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Background The pathogenesis of schizophrenia is still unknown. Nearly a half of schizophrenic patients have depressive symptoms and even some impulsive behaviors. The definite diagnosis of schizophrenia is an immense challenge. Molecular biology plays an essential role in the research on the pathogenesis of schizophrenia. Objective This study aims to analyze the correlations of serum protein factor levels with depressive emotion and impulsive behaviors in drug-naïve patients with first-episode schizophrenia. Methods Seventy drug-naïve patients with first-episode schizophrenia and sixty-nine healthy volunteers from the health check center in the same period participated in this study. In both the patient group and control group, brain-derived neurotrophic factor (BDNF), phosphatidylin-ositol-3-kinase (PI3K), protein kinase B (AKT), and cAMP-response element binding protein (CREB) levels in the peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA). The depressive emotion and impulsive behaviors were evaluated with Chinese versions of the Calgary Depression Scale for Schizophrenia (CDSS) and Short UPPS-P Impulsive Behavior Scale (S-UPPS-P), respectively. Results The serum levels of BDNF, PI3K, and CREB in the patient group were lower than those in the control group, while AKT level, total CDSS score and total S-UPPS-P score were all higher. In the patient group, total CDSS score, and total S-UPPS-P score were both correlated negatively with BDNF, PI3K, and CREB levels but positively with AKT level, and the lack-of-premeditation (PR) sub-scale score was not significantly correlated with BDNF, PI3K, AKT, and CREB levels. Conclusion Our study results showed that the peripheral blood levels of BDNF, PI3K, AKT, and CREB in drug-naïve patients with first-episode schizophrenia were significantly different from those in the control group. The levels of these serum protein factors are promising biomarkers to predict schizophrenic depression and impulsive behaviors.

Background The occurrence and degree of suicidal ideation during the past month in adolescents should be regarded seriously. Several studies have noted that humor expression style and depressive emotion may influence adolescents’ suicidal ideation. However, there is insufficient evidence concerning whether positive emotion reduces such suicidal ideation in adolescents. In addition, the relationships among humor expression, depressive emotion, positive emotion and suicidal ideation remain to be confirmed. Therefore, in this study, we aimed to test the mediating roles of depressive emotion and positive emotion in the relationship between humor expression and recent adolescent’s suicidal ideation. Methods A total of 1551 students in junior high school completed questionnaires. The collected data were analyzed using structural equation modeling (SEM) with LISREL 8.80 and Monte Carlo resampling with R. Results The results indicate that suicidal ideation in adolescents during the past month was related not only to humor expression but also to depressive emotion and positive emotion. The stronger the depressive emotion felt, the stronger the suicidal ideation; in contrast, the stronger the positive emotion, the weaker the suicidal ideation. Moreover, depressive emotion and positive emotion were found to mediate the relationship between humor expression and suicidal ideation; additionally, positive emotion was found to mediate the relationship between depressive emotion and suicidal ideation. Conclusion These results highlight that depressive emotion and positive emotion may mediate the influence of humor expression on suicidal ideation among adolescents, and positive emotion may mediate the influence of depressive emotion on suicidal ideation. More attention should be paid to decreasing adolescents’ self-deprecating humor expression and depressive emotion, whereas more witty response humor expression and positive emotion should be encouraged to prevent their suicidal ideation.

Background Poor adolescent sleep health is a significant public health issue worldwide. In particular, multiple sleep problems disturb the lives of adolescents. It is urgent to identify the key factors (e.g., parent‒child relationships, peer relationships, and teacher‒student relationships) and influential moderators (e.g., depressive emotions) that contribute to adolescent sleep problems. Methods Data were derived from the China Education Panel Survey (CEPS) and collected through self-reported questionnaires. A total of 7405 students (3818 boys and 3587 girls) born between 2000 and 2001 were followed from grade 7 through grade 8. Logistic regression was applied to explore the effects of the independent variables and moderating variable on students’ sleep problems. Results Remaining fatigued after waking up (17.97%), dreaminess (14.21%) and sleep fragmentation (13.07%) were the three most common sleep problems among the students. Peer relationships, teacher praise, and depressive emotions were related to adolescents’ sleep problems (all p  < 0.05). Notably, depressive emotion served as an influential moderator in the relationship between social relationships and sleep problems among students, exhibiting simultaneous and lasting effects (all p  < 0.05). Conclusions Reducing adolescents’ sleep problems is necessary, and enhancing adolescents’ positive social relationships and reducing their depressive emotions should receive increased attention.

Depressive emotion (DE) refers to clinically relevant depressive symptoms without meeting the diagnostic criteria for depression. Studies have demonstrated that DE can cause spatial cognition impairment. However, the brain network mechanisms underlying DE interference spatial cognition remain unclear. This study aimed to reveal the differences in brain network connections between DE and healthy control (HC) groups during resting state and a spatial cognition task. The longer operation time of the DE group during spatial cognition task indicated DE interference spatial cognition. In the resting state stage, the DE group had weaker network connections in theta and alpha bands than the HC group had. Specifically, the electrodes in parietal regions were hubs of the differential networks, which are related to spatial attention. Moreover, in docking task stages, the left frontoparietal network connections in delta, beta, and gamma bands were stronger in the DE group than those of the HC group. The enhanced left frontoparietal connections in the DE group may be related to brain resource reorganization to compensate for spatial cognition decline and ensure the completion of spatial cognition tasks. Thus, these findings might provide new insights into the neural mechanisms of depressive emotion interference spatial cognition.

背景：腦瘤治療以手術為主，然手術後病人仍因疾病與治療因素產生諸多症狀困擾和護理需求，若未及時改善則容易產生憂鬱情緒。目的：探討支持關懷介入措施對腦腫瘤術後病人之症狀困擾、護理需求與憂鬱之成效。方法：本研究採雙組前、後測實驗設計，以隨機抽樣將參與者分配到兩組，實驗組接受術後1個月和3個月的支持性關懷，對照組接受常規性出院衛教。成果測量包括支持性護理需求量表、症狀困擾量表和流行病學研究中心憂鬱量表。資料收集時間包括：出院前（T0）、術後1個月（T1）、3個月（T2）和6個月（T3）。結果：由廣義估計模式分析顯示，支持性關懷介入後，實驗組護理需求在T1（β=-23.61,p＜.001）、T2（β=-22.51,p＜.001）、T3（β=-22.26,p＜.001）顯著低於對照組。症狀困擾在T1（β=-7.03,p=.019）、T2（β=-8.39,p=.003）顯著低於對照組。憂鬱情緒僅在T2（β=-8.55,p=.005）顯著低於對照組。結論：本研究顯示支持性關懷有助改善腦瘤病人手術後護理需求、症狀困擾和憂鬱情緒，醫護團隊人員應注意腦瘤病人術後護理需求、症狀困擾和憂鬱情緒狀況，必要時提供訊息，以提高護理的照護品質。

Brain tumors are mainly treated with surgery. However, patients still experience many symptoms and nursing needs due to disease and treatment-related factors that, if not improved in a timely manner, may result in depression. The purpose of this study was to examine the effectiveness of supportive caring on symptom distress, nursing needs, and depressive symptoms in patients with brain tumor after surgery. This study adopted a two-group, pre- and post-test experimental design. The enrolled participants were randomized into two groups. Those in the experimental group received a phone-based supportive caring intervention twice at 1 and 3 months after surgery. Those in the control group received usual discharge care. The measurement outcomes included a supportive care needs survey, symptom distress scales, and the center for epidemiological studies of depression. Baseline data was collected prior to hospital discharge (T0), with follow-up data collected at one month (T1), three months (T2), and six months (T3) a

Following the United States’ recent engagements in military conflicts, the impact of parent deployment on child adaptation has become an increased focus of research. This study examined the contributions of maternal depressive affect and parenting stress to young children’s (ages 3 to 7) internalizing and externalizing symptomatology. In order to examine how these maternal factors contribute to child well-being, mean level differences and path analysis with group level modelling examined differences between military, single-parent and two-parent civilian families. Mean level differences reflected higher rates of difficulty for military homefront mothers in terms of depressive affect than either single or two-parent families and similar levels of parenting stress with single mothers. Military children demonstrated higher rates of internalizing or externalizing symptoms than children in single or two-parent families. Path analysis results indicated group level differences in links between maternal depressive affect and internalizing symptoms, with military families having stronger associations than single parent families. No group level differences were found between maternal depressive affect and externalizing symptoms. Associations between parenting stress and internalizing symptoms were stronger for military families than two parent families but weaker than single parent families, while the links between parenting stress and externalizing symptoms were the same for military and for single-parent families. These findings have important implications regarding potential intervention/prevention approaches for military families, suggesting that it may be particularly beneficial to target homefront mothers’ depressive affect and parenting stress during deployment as a means for promoting positive child outcomes. Highlights Homefront mothers exhibit higher rates of depressive affect than civilian mothers (i.e. single or two-parent), and more emotion dysregulation and parenting stress than civilian two-parent mothers. Young children from military families demonstrated higher rates of internalizing and externalizing symptoms than children from either group of civilian families. Different patterns of prediction from maternal depressive affect and parenting stress to children’s internalizing and externalizing symptoms were found based on family type. Findings suggest the importance of easily available mental health services, targeting maternal depressive affect and parenting stress for homefront mothers.

The antidepressant effects of ketamine are thought to depend on brain-derived neurotrophic factor (BDNF) genotype and dose. The purpose of this study was to characterize the dose-related antidepressant effects of ketamine in patients with treatment-resistant depression drawn from a Chinese population predominately possessing lower activity BDNF genotypes (Val/Met, Met/Met). We conducted a double-blind, randomized, parallel-group, placebo-controlled trial of a single ketamine infusion (saline, 0.2 mg/kg, 0.5 mg/kg). Patients (N=71; BDNF genotype: Val/Val (N=12, 17%), Val/Met (N=40, 56.3%), and Met/Met (N=19, 26.8%)) received mood ratings before infusion, after infusion, and for the subsequent 14 days. Plasma ketamine levels and BDNF genotypes were assessed. This study found a significant dose-related ketamine effect on scores on the Hamilton Depression Rating Scale (HAMD). The responder analysis (>50% reduction from baseline HAMD on at least 2 days between days 2 and 5) also revealed a significant dose-related effect (saline: 12.5%, 0.2 mg/kg: 39.1%; 0.5 mg/kg: 45.8%). This is the first report to our knowledge to demonstrate the dose-related efficacy of R/S-ketamine for treatment-resistant depression and the first to characterize ketamine effects in a genotyped Chinese population in which most (83%) patients possessed at least one copy of the lower functioning Met allele of the BDNF gene.

Considering the complexity of serotonergic influence on emotions, we conducted a comprehensive investigation of the interplay between emotion processing and the serotonergic system using simultaneous functional and molecular neuroimaging during pharmacological challenge while disentangling the effects of serotonin transporter (SERT) binding, genotype, and diagnosis of major depressive disorder (MDD). Herein, 153 subjects (44 with MDD) performed a facial emotion processing task during functional magnetic resonance imaging (fMRI) before and after an acute intravenous application of 8 mg citalopram or placebo. Patients with MDD were assessed again after at least three months of antidepressant treatment. Citalopram administration resulted in a reduced fMRI activation in regions involved in fear processing, including the anterior cingulate cortex (ACC), when viewing fearful faces contrasted against happy or neutral faces. ACC activation correlated negatively with striatal/thalamic SERT availability across drug conditions as measured by [11 C]DASB positron emission tomography. Across groups, citalopram-induced changes in ACC activation correlated with emotional attribution, indicating stronger reductions for subjects with higher self- versus other- attribution. Moreover, striatal SERT availability mediated the influence of the number of 5-HTTLPR/rs25531 L A alleles on ACC activation under placebo. Patients with MDD exhibited increased activations in the intraparietal and superior frontal sulcus in response to fearful versus happy faces at baseline, and along the parieto-occipital/calcarine fissure after treatment. We interpret our findings on multiple levels of the serotonergic-emotional interaction within the context of enhanced passive coping and acute anxiolytic effects of citalopram following potential changes in serotonin or SERT availability.

Negative neurocognitive bias is a core feature of depression that is reversed by antidepressant drug treatment. However, it is unclear whether modulation of neurocognitive bias is a common mechanism of distinct biological treatments. This randomized controlled functional magnetic resonance imaging study explored the effects of a single electroconvulsive therapy session on self-referent emotional processing. Twenty-nine patients with treatment-resistant major depressive disorder were randomized to one active or sham electroconvulsive therapy session at the beginning of their electroconvulsive therapy course in a double-blind, between-groups design. The following day, patients were given a self-referential emotional word categorization test and a free recall test. This was followed by an incidental word recognition task during whole-brain functional magnetic resonance imaging at 3T. Mood was assessed at baseline, on the functional magnetic resonance imaging day, and after 6 electroconvulsive therapy sessions. Data were complete and analyzed for 25 patients (electroconvulsive therapy: n = 14, sham: n = 11). The functional magnetic resonance imaging data were analyzed using the FMRIB Software Library randomize algorithm, and the Threshold-Free Cluster Enhancement method was used to identify significant clusters (corrected at P < .05). A single electroconvulsive therapy session had no effect on hippocampal activity during retrieval of emotional words. However, electroconvulsive therapy reduced the retrieval-specific neural response for positive words in the left frontopolar cortex. This effect occurred in the absence of differences between groups in behavioral performance or mood symptoms. The observed effect of electroconvulsive therapy on prefrontal response may reflect early facilitation of memory for positive self-referent information, which could contribute to improvements in depressive symptoms including feelings of self-worth with repeated treatments.