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Update of Immune Events in the Murine Contact Hypersensitivity Model: Toward the Understanding of Allergic Contact Dermatitis
Allergic contact dermatitis (ACD) is one of the most common skin diseases, consisting of sensitization and elicitation phases. With the advancement of technology and the discovery of new types of immune cells, our knowledge of the immunological mechanisms of contact hypersensitivity (CHS) as a murine model of ACD has expanded significantly in the past decade. For example, by introducing regulatory T cells, CD4+ T-helper 17 cells, and Langerin-positive dermal dendritic cells, the initiation and termination mechanism of CHS has been revealed. In addition, the role of mast cells in CHS, long a matter of debate, has become apparent by developing conditional mast cell–deficient mice. Moreover, the role of the innate immunity system, such as that of Toll-like receptor signaling, has made a breakthrough in this field. In this review, we will integrate the recent advancement of immunological mechanisms of both the sensitization and elicitation phases of CHS into the classic view, and we will discuss updated mechanisms on its development and future directions.
Journal Article
Contact Dermatitis: Classifications and Management
Contact dermatitis (CD) is a common inflammatory skin disease caused by exposure to contact allergens and irritants. It is also the most common reason of occupational dermatitis and contributes greatly to hand dermatitis and facial dermatitis. Besides the two major forms of contact dermatitis: allergic contact dermatitis and irritant contact dermatitis, other subtypes of CD have been recognized including immediate skin reactions, photoinduced contact dermatitis, systemic contact dermatitis, and non-eczematous contact dermatitis. CD is a great imitator which can mimic many kinds of skin diseases, such as atopic dermatitis, lichen planus, and angioedema. For the diagnosis of CD, a complete medical history, including occupational history, is very important. It can give a clue of CD and provide a list of suspected substances. Besides the well-known diagnostic test, patch testing, there are many other diagnostic tests can be used to help diagnosis of CD and identify the causative allergens, including photopatch test, skin tests for detecting of immediate contact reactions, serum allergen-specific IgE test, and qualitative and quantitative testing of allergen in the suspected materials patients exposed to and challenge test. Before the treatment, the suspected irritants or allergens should be avoided completely. This includes both the removal of the patient from the environment that contains those substances and the promotion of the metabolism and expulsion of the allergens that have been absorbed by the body. In addition, it is also important to restore the skin barrier and reduce skin inflammation through multiple treatments, such as emollients, topical corticosteroids, and antihistamines, as well as systemic corticosteroids and immunosuppressants. Early and appropriate treatments are important to prevent further deterioration and persistence of the skin condition.
Journal Article
Correction: Reaching those at risk: Active case detection of leprosy and contact tracing at Kokosa, a hot spot district in Ethiopia
[This corrects the article DOI: 10.1371/journal.pone.0264100.].
Journal Article
Go-betweens and the Colonization of Brazil
Doña Marina (La Malinche) ...Pocahontas ...Sacagawea-their names live on in historical memory because these women bridged the indigenous American and European worlds, opening the way for the cultural encounters, collisions, and fusions that shaped the social and even physical landscape of the modern Americas. But these famous individuals were only a few of the many thousands of people who, intentionally or otherwise, served as \"go-betweens\" as Europeans explored and colonized the New World.
In this innovative history, Alida Metcalf thoroughly investigates the many roles played by go-betweens in the colonization of sixteenth-century Brazil. She finds that many individuals created physical links among Europe, Africa, and Brazil-explorers, traders, settlers, and slaves circulated goods, plants, animals, and diseases. Intercultural liaisons produced mixed-race children. At the cultural level, Jesuit priests and African slaves infused native Brazilian traditions with their own religious practices, while translators became influential go-betweens, negotiating the terms of trade, interaction, and exchange. Most powerful of all, as Metcalf shows, were those go-betweens who interpreted or represented new lands and peoples through writings, maps, religion, and the oral tradition. Metcalf's convincing demonstration that colonization is always mediated by third parties has relevance far beyond the Brazilian case, even as it opens a revealing new window on the first century of Brazilian history.
eBook
Language acquisition and contact in the Iberian Peninsula
The Spanish language is spoken by an estimated 477 million people worldwide. This volume focuses on the contact between Spanish and other language varieties, including Catalan, Portuguese and Galician in the Spanish Peninsula. The book explores the characteristics of such language contact situations from structural, developmental, societal and cognitive perspectives.
Book
The Unique Molecular Signatures of Contact Dermatitis and Implications for Treatment
Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., nickel and fragrance) in human skin has shown that different allergens have distinct molecular fingerprinting. For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD. While ACD has previously been considered to be constant across all allergens, largely based on mouse models involving strong sensitizers, these new data suggest that ACD differs mechanistically according to allergen. Further, ACD in the setting of concurrent AD shows a different and attenuated phenotype as compared to healthy individuals with ACD, which influences the way AD patients respond to vaccination and other treatment modalities. As in contact sensitization, skin challenged by food patch testing shows that common food allergens (e.g., peanut and barley) also cause distinct immune polarizations in the skin. Additionally, house dust mite reactions in human skin have been profiled to show unique Th2, Th9, and Th17/22 activation as compared to controls, which are similar to the phenotype of psoriasis and contact responses to nickel. Given this information, ACD patients should be treated based on their unique allergen polarity. Refined understanding of the molecular behavior of contact dermatitis and related diseases translates to improved methods of inducing tolerance in sensitized allergic patients, such as with targeted drug therapy and epicutaneous immunotherapy.
Journal Article