Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
1,115,612
result(s) for
"Clinical Science"
Sort by:
Cognitive therapy techniques : a practitioner's guide
\"This indispensable book has given many tens of thousands of practitioners a wealth of evidence-based tools for maximizing the power of cognitive therapy and tailoring it to individual clients. Leading authority Robert L. Leahy describes ways to help clients identify and modify problematic thoughts, core beliefs, and patterns of worry, self-criticism, and approval-seeking; evaluate personal schemas; cope with painful emotions; and take action to achieve their goals. Each technique includes vivid case examples and sample dialogues. Featuring 125 reproducible forms, the print book has a large-size format for easy photocopying; purchasers also get access to a Web page where they can download and print the reproducible materials. New to This Edition *Numerous additional techniques and reproducible tools, including 48 new or revised forms. *Chapters on decision-making problems, intrusive thoughts, and anger management issues. *Incorporates the latest theory and research as well as cutting-edge techniques drawn from acceptance and commitment therapy (ACT), behavioral activation, dialectical behavior therapy (DBT), emotional schema therapy, and the metacognitive model. *Significantly revised chapters on emotion regulation and worries. *Filled-out examples for many of the forms\"-- Provided by publisher.
Book
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge
Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions have been shown to be accelerators for medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this in mind, we organized the PANDA challenge—the largest histopathology competition to date, joined by 1,290 developers—to catalyze development of reproducible AI algorithms for Gleason grading using 10,616 digitized prostate biopsies. We validated that a diverse set of submitted algorithms reached pathologist-level performance on independent cross-continental cohorts, fully blinded to the algorithm developers. On United States and European external validation sets, the algorithms achieved agreements of 0.862 (quadratically weighted κ, 95% confidence interval (CI), 0.840–0.884) and 0.868 (95% CI, 0.835–0.900) with expert uropathologists. Successful generalization across different patient populations, laboratories and reference standards, achieved by a variety of algorithmic approaches, warrants evaluating AI-based Gleason grading in prospective clinical trials.
Through a community-driven competition, the PANDA challenge provides a curated diverse dataset and a catalog of models for prostate cancer pathology, and represents a blueprint for evaluating AI algorithms in digital pathology.
Journal Article
Love sense : the revolutionary new science of romantic relationships
The bestselling author of Hold Me Tight presents a revolutionary new understanding of why and how we love, based on cutting-edge research.
Book
Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults
A study ancillary to a large trial showed that supplemental vitamin D
3
did not lower the risk of fractures among generally healthy midlife and older adults not selected for vitamin D deficiency, low bone mass, or osteoporosis.
Journal Article
Handbook of social work with groups
\"In this book we portray what we see as the critical dimensions of social work with groups and we take a broad view of this domain of social work. We see it as encompassing any and all of the types of groups in which social workers participate as part of their professional activities, either as members or facilitators. This view of group work consequently incorporates groups that individuals of different age groups join to solve problems and attain their individual, administrative, and organizational goals, enrich their lives, ameliorate problems experienced by organizations and communities, produce social change, and promote social justice\"-- Provided by publisher.
Book
Posttraumatic stress disorder in the World Mental Health Surveys
Traumatic events are common globally; however, comprehensive population-based cross-national data on the epidemiology of posttraumatic stress disorder (PTSD), the paradigmatic trauma-related mental disorder, are lacking.
Data were analyzed from 26 population surveys in the World Health Organization World Mental Health Surveys. A total of 71 083 respondents ages 18+ participated. The Composite International Diagnostic Interview assessed exposure to traumatic events as well as 30-day, 12-month, and lifetime PTSD. Respondents were also assessed for treatment in the 12 months preceding the survey. Age of onset distributions were examined by country income level. Associations of PTSD were examined with country income, world region, and respondent demographics.
The cross-national lifetime prevalence of PTSD was 3.9% in the total sample and 5.6% among the trauma exposed. Half of respondents with PTSD reported persistent symptoms. Treatment seeking in high-income countries (53.5%) was roughly double that in low-lower middle income (22.8%) and upper-middle income (28.7%) countries. Social disadvantage, including younger age, female sex, being unmarried, being less educated, having lower household income, and being unemployed, was associated with increased risk of lifetime PTSD among the trauma exposed.
PTSD is prevalent cross-nationally, with half of all global cases being persistent. Only half of those with severe PTSD report receiving any treatment and only a minority receive specialty mental health care. Striking disparities in PTSD treatment exist by country income level. Increasing access to effective treatment, especially in low- and middle-income countries, remains critical for reducing the population burden of PTSD.
Journal Article
Guns and suicide : an American epidemic
\" The majority of gun deaths in the United States are suicide deaths, and the majority of suicide deaths are gun deaths. Most people are unaware that suicide, at nearly 43,000 deaths per year, is more common than homicide and other widely publicized tragedies. And yet, suicide is typically absent from discussions of gun violence. As such, the national conversation on gun violence is inadequate and unrelated to the majority of gun deaths in this country. In Guns and Suicide, Michael Anestis reframes our perspective on gun violence by shifting the focus to suicide. Guns play a uniquely profound role in American suicide, and Anestis explains how they have this effect-not by making otherwise non-suicidal people want to die, but by facilitating suicide attempts among suicidal individuals. He reviews the evidence - in suicide and other public health concerns - that focusing on specific means for contracting an unwanted outcome (e.g., HIV) can successfully reduce the frequency of that outcome. With suicide, this could mean the passage of legislation related to firearm ownership and storage, non-legislative encouragement of safe storage of private firearms, voluntary and temporary removal of firearms from the home during times of distress, or a combination of these factors. Importantly, this is not a book about gun control. Anestis does not argue in favor of tighter restrictions on ownership, assault weapon bans, or longer waiting periods for purchase because these will not substantially reduce the staggering gun suicide rate. Rather, Anestis aims for a cultural shift towards suicide-specific safe gun ownership and puts forth unemotional suggestions in hopes of leveraging common ground in the pursuit of a lower suicide rate. \"-- Provided by publisher.
Book
A clinical approach to diagnosis of autoimmune encephalitis
Encephalitis is a severe inflammatory disorder of the brain with many possible causes and a complex differential diagnosis. Advances in autoimmune encephalitis research in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to these disorders. However, existing criteria for autoimmune encephalitis are too reliant on antibody testing and response to immunotherapy, which might delay the diagnosis. We reviewed the literature and gathered the experience of a team of experts with the aims of developing a practical, syndrome-based diagnostic approach to autoimmune encephalitis and providing guidelines to navigate through the differential diagnosis. Because autoantibody test results and response to therapy are not available at disease onset, we based the initial diagnostic approach on neurological assessment and conventional tests that are accessible to most clinicians. Through logical differential diagnosis, levels of evidence for autoimmune encephalitis (possible, probable, or definite) are achieved, which can lead to prompt immunotherapy.
Journal Article
Handbook of personality disorders : theory, research, and treatment
\"This authoritative work comprehensively reviews what is known about personality disorders, including vital information to guide clinical decision making. Leading experts synthesize contemporary thinking about the classification, etiologies, and development of these complex disorders. Diagnostic issues are explored, and available assessment instruments are discussed. The Handbook provides in-depth coverage of all commonly used psychotherapeutic and pharmacological treatments, with particular attention to the empirical evidence for each approach. Also addressed are special treatment modalities, such as day programs and group therapy, and forensic issues\"-- Provided by publisher.
Book
Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy
Pathological accumulation of abnormally phosphorylated tau protein in astrocytes is a frequent, but poorly characterized feature of the aging brain. Its etiology is uncertain, but its presence is sufficiently ubiquitous to merit further characterization and classification, which may stimulate clinicopathological studies and research into its pathobiology. This paper aims to harmonize evaluation and nomenclature of aging-related tau astrogliopathy (ARTAG), a term that refers to a morphological spectrum of astroglial pathology detected by tau immunohistochemistry, especially with phosphorylation-dependent and 4R isoform-specific antibodies. ARTAG occurs mainly, but not exclusively, in individuals over 60 years of age. Tau-immunoreactive astrocytes in ARTAG include thorn-shaped astrocytes at the glia limitans and in white matter, as well as solitary or clustered astrocytes with perinuclear cytoplasmic tau immunoreactivity that extends into the astroglial processes as fine fibrillar or granular immunopositivity, typically in gray matter. Various forms of ARTAG may coexist in the same brain and might reflect different pathogenic processes. Based on morphology and anatomical distribution, ARTAG can be distinguished from primary tauopathies, but may be concurrent with primary tauopathies or other disorders. We recommend four steps for evaluation of ARTAG: (1) identification of five types based on the location of either morphologies of tau astrogliopathy: subpial, subependymal, perivascular, white matter, gray matter; (2) documentation of the regional involvement: medial temporal lobe, lobar (frontal, parietal, occipital, lateral temporal), subcortical, brainstem; (3) documentation of the severity of tau astrogliopathy; and (4) description of subregional involvement. Some types of ARTAG may underlie neurological symptoms; however, the clinical significance of ARTAG is currently uncertain and awaits further studies. The goal of this proposal is to raise awareness of astroglial tau pathology in the aged brain, facilitating communication among neuropathologists and researchers, and informing interpretation of clinical biomarkers and imaging studies that focus on tau-related indicators.
Journal Article