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We review recent trends in inflationary dynamics in the context of viable modified gravity theories. After providing a general overview of the inflationary paradigm emphasizing on what problems hot Big Bang theory inflation solves, and a somewhat introductory presentation of single-field inflationary theories with minimal and non-minimal couplings, we review how inflation can be realized in terms of several string-motivated models of inflation, which involve Gauss–Bonnet couplings of the scalar field, higher-order derivatives of the scalar field, and some subclasses of viable Horndeski theories. We also present and analyze inflation in the context of Chern–Simons theories of gravity, including various subcases and generalizations of string-corrected modified gravities, which also contain Chern–Simons correction terms, with the scalar field being identified with the invisible axion, which is the most viable to date dark matter candidate. We also provide a detailed account of vacuum f(R) gravity inflation, and also inflation in f(R,ϕ) and kinetic-corrected f(R,ϕ) theories of gravity. At the end of the review, we discuss the technique for calculating the overall effect of modified gravity on the waveform of the standard general relativistic gravitational wave form.

Measurements of the temperature and polarization anisotropy of the cosmic microwave background (CMB) provided strong confirmation of the vanilla flat ΛCDM model of structure formation. Even if this model fits incredibly well, the cosmological and astrophysical observations in a wide range of scales and epochs, some interesting tensions between the cosmological probes, and anomalies in the CMB data, have emerged. These discrepancies have different statistical significance, and although some parts may be due to systematic errors, their persistence strongly indicates possible cracks in the standard ΛCDM cosmological scenario.

Cerebral small vessel disease (CSVD) represents a cluster of various vascular disorders with different pathological backgrounds. The advanced vasculature net of cerebral vessels, including small arteries, capillaries, arterioles and venules, is usually affected. Processes of oxidation underlie the pathology of CSVD, promoting the degenerative status of the epithelial layer. There are several classifications of cerebral small vessel diseases; some of them include diseases such as Binswanger’s disease, leukoaraiosis, cerebral microbleeds (CMBs) and lacunar strokes. This paper presents the characteristics of CSVD and the impact of the current knowledge of this topic on the diagnosis and treatment of patients.

Feedhorn- and orthomode transducer- (OMT) coupled transition edge sensor (TES) bolometers have been designed and micro-fabricated to meet the optical specifications of the LiteBIRD high frequency telescope (HFT) focal plane. We discuss the design and optical characterization of two LiteBIRD HFT detector types: dual-polarization, dual-frequency-band pixels with 195/280 GHz and 235/337 GHz band centers. Results show well-matched passbands between orthogonal polarization channels and frequency centers within 3% of the design values. The optical efficiency of each frequency channel is conservatively reported to be within the range 0.64 - 0.72, determined from the response to a cryogenic, temperature-controlled thermal source. These values are in good agreement with expectations and either exceed or are within 10% of the values used in the LiteBIRD sensitivity forecast. Lastly, we report a measurement of loss in Nb/SiN x /Nb microstrip at 100 mK and over the frequency range 200–350 GHz, which is comparable to values previously reported in the literature.

This Voyage 2050 paper highlights the unique science opportunities using spectral distortions of the cosmic microwave background (CMB). CMB spectral distortions probe many processes throughout the history of the Universe, delivering novel information that complements past, present and future efforts with CMB anisotropy and large-scale structure studies. Precision spectroscopy, possible with existing technology, would not only provide key tests for processes expected within the cosmological standard model but also open an enormous discovery space to new physics. This offers unique scientific opportunities for furthering our understanding of inflation, recombination, reionization and structure formation as well as dark matter and particle physics. A dedicated experimental approach could open this new window to the early Universe in the decades to come, allowing us to turn the long-standing upper distortion limits obtained with COBE/FIRAS some 25 years ago into clear detections of the expected standard distortion signals and also challenge our current understanding of the laws of nature.

Assuming that the Universe at higher redshifts ( z∼4 and beyond) is consistent with Λ CDM model as constrained by the Planck measurements, we reanalyze the low redshift cosmological data to reconstruct the Hubble parameter as a function of redshift. This enables us to address the H0 and other tensions between low z observations and high z Planck measurement from CMB. From the reconstructed H(z), we compute the energy density for the “dark energy” sector of the Universe as a function of redshift without assuming a specific model for dark energy. We find that the dark energy density has a minimum for certain redshift range and that the value of dark energy at this minimum ρDEmin is negative. This behavior can most simply be described by a negative cosmological constant plus an evolving dark energy component. We discuss possible theoretical and observational implications of such a scenario.

A bioassay-guided chemical investigation of a bacterium, Streptomyces sp. CMB-MRB032, isolated from sheep feces collected near Bathurst, Victoria, Australia, yielded the known polyketide antimycins A4a (1) and A2a (2) as potent inhibitors of Dirofilaria immitis (heartworm) microfilaria (mf) motility (EC50 0.0013–0.0021 µg/mL), along with the octapeptide surugamide A (3) and the new N-methylated analog surugamide K (4). With biological data suggesting surugamides may also exhibit activity against D. immitis, a GNPS molecular network analysis of a library of microbes sourced from geographically diverse Australian ecosystems identified a further five taxonomically and chemically distinct surugamide producers. Scaled-up cultivation of one such producer, Streptomyces sp. CMB-M0112 isolated from a marine sediment collected at Shorncliff, Qld, Australia, yielded 3 along with the new acyl-surugamides A1–A4 (5–8). Solid-phase peptide synthesis provided additional synthetic analogs, surugamides S1–S3 (9–11), while derivatization of 3 returned the semi-synthetic surugamide S4 (12) and acyl-surugamides AS1–AS3 (13–15). The natural acyl-surugamide A3 (7) and semi-synthetic acyl-surugamide AS3 (15) were shown to selectively inhibit D. immitis mf motility (EC50 3.3–3.4 µg/mL), however, unlike antimycins 1 and 2, were inactive against the gastrointestinal nematode Haemonchus contortus L1–L3 larvae (EC50 > 25 µg/mL) and were not cytotoxic to mammalian cells (human colorectal carcinoma SW620, IC50 > 30 µg/mL). A structure–activity relationship (SAR) study on the surugamides 3–15 revealed that selective acylation of the Lys3-ε-NH2 correlates with anthelmintic activity.

The existence of the cosmic neutrino background is a robust prediction of the hot big bang model. These neutrinos were a dominant component of the energy density in the early Universe and therefore played an important role in the evolution of cosmological perturbations. The energy density of the cosmic neutrino background has been measured using the abundances of light elements and the anisotropies of the cosmic microwave background. A complementary and more robust probe is provided by a distinct shift in the temporal phase of sound waves in the primordial plasma that is produced by fluctuations in the neutrino density. Here, we report on the first constraint on this neutrino-induced phase shift in the spectrum of baryon acoustic oscillations of the BOSS DR12 data. Constraining the acoustic scale using Planck data while marginalizing over the effects of neutrinos in the cosmic microwave background, we find a non-zero phase shift at greater than 95% confidence. Besides providing a new test of the cosmic neutrino background, our work is the first application of the baryon acoustic oscillation signal to early Universe physics.In the early Universe, fluctuations in the neutrino density produced a distinct shift in the temporal phase of sound waves in the primordial plasma. The size of this phase shift has now been constrained through baryon acoustic oscillation data.

Cerebral micro-bleedings (CMBs) are small chronic brain hemorrhages that have many side effects. For example, CMBs can result in long-term disability, neurologic dysfunction, cognitive impairment and side effects from other medications and treatment. Therefore, it is important and essential to detect CMBs timely and in an early stage for prompt treatment. In this research, because of the limited labeled samples, it is hard to train a classifier to achieve high accuracy. Therefore, we proposed employing Densely connected neural network (DenseNet) as the basic algorithm for transfer learning to detect CMBs. To generate the subsamples for training and test, we used a sliding window to cover the whole original images from left to right and from top to bottom. Based on the central pixel of the subsamples, we could decide the target value. Considering the data imbalance, the cost matrix was also employed. Then, based on the new model, we tested the classification accuracy, and it achieved 97.71%, which provided better performance than the state of art methods.

This paper provides a snapshot of the formal S 8 ≡ σ 8 Ω m / 0.3 tension between Planck 2015 and the Kilo Degree Survey of450 deg 2 of imaging data (KiDS-450) or the Canada France Hawaii Lensing Survey (CFHTLenS). We find that the Cosmic Microwave Bckground (CMB) and cosmic shear datasets are in tension in the standard Λ Cold Dark Matter ( Λ CDM) model, and that adding massive neutrinos does not relieve the tension. If we include an additional scaling parameter on the CMB lensing amplitude A l e n s , we find that this can put in agreement the Planck 2015 with the cosmic shear data. A l e n s is a phenomenological parameter that is found to be more than 2 σ higher than the expected value in the Planck 2015 data, suggesting an higher amount of lensing in the power spectra, not supported by the trispectrum analysis.