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Colorado potato beetle (CPB, Leptinotarsa decemlineata ) is a major pest of potato and other solanaceous vegetables in the Northern Hemisphere. The insect feeds on leaves and can completely defoliate crops. Because of the repeated use of single insecticide classes without rotating active ingredients, many chemicals are no longer effective in controlling CPB. Ledprona is a sprayable double-stranded RNA biopesticide with a new mode of action that triggers the RNA interference pathway. Laboratory assays with second instar larvae fed Ledprona showed a dose–response where 25×10 −6 g/L of dsPSMB5 caused 90% mortality after 6days of initial exposure. We also showed that exposure to Ledprona for 6h caused larval mortality and decreased target messenger RNA (mRNA) expression. Decrease in PSMB5 protein levels was observed after 48h of larval exposure to Ledprona. Both PSMB5 mRNA and protein levels did not recover over time. Ledprona efficacy was demonstrated in a whole plant greenhouse trial and performed similarly to spinosad. Ledprona, currently pending registration at EPA, represents a new biopesticide class integrated pest management and insecticide resistance management programs directed against CPB.

Abstract A 44-year-old man was diagnosed with a giant pheochromocytoma in the right retroperitoneal cavity following treatment for heart failure. Subsequent to improvement in cardiac function, the patient underwent a laparotomy to excise the tumor. Due to its considerable size, partial cardiopulmonary bypass and blood purification therapy were initiated to stabilize hemodynamics during the surgical intervention. Herein, we present the utilization of partial cardiopulmonary bypass and blood purification in the resection of a giant pheochromocytoma in a patient with a history of heart failure, which proved beneficial in ensuring hemodynamic stability.

Cemented paste backfill (CPB) gains strength through the hydration of the binder constituent of the CPB, where mix temperature is a key influencing factor. Both rate of strength development and ultimate strength are influenced by the overarching temperature conditions in which the binder hydration occurs. This study investigates the influence of mixing water temperature on the thermal behaviour, hydration kinetics, and microstructural development of CPB using a combination of thermal finite element modelling, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS). Five CPB mixtures were prepared, with water temperatures ranging from 5 °C to 50 °C, and tested under controlled conditions to isolate the effects of the initial thermal input. Results show that moderate mixing water temperatures (20–35 °C) optimize hydration and mechanical strength, while excessive temperatures (≥50 °C) increase the risk of thermal cracking due to generation of excessive heat. The thermal modelling results demonstrated that the highest temperatures were observed in the bottom section of the fill mass, in contact with the surrounding rock, where the combined effects of mix-generated heat and rock conduction were most pronounced. The 50 °C mix reached a peak internal temperature of 85.6 °C with a thermal gradient of 40.5 °C, while the 5 °C mix recorded a much lower peak of 55.7 °C and a gradient of 16.8 °C. These results highlight that higher mixing water temperatures accelerate early hydration reactions and significantly influence the internal thermal profile during the first 21 days of curing. Based on these findings, the design of paste plants can be improved by incorporating a heating/cooling system for the mixing water tank—firstly, to ensure the water temperature does not exceed 50 °C and secondly, to maintain water within an optimal temperature range, potentially reducing binder consumption.

The rheological properties (yield stress, flow index and infinite dynamic viscosity) and mechanical properties (unconfined compressive strength, UCS) of different cemented paste backfill (CPB) recipes must be determined during the laboratory optimization phase. However, the influence of the mixing procedure on these properties has scarcely been studied so far. The objective of this paper is to assess to what extent these properties depend on the specific mixing energy (SME) for a given type of mixer. CPB recipes were prepared based on two types of tailing (CPB-T1 and CPB-T2, also referred to as T1 and T2) at a fixed solid percentage for each type of tailing using the Omcan laboratory mixer. A mixture of 80% slag and 20% GU was used as a binder. The mixing time and the rotation speed of the mixer were successively varied. For each recipe prepared, we determined the SME, the rheological properties of fresh CPB (at the end of mixing) and the UCS at 7, 28 and 90 days of curing. The results show that yield stress and infinite viscosity decreased when SME increased in an interval going from 0.3 to 3.8 Wh/kg and 0.6 to 6 Wh/kg for CPB-T1 and CPB-T2, respectively. An increasing trend in UCS with increasing SME was also observed. Empirical equations describing the change of the rheological properties with the SME are used to estimate the change in rheological properties of CPB along the distribution system, considering the specific energy dissipation during CPB transportation. A mixing procedure for obtaining CPB mixtures that are representative of CPB deposited in underground mine stopes is suggested for laboratories who currently use a same mixing procedure, irrespective of the variable field specific energy.

The vibronic spectra of the first excited singlet state (S1) and the cation spectra of the ground state of the cation (D0) of jet-cooled cyclopropylbenzene (CPB) were investigated using resonance-enhanced multiphoton ionization (REMPI) and photoelectron velocity-map imaging techniques, respectively. The vibronic spectra indicated the existence of only the bisected conformer, a finding corroborated by quantum chemical calculations. The S0 → S1 electronic transition originated at 36,858.5 cm−1, with an adiabatic ionization energy of 66,846 ± 15 cm−1. Vibrational levels in both states were assigned with the assistance of theoretical geometry optimization and frequency calculations. These experimental spectra and theoretical calculations provided valuable insights into the structural and vibrational characteristics of CPB in its excited and cationic states.

The incidence of acute kidney injury (AKI) post-cardiopulmonary bypass (CPB) can cause an increase in the rate of renal replacement therapy (RRT) and mortality rate. Compared to brain and liver damage post-CPB, AKI has the highest incidence of 83%. Based on this phenomenon, various efforts have been made to reduce the incidence of AKI post-CPB, both pharmacologically and non-pharmacologically interventions. The purpose of this review is to emphasize several renal protector agents which under optimal conditions can provide significant benefits in reducing the incidence of AKI post-CPB. This article was obtained by conducting a study on several kinds of literature, including the original article, RCT study, systematic review and meta-analysis, and other review articles. There are five renal protector agents that are the focus of this article, those are fenoldopam which effectively works to prevent the incidence of AKI post-CPB, while furosemide has shown satisfactory results in patients with decreased renal function when administered in the Renal Guard (RG) system, mannitol, and nitric oxide, both of these can also effectively reduce the incidence of AKI post‐CPB by controlling its blood concentration and timing of administration, and another form of N-Acetylcysteine, namely N‐Acetylcysteine amide has better activity as a renoprotective agent than N‐Acetylcysteine itself. The benefits of these agents can be obtained by developing devices that can control drug levels in the blood and create optimal conditions for drugs during the use of a CPB machine.

Cardiopulmonary bypass (CPB) is a fundamental approach for managing complex congenital heart diseases (CHD). This study aims to examine the changes in respiratory function before and after CPB in children under 12 years diagnosed with CHD with different types of shunts. A retrospective analysis was conducted on the clinical data of 60 pediatric patients with CHD admitted to the hospital between January 2022 and December 2023. Based on shunt type, the patients were divided into Group A (increased pulmonary blood flow, n = 30) and Group B (decreased pulmonary blood flow, n = 30). Changes in the diameters of the pulmonary artery and aorta, as well as respiratory mechanics before and 24 hours after CPB, were assessed in both groups. There were no significant differences in general characteristics between the two groups ( > 0.05). The external diameter of the pulmonary artery among patients in Group A was significantly larger than that in Group B (2.50±0.38 vs 1.31±0.29 cm, < 0.05), while the external diameter of the aorta was significantly smaller in those in Group A compared to Group B (1.60±0.26 vs 1.91±0.37, < 0.05). Significant differences were observed in the respiratory mechanics indexes before and after CPB within and between the two groups, including peak airway pressure, plateau airway pressure, inspiratory resistance, expiratory resistance, and lung-thorax compliance ( < 0.05). Significant differences in the diameters of the pulmonary artery and aorta were observed among pediatric patients with CHD, depending on the type of shunt used. Dynamic monitoring of respiratory mechanics before and after CPB is essential for optimizing clinical respiratory management to facilitate timely adjustments in respiratory support strategies.

PurposeInvestigate inhaled nitric oxide’s influence on mortality rates, mechanical ventilation and cardiopulmonary bypass duration, and length of stay in the intensive care unit and hospital when administered during cardiopulmonary bypass.MethodsFollowing the PRISMA guidelines, we searched four electronic databases (PubMed, EMBASE, Cochrane Library, and Web of Science) up to 4th March 2023. The protocol was registered in the PROSPERO database with ID: CRD42023423007. Using Review Manager software, we reported outcomes as risk ratios (RRs) or mean difference (MD) and confidence intervals (CIs).ResultsThe meta-analysis included a total of 17 studies with 2897 patients. Overall, there were no significant differences in using nitric oxide over control concerning mortality (RR = 1.03, 95% CI 0.73 to 1.45; P = 0.88) or cardiopulmonary bypass duration (MD = −0.14, 95% CI − 0.96 to 0.69; P = 0.74). The intensive care unit days were significantly lower in the nitric oxide group than control (MD = −0.80, 95% CI − 1.31 to −0.29; P = 0.002). Difference results were obtained in terms of the length of stay in the hospital according to sensitivity analysis (without sensitivity [MD = −0.41, 95% CI − 0.79 to −0.02; P = 0.04] vs. with sensitivity [MD = −0.31, 95% CI − 0.69 to 0.07; P = 0.11]. Subgroup analysis shows that, in children, nitric oxide was favored over control in significantly reducing the duration of mechanical ventilation (MD = −4.58, 95% CI − 5.63 to −3.53; P < 0.001).ConclusionUsing inhaled nitric oxide during cardiopulmonary bypass reduces the length of stay in the intensive care unit, and for children, it reduces the duration of mechanical ventilation.

An innovative, sustainable analytical approach was developed by coupling an Epsom salt, E518 (magnesium sulfate)–facilitated salting-out assisted liquid–liquid extraction (SALLE) system with a safe molecular fluorescent probe, Celfia Pink B (CPB), employing a fluorescence turn-off sensing strategy. MgSO₄ acts as a green salting-out agent, enhancing phase separation efficiency and producing cleaner extracts with higher analyte recovery. CPB, a safe, food-grade dye, serves as a selective fluorogenic probe whose emission at 553 nm is quenched upon electrostatic ion-pair complex formation with Cinacalcet HCl under mildly acidic conditions. The method exhibited excellent linearity (0.08–1.3 µg/mL) with high sensitivity (LOD = 0.024 µg/mL; LOQ = 0.075 µg/mL). Validation according to ICH guidelines demonstrated robustness, precision, and accuracy across pharmaceutical formulations and biological matrices. Sustainability assessment using the WAC framework categorized the platform as “white,” highlighting low environmental impact, safe operation, and simplicity. By minimizing organic solvent use and eliminating hazardous reagents, this MgSO₄-assisted SALLE/fluorescence turn-off approach provides a green, highly sensitive, and versatile tool for trace-level determination of Cinacalcet HCl in pharmaceutical and biological matrices.

In this study, different influence mechanisms associated with temperatures and pH values were investigated through cemented paste backfill (CPB) systems. CPB samples were prepared with temperatures ranging from 10 to 50 °C in 10 °C increments and pH values of 3, 7, and 13. Then, the CPB mixture were subjected to rheological tests, thermogravimetric analysis (TG), derivative thermogravimetry analysis (DTG), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). Results demonstrated that the temperatures had significant effects on the rheological properties of CPB, whereas the effects of pH values were relatively unapparent. Higher temperatures (over 20 °C) were prone to bring higher shear stress, yield stress, and apparent viscosity with the same pH value condition. However, an overly high temperature (50 °C) cannot raise the apparent viscosity. Non-neutral conditions, for pH values of 3 and 13, could strengthen the shear stress and apparent viscosity at the same temperature. Two different yield stress curves could be discovered by uprising pH values, which also led to apparent viscosity of two various curves under the same temperatures (under 50 °C). Microscopically, rheological properties of CPB were affected by temperatures and pH values which enhanced or reduced the cement hydration procedures, rates, products and space structures.