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Although perovskite wafers with a scalable size and thickness are suitable for direct X‐ray detection, polycrystalline perovskite wafers have drawbacks such as the high defect density, defective grain boundaries, and low crystallinity. Herein, PbI2‐DMSO powders are introduced into the MAPbI3 wafer to facilitate crystal growth. The PbI2 powders absorb a certain amount of DMSO to form the PbI2‐DMSO powders and PbI2‐DMSO is converted back into PbI2 under heating while releasing DMSO vapor. During isostatic pressing of the MAPbI3 wafer with the PbI2‐DMSO solid additive, the released DMSO vapor facilitates in situ growth in the MAPbI3 wafer with enhanced crystallinity and reduced defect density. A dense and compact MAPbI3 wafer with a high mobility‐lifetime (µτ) product of 8.70 × 10−4 cm2 V−1 is produced. The MAPbI3‐based direct X‐ray detector fabricated for demonstration shows a high sensitivity of 1.58 × 104 µC Gyair−1 cm−2 and a low detection limit of 410 nGyair s−1. PbI2‐DMSO powders are adopted as a solid additive for isostatic pressing of MAPbI3 wafers to promote in situ crystal growth. A dense and compact MAPbI3 wafer exhibits high mobility‐lifetime product of 8.70 × 10−4 cm2 V–1. The X‐ray detector shows high sensitivity of 1.58 × 104 µC Gyair –1 cm–2 and low detection limit of 410 nGyair s–1.

Dimethyl sulfoxide (DMSO) is the cryoprotectant of choice for most animal cell systems since the early history of cryopreservation. It has been used for decades in many thousands of cell transplants. These treatments would not have taken place without suitable sources of DMSO that enabled stable and safe storage of bone marrow and blood cells until needed for transfusion. Nevertheless, its effects on cell biology and apparent toxicity in patients have been an ongoing topic of debate, driving the search for less cytotoxic cryoprotectants. This review seeks to place the toxicity of DMSO in context of its effectiveness. It will also consider means of reducing its toxic effects, the alternatives to its use and their readiness for active use in clinical settings.

Ti3C2Tx Quantum dots (QDs)/L‐Ti3C2Tx fiber electrode (Q3M7) with high capacitance and excellent flexibility is prepared by a wet spinning method. The assembled units Ti3C2Tx nanosheets (NSs) with large size (denoted as L‐Ti3C2Tx) is obtained by natural sedimentation screen raw Ti3AlC2, etching, and mechanical delamination. The pillar agent Ti3C2Tx QDs is fabricated by an ultrasound method. Q3M7 fiber electrode gave a specific capacitance of 1560 F cm−3, with a capacity retention rate of 79% at 20 A cm−3, and excellent mechanical strength of 130 Mpa. A wide temperature all‐solid‐state the delaminated montmorillonite (F‐MMT)/Polyvinyl alcohol (PVA) dimethyl sulfoxide (DMSO) flexible hydrogel (DHGE) (F‐MMT/PVA DHGE) Q3M7 fiber supercapacitor is assembled by using Q3M7 fiber as electrodes and F‐MMT/PVA DHGE as electrolyte and separator. It showed a volume specific capacitance of 413 F cm−3 at 0.5 A cm−3, a capacity retention of 97% after 10 000 cycles, an energy density of 36.7 mWh cm−3 at a power density of 311 mW cm−3, and impressive capacitance and flexibility over a wide temperature range of −40 to 60 °C. This work provides an effective strategy for designing and assembling wide temperature all‐solid‐state fiber supercapacitors with optimal balance of capacitive performance and flexibility. Ti3C2Tx Quantum dots (QDs)/L‐Ti3C2Tx fiber electrode (Q3M7) with high capacitance and excellent flexibility is prepared by a wet spinning method, and all‐solid‐state symmetric fiber supercapacitor (F‐MMT/PVA DHGE Q3M7) with excellent energy storage in a wide temperature from ‐40 to 60 °C is assembled on the basis of the optimizing balance of capacitive performance and flexibility.

Cryopreservation is a well-established method for extending platelet shelf-life and addressing supply shortages. Traditionally, this involves dimethyl sulfoxide (DMSO) as a cryoprotective agent (CPA), but recent studies suggest that using controlled rate freezing (CRF) with only NaCl may offer a less toxic alternative. To explore further optimization, this study assessed whether adding 10% choline chloride–glycerol, a deep eutectic solvent (DES), could enhance platelet quality in CRF/NaCl cryopreservation. Ten double-dose buffy coat platelet units were divided into test (DES-treated) and control (NaCl-only) groups. After DES exposure (10% for 20 min), all units were prepared using the NaCl protocol and frozen at −80 °C with CRF equipment, then stored for over 90 days. Upon thawing and reconstitution in AB plasma, no significant differences were observed in platelet content post-thaw between control and test units (255 ± 43 vs. 257 ± 41 × 109/unit), post-thaw recovery (>85%): respectively, Δψ (JC-1% pos 63 ± 15 vs. 68 ± 17), LDH (% of total 10 ± 6 vs. 9 ± 6), (CD63% 77 ± 9 vs. 82 ± 7), (CD62P % 72 ± 15 vs. 76 ± 11), (CD42b % 78 ± 9 vs. 80 ± 9), (CD61% 79 ± 9 vs. 78 ± 9), (CD41% 81 ± 11 vs. 83 ± 7), (PAC-1% 33 ± 10 vs. 32 ± 8), (Pecam-1% 78 ± 11 vs. 80 ± 8), (GPIV % 72 ± 10 vs. 74 ± 11), (LAMP-1% 26 ± 14 vs. 11 ± 9), (MPCD61+ % 41 ± 11 vs. 46 ± 10), (ROTEM CT 56 ± 7 vs. 55 ± 6), (ROTEM CFT 110 ± 70 vs. 106 ± 67) and (ROTEM MCF 35 ± 6 vs. 36 ± 6). These findings support the feasibility of CPA-free CRF-based platelet cryopreservation while maintaining functional integrity.

Low‐dimensional hybrid halide perovskites represent a promising class of materials in optoelectronic applications because of strong broad self‐trapped exciton (STE) emissions. However, there exists a limitation in designing the ideal A‐site cation that makes the material satisfy the structure tolerance and exhibit STE emission raised by the appropriate electron–phonon coupling effect. To overcome this dilemma, we developed an inorganic metal‐organic dimethyl sulfoxide (DMSO) coordinating strategy to synthesize a series of zero‐dimensional (0D) Sb‐based halide perovskites including Na3SbBr6·DMSO6 (1), AlSbBr6·DMSO6 (2), AlSbCl6·DMSO6 (3), GaSbCl6·DMSO6 (4), Mn2Sb2Br10·DMSO13 (5) and MgSbBr5·DMSO7 (6), in which the distinctive coordinating A‐site cation [Am‐DMSO6]n+ efficiently separate the [SbXz] polyhedrons. Advantageously, these materials all exhibit broadband‐emissions with full widths at half maxima (FWHM) of 95–184 nm, and the highest photoluminescent quantum yield (PLQY) of 3 reaches 92%. Notably, compounds 2–4 are able to remain stable after storage of more than 120 d. First‐principles calculations indicate that the origin of the efficient STE emission can be attributed to the localized distortion in [SbXz] polyhedron upon optical excitation. Experimental and calculational results demonstrate that the proposed coordinating strategy provides a way to efficiently expand the variety of novel high‐performance STE emitters and continuously regulate their emission behaviors. For low‐dimensional perovskites exhibiting broad‐band emission by self‐trapped excitons (STEs), satisfying the structure tolerance while exhibiting strong emission is a roadblock. By designing a unique cation [Am‐DMSO6]n+, a series of zero‐dimensional perovskites as AmSbXz·DMSOi has been synthesized, boosting the variety of antimony‐based STE‐emitting perovskites with excellent photoluminescent properties such as high photoluminescent quantum yields and adjustable correlated color temperature range.

Cryoprotective and cytoprotective agents (Cytoprotective Agents) are fundamental components of the cryopreservation process. This review presents the essentials of the cryopreservation process by examining its drawbacks and the role of cytoprotective agents in protecting cell physiology. Natural cryoprotective and cytoprotective agents, such as antifreeze proteins, sugars and natural deep eutectic systems, have been compared with synthetic ones, addressing their mechanisms of action and efficacy of protection. The final part of this article focuses melatonin, a hormonal substance with antioxidant properties, and its emerging role as a cytoprotective agent for somatic cells and gametes, including ovarian tissue, spermatozoa and spermatogonial stem cells.

The ability of natural killer (NK) cells to mediate potent antitumor immunity in clinical adoptive transfer settings relies, in large part, on their ability to retain cytotoxic function following cryopreservation. To avoid potential systemic toxicities associated with infusions of NK cells into patients in the presence of dimethylsulfoxide (DMSO), interest in alternative cryoprotective agents (CPAs) with improved safety profiles has grown. Despite the development of various sugars, amino acids, polyols, and polyampholytes as cryoprotectants, their ability to promote protection from intracellular cryodamage is limited because they mostly act outside of the cell. Though ways to shuttle cryoprotectants intracellularly exist, NK cells' high aversity to manipulation and freezing has meant they are highly understudied as targets for the development of new cryopreservation approaches. Here, the first example of a safe and efficient platform for the intracellular delivery of non‐DMSO CPAs to NK cells is presented. Biocompatible chitosan‐based nanoparticles are engineered to mediate the efficient DMSO‐free cryopreservation of NK cells. NK cells cryopreserved in this way retain potent cytotoxic, degranulation, and cytokine production functions against tumor targets. This not only represents the first example of delivering nanoparticles to NK cells, but illustrates the clinical potential in manufacturing safer allogeneic adoptive immunotherapies “off the shelf.” The clinical use of natural killer (NK) cells in immunotherapy requires cryopreservation prior to administration to patients. The process of cryopreservation, however, damages NK cells and, when DMSO is used, risks severe toxicities. Here, the development of a safe new nanoparticle‐based approach is described for the intracellular cryoprotection of NK cells, which yields functional effectors post cryopreservation devoid of DMSO.

In this study, a solution-processing based galvanic deposition approach is described for in-situ deposition of gold nanoparticles (AuNP) on delaminated titanium Ti 3 C 2 T x nanosheets under ultrasonication. The nanocomposite (AuNP@Ti 3 C 2 T x ) was placed on a glassy carbon electrode (GCE) and then applied to electrochemically with label-free, and simultaneously sense uric acid (UA), and folic acid (FA) at physiological pH. The modified GCE has attractive figures of merit: (i) The working potentials for UA and AA are well separated (+0.35 V and 0.70 V vs. Ag|AgCl); (ii) wide linear responses (from 0.03–1520 μM for UA and from 0.02–3580 μM for FA; (iii) good electrochemical sensitivities for both UA and FA (0.53 and 0.494 μAμM −1 .cm −2 , respectively), and (iv) detection limits of 11.5 nM (UA) and 6.20 nM (FA). The electrode exhibited good repeatability (RSD = 4.4%), acceptable reproducibility (RSD = 4.1%), and excellent stability (91.8% over one-month storage). The method was applied to analyze spiked serum samples, and modified GCE is shown appreciable recoveries (97.1–98.8% and 96.8–98.0% for UA, and FA, respectively). Graphical abstract A photograph (top left) of colloidal suspension of gold nanoparticles (AuNPs). They were grown on the delaminated titanium carbide Ti 3 C 2 T x MXene nanosheet via galvanic displacement deposition method, and their corresponding a low-resolution transmission electron microscopy micrograph (top right) of AuNP@Ti 3 C 2 T x . The graphical representation of AuNP@Ti 3 C 2 T x drop-casted on glassy carbon electrode (GCE) (bottom left), and their voltammetric measurement were applied in the presence of both uric acid and folic acid with increasing the concentration of both analytes (bottom right).

Tin perovskite solar cells are emerging as a sustainable lead‐free alternative in thin film photovoltaics. DMSO‐free processed tin perovskites are gaining interest due to the detrimental effects of DMSO on tin oxidation. However, replacing DMSO with other solvents remains challenging due to the accelerated crystallization dynamics in non‐DMSO systems. In this study, the crystallization process in a DMSO‐free solvent system is regulated by managing the transition from the sol‐gel phase to the solid film. Specifically, piperazine dihydriodide (PDAI) and 4‐tert‐butylpyridine (tBP) are utilized to coordinately tune the colloidal chemistry through forming large pre‐nucleation clusters in perovskite ink, further, facilitating the film formation process. By combining tBP and PDAI, a controllable crystallization rate is achieved as evidenced by in situ photoluminescence (PL) measurement during spin‐coating. As a result, tin perovskite films show high crystallinity and improved microstructure. Devices treated with tBP+PDAI exhibit a champion power conversion efficiency of 7.8% and excellent stability without observable degradation for over 3000 h stored in the N2 glovebox. These findings advance understanding and managing crystallization in DMSO‐free solvents processed tin perovskite solar cells. In this work, the authors investigated the crystallization process of tin perovskites in a DMSO‐free solvent system using in situ PL technique. The authors discovered that a synergistic approach effectively facilitates the formation of high‐quality DMSO‐free tin perovskite films by modulating the emergence of crystallites and the aggregation process. As a result, they achieved efficient and stable tin devices without DMSO.