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Background After witnessing the implementations of Banach fixed point theory which is stated that a mapping T: X→X has always a unique fixed point in X in giving the existence and uniqueness solutions for many integral and differential equations, various extensions of Banach fixed point theory were established. Consequently, the theory has evolved to encompass diverse extensions and is fruitful in many fields. One of the most significant advances in pure and applied mathematics is the discovery of solutions for linear and nonlinear systems as well fractal graphics, optimization theory, approximation theory, discrete dynamics and numerous other areas. Our main outcomes in this manuscript represent one of the most important of these extensions. Methods and Results Vital concepts such as D d ∗ -Symmetric spaces and weakly compatible maps are reviewed to establish the framework for our main results. The major objective of the present study is to investigate and verify the uniqueness of some common fixed point theorems for three pairs of self-maps under the influence of other enhanced categories of extended contractive conditions in the context of D d ∗ -Symmetric spaces. Our first main outcomes were established by applying the concepts of weak compatibility and common limit in the range property, whereas we obtained our second major results by utilizing the notion of occasionally weakly compatible mapping. Additionally, various common fixed point outcomes for the two pairs of self-maps were determined. Conclusion This manuscript explores novel outcomes regarding the uniqueness of various common fixed point theorems for three pairs of self-maps under the influence of other enhanced types of extended contractive conditions in the context of D d ∗ -Symmetric spaces. We anticipate that the discoveries in this manuscript will aid scientists in enhancing the authors on popularized extended symmetric-spaces to elevate a universal framework for their practical implementations in each advanced branches of science.

Large-scale losses of honey bee colonies represent a poorly understood problem of global importance. Both biotic and abiotic factors are involved in this phenomenon that is often associated with high loads of parasites and pathogens. A stronger impact of pathogens in honey bees exposed to neonicotinoid insecticides has been reported, but the causal link between insecticide exposure and the possible immune alteration of honey bees remains elusive. Here, we demonstrate that the neonicotinoid insecticide clothianidin negatively modulates NF-κB immune signaling in insects and adversely affects honey bee antiviral defenses controlled by this transcription factor. We have identified in insects a negative modulator of NF-κB activation, which is a leucine-rich repeat protein. Exposure to clothianidin, by enhancing the transcription of the gene encoding this inhibitor, reduces immune defenses and promotes the replication of the deformed wing virus in honey bees bearing covert infections. This honey bee immunosuppression is similarly induced by a different neonicotinoid, imidacloprid, but not by the organophosphate chlorpyriphos, which does not affect NF-κB signaling. The occurrence at sublethal doses of this insecticide-induced viral proliferation suggests that the studied neonicotinoids might have a negative effect at the field level. Our experiments uncover a further level of regulation of the immune response in insects and set the stage for studies on neural modulation of immunity in animals. Furthermore, this study has implications for the conservation of bees, as it will contribute to the definition of more appropriate guidelines for testing chronic or sublethal effects of pesticides used in agriculture.

In a 2012 review article, Anthony P. Maingot made a case for each generation rewriting history according to its own needs and preoccupations. Everyone, he suggested, has their own C.L.R. James. Everyone, perhaps, except students of international relations (IR) and international history, where references to James's copious and critical body of work are less common. In the spirit of finding one's own James, this article employs The Black Jacobins and James's other magnum opus, World Revolution, 1917–1936: The Rise and Fall of the Communist International, to think historically about two interrelated processes of the twentieth century: the rise of the state, and the relationship between nationalisms and internationalisms. Along with encounters with revolutionary Marxism and pan-Africanism, James bore witness to the challenges of the state, and the tensions between nationalism and internationalism that were so central to understanding the twentieth century.

This essay seeks to bring into focus the latent political theory of CLR James's World Revolution, 1917-1936, and to show, on this basis, how World Revolution explains certain difficult aspects of The Black Jacobins. The core of James's theory is the thesis that social classes are organically and internally identified, and that each has a preformed and unitary interest, which can be articulated as a set of political principles. A class is called to act by the voice that expresses the class's interest in the terms of its political principles. Once these points are made clear, several problems regarding the interpretation of The Black Jacobins disappear. First, James's claim that the slaves of San Domingo were \"closer to a modern proletariat than any group of workers in existence at the time\" follows from his organic concept of the proletariat. Second, James's revision of his account of the Haitian Revolution over the decades does not signify a move in the direction of \"history from below\" but a changed estimation of the conditions under which the mirroring operation he assigned to political leadership might take place. What seems to be James's inordinate interest in the individual leader, finally, is more properly understood to be his antipathy to institutions and organizations.

This paper seeks to situate the idea and intellectual narrative of \"world revolution\" in its modern historical context, tracing it back to the age of democratic revolution in the late eighteenth century, and then developed by great revolutionary thinkers like Marx and Engels. It examines the possible limitations of Marx and Engels's vision of world revolution with respect to the Third World as a result of their European intellectual formation in the tradition of the Enlightenment, and examines the charge of \"Eurocentrism\" advanced by post-colonialist theorists among others against classical Marxism. It then explores the inspiration of the Russian Revolution for those fighting racism and imperialism, and how black radicals brought their revolutionary narratives of black liberation into communist narratives for the first time in its aftermath. The essay then discusses C.L.R. James's pioneering 1937 history of the Comintern, World Revolution, among other things a theoretical intervention into the debates raging among socialist black radicals during the 1930s, and critically examines the charge of \"Eurocentrism\" often levelled at World Revolution.

Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that especially plays an important role in innate immune. However, the roles of LECT2 in the immune response of the economically important fish Nile tilapia ( Oreochromis niloticus ) against bacterial infection remains unclear. In this study, a lect2 gene from Nile tilapia ( On-lect2 ) was identified, and its roles in the fish’s immune response against bacterial infection were determined and characterised. On-lect2 contains an open reading frame of 456 bp that encodes a peptide of 151 amino acids, as well as the conservative peptidase M23 domain. On-LECT2 is 62%–84% identical to other fish species and about 50% identical to mammals. The highest transcriptional level of On-lect2 was detected in the liver, whereas the lowest levels were detected in the other tissues. Moreover, the On-LECT2 protein is located mainly in the brain and head kidney. The transcriptional levels of On-lect2 substantially increased in the head kidney, brain, liver and spleen after Streptococcus agalactiae infection. Knockdown On-lect2 led to higher mortality due to liver necrosis or haemorrhage and splenomegaly. In vitro analysis indicated that the recombinant protein of On-LECT2 improved phagocytic activity of head kidney-derived macrophages. In vivo challenge experiments revealed several functions of On-LECT2 in the immune response of Nile tilapia against bacterial infection, including promotion of inflammation, reduction of tissue damages and improvement of survival rate.

Remote sensing image scene classification has a high application value in the agricultural, military, as well as other fields. A large amount of remote sensing data is obtained every day. After learning the new batch data, scene classification algorithms based on deep learning face the problem of catastrophic forgetting, that is, they cannot maintain the performance of the old batch data. Therefore, it has become more and more important to ensure that the scene classification model has the ability of continual learning, that is, to learn new batch data without forgetting the performance of the old batch data. However, the existing remote sensing image scene classification datasets all use static benchmarks and lack the standard to divide the datasets into a number of sequential learning training batches, which largely limits the development of continual learning in remote sensing image scene classification. First, this study gives the criteria for training batches that have been partitioned into three continual learning scenarios, and proposes a large-scale remote sensing image scene classification database called the Continual Learning Benchmark for Remote Sensing (CLRS). The goal of CLRS is to help develop state-of-the-art continual learning algorithms in the field of remote sensing image scene classification. In addition, in this paper, a new method of constructing a large-scale remote sensing image classification database based on the target detection pretrained model is proposed, which can effectively reduce manual annotations. Finally, several mainstream continual learning methods are tested and analyzed under three continual learning scenarios, and the results can be used as a baseline for future work.

Abstract Coffee leaf rust (CLR) caused by Hemileia vastatrix, has emerged as a growing threat to coffee production in China. This study focused on the identification and characterization of the hyperparasitic fungus Acremonium persicinum using integrated plant pathology and molecular biology approaches. The spore suspension of the fungal strain HY85 exhibited a 91.18% inhibition rate against the germination of H. vastatrix urediniospores. Inoculation of coffee leaf discs with H. vastatrix urediniospores resulted in the development of visible chlorotic lesions after 16 days. However, other inoculation methods did not yield early chlorotic lesions, indicating an absence of H. vastatrix infection. Quantitative PCR analysis revealed that the copy numbers of H. vastatrix DNA after 16 days postinoculation were 1.41 × 108, 7.59 × 108, and 1.66 × 108, respectively. Notably, H. vastatrix DNA was undetectable in leaf discs coinoculated with H. vastatrix urediniospores and the hyperparasitic strain HY85, suggesting complete suppression of the pathogen. In vitro lesion control experiments demonstrated that 96 h after inoculation with HY85, the characteristic yellow urediniospore masses on the lesions were entirely replaced by the white mycelium of the hyperparasitic fungus. The control efficacy of strain HY85 against coffee rust fungus was 66.67%. Scanning electron microscopy revealed that strain HY85 caused significant morphological alterations in the urediniospores, including indentation and collapse, leading to severe structural damage. These findings underscore the capability of A. persicinum to disrupt the life cycle of H. vastatrix and its potential as an effective biocontrol agent strain for CLR management. While other hyperparasitic species have been reported to control coffee rust, Acremonium persicinum is the first to be identified in this study.

Abstract Background Human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) poses an ongoing threat to public health worldwide. The studies of MERS patients with severe disease and experimentally infected animals showed that robust viral replication and intensive proinflammatory response in lung tissues contribute to high pathogenicity of MERS-CoV. We sought to identify pattern recognition receptor (PRR) signaling pathway(s) that mediates the inflammatory cascade in human macrophages upon MERS-CoV infection. Methods The potential signaling pathways were manipulated individually by pharmacological inhibition, small interfering ribonucleic acid (siRNA) depletion, and antibody blocking. The MERS-CoV-induced proinflammatory response was evaluated by measuring the expression levels of key cytokines and/or chemokines. Reverse transcription-quantitative polymerase chain reaction assay, flow cytometry analysis, and Western blotting were applied to evaluate the activation of related PRRs and engagement of adaptors. Results MERS-CoV replication significantly upregulated C-type lectin receptor (CLR) macrophage-inducible Ca2+-dependent lectin receptor (Mincle). The role of Mincle for MERS-CoV-triggered cytokine/chemokine induction was established based on the results of antibody blockage, siRNA depletion of Mincle and its adaptor spleen tyrosine kinase (Syk), and Syk pharmacological inhibition. The cytokine and/or chemokine induction was significantly attenuated by siRNA depletion of retinoic acid-inducible-I-like receptors (RLR) or adaptor, indicating that RLR signaling also contributed to MERS-CoV-induced proinflammatory response. Conclusions The CLR and RLR pathways are activated and contribute to the proinflammatory response in MERS-CoV-infected macrophages.

The innate immune system provides an adequate response to stress factors and pathogens through pattern recognition receptors (PRRs), located on the surface of cell membranes and in the cytoplasm. Generally, the structures of PRRs are formed by several domains that are evolutionarily conserved, with a fairly high degree of homology in representatives of different species. The orthologs of TLRs, NLRs, RLRs and CLRs are widely represented, not only in marine chordates, but also in invertebrates. Study of the interactions of the most ancient marine multicellular organisms with microorganisms gives us an idea of the evolution of molecular mechanisms of protection against pathogens and reveals new functions of already known proteins in ensuring the body’s homeostasis. The review discusses innate immunity mechanisms of protection of marine invertebrate organisms against infections, using the examples of ancient multicellular hydroids, tunicates, echinoderms, and marine worms in the context of searching for analogies with vertebrate innate immunity. Due to the fact that mucous membranes first arose in marine invertebrates that have existed for several hundred million years, study of their innate immune system is both of fundamental importance in terms of understanding molecular mechanisms of host defense, and of practical application, including the search of new antimicrobial agents for subsequent use in medicine, veterinary and biotechnology.