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To mitigate dangerous climate change effects, the 195 countries that signed the 2015 Paris Agreement agreed to “keep the increase in average global surface temperature below 2 °C and limit the increase to 1.5 °C” by reducing carbon emissions. One promising option for reducing carbon emissions is the deployment of carbon capture, utilization, and storage technologies (CCUS) to achieve climate goals. However, for large-scale deployment of underground carbon storage, it is essential to develop technically sound, safe, and cost-effective CO2 injection and well control strategies. This involves sophisticated balancing of various factors such as subsurface engineering policies, technical constraints, and economic trade-offs. Optimization techniques are the best tools to manage this complexity and ensure that CCUS projects are economically viable while maintaining safety and environmental standards. This work reviews thoroughly and critically carbon storage studies, along with the optimization of CO2 injection and well control strategies in saline aquifers. The result of this review provides the foundation for carbon storage by outlining the key subsurface policies and the application of these policies in carbon storage development plans. It also focusses on examining applied optimization techniques to develop CO2 injection and well control strategies in saline aquifers, providing insights for future work and commercial CCUS applications.