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Material characterization of ascending thoracic aortic aneurysms is indispensable for the determination of stress distributions across wall thickness and the different aneurysm regions that may be responsible for their catastrophic rupture or dissection, but only few studies have addressed this issue hitherto. In this article, we are presenting our findings of implementing microstructure-based formulations for characterizing layer- and region-specific variations in wall properties, which is a reasonable consensus today. Together, we performed image-based analysis to derive collagen-fiber orientation angles that may serve as validation of the preferred candidate for a fiber-reinforced constitutive descriptor. We considered a four-fiber model with dispersions of fiber angles about the main directions, based on our histological observations, demonstrating a wide distribution of fiber orientations spanning circumferential to longitudinal directions, and its successful implementation to our biomechanical data from tensile testing. However, an in-depth parametric analysis showed that a condensed model without longitudinal-fiber family described the data just as well and did not omit essential histological organization of collagen fibers, while reserving a smaller number of parameters, which makes it advantageous for computational applications. A major aberration from almost all existing models in the literature is the hypothesis made that fibers can support compressive stresses. Such a hypothesis needs further examination but it has the benefits of allowing improved fits to the vanishing transverse stresses under uniaxial test conditions and of properly reflecting the exponential nature of the compressive stress–strain response of aortic tissue, being consistent with observations of collagen being under compression in the unloaded wall.

Several studies have highlighted the potential of crushed brick aggregates in non-structural concrete. This is because crushed brick aggregates offer substandard mechanical properties in comparison to natural stone aggregates. Synthetic Fiber Reinforced Polymer (FRP) sheets have been known to overcome this issue. However, enormous costs associated with synthetic FRPs may limit their use in several low-budget applications. This study recognizes this issue and propose a cost-effective solution in the form of low-cost glass fiber (LC-GFRP) sheets. Two types of brick aggregates (i.e., solid-clay and hollow-clay brick aggregates) were used to fabricate concrete by replacing 50% of natural aggregates. Experimental results of 32 non-circular specimens were reported in this study. To overcome the substandard mechanical properties of recycled brick aggregate concrete (RBAC), specimens were strengthened with 2, 4, and 6 layers of LC-GFRP sheets. Noticeable improvements in ultimate compressive stress and corresponding strain were observed and were found to correlate positively with the number of LC-GFRP sheets. It was found that 4 and 6 layers of LC-GFRP sheets imparted significant axial ductility irrespective of the brick aggregate type and inherent concrete strength. Several existing stress-strain models for confined concrete were considered to predict ultimate confined compressive stress and corresponding strain. Accuracy of existing models was assessed by mean of the ratio of analytical to experimental values and associated standard deviations. For ultimate stress predictions, the lowest mean value of the ratio of analytical to experimental ultimate compressive stress was 1.07 with a standard deviation of 0.10. However, none of the considered models was able to provide good estimates of ultimate strains.

In this research, two components were developed jointly: On the one hand, an experimental plan was created to obtain specific variables of the concrete and serve as a reference for the second model, a numerical and computational type created to address the variability in parameters, such as the elasticity and flow of coarse aggregate and mortar. The experimental work reproduced a specific gradation with a 1” nominal maximum size TMN on spheroidal-shaped particles. To address the diversity of limestone in the national territory, rocks were extracted from five calcareous areas of the country, which were transformed through different activities from lamination and turning with different bits to being carved into spheres until the reference gradation formed. The next stage consisted of determining the mechanical and stress–strain properties of both the mortar and coarse aggregate. In the case of mortar, the compressive stress was obtained from 50 mm × 50 mm × 50 mm cubes and the modulus of elasticity from 100 mm × 200 mm cylinders; for the coarse aggregate, the compressive stress was obtained through tests on cylinders of the calcareous rock used to form the spherical aggregate particles. The materials were mixed according to a previous proportioning for f′c = 28 MPa and cast in cylinders of 100 mm × 200 mm. Finally, the compressive stress and the modulus of elasticity in these specimens were determined. Separately, a computational model was created to reproduce the experimental model with the same type of materials and load conditions and thereby estimate the compressive stress and modulus of elasticity of the tested material. This model was developed based on finite elements simulating concrete under a two-phase model, in which the coarse aggregate phase was arranged with spheroidal particles that were assembled with the mortar paste, thus finally reproducing a concrete cylinder of 100 mm × 200 mm. Material properties, taken from experimental work, were assigned to these materials. Initially, work was carried out in the elastic range, obtaining, as a result, the modulus of elasticity Ec, and then the specimen was brought to failure, obtaining, as a result, the maximum compressive stress f′c. To attend to the influence of the effect of the mesh size for modeling on the numerical results of both parameters, several simulations were carried out in which mesh sizes of 4.0, 3.5, 3.0, and 2.5 mm were established for the mortar and the coarse aggregate, respectively, for carrying out the modeling. The results in the computational model showed that the compressive stress turned out to be more sensitive than the modulus of elasticity to the variation in the size of the mesh. For the first, the differences between the 4 mm mesh and the 2.5 mm mesh reached 3%, but for the second, the difference only reached 1% between the results for the same meshes. When the results between the experimental and computational models were compared, we found that the experimental values had the best closeness with results in the 2.5 mm mesh.

Gradient structures have evolved over millions of years through natural selection and optimization in many biological systems such as bones and plant stems, where the structures change gradually from the surface to interior. The advantage of gradient structures is their maximization of physical and mechanical performance while minimizing material cost. Here we report that the gradient structure in engineering materials such as metals renders a unique extra strain hardening, which leads to high ductility. The grain-size gradient under uniaxial tension induces a macroscopic strain gradient and converts the applied uniaxial stress to multiaxial stresses due to the evolution of incompatible deformation along the gradient depth. Thereby the accumulation and interaction of dislocations are promoted, resulting in an extra strain hardening and an obvious strain hardening rate up-turn. Such extraordinary strain hardening, which is inherent to gradient structures and does not exist in homogeneous materials, provides a hitherto unknown strategy to develop strong and ductile materials by architecting heterogeneous nanostructures.

Additive-manufactured metals have a low fatigue limit due to the defects formed during the manufacturing process. Surface defects, in particular, considerably degrade the fatigue limit. In order to expand the application range of additive-manufactured metals, it is necessary to improve the fatigue limit and render the surface defects harmless. This study aims to investigate the effect of laser peening (LP) on the fatigue strength of additive-manufactured maraging steel with crack-like surface defects. Semicircular surface slits with depths of 0.2 and 0.6 mm are introduced on the specimen surface, and plane bending-fatigue tests are performed. On LP application, compressive residual stress is introduced from the specimen surface to a depth of 0.7 mm and the fatigue limit increases by 114%. In a specimen with a 0.2 mm deep slit, LP results in a high-fatigue-limit equivalent to that of a smooth specimen. Therefore, a semicircular slit with a depth of 0.2 mm can be rendered harmless by LP in terms of the fatigue limit. The defect size of a 0.2 mm deep semicircular slit is greater than that of the largest defect induced by additive manufacturing (AM). Thus, the LP process can contribute to improving the reliability of additive-manufactured metals. Compressive residual stress is the dominant factor in improving fatigue strength and rendering surface defects harmless. Moreover, the trend of the defect size that can be rendered harmless, estimated based on fracture mechanics, is consistent with the experimental results.

Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted by myosin thick filaments. Myosin motors generate both compressive and tensile stresses on F-actin and consequently induce large bending fluctuations, which reduces their effective persistence length to <1 µm. Over a large range of conditions, we show the extent of network contraction corresponds exactly to the extent of individual F-actin shortening via buckling. This demonstrates an essential role of buckling in breaking the symmetry between tensile and compressive stresses to facilitate mesoscale network contraction of up to 80% strain. Portions of buckled F-actin with a radius of curvature ~300 nm are prone to severing and thus compressive stresses mechanically coordinate contractility with F-actin severing, the initial step of F-actin turnover. Finally, the F-actin curvature acquired by myosin-induced stresses can be further constrained by adhesion of the network to a membrane, accelerating filament severing but inhibiting the long-range transmission of the stresses necessary for network contractility. Thus, the extent of membrane adhesion can regulate the coupling between network contraction and F-actin severing. These data demonstrate the essential role of the nonlinear response of F-actin to compressive stresses in potentiating both myosin-mediated contractility and filament severing. This may serve as a general mechanism to mechanically coordinate contractility and cortical dynamics across diverse actomyosin assemblies in smooth muscle and nonmuscle cells.

In this research, the authors have developed an algorithm for predicting the compressive strength and compressive stress–strain curve of Basalt Fiber High-Performance Concrete (BFHPC), which is enhanced by a classical programming algorithm and Logistic Map. For this purpose, different percentages of basalt fiber from 0.6 to 1.8 are mixed with High-Performance Concrete with high-volume contact of cement, fine and coarse aggregate. Compressive strengths and compressive stress–strain curves are applied after 7-, 14-, and 28-day curing periods. To find the compressive strength and predict the compressive stress–strain curve, the Logistic Map algorithm was prepared through classical programming. The results of this study prove that the logistic map is able to predict the compressive strength and compressive stress–strain of BFHPC with high accuracy. In addition, various types of methods, such as Coefficient of Determination (R2), are applied to ensure the accuracy of the algorithm. For this purpose, the value of R2 was equal to 0.96, which showed that the algorithm is reliable for predicting compressive strength. Finally, it was concluded that The Logistic Map algorithm developed through classical programming could be used as an easy and reliable method to predict the compressive strength and compressive stress–strain of BFHPC.

The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and blood vessels. Compression of lymphatic vessels elevates interstitial fluid pressure, whereas compression of blood vessels reduces blood flow. Reduced blood flow, in turn, leads to hypoxia, which promotes tumor progression, immunosuppression, inflammation, invasion, and metastasis and lowers the efficacy of chemo-, radio-, and immunotherapies. Thus, strategies designed to alleviate solid stress have the potential to improve cancer treatment. However, a lack of methods for measuring solid stress has hindered the development of solid stress-alleviating drugs. Here, we present a simple technique to estimate the growth-induced solid stress accumulated within animal and human tumors, and we show that this stress can be reduced by depleting cancer cells, fibroblasts, collagen, and/or hyaluronan, resulting in improved tumor perfusion. Furthermore, we show that therapeutic depletion of carcinoma-associated fibroblasts with an inhibitor of the sonic hedgehog pathway reduces solid stress, decompresses blood and lymphatic vessels, and increases perfusion. In addition to providing insights into the mechanopathology of tumors, our approach can serve as a rapid screen for stress-reducing and perfusion-enhancing drugs.

Gripping and holding of objects are key tasks for robotic manipulators. The development of universal grippers able to pick up unfamiliar objects of widely varying shape and surface properties remains, however, challenging. Most current designs are based on the multifingered hand, but this approach introduces hardware and software complexities. These include large numbers of controllable joints, the need for force sensing if objects are to be handled securely without crushing them, and the computational overhead to decide how much stress each finger should apply and where. Here we demonstrate a completely different approach to a universal gripper. Individual fingers are replaced by a single mass of granular material that, when pressed onto a target object, flows around it and conforms to its shape. Upon application of a vacuum the granular material contracts and hardens quickly to pinch and hold the object without requiring sensory feedback. We find that volume changes of less than 0.5% suffice to grip objects reliably and hold them with forces exceeding many times their weight. We show that the operating principle is the ability of granular materials to transition between an unjammed, deformable state and a jammed state with solid-like rigidity. We delineate three separate mechanisms, friction, suction, and interlocking, that contribute to the gripping force. Using a simple model we relate each of them to the mechanical strength of the jammed state. This advance opens up new possibilities for the design of simple, yet highly adaptive systems that excel at fast gripping of complex objects.

This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regardedThe Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background,Bonesis both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.