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Seeds of discovery : how Barbara McClintock used corn and curiosity to solve a science mystery and win a Nobel prize
\"As a rare female botanist in early twentieth-century America, Barbara McClintock never let other people's notions of what was proper slow her down. When she faced doubting colleagues and unsupportive institutions, she drove across the United States, climbed through windows, and even slept in her laboratory to conduct her research. In so doing, she helped pave the way for future scientific discoveries that can cure diseases and save lives -- and won a Nobel Prize in the process!\" -- Provided by publisher.
CHILDBOOK
Mechanisms of Karyotypic Diversification in IAncistrus/I : Inferences from Repetitive Sequence Analysis
Ancistrus is a highly diverse neotropical fish genus that exhibits extensive chromosomal variability, encompassing karyotypic morphology, diploid chromosome number (2n = 34–54), and the evolution of various types of sex chromosome systems. Robertsonian rearrangements related to unstable chromosomal sites are here described. Here, the karyotypes of two Ancistrus species were comparatively analyzed using classical cytogenetic techniques, in addition to isolation, cloning, sequencing, molecular characterization, and fluorescence in situ hybridization of repetitive sequences (i.e., 18S and 5S rDNA; U1, U2, and U5 snDNA; and telomere sequences). The species analyzed here have different karyotypes: Ancistrus sp. 1 (2n = 38, XX/XY) and Ancistrus cirrhosus (2n = 34, no heteromorphic sex chromosomes). Comparative mapping showed different organizations for the analyzed repetitive sequences: 18S and U1 sequences occurred in a single site in all populations of the analyzed species, while 5S and U2 sequences could occur in single or multiple sites. A sequencing analysis confirmed the identities of the U1, U2, and U5 snDNA sequences. Additionally, a syntenic condition for U2-U5 snDNA was found in Ancistrus. In a comparative analysis, the sequences of rDNA and U snDNA showed inter- and intraspecific chromosomal diversification. The occurrence of Robertsonian rearrangements and other dispersal mechanisms of repetitive sequences are discussed.
Journal Article
Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia
Patients with TP53 mutations or unfavorable cytogenetics showed high rates of response.
Journal Article
Correction: Embryos of Robertsonian Translocation Carriers Exhibit a Mitotic Interchromosomal Effect That Enhances Genetic Instability during Early Development
[This corrects the article DOI: 10.1371/journal.pgen.1003025.].[This corrects the article DOI: 10.1371/journal.pgen.1003025.].
Journal Article