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Bartending for dummies
Make drinks like a master mixologist with 1, 000 recipes Bartenders are the life of the party—and it's never been easier to prepare and serve drinks that keep partygoers coming back for more! Whether you want to break into professional bartending or up your ante as a home mixologist, this clear, easy-to-follow guide has you covered. With tips on stocking your bar and working with the right tools and garnishes, as well as information on the latest liquor trends and popular new cocktails, it won't be long before you hear, \"Bartender, may I have another?\" * Concoct the perfect timeless and modern drinks * Learn how to create perfect low and no-alcohol options * Replicate everyone's favorite ready-to-drink cocktails * Stock your bar with the best glasses and tools If you're looking for fresh ideas to keep your friends or customers happy, Bartending For Dummies is the perfect how-to resource for making a splash with great drinks.
eBook
Dead to the world
When cocktail waitress Sookie Stackhouse sees a naked man on the side of the road, it turns out he doesn't remember who he is. It's Eric, who's now a kindler, gentler vampire. He's also scared because whoever took his memory now wants his life.
Independent component analysis: An introduction
Independent component analysis (ICA) is a widely-used blind source separation technique. ICA has been applied to many applications. ICA is usually utilized as a black box, without understanding its internal details. Therefore, in this paper, the basics of ICA are provided to show how it works to serve as a comprehensive source for researchers who are interested in this field. This paper starts by introducing the definition and underlying principles of ICA. Additionally, different numerical examples in a step-by-step approach are demonstrated to explain the preprocessing steps of ICA and the mixing and unmixing processes in ICA. Moreover, different ICA algorithms, challenges, and applications are presented.
Journal Article
Dead in the family
After the brief but deadly Faery War, Sookie Stackhouse is hurt and she's angry. Just about the only bright spot in her life is the love she thinks she feels for vampire Eric Northman who is under scrutiny by the new Vampire King because of their relationship. And as the political implications of the Shifters coming out are beginning to be felt, Sookie's connection to the Shreveport pack draws her into the debate and up against a Fae who wants her dead.
Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniae
The increasing occurrence of hospital-associated infections, particularly bacteremia, caused by extensively drug-resistant (XDR) carbapenemase-producing colistin-resistant
Klebsiella pneumoniae
highlights a critical requirement to discover new therapeutic alternatives. Bacteriophages having host-specific bacteriolytic effects are promising alternatives for combating these pathogens. Among 12 phages isolated from public wastewater in Thailand, two phages-vB_kpnM_05 (myovirus) and vB_kpnP_08 (podovirus) showed broad-host range, producing bacteriolytic activities against 81.3% (n = 26) and 78.1% (n = 25) of 32 XDR carbapenemase-producing colistin-resistant
K. pneumoniae,
with capsular types—K15, K17, K50, K51, K52/
wzi
-50 and K2/
wzi
-2. Both phages showed short replication times, large burst sizes with rapid adsorptions. They exhibited significant stability under various environmental conditions. Genomic analysis revealed that both phages are genetically distinct phages from
Myoviridae
and
Podoviridae
family, with the lack of toxin, virulence, lysogeny and antibiotic resistance genes. These characteristics highlighted their promising potential for utilizing in phage therapy for combating XDR
K. pneumoniae
. Although phage cocktail combining vB_kpnM_05 and vB_kpnP_08 provided significant bacteriolysis for longer duration (8 h) than its monophage (6 h), bacterial regrowth was observed which suggested an evitable development of phage resistance under phages’ selection pressures. Future study will be undertaken to elucidate the precise mechanisms by which these XDR
K. pneumoniae
developed phage resistance and their associated fitness cost. Remarkably, combining phage cocktail with amikacin at their sub-inhibitory concentrations produced potent synergy by completely suppressing bacterial regrowth in vitro. Our study demonstrated the significant therapeutic and prophylactic effectiveness of a phage cocktail-amikacin combination as a promising alternative strategy for overcoming bacteremia associated with XDR
K. pneumoniae
having carbapenemase and colistin resistance in vivo.
Journal Article
Living dead in Dallas
Cocktail waitress Sookie Stackhouse isn't happy. Her co-worker has been murdered and no one seems to care. If that wasn't enough she's got blood poisoning and a raging fever. Luckily, some friendly vampires suck the posion from her veins. But when they ask her for a favour in return things really do go wrong.
Corrigendum: Development of a lytic Ralstonia phage cocktail and evaluation of its control efficacy against tobacco bacterial wilt
[This corrects the article DOI: 10.3389/fpls.2025.1554992.].
Journal Article
Pesticide impacts on avian species with special reference to farmland birds: a review
For decades, we have observed a major biodiversity crisis impacting all taxa. Avian species have been particularly well monitored over the long term, documenting their declines. In particular, farmland birds are decreasing worldwide, but the contribution of pesticides to their decline remains controversial. Most studies addressing the effects of agrochemicals are limited to their assessment under controlled laboratory conditions, the determination of lethal dose 50 (LD50) values and testing in a few species, most belonging to Galliformes. They often ignore the high interspecies variability in sensitivity, delayed sublethal effects on the physiology, behaviour and life-history traits of individuals and their consequences at the population and community levels. Most importantly, they have entirely neglected to test for the multiple exposure pathways to which individuals are subjected in the field (cocktail effects). The present review aims to provide a comprehensive overview for ecologists, evolutionary ecologists and conservationists. We aimed to compile the literature on the effects of pesticides on bird physiology, behaviour and life-history traits, collecting evidence from model and wild species and from field and lab experiments to highlight the gaps that remain to be filled. We show how subtle nonlethal exposure might be pernicious, with major consequences for bird populations and communities. We finally propose several prospective guidelines for future studies that may be considered to meet urgent needs.
Journal Article
Therapeutic Efficacy of Modified Cocktail Analgesia After Minimally Invasive Chevron Osteotomy for Hallux Valgus: A Retrospective Case Series Study
To evaluate the efficacy of modified cocktail analgesia in relieving pain after minimally invasive chevron osteotomy for hallux valgus.
A retrospective cohort study was conducted to analyze the clinical data of 90 patients with moderate to severe hallux valgus admitted to our hospital from January 2020 to December 2023. Based on the treatment method and the number of affected limbs, the patients were divided into three groups: the modified group (Imp) treated with minimally invasive chevron and Akin (MICA) osteotomy combined with modified cocktail therapy, the traditional group (Tro) treated with MICA osteotomy combined with conventional cocktail therapy, and the control group (NC) treated with MICA osteotomy alone without cocktail therapy. The visual analog scale (VAS) scores for ankle-foot pain from 6 hours preoperatively to 14 days postoperatively, the need for postoperative rescue analgesia, adverse reactions, and complications were observed and compared among the three groups.
There were no significant differences in basic conditions such as age and BMI among the three groups. It is in line with the epidemiological statistics of hallux valgus in terms of gender. The VAS scores at 6 hours and 1 day postoperatively were significantly lower in the modified group [(0.67±0.60), (0.68±0.59) respectively] compared to the traditional group [(0.82±0.50), (0.78±0.90) respectively] (P < 0.05). There were no statistically significant differences in VAS scores between groups at 6 hours preoperatively and 7 days and 14 days postoperatively (P > 0.05). Five patients (5.56%) in the modified group required postoperative rescue analgesia, which was significantly fewer than the 12 patients (13.33%) in the traditional group (P < 0.05).
Based on the comprehensive statistical results and clinical significance, the modified cocktail therapy has certain clinical reference value in the short-term analgesia management after MICA. It is beneficial for the early postoperative rehabilitation functional exercise of patients and has a good safety effect. It can be used as an optional option for early postoperative pain control. However, it is necessary to objectively recognize the timeliness of its therapeutic advantages. Its long-term analgesic effect shows no significant clinical difference from the traditional cocktail therapy and the simple MICA procedure.
Journal Article