Delayed second dosing should be avoided in patients treated with infliximab.Trial registration number ISRCTN45176516.

Many would argue that artificial intelligence (AI) is not only technology but also a paradigmatic shift in the relationship between humans and machines. Much literature assumes that AI-powered practices substantially differ from and profoundly change organizational structures, communication, affordances, and ecosystems. However, AI research remains fragmented and often lacks clarity. While the information systems (IS) discipline can play a pivotal role in AI’s emergence and use, the discipline needs a clear direction that specifies how it can contribute and its key research themes and questions. This paper draws on a professional development workshop that we organized at the 2020 International Conference on Information Systems and the discussions that followed. We summarize and synthesize how AI has impacted organizational practices over five decades and provide views from various perspectives. We identify weaknesses in the current AI literature as measured against conceptual clarity, theoretical glue, cumulative tradition, parsimony, and applicability. We also identify direct actions that the IS research community can undertake to address these issues. Finally, we propose a next-step research agenda to guide AI research in the coming years.

Organizations operate in dynamic environments, which not only requires organizations to adjust, but also for employees to adapt quickly to align with new or adjusted organizational goals. Servant leadership has been shown to help employees develop and grow and behave in a moral and fair manner which are important elements for successful change. We aim to provide a further understanding of the associations between servant leadership and organizational outcomes during changing times. Drawing on the theories of social exchange and goal-setting, and the norm of reciprocity, we propose the mediating role of organizational goal clarity in the associations between servant leadership and five organizational outcomes. The hypotheses are tested in four studies: a two-wave time-lagged survey study conducted in a service company going through a merger, and three experimental studies. The results show that servant leadership relates positively to goal clarity and negatively to uncertainty of employees during organizational change. Furthermore, organizational goal clarity positively mediates the associations between servant leadership and employees’ organizational change commitment and service performance (e.g., organizational citizenship behavior, customer service and customer orientation). This investigation provides a theoretical and empirical validation of a mechanism through which servant leaders enhance organizational performance during changing times.

Concerns about the effects of bisphenol A (BPA) on human brain and behavior are not novel; however, Grohs and colleagues have contributed groundbreaking data on this topic in a recent issue of Environmental Health . For the first time, associations were reported between prenatal BPA exposure and differences in children’s brain microstructure, which appeared to mediate the association between this exposure and children’s behavioral symptoms. Findings in numerous previous mother-child cohorts have pointed in a similar worrying direction, linking higher BPA exposure during pregnancy to more behavioral problems throughout childhood as assessed by neuropsychological questionnaires. Notwithstanding, this body of work has not been adequately considered in risk assessment. From a toxicological perspective, results are now available from the CLARITY-BPA consortium, designed to reconcile academic and regulatory toxicology findings. In fact, the brain has consistently emerged as one of the most sensitive organs disrupted by BPA, even at doses below those considered safe by regulatory agencies such as the European Food Safety Authority (EFSA). In this Commentary, we contextualize the results of Grohs et al. within the setting of previous epidemiologic and CLARITY-BPA data and express our disquiet about the “all-or-nothing” criterion adopted to select human data in a recent EFSA report on the appraisal methodology for their upcoming BPA risk assessment. We discuss the most relevant human studies, identify emerging patterns, and highlight the need for adequate assessment and interpretation of the increasing epidemiologic literature in this field in order to support decision-making. With the aim of avoiding a myopic or biased selection of a few studies in traditional risk assessment procedures, we propose a future reevaluation of BPA focused on neurotoxicity and based on a systematic and comprehensive integration of available mechanistic, animal, and human data. Taken together, the experimental and epidemiologic evidence converge in the same direction: BPA is a probable developmental neurotoxicant at low doses. Accordingly, the precautionary principle should be followed, progressively implementing stringent preventive policies worldwide, including the banning of BPA in food contact materials and thermal receipts, with a focus on the utilization of safer substitutes.