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"Cholesterol Juvenile literature."
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Lipid profiles in patients with juvenile idiopathic arthritis: a systematic literature review and meta-analysis
Objective
The purpose of this study was to comprehensively evaluate the lipid profiles in patients with juvenile idiopathic arthritis (JIA).
Methods
The literature and relevant reviews were searched for published clinical studies on the relationship between JIA and blood lipid levels. The Newcastle–Ottawa scale (NOS) was applied to evaluate the risk and methodological value of the included case‒control and cohort studies. Standardized mean differences (SMDs) and 95% confidence intervals were derived for all variables with adequate unprocessed data. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
Results
In total, 16 studies were incorporated through screening. The analysis findings revealed that the levels of very low-density lipoprotein cholesterol [SMD=-0.411, 95% CI (-0.774~-0.048),
P
= 0.026], high-density lipoprotein cholesterol [SMD=-0.528, 95% CI (-0.976~-0.079),
P
= 0.021], and apolipoprotein A1 [SMD=-1.050, 95% CI (-1.452~-0.647),
P
= 0.000] in JIA patients were statistically lower than those observed in healthy controls. The level of low-density lipoprotein cholesterol [SMD = 0.202, 95% CI (0.003 ~ 0.400),
P
= 0.046] was significantly higher in JIA patients than in healthy controls. In JIA patients, body mass index [SMD=-0.189, 95% CI (-0.690 ~ 0.311),
P
= 0.459], high-density lipoprotein [SMD =-1.235, 95% CI (-2.845 ~ 0.374),
P
= 0.133), low-density lipoprotein [SMD = 0.616, 95% CI (-0.813 ~ 2.046),
P
= 0.398), triglycerides (SMD = 0.278, 95% CI (-0.182 ~ 0.738),
P
= 0.236], total cholesterol [SMD=-0.073, 95% CI (-0.438 ~ 0.293),
P
= 0.696] and apolipoprotein B levels [SMD = 0.226, 95% CI (-0.133 ~ 0.585),
P
= 0.217] were not significantly different from those in healthy controls.
Conclusions
The outcomes of this meta-analysis suggest that dyslipidemia is common in JIA patients compared to healthy controls. Patients with JIA have a significantly increased risk of atherosclerosis and cardiovascular disease later in life.
Journal Article
mevalonate pathway and the synthesis of juvenile hormone in insects
▪ Abstract The mevalonate pathway in insects has two important peculiarities, the absence of the sterol branch and the synthesis of juvenile hormone (JH), that may have influenced the mechanisms of regulation. The data available on these mechanisms indicate that cholesterol does not play a regulatory role and that JH modulates transcript levels of a number of genes of the mevalonate pathway or can influence the translatability and/or stability of the transcripts themselves. These data suggest that the mevalonate pathway in insects can best be interpreted in terms of coordinated regulation, in which regulators act in parallel to a number of enzymes, as occurs in the cholesterol-driven pathway in vertebrates.
Journal Article