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Recent years have seen a tremendous growth in Artificial Intelligence (AI)-based methodological development in a broad range of domains. In this rapidly evolving field, large number of methods are being reported using machine learning (ML) and Deep Learning (DL) models. Majority of these models are inherently complex and lacks explanations of the decision making process causing these models to be termed as 'Black-Box'. One of the major bottlenecks to adopt such models in mission-critical application domains, such as banking, e-commerce, healthcare, and public services and safety, is the difficulty in interpreting them. Due to the rapid proleferation of these AI models, explaining their learning and decision making process are getting harder which require transparency and easy predictability. Aiming to collate the current state-of-the-art in interpreting the black-box models, this study provides a comprehensive analysis of the explainable AI (XAI) models. To reduce false negative and false positive outcomes of these back-box models, finding flaws in them is still difficult and inefficient. In this paper, the development of XAI is reviewed meticulously through careful selection and analysis of the current state-of-the-art of XAI research. It also provides a comprehensive and in-depth evaluation of the XAI frameworks and their efficacy to serve as a starting point of XAI for applied and theoretical researchers. Towards the end, it highlights emerging and critical issues pertaining to XAI research to showcase major, model-specific trends for better explanation, enhanced transparency, and improved prediction accuracy.

This work aims to implement an automated data-driven model for breast cancer detection in mammograms to support physicians’ decision process within a breast cancer screening or detection program. The public available CBIS-DDSM and the INbreast datasets were used as sources to implement the transfer learning technique on full-field digital mammography proprietary dataset. The proprietary dataset reflects a real heterogeneous case study, consisting of 190 masses, 46 asymmetries, and 71 distortions. Several Yolo architectures were compared, including YoloV3, YoloV5, and YoloV5-Transformer. In addition, Eigen-CAM was implemented for model introspection and outputs explanation by highlighting all the suspicious regions of interest within the mammogram. The small YoloV5 model resulted in the best developed solution obtaining an mAP of 0.621 on proprietary dataset. The saliency maps computed via Eigen-CAM have proven capable solution reporting all regions of interest also on incorrect prediction scenarios. In particular, Eigen-CAM produces a substantial reduction in the incidence of false negatives, although accompanied by an increase in false positives. Despite the presence of hard-to-recognize anomalies such as asymmetries and distortions on the proprietary dataset, the trained model showed encouraging detection capabilities. The combination of Yolo predictions and the generated saliency maps represent two complementary outputs for the reduction of false negatives. Nevertheless, it is imperative to regard these outputs as qualitative tools that invariably necessitate clinical radiologic evaluation. In this view, the model represents a trusted predictive system to support cognitive and decision-making, encouraging its integration into real clinical practice.

Explainable artificial intelligence (XAI) has gained much interest in recent years for its ability to explain the complex decision-making process of machine learning (ML) and deep learning (DL) models. The Local Interpretable Model-agnostic Explanations (LIME) and Shaply Additive exPlanation (SHAP) frameworks have grown as popular interpretive tools for ML and DL models. This article provides a systematic review of the application of LIME and SHAP in interpreting the detection of Alzheimer’s disease (AD). Adhering to PRISMA and Kitchenham’s guidelines, we identified 23 relevant articles and investigated these frameworks’ prospective capabilities, benefits, and challenges in depth. The results emphasise XAI’s crucial role in strengthening the trustworthiness of AI-based AD predictions. This review aims to provide fundamental capabilities of LIME and SHAP XAI frameworks in enhancing fidelity within clinical decision support systems for AD prognosis.

The outbreak of the novel corona virus disease (COVID-19) in December 2019 has led to global crisis around the world. The disease was declared pandemic by World Health Organization (WHO) on 11th of March 2020. Currently, the outbreak has affected more than 200 countries with more than 37 million confirmed cases and more than 1 million death tolls as of 10 October 2020. Reverse-transcription polymerase chain reaction (RT-PCR) is the standard method for detection of COVID-19 disease, but it has many challenges such as false positives, low sensitivity, expensive, and requires experts to conduct the test. As the number of cases continue to grow, there is a high need for developing a rapid screening method that is accurate, fast, and cheap. Chest X-ray (CXR) scan images can be considered as an alternative or a confirmatory approach as they are fast to obtain and easily accessible. Though the literature reports a number of approaches to classify CXR images and detect the COVID-19 infections, the majority of these approaches can only recognize two classes (e.g., COVID-19 vs. normal). However, there is a need for well-developed models that can classify a wider range of CXR images belonging to the COVID-19 class itself such as the bacterial pneumonia, the non-COVID-19 viral pneumonia, and the normal CXR scans. The current work proposes the use of a deep learning approach based on pretrained AlexNet model for the classification of COVID-19, non-COVID-19 viral pneumonia, bacterial pneumonia, and normal CXR scans obtained from different public databases. The model was trained to perform two-way classification (i.e., COVID-19 vs. normal, bacterial pneumonia vs. normal, non-COVID-19 viral pneumonia vs. normal, and COVID-19 vs. bacterial pneumonia), three-way classification (i.e., COVID-19 vs. bacterial pneumonia vs. normal), and four-way classification (i.e., COVID-19 vs. bacterial pneumonia vs. non-COVID-19 viral pneumonia vs. normal). For non-COVID-19 viral pneumonia and normal (healthy) CXR images, the proposed model achieved 94.43% accuracy, 98.19% sensitivity, and 95.78% specificity. For bacterial pneumonia and normal CXR images, the model achieved 91.43% accuracy, 91.94% sensitivity, and 100% specificity. For COVID-19 pneumonia and normal CXR images, the model achieved 99.16% accuracy, 97.44% sensitivity, and 100% specificity. For classification CXR images of COVID-19 pneumonia and non-COVID-19 viral pneumonia, the model achieved 99.62% accuracy, 90.63% sensitivity, and 99.89% specificity. For the three-way classification, the model achieved 94.00% accuracy, 91.30% sensitivity, and 84.78%. Finally, for the four-way classification, the model achieved an accuracy of 93.42%, sensitivity of 89.18%, and specificity of 98.92%.

Alzheimer’s disease (AD) is a chronic, irreversible brain disorder, no effective cure for it till now. However, available medicines can delay its progress. Therefore, the early detection of AD plays a crucial role in preventing and controlling its progression. The main objective is to design an end-to-end framework for early detection of Alzheimer’s disease and medical image classification for various AD stages. A deep learning approach, specifically convolutional neural networks (CNN), is used in this work. Four stages of the AD spectrum are multi-classified. Furthermore, separate binary medical image classifications are implemented between each two-pair class of AD stages. Two methods are used to classify the medical images and detect AD. The first method uses simple CNN architectures that deal with 2D and 3D structural brain scans from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset based on 2D and 3D convolution. The second method applies the transfer learning principle to take advantage of the pre-trained models for medical image classifications, such as the VGG19 model. Due to the COVID-19 pandemic, it is difficult for people to go to hospitals periodically to avoid gatherings and infections. As a result, Alzheimer’s checking web application is proposed using the final qualified proposed architectures. It helps doctors and patients to check AD remotely. It also determines the AD stage of the patient based on the AD spectrum and advises the patient according to its AD stage. Nine performance metrics are used in the evaluation and the comparison between the two methods. The experimental results prove that the CNN architectures for the first method have the following characteristics: suitable simple structures that reduce computational complexity, memory requirements, overfitting, and provide manageable time. Besides, they achieve very promising accuracies, 93.61% and 95.17% for 2D and 3D multi-class AD stage classifications. The VGG19 pre-trained model is fine-tuned and achieved an accuracy of 97% for multi-class AD stage classifications.

ChatGPT is another large language model (LLM) vastly available for the consumers on their devices but due to its performance and ability to converse effectively, it has gained a huge popularity amongst research as well as industrial community. Recently, many studies have been published to show the effectiveness, efficiency, integration, and sentiments of chatGPT and other LLMs. In contrast, this study focuses on the important aspects that are mostly overlooked, i.e. sustainability, privacy, digital divide, and ethics and suggests that not only chatGPT but every subsequent entry in the category of conversational bots should undergo Sustainability, PrivAcy, Digital divide, and Ethics (SPADE) evaluation. This paper discusses in detail the issues and concerns raised over chatGPT in line with aforementioned characteristics. We also discuss the recent EU AI Act briefly in accordance with the SPADE evaluation. We support our hypothesis by some preliminary data collection and visualizations along with hypothesized facts. We also suggest mitigations and recommendations for each of the concerns. Furthermore, we also suggest some policies and recommendations for EU AI policy act concerning ethics, digital divide, and sustainability.

Epilepsy is a serious chronic neurological disorder, can be detected by analyzing the brain signals produced by brain neurons. Neurons are connected to each other in a complex way to communicate with human organs and generate signals. The monitoring of these brain signals is commonly done using Electroencephalogram (EEG) and Electrocorticography (ECoG) media. These signals are complex, noisy, non-linear, non-stationary and produce a high volume of data. Hence, the detection of seizures and discovery of the brain-related knowledge is a challenging task. Machine learning classifiers are able to classify EEG data and detect seizures along with revealing relevant sensible patterns without compromising performance. As such, various researchers have developed number of approaches to seizure detection using machine learning classifiers and statistical features. The main challenges are selecting appropriate classifiers and features. The aim of this paper is to present an overview of the wide varieties of these techniques over the last few years based on the taxonomy of statistical features and machine learning classifiers—‘black-box’ and ‘non-black-box’. The presented state-of-the-art methods and ideas will give a detailed understanding about seizure detection and classification, and research directions in the future.

Machine learning (ML) is the fastest growing field in computer science, and health informatics is among the greatest challenges. The goal of ML is to develop algorithms which can learn and improve over time and can be used for predictions. Most ML researchers concentrate on automatic machine learning (aML), where great advances have been made, for example, in speech recognition, recommender systems, or autonomous vehicles. Automatic approaches greatly benefit from big data with many training sets. However, in the health domain, sometimes we are confronted with a small number of data sets or rare events, where aML-approaches suffer of insufficient training samples. Here interactive machine learning (iML) may be of help, having its roots in reinforcement learning, preference learning, and active learning. The term iML is not yet well used, so we define it as “algorithms that can interact with agents and can optimize their learning behavior through these interactions, where the agents can also be human.” This “human-in-the-loop” can be beneficial in solving computationally hard problems, e.g., subspace clustering, protein folding, or k-anonymization of health data, where human expertise can help to reduce an exponential search space through heuristic selection of samples. Therefore, what would otherwise be an NP-hard problem, reduces greatly in complexity through the input and the assistance of a human agent involved in the learning phase.

Recent technological advancements in data acquisition tools allowed life scientists to acquire multimodal data from different biological application domains. Categorized in three broad types (i.e. images, signals, and sequences), these data are huge in amount and complex in nature. Mining such enormous amount of data for pattern recognition is a big challenge and requires sophisticated data-intensive machine learning techniques. Artificial neural network-based learning systems are well known for their pattern recognition capabilities, and lately their deep architectures—known as deep learning (DL)—have been successfully applied to solve many complex pattern recognition problems. To investigate how DL—especially its different architectures—has contributed and been utilized in the mining of biological data pertaining to those three types, a meta-analysis has been performed and the resulting resources have been critically analysed. Focusing on the use of DL to analyse patterns in data from diverse biological domains, this work investigates different DL architectures’ applications to these data. This is followed by an exploration of available open access data sources pertaining to the three data types along with popular open-source DL tools applicable to these data. Also, comparative investigations of these tools from qualitative, quantitative, and benchmarking perspectives are provided. Finally, some open research challenges in using DL to mine biological data are outlined and a number of possible future perspectives are put forward.

Deep neural networks are generally designed as a stack of differentiable layers, in which a prediction is obtained only after running the full stack. Recently, some contributions have proposed techniques to endow the networks with early exits , allowing to obtain predictions at intermediate points of the stack. These multi-output networks have a number of advantages, including (i) significant reductions of the inference time, (ii) reduced tendency to overfitting and vanishing gradients, and (iii) capability of being distributed over multi-tier computation platforms. In addition, they connect to the wider themes of biological plausibility and layered cognitive reasoning. In this paper, we provide a comprehensive introduction to this family of neural networks, by describing in a unified fashion the way these architectures can be designed, trained, and actually deployed in time-constrained scenarios. We also describe in-depth their application scenarios in 5G and Fog computing environments, as long as some of the open research questions connected to them.