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\"The WHO Handbook on Indoor Radon\" is a key product of the WHO International Radon Project, which was launched in 2005. The \"Handbook\" focuses on residential radon exposure from a public health point of view and provides detailed recommendations on reducing health risks from radon and sound policy options for preventing and mitigating radon exposure. The material in the \"Handbook\" reflects the epidemiological evidence that indoor radon exposure is responsible for a substantial number of lung cancers in the general population. The material is organized into six chapters, each introduced by key messages. Usually, technical terms are defined the first time they are used, and a glossary is also included. Information is provided on the selection of devices to measure radon levels and on procedures for the reliable measurement of these levels. Discussed also are control options for radon in new dwellings, radon reduction in existing dwellings as well as assessment of the costs and benefits of different radon prevention and remedial actions. Also covered are radon risk communication strategies and organization of national radon programs.This publication is intended for countries planning to develop their national radon programs or extend such activities, as well as for stakeholders involved in radon control such as the construction industry and building professionals.The overall goal of this \"Handbook\" is to provide an up-to-date overview of the major aspects of radon and health. It does not aim to replace existing radiation protection standards, rather it emphasizes issues relevant to the comprehensive planning, implementation and evaluation of national radon programs.

Alpinia oxyphylla, a traditional herb, is widely used for its neuroprotective, antioxidant and memory-improving effects. However, the neuroprotective mechanisms of action of its active ingredients are unclear. In this study, we investigated the neuroprotective effects of various organic extracts of Alpinia oxyphylla on PC12 cells exposed to hydrogen peroxide-induced oxidative injury in vitro. Alpinia oxyphylla was extracted three times with 95% ethanol (representing extracts 1-3). The third 95% ethanol extract was dried and resuspended in water, and then extracted successively with petroleum ether, ethyl acetate and n-butanol (representing extracts 4-6). The cell counting kit-8 assay and microscopy were used to evaluate cell viability and observe the morphology of PC12 cells. The protective effect of the three ethanol extracts (at tested concentrations of 50, 100 and 200 µg/mL) against cytotoxicity to PC12 cells increased in a concentration-dependent manner. The ethyl acetate, petroleum ether and n-butanol extracts (each tested at 100, 150 and 200 μg/mL) had neuroprotective effects as well. The optimum effective concentration ranged from 50-200 μg/mL, and the protective effect of the ethyl acetate extract was comparatively robust. These results demonstrate that organic extracts of Alpinia oxyphylla protect PC12 cells against apoptosis induced by hydrogen peroxide. Our findings should help identify the bioactive neuroprotective components in Alpinia oxyphylla.

This study aims to investigate the influence of adding Lonicera japonica (L. japonica) and Radix Puerariae crude extracts and their mixture to the diet of finishing pigs on their fecal microbes and nutrient apparent digestibility. A total of 72 healthy Duroc × Landrace × Yorkshire crossbred barrows without significant differences in body weight (93 ± 2 kg) were selected and randomly divided into four groups (18 in each group). Three replicate pens per group (six pigs per pen) were used, and two pigs were evaluated for each pen. The groups were fed the following diets: control group (CON), basic diet; chlorogenic acid group (CGA group), basic diet + 1 kg/ton L. japonica crude extract; Pueraria flavonoid group (PF group), basic diet + 1 kg/ton Radix Puerariae crude extract; and mix group (Mix group), basic diet + 0.5 kg/ton L. japonica crude extract + 0.5 kg/ton Radix Puerariae crude extract. The following results were obtained: (1) At the phylum level, Bacteroidetes, Firmicutes, Spirochaetes, Proteobacteria, Fibrobaeteres, and Kiritimatiellaeota were the main components of the fecal microbiota (top 5); the relative abundance of bacteria from phyla Firmicutes significantly increased in the Mix group than in the CON group (p < 0.05). At the genus level, Treponema_2, Rikenellaceae_RC9_gut_group, uncultured_bacterium_f_Lachnospiraceae, uncultured_bacterium_f_Prevotellaceae, and Prevotellaceae_NK3B31_group were the main components of the fecal microbiota (top 5); the relative abundance of bacteria from genus Lactobacillus significantly increased in the Mix group than in the CON group (p < 0.05). Chao1 and Ace counts were significantly higher in group CGA than in the CON group and group Mix (p < 0.05). The alpha and beta diversities and the relative abundance of fecal microbes were higher in all test groups than in the CON group. (2) The protein digestibility was significantly higher in the CGA and PF groups than in the CON group, and the TP digestibility was significantly higher in the CGA than in the CON and Mix groups (p < 0.05). In conclusion, Lonicera japonica and Radix Puerariae crude extract supplementation in the diet significantly changed fecal microbiota and improved the protein and TP digestibility of finishing pigs.

Puccinia arachidis is an obligate pathogen which infects peanut leaves and causes rust disease. Alternative controls of this disease, particularly to limit the frequent use of synthetic fungicide, have been conducted. One of which is by applying botanical fungicides. Crude extracts of Ageratum conyzoides, Amaranthus spinosus, and Cyperus rotundus were used to suppress the rust disease intensity on Bima peanut cultivar. A. conyzoides extracts at 2.5% and 5.0% concentrations were the most effective biofungicide to reduce the disease. The disease intensity (29.8 % and 30.2 %) recorded at 10 weeks after planting (WAP) was significantly lower than the untreated crops (41.4 %). Both weed extract applications reduced about 50 % of pustule number compared to untreated crops at 10 WAP. Applications of 2.5 % and 5.0 % of ageratum extracts saved yield loss of 67.5 % and 63.5 %. Caryophyllene was observed in the roots, stems, leaves, and flowers of ageratum extracts in considerable amounts based on GC-MS analysis and may attribute to its significant antifungal activity. Higher total phenolic and flavonoid contents were observed in ageratum extracts than in amaranthus and cyperus extracts. Ageratum extracts at concentrations of 2.5 % to 5 % could be used to control peanut rust disease.

This book presents a systematic review on traditional Arab herbal medicine including historical background, medical innovations introduced by Arab physicians, common roots of Arab medicine and western medicine, methodology of drug discovery and therapy in Arabic and Islamic medicine, a state-of-the-art description of traditional Arab herbal.

This study was aimed to investigate the effect of earthworms after their decomposition on yeast growth. To achieve this objective, in vitro crude soluble extracts were prepared from two earthworms lots: freshly harvested from the field “FHE” and the other previously starved for one week “SE”. The dry residues of these two crude extracts were used at different concentrations as a solid media for the growth of two yeast species: one “Candida tropicalis” got from another laboratory and the other was isolated by our team from earthworms’ casts “Filobasidium uniguttulatum”, and their growth was evaluated by colonies counting. The results obtained, compared with the Sabouraud Dextrose Agar (SDA), showed that the growth of both yeast isolates was significantly higher on mediums prepared using exclusively earthworms’ crude extracts and agar. Optimal growth was obtained at a concentration corresponding to 0.375g/100 mL of earthworms’ soluble matter of the two types of earthworms’ lots. These results affirmed the richness and the diversification of those extracts, in nutrients and growth factors, that comes mainly from the intrinsic composition of earthworm’s body biomass. The efficiency of the FHE and SE extracts for cultivation of yeast shows their possible use as a culture media that may be applied to other soil microorganisms and even in vivo as soil amendments or biofertilizers.

The wild plant Prangos platychlaena Boiss belonged to the family Apiaceae, is a native plant of Kurdistan-Iraq. The root, leaves, stem and flowers of the plant were collected in the Hlgurd mountain of Kurdistan region of Iraq, and extracted by ethanol solvent to obtain the crude extracts. Our results showed that the phytochemical contents are more concentrated in the initiated growth stage than the other stages and the phytochemical concentration posatively correlated with temperature and negatively correlated with humidity.The physiochemical contents such as total carbohydrate, protein, coumarin and dry weight more concentrated in the leaves and flower than other parts.This experiment was conducted to reveal the toxicity of leaves of the P.platychlaena Boiss on the rat. The results revealed that leaves cause toxicity of rats and its lethal dose was 3.95g/kg this is due to the leaves part containing large amount of coumarin than other aerial parts. These finding sugested that this plant, specially their leaves must not be used as the fooder for animals

Although traditional healers in Ethiopia have a long history of using medicinal plants to treat diseases in animals and humans, studies on the antibacterial activities and potential bioactive ingredients of most medicinal plants have been insufficient. Therefore, this study aimed to evaluate the in-vitro antibacterial activities and to screen phytochemical constituents of selected medicinal plants against reference bacterial strains. The fresh and healthy roots of , fruits of , and leaves of were collected from West Shewa Zone, Ethiopia. Agar well diffusion and agar dilution methods were used to evaluate antibacterial activities and minimum inhibitory concentrations (MIC). All the crude plant extracts were tested against and at concentrations of 100, 50, and 25 mg/mL in each triplet (3x). MIC of crude extracts ranging from 1.5625 to 12.50 mg/mL was applied to all bacterial strains. The positive control was ciprofloxacin disk (5 μg) and the negative control was 5% dimethyl sulfoxide. The presence of secondary metabolites of each crude extract was screened. The group means comparisons were done using one-way ANOVA and results were presented as mean ± standard deviation. Although all selected plant extracts had shown antibacterial activities, methanol extracts had a greater zone of inhibition against all reference bacterial strains when compared to petroleum ether extracts. The growth of was inhibited at a minimum concentration of both methanol and petroleum extracts (1.5625 mg/mL) when compared to the remaining bacterial strains. Phytochemical screening showed that saponins and alkaloids were found in all crude plant extracts, while phytosterol was meager. This study revealed that all tested plants had significant secondary metabolites and antibacterial activities against reference bacterial strains.

The purpose of this study was to investigate the major flavonoids content and bioactivities of Tartary buckwheat sprouts. The crude methanol extract (ME) of Tartary buckwheat sprouts was abundant in flavonoids, and six major flavonoids, including isoorientin, vitexin, isovitexin, rutin, quercetin, and kaemferol were successfully determined from the sprouts by the high-performance liquid chromatography (HPLC) method. Generally, the flavonoid content of buckwheat sprouts was in the order of rutin > quercetin > isovitexin > vitexin> isoorientin > kaemferol. The highest rutin content of the ME and sprout cultures was 89.81 mg/g and 31.50 mg/g, respectively. Antibacterial activity results indicated the ME displayed notable inhibitory activity against the five tested bacteria, and its minimum inhibitory concentration (MIC) values ranged from 0.8 mg/mL to 3.2 mg/mL. Among the six flavonoids, quercetin was the most active compound, which exhibited strong activity against all tested bacteria except for E. coli and S. epidermidis, with its MIC values ranging from 0.2 mg/mL to 0.4 mg/mL. For the antifungal activity assay, the ME of Tartary buckwheat sprouts and four flavonoids could significantly inhibit the spore germination of two pathogenic fungi, and their inhibitory efficiency was concentration dependent. Quercetin was the most active one, which significantly inhibited the spore germination of F. oxysporum f. sp. vasinfectum and F. oxysporum f. sp. cucumerinum, and its median effective inhibitory concentration (IC50) value was 42.36 and 32.85 µg/mL, respectively. The antioxidant activity results showed that quercetin, kaemferol, and rutin displayed excellent antioxidant activity in the DPPH radical scavenging test, and their IC50 value was calculated as 5.60, 16.23, and 27.95 µg/mL, respectively. This is the first report on the antimicrobial activity of the crude extract of Tartary buckwheat sprouts. These results indicated that the methanol extract of Tartary buckwheat sprouts could be used as a potential antimicrobial or antioxidant agent in the future.

Aedes aegypti is a mosquito that carries dengue virus, yellow fever and other diseases transmitted to humans. Organophosphorus larvicides are used to control the proliferation of this mosquito, which has generated a high degree of resistance; hence, new alternatives such as bio-larvicides formulated with plant extracts are of great interest. The aims of this study were to evaluate the ethanolic extract of Azadirachta indica leaves as a larvicide against Aedes aegypti and to determine the main compounds present in it by GC-MS. In the assay, three concentrations of ethanolic extract were used (10 mg L-1, 20 mg L-1, and 50 mg L-1). This was performed thrice against a positive control (commercial larvicide: spores and endotoxic crystals of Bacillus thuringiensis var. israelensis Serotype H-14) and negative control (water). After 72 h of incubation, it was observed higher larval mortality (93%) in the ethanolic extract at a concentration of 50 mg L-1; the extracts at 10 mg L-1 and 20 mg L-1 shown larval mortality of 47% and 70%, respectively. The majority compound determined by the GC-MS analysis was phytol (14.4% area). The results obtained in this study demonstrated the larvicidal potential of the ethanolic extract of A. indica against larvae of A. aegypti.