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Great attention has been paid to indoor localization due to its wide range of associated applications and services. Fingerprinting and time-based localization techniques are among the most popular approaches in the field due to their promising performance. However, fingerprinting techniques usually suffer from signal fluctuations and interference, which yields unstable localization performance. On the other hand, the accuracy of time-based techniques is highly affected by multipath propagation errors and non-line-of-sight transmissions. To combat these challenges, this paper presents a hybrid deep-learning-based indoor localization system called RRLoc which fuses fingerprinting and time-based techniques with a view of combining their advantages. RRLoc leverages a novel approach for fusing received signal strength indication (RSSI) and round-trip time (RTT) measurements and extracting high-level features using deep canonical correlation analysis. The extracted features are then used in training a localization model for facilitating the location estimation process. Different modules are incorporated to improve the deep model’s generalization against overtraining and noise. The experimental results obtained at two different indoor environments show that RRLoc improves localization accuracy by at least 267% and 496% compared to the state-of-the-art fingerprinting and ranging-based-multilateration techniques, respectively.

This paper is dedicated to studying and modeling the interdependence between the oil returns and exchange-rate movements of oil-exporting and oil-importing countries. Globally, twelve countries/regions are investigated, representing more than 60% and 67% of all oil exports and imports. The sample period encompasses economic and natural events like the Great Recession period (2007–2009) and the COVID-19 pandemic. We use the dynamic conditional correlation mixed-data sampling (DCC-MIDAS) model, with the aim of investigating the interdependencies expressed by the long-run correlation, which is a smoother (but always daily observed) version of the (daily) time-varying correlation. Focusing on the advent of the COVID-19 pandemic in 2020, the long-run correlations of the oil-exporting countries (Saudia Arabia, Russia, Iraq, Canada, United States, United Arab Emirates, and Nigeria) and (lagged) WTI crude oil returns strongly increase. For a subset of these countries (that is, Saudia Arabia, Iraq, United States, United Arab Emirates, and Nigeria), the (lagged) correlations turn out to be positive, while for Canada and Russia they remain negative as before the advent of the pandemic. In addition, the oil-importing countries and regions under investigation (Europe, China, India, Japan, and South Korea) experience a similar pattern: before the COVID-19 pandemic, the (lagged) correlations were negative for China, India, and South Korea. After the COVID-19 pandemic, the correlations of these latter countries increased.

In the era of healthcare, and its related research fields, the dimensionality problem of high dimensional data is a massive challenge as it contains a huge number of variables forming complex data matrices. The demand for dimension reduction of complex data is growing immensely to improvise data prediction, analysis and visualization. In general, dimension reduction techniques are defined as a compression of dataset from higher dimensional matrix to lower dimensional matrix. Several computational techniques have been implemented for data dimension reduction, which is further segregated into two categories such as feature extraction and feature selection. In this review, a detailed investigation of various feature extraction and feature selection methods has been carried out with a systematic comparison of several dimension reduction techniques for the analysis of high dimensional data and to overcome the problem of data loss. Then, some case studies are also cited to verify the better approach for data dimension reduction by considering few advances described in the technical literature. This review paper may guide researchers to choose the most effective method for satisfactory analysis of high dimensional data.

Background Classifying breast cancer subtypes is crucial for clinical diagnosis and treatment. However, the early symptoms of breast cancer may not be apparent. Rapid advances in high-throughput sequencing technology have led to generating large number of multi-omics biological data. Leveraging and integrating the available multi-omics data can effectively enhance the accuracy of identifying breast cancer subtypes. However, few efforts focus on identifying the associations of different omics data to predict the breast cancer subtypes. Results In this paper, we propose a differential sparse canonical correlation analysis network (DSCCN) for classifying the breast cancer subtypes. DSCCN performs differential analysis on multi-omics expression data to identify differentially expressed (DE) genes and adopts sparse canonical correlation analysis (SCCA) to mine highly correlated features between multi-omics DE-genes. Meanwhile, DSCCN uses multi-task deep learning neural network separately to train the correlated DE-genes to predict breast cancer subtypes, which spontaneously tackle the data heterogeneity problem in integrating multi-omics data. Conclusions The experimental results show that by mining the associations among multi-omics data, DSCCN is more capable of accurately classifying breast cancer subtypes than the existing methods.

Perturbation bounds for singular spaces, in particular Wedin’s sin Θ theorem, are a fundamental tool in many fields including high-dimensional statistics, machine learning and applied mathematics. In this paper, we establish separate perturbation bounds, measured in both spectral and Frobenius sin Θ distances, for the left and right singular subspaces. Lower bounds, which show that the individual perturbation bounds are rate-optimal, are also given. The new perturbation bounds are applicable to a wide range of problems. In this paper, we consider in detail applications to low-rank matrix denoising and singular space estimation, high-dimensional clustering and canonical correlation analysis (CCA). In particular, separate matching upper and lower bounds are obtained for estimating the left and right singular spaces. To the best of our knowledge, this is the first result that gives different optimal rates for the left and right singular spaces under the same perturbation.

For the robust estimation of evoked brain activity from functional Near-Infrared Spectroscopy (fNIRS) signals, it is crucial to reduce nuisance signals from systemic physiology and motion. The current best practice incorporates short-separation (SS) fNIRS measurements as regressors in a General Linear Model (GLM). However, several challenging signal characteristics such as non-instantaneous and non-constant coupling are not yet addressed by this approach and additional auxiliary signals are not optimally exploited. We have recently introduced a new methodological framework for the unsupervised multivariate analysis of fNIRS signals using Blind Source Separation (BSS) methods. Building onto the framework, in this manuscript we show how to incorporate the advantages of regularized temporally embedded Canonical Correlation Analysis (tCCA) into the supervised GLM. This approach allows flexible integration of any number of auxiliary modalities and signals. We provide guidance for the selection of optimal parameters and auxiliary signals for the proposed GLM extension. Its performance in the recovery of evoked HRFs is then evaluated using both simulated ground truth data and real experimental data and compared with the GLM with short-separation regression. Our results show that the GLM with tCCA significantly improves upon the current best practice, yielding significantly better results across all applied metrics: Correlation (HbO max. +45%), Root Mean Squared Error (HbO max. −55%), F-Score (HbO up to 3.25-fold) and p-value as well as power spectral density of the noise floor. The proposed method can be incorporated into the GLM in an easily applicable way that flexibly combines any available auxiliary signals into optimal nuisance regressors. This work has potential significance both for conventional neuroscientific fNIRS experiments as well as for emerging applications of fNIRS in everyday environments, medicine and BCI, where high Contrast to Noise Ratio is of importance for single trial analysis. •Reducing nuisance signals in fNIRS leads to more robust estimation of evoked brain activity.•GLM with tCCA flexibly combines any available auxiliary signals into optimal nuisance regressors.•The proposed method significantly improves upon conventional GLM with short separation regression.•Improved HRF recovery particularly for low Contrast to Noise Ratios and low number of stimuli/trials.

Integrative approaches that simultaneously model multi-omics data have gained increasing popularity because they provide holistic system biology views of multiple or all components in a biological system of interest. Canonical correlation analysis (CCA) is a correlation-based integrative method designed to extract latent features shared between multiple assays by finding the linear combinations of features–referred to as canonical variables (CVs)–within each assay that achieve maximal across-assay correlation. Although widely acknowledged as a powerful approach for multi-omics data, CCA has not been systematically applied to multi-omics data in large cohort studies, which has only recently become available. Here, we adapted sparse multiple CCA (SMCCA), a widely-used derivative of CCA, to proteomics and methylomics data from the Multi-Ethnic Study of Atherosclerosis (MESA) and Jackson Heart Study (JHS). To tackle challenges encountered when applying SMCCA to MESA and JHS, our adaptations include the incorporation of the Gram-Schmidt (GS) algorithm with SMCCA to improve orthogonality among CVs, and the development of Sparse Supervised Multiple CCA (SSMCCA) to allow supervised integration analysis for more than two assays. Effective application of SMCCA to the two real datasets reveals important findings. Applying our SMCCA-GS to MESA and JHS, we identified strong associations between blood cell counts and protein abundance, suggesting that adjustment of blood cell composition should be considered in protein-based association studies. Importantly, CVs obtained from two independent cohorts also demonstrate transferability across the cohorts. For example, proteomic CVs learned from JHS, when transferred to MESA, explain similar amounts of blood cell count phenotypic variance in MESA, explaining 39.0% ~ 50.0% variation in JHS and 38.9% ~ 49.1% in MESA. Similar transferability was observed for other omics-CV-trait pairs. This suggests that biologically meaningful and cohort-agnostic variation is captured by CVs. We anticipate that applying our SMCCA-GS and SSMCCA on various cohorts would help identify cohort-agnostic biologically meaningful relationships between multi-omics data and phenotypic traits.

The electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) signals, highly non-stationary in nature, greatly suffers from motion artifacts while recorded using wearable sensors. Since successful detection of various neurological and neuromuscular disorders is greatly dependent upon clean EEG and fNIRS signals, it is a matter of utmost importance to remove/reduce motion artifacts from EEG and fNIRS signals using reliable and robust methods. In this regard, this paper proposes two robust methods: (i) Wavelet packet decomposition (WPD) and (ii) WPD in combination with canonical correlation analysis (WPD-CCA), for motion artifact correction from single-channel EEG and fNIRS signals. The efficacy of these proposed techniques is tested using a benchmark dataset and the performance of the proposed methods is measured using two well-established performance matrices: (i) difference in the signal to noise ratio ( ) and (ii) percentage reduction in motion artifacts ( ). The proposed WPD-based single-stage motion artifacts correction technique produces the highest average  (29.44 dB) when db2 wavelet packet is incorporated whereas the greatest average  (53.48%) is obtained using db1 wavelet packet for all the available 23 EEG recordings. Our proposed two-stage motion artifacts correction technique, i.e., the WPD-CCA method utilizing db1 wavelet packet has shown the best denoising performance producing an average  and  values of 30.76 dB and 59.51%, respectively, for all the EEG recordings. On the other hand, for the available 16 fNIRS recordings, the two-stage motion artifacts removal technique, i.e., WPD-CCA has produced the best average  (16.55 dB, utilizing db1 wavelet packet) and largest average  (41.40%, using fk8 wavelet packet). The highest average  and  using single-stage artifacts removal techniques (WPD) are found as 16.11 dB and 26.40%, respectively, for all the fNIRS signals using fk4 wavelet packet. In both EEG and fNIRS modalities, the percentage reduction in motion artifacts increases by 11.28% and 56.82%, respectively when two-stage WPD-CCA techniques are employed in comparison with the single-stage WPD method. In addition, the average  also increases when WPD-CCA techniques are used instead of single-stage WPD for both EEG and fNIRS signals. The increment in both  and  values is a clear indication that two-stage WPD-CCA performs relatively better compared to single-stage WPD. The results reported using the proposed methods outperform most of the existing state-of-the-art techniques.

Several studies have been conducted on droughts, precipitation, and temperature, whereas none have addressed the underlying relationship between nonlinear dynamic properties and patterns of two main hydrological parameters, precipitation and temperature, and meteorological and hydrological droughts. Monthly datasets of Midlands in the UK between 1921 and 2019 were collected for analysis. Subsequent to apply a multifractal approach to attain the nonlinear features of the datasets, the relationship between two hydrological parameters and droughts was investigated through the cross-correlation technique. A similar process was performed to analyze the relationship between multifractal strength variations in time series of precipitation and temperature and droughts. The nonlinear dynamic results indicated that droughts (meteorological and hydrological) were substantially affected by precipitation than temperature. In other words, droughts were more sensitive to precipitation fluctuations than temperature fluctuations. Concerning temperature, meteorological, and hydrological droughts were dependent on the minimum and maximum temperatures (Tmin and Tmax), respectively. The correlation between precipitation and meteorological drought was more long-range persistence than precipitation and hydrological drought. Besides, the correlation between Tmax and droughts was more long-range persistence than Tmin and droughts. Analysis of nonlinear dynamic patterns proved that the multifractal strength of meteorological drought depended on the multifractal strength of precipitation and Tmax, whereas the multifractal strength of hydrological drought depended on the multifractal strength of the Tmin. The correlation between precipitation and drought indices exhibited more multifractal strength than temperature and drought indices. Finally, the pivotal role of maximum temperature on drought events was quite alerting due to global warming intensification.