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Politics of the female body : postcolonial women writers of the Third World
Is it possible to simultaneously belong to and be exiled from a community? In \"\"Politics of the Female Body,\"\" Ketu H. Katrak argues that it is not only possible, but common, especially for women who have been subjects of colonial empires. Through her careful analysis of postcolonial literary texts, Katrak uncovers the ways that the female body becomes a site of both oppression and resistance. She examines writers working in the English language, including Anita Desai from India, Ama Ata Aidoo from Ghana, and Merle Hodge from Trinidad. The writers share colonial histories, a sense of solidarity, and resistance strategies in the on-going struggles of decolonization that center on the body. Bringing together a rich selection of primary texts, Katrak examines published novels, poems, stories, and essays, as well as activist materials, oral histories, pamphlets, and street theater scripts - forms that push against the boundaries of what is considered strictly literary. In these varied materials, she reveals common political and feminist alliances across geographic boundaries. A unique comparative look at women's literary work and its relationship to the body in third world societies, this text will be of interest to literary scholars and to those working in the fields of women's studies and human rights.
eBook
Postcolonial Writers in the Global Literary Marketplace
Combining analysis with detailed accounts of authors' careers and the global trade in literature, this book assesses how postcolonial writers respond to their own reception and niche positioning, parading their exotic otherness to metropolitan audiences, within a global marketplace.
eBook
Common as air : revolution, art, and ownership
In this lively, carefully argued, and well-documented book, Hyde brings the past to bear on present matters, shedding fresh light on everything from the Human Genome Project to Bob Dylan's musical root, revealing a vision of how to reclaim the commonwealth of art and ideas that we were meant to inherit.
Book
Clades of huge phages from across Earth’s ecosystems
Bacteriophages typically have small genomes
1
and depend on their bacterial hosts for replication
2
. Here we sequenced DNA from diverse ecosystems and found hundreds of phage genomes with lengths of more than 200 kilobases (kb), including a genome of 735 kb, which is—to our knowledge—the largest phage genome to be described to date. Thirty-five genomes were manually curated to completion (circular and no gaps). Expanded genetic repertoires include diverse and previously undescribed CRISPR–Cas systems, transfer RNAs (tRNAs), tRNA synthetases, tRNA-modification enzymes, translation-initiation and elongation factors, and ribosomal proteins. The CRISPR–Cas systems of phages have the capacity to silence host transcription factors and translational genes, potentially as part of a larger interaction network that intercepts translation to redirect biosynthesis to phage-encoded functions. In addition, some phages may repurpose bacterial CRISPR–Cas systems to eliminate competing phages. We phylogenetically define the major clades of huge phages from human and other animal microbiomes, as well as from oceans, lakes, sediments, soils and the built environment. We conclude that the large gene inventories of huge phages reflect a conserved biological strategy, and that the phages are distributed across a broad bacterial host range and across Earth’s ecosystems.
Genomic analyses of major clades of huge phages sampled from across Earth’s ecosystems show that they have diverse genetic inventories, including a variety of CRISPR–Cas systems and translation-relevant genes.
Journal Article
Pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy for pancreatic or periampullary tumours: a multicentre randomised trial
Postoperative pancreatic fistula is the leading cause of death and morbidity after pancreaticoduodenectomy. However, the best reconstruction method to reduce occurrence of fistula is debated. We did a multicentre, randomised superiority trial to compare the outcomes of different reconstructive techniques in patients undergoing pancreaticoduodenectomy for pancreatic or periampullary tumours.
Patients aged 18–85 years with confirmed or suspected neoplasms of the pancreas, distal bile duct, ampulla vateri, duodenum, or periampullary tumours were eligible for inclusion. An internet-based platform was used to randomly assign patients to either pancreaticojejunostomy or pancreaticogastrostomy as reconstruction after pancreaticoduodenectomy, using permuted blocks with six patients per block. Within each centre the randomisation was stratified on the pancreatic duct diameter (≤3 mm vs >3 mm) measured at the time of surgery. The primary endpoint was the occurrence of clinical postoperative pancreatic fistula (grade B or C) as defined by the International Study Group on Pancreatic Fistula. The study was not masked and analyses were done by intention to treat. Patient follow-up was closed 2 months after discharge from the hospital. This study is registered with ClinicalTrials.gov, number NCT00830778.
Between June, 2009, and August, 2012, we randomly allocated 167 patients to receive pancreaticojejunostomy and 162 to receive pancreaticogastrostomy. 33 (19·8%) patients in the pancreaticojejunostomy group and 13 (8·0%) in the pancreaticogastrostomy group had clinical postoperative pancreatic fistula (OR 2·86, 95% CI 1·38–6·17; p=0·002). The overall incidence of postoperative complications did not differ significantly between the groups (99 in the pancreaticojejunostomy group vs 100 in the pancreaticogastrostomy group), although more events in the pancreaticojejunostomy group were of grade ≥3a than in the pancreaticogastrostomy group (39 vs 35).
In patients undergoing pancreaticoduodenectomy for pancreatic head or periampullary tumours, pancreaticogastrostomy is more efficient than pancreaticojejunostomy in reducing the incidence of postoperative pancreatic fistula.
Funding Johnson & Johnson Medical Devices, Belgium.
Journal Article
The dog I loved
\"Two strong women on a journey toward independence whose paths collide in extraordinary ways. Two dogs who somehow manage to save them both. A tale of survival and a testament to the human spirit, this is an emotional and inspiring novel that no reader will soon forget.\"-- Publisher's description.
Book
Use of Combination Chemotherapy for Treatment of Granulomatous and Lymphocytic Interstitial Lung Disease (GLILD) in Patients with Common Variable Immunodeficiency (CVID)
Purpose
A subset of patients with common variable immunodeficiency (CVID) develops granulomatous and lymphocytic interstitial lung disease (GLILD), a restrictive lung disease associated with early mortality. The optimal therapy for GLILD is unknown. This study was undertaken to see if rituximab and azathioprine (combination chemotherapy) would improve pulmonary function and/or radiographic abnormalities in patients with CVID and GLILD.
Methods
A retrospective chart review of patients with CVID and GLILD who were treated with combination chemotherapy was performed. Complete pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) scans of the chest were done prior to therapy and >6 months later. HRCT scans of the chest were blinded, randomized, and scored independently (in pairs) by two radiologists. The differences between pre- and post-treatment HRCT scores and PFT parameters were analyzed.
Results
Seven patients with CVID and GLILD met inclusion criteria. Post-treatment increases were noted in both FEV1 (
p
= 0.034) and FVC (
p
= 0.043). HRCT scans of the chest demonstrated improvement in total score (
p
= 0.018), pulmonary consolidations (
p
= 0.041), ground-glass opacities (
p
= 0.020) nodular opacities (
p
= 0.024), and both the presence and extent of bronchial wall thickening (
p
= 0.014, 0.026 respectively). No significant chemotherapy-related complications occurred.
Conclusions
Combination chemotherapy improved pulmonary function and decreased radiographic abnormalities in patients with CVID and GLILD.
Journal Article