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Fil: Blendinger, Pedro G. Universidad Nacional de Tucumán. Facultad de Ciencias Naturales e Instituto Miguel Lillo. Instituto de Ecología Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán; Argentina.

Area‐concentrated search (ACS) is a simple movement rule implying that an animal searches for resources using a “state‐dependent correlated random walk.” Accordingly, a forager increases its searching intensity by reducing the directionality of movement (“intensive search mode” or ISM) when it detects a resource item, but if it searches unsuccessfully for a while, it returns to a more straight‐line movement to search for new resource locations elsewhere (“extensive search mode” or ESM). We propose a modified ACS, called delayed‐response ACS (dACS), which is more efficient in resource collection than standard ACS. Instead of immediately switching from ESM to ISM when encountering a resource, as is done in standard ACS, an individual foraging in the dACS mode delays this switch by x $$ x $$steps so that it continues moving in a straight line for a while before switching to ISM. Our results showed that an individual with a suitable delay parameter x $$ x $$for the dACS achieved substantially higher foraging success than an individual with standard ACS (x=0 $$ x=0 $$ ). Optimal foraging success occurred when x $$ x $$was approximately similar to the patch radius r $$ r $$ . This is because, with dACS, an individual can penetrate deeper into and stay longer within a cluster, ultimately increasing the number of resources collected. Modifying the half‐saturation constant h $$ h $$also affected the success of foraging, but the effects depended on resource density and cluster size. Generally, h $$ h $$modulated the optimal x $$ x $$value only slightly. dACS can be interpreted as a survey movement within a resource cluster before switching from ESM to ISM. The dACS rule does not rely on complex spatial memory but only on memorizing how long ago resources were found or not. It may thus occur in a wide range of taxa, from organisms without a central nervous system to animals with complex brain systems. We propose a modified area‐concentrated search (ACS), called delayed‐response ACS (dACS), which is more efficient in resource collection than standard ACS. Instead of immediately switching from “extensive search mode” ESM to “intensive search mode” (ISM) when encountering a resource, as is done in standard ACS, an individual foraging in the dACS mode delays this switch by “x” steps so it continues moving in a straight line for a while before switching to ISM. Our results show that an individual with a suitable delay parameter “x” for the dACS achieves substantially higher foraging success than an individual with standard ACS.

Rationale Dopamine (DA) signaling through the D1 receptor has been shown to be integral to multiple aspects of cognition, including the core process of working memory. The discovery of positive allosteric modulators (PAMs) of the D1 receptor has enabled treatment modalities that may have alternative benefits to orthosteric D1 agonists arising from a synergism of action with functional D1 receptor signaling. Objectives To investigate this potential, we have studied the effects of the novel D1 PAM DPTQ on a spatial delayed response working memory task in the rhesus monkey. Initial studies indicated that DPTQ binds to primate D1R with high affinity and selectivity and elevates spontaneous eye blink rate in rhesus monkeys in a dose-dependent manner consistent with plasma ligand exposures and central D1activation. Results Based on those results, DPTQ was tested at 2.5 mg/kg IM in the working memory task. No acute effect was observed 1 h after dosing, but performance was impaired 48 h later. Remarkably, this deficit was immediately followed by a significant enhancement in cognition over the next 3 days. In a second experiment in which DPTQ was administered on days 1 and 5, the early impairment was smaller and did not reach statistical significance, but statistically significant enhancement of performance was observed over the following week. Lower doses of 0.1 and 1.0 mg/kg were also capable of producing this protracted enhancement without inducing any transient impairment. Conclusions DPTQ exemplifies a class of D1PAMs that may be capable of providing long-term improvements in working memory.

RationalePhencyclidine (PCP) could induce schizophrenia (Sz) like behavior in both humans and animals, therefore, has been widely utilized to establish Sz animal models. It induced cognitive deficits, the core symptom of Sz, mainly through influencing frontal dopaminergic function. Nonhuman primate (NHP) studies demonstrated impaired object retrieval detour (ORD) and spatial delayed response (SDR) task performance by acute or chronic PCP treatment. However, NHP investigations, continually monitoring SDR performance before, during and after PCP treatment, are lacking.ObjectivesPresent study investigated the long-term influence of chronic PCP treatment on SDR performance and the possible increase of SDR deficit severity and duration by the incremental dosing procedure in rhesus monkeys.MethodsSDR task was performed repeatedly up to eight weeks after constant dosing procedure (i.m., 0.3 mg/kg, day 12-25), during which drug effects on locomotor activity and blood cortisol concentration were assessed. Incremental dosing procedure (starting dose 0.3 mg/kg, day 6-19) began five months later.ResultsConstant dosing procedure induced differential level of hyperactivity across testing days, without significant influence on blood cortisol concentration. It reduced SDR performance, until occurrence of the first and worst impairment on day 15 and 23 respectively. The impaired performance recovered to pretreatment level over one week after drug cessation. In contrast, incremental dosing procedure impaired SDR performance on the first treatment day, which recovered within treatment period.ConclusionResults suggested increase of SDR deficit severity by repeated PCP administrations, whereas the incremental dosing procedure did not increase SDR deficit severity and duration.

Task parameters still affect reaction times even when all necessary information for executing an action is presented prior to a Go signal to execute the action. Hypotheses in terms of short-term memory capacity, residual activation, and a separate motor-programming stage have been suggested to explain what can and cannot be prepared prior to a delayed Go signal. To test these hypotheses, we used a delayed response task, in which participants were to initiate a movement at onset of an imperative Go signal following the target stimulus. Across Experiments 1–3 we varied task properties including stimulus type, information uncertainty and response complexity, respectively, while controlling other factors. We also varied the time available to process the response by randomly varying the interval between onset of the target and the Go signal (i.e., the stimulus onset asynchrony, or SOA). If the preparation process is completed before initiation, the examined factor should display a strong interaction with SOA, with its effect disappearing at long SOAs. Our results showed strong, weaker, and no interaction patterns for the three factors, respectively, favoring the separate stage hypothesis, according to which response preparation is separated into steps to arrange kinematic specifications into muscle-controllable terms.

Neurone firing behaviour is a result of complex interaction between synaptic inputs and cellular intrinsic properties. Intriguing firing behaviour, delayed spiking, was shown in some neurones, in particular, in cat neocortical neurones and rat pyramidal hippocampal neurones. In contrast, the similar spiking mode was not reported for animal spinal motoneurones. In the present study, an attempt was made to look for possible evidence of delayed spiking in human motoneurones firing within the low-frequency, sub-primary range, characteristic for voluntary muscle contractions and postural tasks. Forty-seven firing motor units (MUs) were analyzed in ten experiments on three muscles (the flexor carpi ulnaris, the tibialis anterior, and the abductor pollicis brevis) in four healthy humans. Single MUs were activated by gentle voluntary muscle contractions. MU peri-stimulus time histograms, durations of inter-spike intervals, and motoneurone excitability changes within a target interspike interval were analyzed. It was found that during testing the firing motoneurone excitability by small, transient excitatory Ia afferent volley, depending firstly on volley timing within a target interspike interval and excitatory volley strength, the same motoneurone displayed either the direct short-latency response (the H-reflex) or the delayed response (with prolonged and variable latency). Thus, the findings, for the first time, provide evidence for a possibility of two modes of spiking in firing motoneurones. Methods of the estimation of delayed responses and their possible functional significance are discussed. It is emphasized that, for understanding of this issue, the integration of data from studies on experimental animals and humans is desirable.

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) created an exceptional situation in which numerous laboratories in Europe simultaneously implemented SARS-CoV-2 diagnostics. These laboratories reported in February 2020 that commercial primer and probe batches for SARS-CoV-2 detection were contaminated with synthetic control material, causing delays of regional testing roll-out in various countries.

Short-term memories link events separated in time, such as past sensation and future actions. Short-term memories are correlated with slow neural dynamics, including selective persistent activity, which can be maintained over seconds. In a delayed response task that requires short-term memory, neurons in the mouse anterior lateral motor cortex (ALM) show persistent activity that instructs future actions. To determine the principles that underlie this persistent activity, here we combined intracellular and extracellular electrophysiology with optogenetic perturbations and network modelling. We show that during the delay epoch, the activity of ALM neurons moved towards discrete end points that correspond to specific movement directions. These end points were robust to transient shifts in ALM activity caused by optogenetic perturbations. Perturbations occasionally switched the population dynamics to the other end point, followed by incorrect actions. Our results show that discrete attractor dynamics underlie short-term memory related to motor planning. Neuronal networks involving the frontal cortex follow discrete attractor dynamics to maintain short-term memories over times of seconds, much longer than the time-constant of individual neurons.

Recent experiments have shown that visual cognition blends current input with that from the recent past to guide ongoing decision making. This serial dependence appears to exploit the temporal autocorrelation normally present in visual scenes to promote perceptual stability. While this benefit has been assumed, evidence that serial dependence directly alters stimulus perception has been limited. In the present study, we parametrically vary the delay between stimulus and response in a spatial delayed response task to explore the trajectory of serial dependence from the moment of perception into post-perceptual visual working memory. We find that behavioral responses made immediately after viewing a stimulus show evidence of adaptation, but not attractive serial dependence. Only as the memory period lengthens is a blending of past and present information apparent in behavior, reaching its maximum with a delay of six seconds. These results dovetail with other recent findings to bolster the interpretation that serial dependence is a phenomenon of mnemonic rather than perceptual processes. However, even while this pattern of effects in group-averaged data has now been found consistently, we show that the relative strengths of adaptation and serial dependence vary widely across individuals. Finally, we demonstrate that when leading mathematical models of working memory are adjusted to account for these trial-history effects, their fit to behavioral data is substantially improved.

Motor cortical beta activity (13-30 Hz) is a hallmark signature of healthy and pathological movement, but its behavioural relevance remains unclear. Using high-precision magnetoencephalography (MEG), we show that during the classical event-related desynchronisation (ERD) and event-related synchronisation (ERS) periods, motor cortical beta activity in individual trials (n > 12,000) is dominated by high amplitude, transient, and infrequent bursts. Beta burst probability closely matched the trial-averaged beta amplitude in both the pre- and post-movement periods, but individual bursts were spatially more focal than the classical ERS peak. Furthermore, prior to movement (ERD period), beta burst timing was related to the degree of motor preparation, with later bursts resulting in delayed response times. Following movement (ERS period), the first beta burst was delayed by approximately 100 milliseconds when an incorrect response was made. Overall, beta burst timing was a stronger predictor of single trial behaviour than beta burst rate or single trial beta amplitude. This transient nature of motor cortical beta provides new constraints for theories of its role in information processing within and across cortical circuits, and its functional relevance for behaviour in both healthy and pathological movement.