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"COVID- 19"
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Understanding coronavirus
\"Since the identification of the first cases of the coronavirus in December 2019 in Wuhan, China, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', officially named SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the newly emerging virus and the inconsistent public health measures across different countries, have all served to increase the level of anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? What can we do to stop its spread? Written by a leading expert, this concise and accessible introduction provides answers to the most common questions surrounding coronavirus for a general audience\"-- Provided by publisher.
Associations between persistent symptoms after mild COVID‐19 and long‐term health status, quality of life, and psychological distress
2022
Background We sought to assess whether persistent COVID‐19 symptoms beyond 6 months (Long‐COVID) among patients with mild COVID‐19 is associated with poorer health status, quality of life, and psychological distress. Methods This was a multicenter prospective cohort study that included adult outpatients with acute COVID‐19 from eight sites during 2‐week sampling periods from April 1 and July 28, 2020. Participants were contacted 6–11 months after their first positive SARS‐CoV‐2 to complete a survey, which collected information on the severity of eight COVID‐19 symptoms using a 4‐point scale ranging from 0 (not present) to 3 (severe) at 1 month before COVID‐19 (pre‐illness) and at follow‐up; the difference for each was calculated as an attributable persistent symptom severity score. A total attributable persistent COVID‐19 symptom burden score was calculated by summing the attributable persistent severity scores for all eight symptoms. Outcomes measured at long‐term follow‐up comprised overall health status (EuroQol visual analogue scale), quality of life (EQ‐5D‐5L), and psychological distress (Patient Health Questionnaire‐4). The association between the total attributable persistent COVID‐19 burden score and each outcome was analyzed using multivariable proportional odds regression. Results Of the 2092 outpatients with COVID‐19, 436 (21%) responded to the survey. The median (IQR) attributable persistent COVID‐19 symptom burden score was 2 (0, 4); higher scores were associated with lower overall health status (aOR 0.63; 95% CI: 0.57–0.69), lower quality of life (aOR: 0.65; 95%CI: 0.59–0.72), and higher psychological distress (aOR: 1.40; 95%CI, 1.28–1.54) after adjusting for age, race, ethnicity, education, and income. Conclusions In participants with mild acute COVID‐19, the burden of persistent symptoms was significantly associated with poorer long‐term health status, poorer quality of life, and psychological distress.
Journal Article
The COVID-19 reader : the science and what it says about the social
by
Cockerham, William C. editor
,
Cockerham, Geoffrey B. editor
in
COVID-19 (Disease) History
,
COVID-19 (Disease) Social aspects
,
COVID-19 (Disease) Transmission
2021
\"This reader offers the most important writing to date from the science of COVID-19 and what science says for its spread and social implications. With carefully selected chapters for an introductory or graduate student readership by a distinguished medical sociology team, this reader is an essential teaching resource on COVID-19\"-- Provided by publisher.
Assessment and characterisation of post‐COVID‐19 manifestations
by
Saeed, Haitham
,
Hussein, Amal
,
Abo Omirah, Marwa
in
Comorbidity
,
Coronaviridae
,
Coronaviruses
2021
Background Post‐COVID‐19 symptoms and diseases appeared on many survivors from COVID‐19 which are similar to that of the post‐severe acute respiratory syndrome (SARS) fatigue. Hence, the study aims to investigate and characterise the manifestations which appear after eradication of the coronavirus infection and its relation to disease severity. Method About 287 survivors from COVID‐19 were included in the study, each received a questionnaire divided into three main parts starting from subjects’ demographic data, data about the COVID‐19 status and other comorbidities of the subject, and finally data about post‐COVID‐19 manifestations. Response surface plots were produced to visualise the link between several factors. Results Only 10.8% of all subjects have no manifestation after recovery from the disease while a large percentage of subjects suffered from several symptoms and diseases. The most common symptom reported was fatigue (72.8%), more critical manifestations like stroke, renal failure, myocarditis and pulmonary fibrosis were reported by a few percent of the subjects. There was a relationship between the presence of other comorbidities and severity of the disease. Also, the severity of COVID‐19 was related to the severity of post‐COVID‐19 manifestations. Conclusion The post‐COVID‐19 manifestation is largely similar to the post‐SARS syndrome. All subjects recovered from COVID‐19 should undergo long‐term monitoring for evaluation and treatment of symptoms and conditions that might be precipitated with the new coronavirus infection.
Journal Article
COVID-19 and Inequalities
2020
This paper brings together evidence from various data sources and the most recent studies to describe what we know so far about the impacts of the COVID-19 crisis on inequalities across several key domains of life, including employment and ability to earn, family life and health. We show how these new fissures interact with existing inequalities along various key dimensions, including socio-economic status, education, age, gender, ethnicity and geography. We find that the deep underlying inequalities and policy challenges that we already had are crucial in understanding the complex impacts of the pandemic itself and our response to it, and that the crisis does in itself have the potential to exacerbate some of these pre-existing inequalities fairly directly. Moreover, it seems likely that the current crisis will leave legacies that will impact inequalities in the long term. These possibilities are not all disequalising, but many are.
Journal Article
First, wear a face mask : a doctor's guide to reducing risk of infection during the pandemic and beyond
by
Tierno, Philip M., author
in
COVID-19 (Disease)
,
COVID-19 (Disease) Health aspects.
,
COVID-19 (Disease) Safety measures.
2020
\"With the spread of COVID-19, the world has never felt less safe. And with so much advice out there, it's hard to know whether you're taking the right precautions to stay safe. Don't panic: there are simple steps you can take to best protect yourself from infection. Professor of microbiology and pathology at NYU School of Medicine Dr. Philip M. Tierno Jr. cuts through the noise with to-the-point explanations, checklists, and best practices in this brief yet authoritative guide to protecting yourself from infectious diseases. First walking you through what germs are and how every infection happens, First, Wear a Face Mask offers calming, straightforward advice to address the ongoing spread of COVID-19 as well as the germs that imperil us every year.\" -- Amazon.com
Parenting During COVID‐19: A Study of Parents' Experiences Across Gender and Income Levels
2021
Objective This study describes parenting experiences at the beginning of the COVID‐19 pandemic and examines differences across parent gender and family income level. Background The COVID‐19 pandemic had unprecedented impacts on families. Many parents faced employment changes, including job loss, reduced pay, and working remotely, while simultaneously experiencing increased childcare responsibilities due to school and childcare closures. Research is needed to document the ongoing impact of these changes on parents and families. Method An online convenience sample of parents (N = 1,009) reported on their parenting experiences during the beginning of the COVID‐19 pandemic (April 2020) in an online survey. Results Parents reported high levels of depression, anxiety, and parental burnout. Further, many parents reported increased negative emotions, such as anger and worry, while simultaneously feeling closer to their children and offering more comfort and soothing. Differences across gender and income levels are presented. Conclusion These results align with other emerging findings of increased impacts to mental health and well‐being for parents and children and document the disproportionate effects on women and low‐income families. Implications Implications include needing additional support (e.g., financial, caregiving) for parents and families as we continue to face the impacts and consequences of COVID‐19.
Journal Article
The COVID-19 pandemic : the deadly coronavirus outbreak in the 21st century
\"This volume presents a comprehensive account of the COVID-19 pandemic, also known as the novel coronavirus pandemic, as it happened. Originating in China in late 2019, the COVID-19 outbreak spread across the entire world in a matter of 3-4 months. This volume examines the first responses to the pandemic, the contexts of earlier epidemics and the epidemiological basics of infectious diseases. Further, it also discusses patterns in the spread of the disease; the management and containment of infections at the personal, national and global level; effects on trade and commerce; the social and psychological impact on people; disruption and postponement of international events; the role of various international organizations like WHO in the search for solutions; and, the race for a vaccine or the cure. Authored by a medical professional and an economist working on the frontlines, this book gives a nuanced, verified, and fact-checked analysis of the COVID-19 pandemic and its global response. A one-stop resource on the COVID-19 outbreak, it is an indispensable read for every reader, as well as a holistic work for scholars and researchers of medical sociology, public health, political economy, public policy and governance, sociology of health and medicine, para-medical and medical practitioners. It will also be a great resource for policy makers, government departments, and civil society organizations working in the area\"-- Provided by publisher.
Severity of COVID-19 Patients Predicted by Serum Sphingolipids Signature
by
Capitanio, Daniele
,
Lo Caputo, Sergio
,
Biasin, Mara
in
Blood
,
Chronic obstructive pulmonary disease
,
Coronaviruses
2021
The reason behind the high inter-individual variability in response to SARS-CoV-2 infection and patient’s outcome is poorly understood. The present study targets the sphingolipid profile of twenty-four healthy controls and fifty-nine COVID-19 patients with different disease severity. Sera were analyzed by untargeted and targeted mass spectrometry and ELISA. Results indicated a progressive increase in dihydrosphingosine, dihydroceramides, ceramides, sphingosine, and a decrease in sphingosine-1-phosphate. These changes are associated with a serine palmitoyltransferase long chain base subunit 1 (SPTLC1) increase in relation to COVID-19 severity. Severe patients showed a decrease in sphingomyelins and a high level of acid sphingomyelinase (aSMase) that influences monosialodihexosyl ganglioside (GM3) C16:0 levels. Critical patients are characterized by high levels of dihydrosphingosine and dihydroceramide but not of glycosphingolipids. In severe and critical patients, unbalanced lipid metabolism induces lipid raft remodeling, leads to cell apoptosis and immunoescape, suggesting active sphingolipid participation in viral infection. Furthermore, results indicated that the sphingolipid and glycosphingolipid metabolic rewiring promoted by aSMase and GM3 is age-dependent but also characteristic of severe and critical patients influencing prognosis and increasing viral load. AUCs calculated from ROC curves indicated ceramides C16:0, C18:0, C24:1, sphingosine and SPTLC1 as putative biomarkers of disease evolution.
Journal Article