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"Computer science Juvenile literature."
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Careers in computer science
Careers in computer science are among the hottest, most in-demand occupations in the United States today. Comments from people in the industry, current statistics and forecasts, and realistic descriptions provide a useful look at computer science jobs ranging from software developers to information security analysts to database administrators.
Book
Security Architect
Security architects are responsible for maintaining the security of an organisation's computer systems as well as designing, developing and reviewing security architectures that fit business requirements, mitigate risk and conform to security policies. This book gives practical career guidance to those interested in the security architect role. It covers areas such as required skills, responsibilities, dependencies and career progression as well as relevant tools, standards and frameworks.
eBook
Think like a computer
\"From algorithms and viruses to virtual reality and beyond, this book presents the ins and outs of what it means to think like a computer.\"--Provided by publisher.
Book
Application of systems biology-based in silico tools to optimize treatment strategy identification in Still’s disease
Background
Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder with complex pathophysiology and significant morbidity, together also termed Still’s disease. The objective of the current study is to set in silico models based on systems biology and investigate the optimal treat-to-target strategy for Still’s disease as a proof-of-concept of the modeling approach.
Methods
Molecular characteristics of Still’s disease and data on biological inhibitors of interleukin (IL)-1 (anakinra, canakinumab), IL-6 (tocilizumab, sarilumab), and glucocorticoids as well as conventional disease-modifying anti-rheumatic drugs (DMARDs, methotrexate) were used to construct
in silico
mechanisms of action (MoA) models by means of Therapeutic Performance Mapping System (TPMS) technology. TPMS combines artificial neuronal networks, sampling-based methods, and artificial intelligence. Model outcomes were validated with published expression data from sJIA patients.
Results
Biologicals demonstrated more pathophysiology-directed efficiency than non-biological drugs. IL-1 blockade mainly acts on proteins implicated in the innate immune system, while IL-6 signaling blockade has a weaker effect on innate immunity and rather affects adaptive immune mechanisms. The MoA models showed that in the autoinflammatory/systemic phases of Still’s disease, in which the innate immunity plays a pivotal role, the IL-1β-neutralizing antibody canakinumab is more efficient than the IL-6 receptor-inhibiting antibody tocilizumab. MoA models reproduced 67% of the information obtained from expression data.
Conclusions
Systems biology-based modeling supported the preferred use of biologics as an immunomodulatory treatment strategy for Still’s disease. Our results reinforce the role for IL-1 blockade on innate immunity regulation, which is critical in systemic autoinflammatory diseases. This further encourages early use on Still’s disease IL-1 blockade to prevent the development of disease or drug-related complications. Further analysis at the clinical level will validate the findings and help determining the timeframe of the window of opportunity for canakinumab treatment.
Journal Article
The science of computers
\"The Science of Computers takes an overall look at information technology, exploring how computers operate and the amazing devices that are used in homes, schools, and businesses today. Students will be fascinated by the history of the development of information technology and digital devices from the early computers that filled entire buildings to the tiny silicon chips being produced today. This practical learning guide lays the groundwork for further exploration of computational thinking. \"Stretch Yourself\" features give practical activities to help readers explore and test key principles to help reinforce learning and are not linked to specific software or operating systems. \"True Story\" features give real-world anecdotes from the world of information technology. \"Computer Hero\" features look at the groundbreaking scientists that paved the way for digital technology today.\"-- Provided by publisher.
Book
Explaining Cyber Deviance among School-Aged Youth
With the increasing access to and ownership of computer-mediated devices among children and youth nowadays, it is important to understand the determinants associated with their participation in deviant activities online. The current study extends prior research by utilizing a South Korean adolescent sample and multivariate analyses in order to explore the theoretical and demographic correlates of multiple types of cyber deviance – media and software piracy, computer hacking, and online harassment. Findings reveal that low self-control and deviant peer association are related to specific forms of cyber deviance. Additionally, this study illustrates that while time spent online engaging activities is associated with youth participation in deviant behaviors online, smartphone ownership did not have an effect on their deviance. Implications for research and policy are discussed.
Journal Article
Adventures in Raspberry Pi
Build cool Raspberry Pi projects with no experience required!
Adventures in Raspberry Pi, 3rd Edition is the fun guide to learning programming. Starting from the very basics and building skill upon skill, you'll learn developing fundamentals—even if you've never programmed before. Learning is exciting when you're working your way through cool projects, but the concepts you learn and the skills you master will take you further than you ever thought possible. You'll learn how your Raspberry Pi 3 works and what it can do as you create stories and games, program shapes, code music, and even build Minecraft worlds with projects designed specifically for kids 11 to 15. Author Carrie Anne Philbin is a former high school teacher, and she showcases her skills with clear, easy to follow instructions and explanations every step of the way. If you're interested in programming but find other books hard to understand, this book is your ideal starting point for mastering the Raspberry Pi.
Inexpensive, non-intimidating, yet surprisingly versatile, the Raspberry Pi 3 is an ideal way to learn programming. Updated to align with the newest board, this book will teach you fundamental programming skills while having a ton of fun!
* Get acquainted with your Raspberry Pi's bits and pieces
* Take control of your Pi's \"insides\" with simple commands
* Program games, code music, and build a jukebox
* Discover where your new skills can take you next
The tiny, credit-card sized Raspberry Pi has become a huge hit among kids—and adults—interested in programming. It does everything your desktop can do, but with a few basic programming skills, you can make it do so much more. With simple instructions, fun projects, and solid skills, Adventures in Raspberry Pi is the ultimate kids' programming guide!
eBook
Information technology
In this book, check out many stories from the world of Information Technology, including breaking headlines about psychology's impact on social media technology, 3D Printing, engineering new batteries, and math models to break secret codes.
Book
Multiple stressors: modeling the effect of pollution, climate, and predation on viability of a sub-arctic marine bird
Negative effects of long-transported pollutants, such as many persistent organic pollutants (POPs), on seabirds and other top predators have been documented for decades. Yet, the concentrations, and hence, the negative impacts of many POPs have recently declined in the Northern Hemisphere. However, organisms are exposed to multiple stressors and the impacts of pollution act in concert with both natural and other anthropogenic stressors. In theory, this means that even sub-lethal POP concentrations may cause adverse effects if they co-occur with increased levels of other stressors. We tested the multiple stress hypothesis on common eiders, a marine duck with a northern geographical distribution, by assessing the relative importance of pollution, climate (winter sea surface temperature; SSTw), and egg predation on population dynamics and viability (i.e., extinction risk) using Leslie-matrix population models. The model was parametrized by estimating reproduction and apparent adult survival using long-term data from a common eider population in sub-arctic Europe. Average annual adult survival was 0.80 (coefficient of variation [CV] = 22.00%) and showed a negative, both direct and delayed, relationship with SSTw. Average clutch size was 4.41 eggs (CV = 5.12%) and varied in time showing periods of both positive and negative trends, but showed no relationship with SSTw. We based immature survival on estimates from literature: 0.52 and 0.68 for juveniles and yearlings, respectively. Our model supported the multiple stress hypothesis as changes in a single stressor did not induce extinctions, unless the magnitude of our manipulations was extreme except for egg predation. The effect of pollution was, however, increasingly negative when it cooccurred with a warming climate and egg predation—and population viability was lowest when all the stressors occurred simultaneously.
Journal Article