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AbstractObjectivesTo study circadian rhythm aspects, national holidays, and major sports events as triggers of myocardial infarction.DesignRetrospective observational study using the nationwide coronary care unit registry, SWEDEHEART.SettingSweden.Participants283 014 cases of myocardial infarction reported to SWEDEHEART between 1998 and 2013. Symptom onset date was documented for all cases, and time to the nearest minute for 88%.InterventionsMyocardial infarctions with symptom onset on Christmas/New Year, Easter, and Midsummer holiday were identified. Similarly, myocardial infarctions that occurred during a FIFA World Cup, UEFA European Championship, and winter and summer Olympic Games were identified. The two weeks before and after a holiday were set as a control period, and for sports events the control period was set to the same time one year before and after the tournament. Circadian and circaseptan analyses were performed with Sunday and 24:00 as the reference day and hour with which all other days and hours were compared. Incidence rate ratios were calculated using a count regression model.Main outcome measuresDaily count of myocardial infarction.ResultsChristmas and Midsummer holidays were associated with a higher risk of myocardial infarction (incidence rate ratio 1.15, 95% confidence interval 1.12 to 1.19, P<0.001, and 1.12, 1.07 to 1.18, P<0.001, respectively). The highest associated risk was observed for Christmas Eve (1.37, 1.29 to 1.46, P<0.001). No increased risk was observed during Easter holiday or sports events. A circaseptan and circadian variation in the risk of myocardial infarction was observed, with higher risk during early mornings and on Mondays. Results were more pronounced in patients aged over 75 and those with diabetes and a history of coronary artery disease.ConclusionsIn this nationwide real world study covering 16 years of hospital admissions for myocardial infarction with symptom onset documented to the nearest minute, Christmas, and Midsummer holidays were associated with higher risk of myocardial infarction, particularly in older and sicker patients, suggesting a role of external triggers in vulnerable individuals.

Should employees nap at work? The Economist’s audience editor, Harry Taunton, and co-host of The Intelligence podcast, Rosie Blau, discuss the science behind snoozing, how modern work disrupts natural sleep rhythms, and why short 10–30 minute “power naps” may improve alertness, memory, mood, and even health.

Morgan W. McCall Jr, High Flyers: Developing the Next Generation of Leaders (Harvard Business School Publishing, 1998). enduring challenge-the temptation to give up rather than persist and pursue a larger mission; (3) human treachery-betrayal from people one trusts and the opportunity for building greater self-awareness and self-correction; (4) awakened moral conscience-when one fails to live up to one's own convictions and the potential to build one's character and integrity; (5) social conflict-creating environments not of conflict but of belonging where individuals are celebrated for the diversity that is the kingdom of God; (6) human suffering-facing evil and anguish and drawing on God and a faithful community to endure; and (7) personal choice-making choices that go wrong and preparing for future decision points. In the middle of a crucible, leaders need permission to feel the dark night of the soul, and there are people Beebe cites who have written vulnerably about those times in their lives. [...]it would be good to pair The Crucibles That Shape Us with the autobiographies of leaders referenced in the book such as Frederick Douglass, Winston Churchill, Martin Luther King Jr., Rosa Parks, or Simone Weil, to understand what they held onto when everything felt like it was falling apart. [...]leaders who adopt a stewardship model understand their roles as overseeing the responsibilities God has entrusted to them, but in the extreme, this can become a quest to build barns and riches that do not last. [...]Christian leaders could use more guidance on how they can draw on their faith to ensure they are capturing the lessons of experience.

Removing the “reasonable punishment” defence and prohibiting corporal punishment of children can help to reduce family violence, says Andrew Rowland

We learn how Churchill's dentures were crafted specifically to ensure his signature lisp remained.

Null results are important, and a strong signal to try something else

Willfully taking on the challenge of writing in an adopted language, many translingual writers regard their activity as a spiritual discipline. Latin and Sanskrit serve no contemporary purpose, but their devotees apply themselves to it as a kind of ascesis reminiscent of Ignatius of Loyola's exercises in self-effacement. For Samuel Beckett, Milan Kundera, Aharon Appelfeld, and Jhumpa Lahiri, writing in an adopted language forces them into a kind of liberating constraint. They embrace its austerity.