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The crow trap
Three very different women come together to complete an environmental survey. Three women who, in some way or another, know the meaning of betrayal....For team leader Rachael Lambert the project is the perfect opportunity to rebuild her confidence after a double-betrayal by her lover and boss, Peter Kemp. Botanist Anne Preece, on the other hand, sees it as a chance to indulge in a little deception of her own. And then there is Grace Fulwell, a strange, uncommunicative young woman with plenty of her own secrets to hide... When Rachael arrives at the cottage, however, she is horrified to discover the body of her friend Bella Furness. Bella, it appears, has committed suicide--a verdict Rachael finds impossible to accept. Only when the next death occurs does a fourth woman enter the picture--the unconventional Detective Inspector Vera Stanhope, who must piece together the truth from these women's tangled lives in The Crow Trap . Ann Cleeves's popular Vera Stanhope books have been made into the hit series \"Vera\" starring Brenda Blethyn and are available in the U.S.
Book
Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis
In a randomized trial of bortezomib, cyclophosphamide, and dexamethasone as compared with the same therapy plus daratumumab, patients with light-chain amyloidosis who received daratumumab had a higher frequency of hematologic complete response than those who did not (53.3% vs. 18.1%). Deaths were most commonly due to cardiac failure.
Journal Article
Green, resilient, agile, and sustainable fresh food supply chain enablers: evidence from India
The existing research on fresh food supply chains (FFSC) sustainability consisting of fur fundamental pillars, namely green (G), resilient (R), agile (A), and sustainability (S) (hereafter GRAS), is explored sparsely and needs thorough investigation. Further, conceptualization and mutual interactions among GRAS enablers that can help perpetuate sustainable supply chains (SSC) still need to be addressed. This study proposes a methodological framework to evaluate the SCS from the perspective of GRAS enablers with an application for the Indian FFSC. A mixed-method sequential approach was used with interviews followed by integrated fuzzy interpretive structural modelling—decision-making trial and evaluation laboratory (FISM-DEMATEL) techniques. The study recognizes twenty supply chain sustainability (SCS) enablers through an extensive literature review and discussions with the expert group. The research discloses that the firms' ‘organization culture’ acts as the most powerful driver in achieving sustainability in FFSC, followed by the firms’ ‘environmental certification program’ and ‘financial strength.’ This investigation helps the managers/policymakers of the Indian FFSC to ascertain and comprehend the most significant SCS enablers to achieve sustainability in the supply chain (SC). The causation of SCS enablers supports the managers in systematically focusing on the most significant enablers and working towards their successful implementation. According to our knowledge, this is the first scholarly work that establishes hierarchies and interrelationships among GRAS enablers, thereby providing a holistic picture to decision-makers while adapting such practices.
Journal Article
Navigating supply chain turbulence : leveraging modern technologies for safety, resilience, and risk reduction
Analyses critical external elements affecting modern logistics, including pandemics, geopolitical conflicts, energy crises, and trade embargoes, and investigates how these circumstances necessitate logistics networks to implement more resilient and adaptable strategies to maintain operational continuity.
BOOK
Resilience in global supply chains: analysis of responses, recovery actions and strategic changes triggered by major disruptions
Purpose
Are major and frequent disruptions transforming global supply chains? This study aims to investigate how multinational companies (MNCs) are responding to the phenomenon of accumulated major disruptions in recent years and plausible new paradigm of unstable conditions and environmental uncertainty from a supply chain resilience (SCRES) perspective.
Design/methodology/approach
Following an inductive interpretivist approach based on interpretive phenomenology, this study gathers insights from ten MNCs supply chain managers and international consultants who participated as key informants via semi-structured interviews, sharing their experience of the phenomenon. Additionally, secondary sources such as press releases, media articles and industry reports were used for data collection.
Findings
Findings include five categories of recovery actions, i.e. levelling, rationing, buffering, bridging and boundary redefining, key strategic changes in competitive priorities, internal organisation and coordination structures, and a hierarchy between SCRES characteristics, integrated in an empirically derived conceptual framework connecting these constructs. This contributes to middle-range theories within SCRES body of knowledge. The authors also identify a set of areas for future SCRES research.
Practical implications
Findings can support MNCs’ supply chain professionals in designing and managing resilient global supply chains, based on learnings from the recent highly disruptive environment, particularly, regarding recovery actions and resilience-building strategic changes contributing to agility and robustness in global supply chains.
Originality/value
Non-positivist interpretive and inductive works are scarce in SCRES research. By adopting this novel approach for this field, the authors broadened the categorisation of responses used in previous works and identified prominent strategic changes and SCRES characteristics and relations among constructs, thus bringing conceptual clarity to SCRES research within the context of the study.
Journal Article
Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient
Systemic light chain amyloidosis (AL) is a life-threatening disease caused by aggregation and deposition of monoclonal immunoglobulin light chains (LC) in target organs. Severity of heart involvement is the most important factor determining prognosis. Here, we report the 4.0 Å resolution cryo-electron microscopy map and molecular model of amyloid fibrils extracted from the heart of an AL amyloidosis patient with severe amyloid cardiomyopathy. The helical fibrils are composed of a single protofilament, showing typical 4.9 Å stacking and cross-β architecture. Two distinct polypeptide stretches (total of 77 residues) from the LC variable domain (V
l
) fit the fibril density. Despite V
l
high sequence variability, residues stabilizing the fibril core are conserved through different cardiotoxic V
l
, highlighting structural motifs that may be common to misfolding-prone LCs. Our data shed light on the architecture of LC amyloids, correlate amino acid sequences with fibril assembly, providing the grounds for development of innovative medicines.
Immunoglobulin Light Chain Amyloidosis (AL) is the most common systemic amyloidosis occurring in Western countries. Here the authors present the 4.0 Å cryo-EM structure of light chain AL55 fibrils that were isolated from the heart of an AL systemic amyloidosis patient.
Journal Article
Research on the phenomenon of supply chain resilience
Purpose – This paper provides a robust and structured literature review on supply chain resilience (SCRES), the supply chain’s ability to be prepared for unexpected risk events, responding and recovering quickly to potential disruptions to return to its original situation or grow by moving to a new, more desirable state. The purpose of this paper is to analyze the extant research through focussed questions and provide an insightful framework with propositions to guide further publications and identify future research needs. Design/methodology/approach – The findings underlie a systematic literature review methodology requiring a robust method of literature analysis. The sand cone model is adopted to develop a comprehensive SCRES framework. Findings – The literature review reveals a strong need for an overarching SCRES definition and a clear terminology for its building elements. It indicates that most research has been qualitative and lacks in assessing and measuring SCRES performance. Originality/value – This paper contributes a structured overview of 67 peer-reviewed articles from 2003 to 2013 on an emerging area of supply chain research. The review formulates an overarching definition of SCRES, groups and synthesizes the various SCRES elements into proactive and reactive strategies for the ex-ante/ex-post disruption stage and illustrates SCRES measurement through performance metrics. It provides a comprehensive SCRES framework with propositions and indicates gaps in the literature to target for further development.
Journal Article