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Solar still, which uses solar renewable energy sources, especially solar energy, to produce pure water, is a promising technology as it is abundantly available and eco-friendly. Researchers have innovated in internal and external designs to enhance distillate productivity in solar desalination systems. The present review paper discusses the major internal modifications done in history and recent past to enhance the distillate output. Six sub-sections have been developed concerning historic internal modifications that discuss types of basin liners, water depth, stones, dyes, phase change materials, and weirs. It has been found that among all the historic internal modifications, phase change materials were the most effective with distillate yield enhancement of up to 80%. The limitation in distillate yield made the researchers to perform further modifications to enhance the productivity, and hence, recent internal designs have also been discussed. Recent internal modifications have six sub-sections: fins, wicks, nanofluids, nanostructures, dynamic modifications, and natural materials. Among the recent, dynamic modifications were the most efficient with productivity enhancement of up to 300%, with a maximum cumulative yield of 8.78 kg/m 2 /day for the rotating wick solar still compared to CSS which gave only 2.21 kg/m 2 /day. Such a kind of review work has not been performed till date, which covers all the internal design modifications in one paper exhaustively. Furthermore, gaps have been identified, and future perspectives have been presented in the conclusion section. It has been observed that nanostructures, nanoparticles, and dynamic modifications are the most promising internal modifications in recent times that can boost distillate productivity to a greater degree.

Due to the expansion of residents, the consumption of non-renewable energy increased enormously, thus indirectly increasing pollution and affecting the surroundings. To reduce pollutions in the surroundings, it is recommended to choose non-conventional energy sources. By satisfying this, we can probably decrease the non-renewable sources of energy, by consuming the solar power in day-to-day life in the application of food drying process. In this review article, we have discussed the classification of solar dryer and the impact of design modifications performed in the components of solar dryer and assessed the various types of solar dryer performance, cost estimations and designs performed in solar dryer of food applications which were not discussed in the earlier research. The primary and critical task in designing the solar dryer is to achieve higher efficiency at minimum cost. Hence, proper analysis of drying application, selection of suitable components and suitable design must be carried out to attain efficient dryer. Considering these characteristics, this paper primarily focuses on the effective design parameters incorporated with various efficiency enhancement processes of the solar dryer in the applications of food drying techniques. Thus, this review paper delivers the various classifications, design parameters, performance enhancement methods, properties and valuable assets of solar dryer, which helps to develop the sustainable green eco-friendly environment most primarily, in the application of food drying process. This review article concreted the way for upcoming considerations and provided the techniques for the studies to convey the work for promoting method enhancements.

This work reviews the current operational condition and activities on design modification for different applications of ejectors. Ejectors being a simple mechanical system capable of performing multiple fluid related functions (vacuum generation, pumping, mixing, condensing and heat exchanging), have been an essential part of several industrial processes. Two areas have been emphasized; internal flow and application-based modifications in components of ejectors. The geometry and inlet flow conditions were found to be the prime influencing factor of its performance. The objective and application-based modifications were performed on the primary nozzle, secondary nozzle, mixing chamber, throat and diffuser. The resultant performance was found to be dependent on operational condition and fluid type. This emphasizes the requirement of application-based design selection of the technology. In addition, the flow dynamics of condensing, non-condensing, particle and slurry flow has been studied based on available literatures. The one-point final objective is to identify the usability of primary water jet ejectors for active vapor transport and condensation, to replace vacuum pump and condenser in compact domestic water desalination system.

The engineering of catalysts with desirable properties can be accelerated by computer-aided design. To achieve this aim, features of molecular catalysts can be condensed into numerical descriptors that can then be used to correlate reactivity and structure. Based on such descriptors, we have introduced topographic steric maps that provide a three-dimensional image of the catalytic pocket—the region of the catalyst where the substrate binds and reacts—enabling it to be visualized and also reshaped by changing various parameters. These topographic steric maps, especially when used in conjunction with density functional theory calculations, enable catalyst structural modifications to be explored quickly, making the online design of new catalysts accessible to the wide chemical community. In this Perspective, we discuss the application of topographic steric maps either to rationalize the behaviour of known catalysts—from synthetic molecular species to metalloenzymes—or to design improved catalysts. The shape complementarity between the active site of a catalyst and a substrate influences how effectively a reaction can be catalysed. Computational tools can be used to visualize the shape around the active centre of a range of catalysts and the application of such approaches to rationalize the behaviour of known catalysts — and to design new ones — is discussed.

Additive manufacturing (AM) has been commonly used for the prototyping of three-dimensional (3D) models. The input model of the AM technology is a triangular model representing the surface shape of an object. The design features on a triangular model are generally not clear as the vertices are irregularly distributed. If design modification is necessary, it is difficult to segment and extract the meshes from the model. The objective of this study is to propose a method for extracting the design features on an object model by using the texture information. A 3D color model including a triangular model representing the object shape and a texture map describing the object texture is employed. The 3D model is generated by using a set of object images captured from different views surrounding the object. A texture mapping algorithm is then employed to generate the texture map corresponding to the 3D model. With both meshes and texture displayed in a texture mode, a region extraction technique is employed to extract the design features. All parts separated can then be fabricated with an AM machine, and assembled for checking the feasibility of design modification. Several products are employed to demonstrate the feasibility of the proposed technique.

Notice of Republication This article was re 1. Constraint Modification Provides Insight into Design of Biochemical Networks.

The energy landscape of reduced-dimensional perovskites (RDPs) can be tailored by adjusting their layer width (n). Recently, two/three-dimensional (2D/3D) heterostructures containing n = 1 and 2 RDPs have produced perovskite solar cells (PSCs) with >25% power conversion efficiency (PCE). Unfortunately, this method does not translate to inverted PSCs due to electron blocking at the 2D/3D interface. Here we report a method to increase the layer width of RDPs in 2D/3D heterostructures to address this problem. We discover that bulkier organics form 2D heterostructures more slowly, resulting in wider RDPs; and that small modifications to ligand design induce preferential growth of n ≥ 3 RDPs. Leveraging these insights, we developed efficient inverted PSCs (with a certified quasi-steady-state PCE of 23.91%). Unencapsulated devices operate at room temperature and around 50% relative humidity for over 1,000 h without loss of PCE; and, when subjected to ISOS-L3 accelerated ageing, encapsulated devices retain 92% of initial PCE after 500 h.A scheme to control the confinement within 2D/3D perovskite heterostructures results in stable, efficient inverted perovskite solar cells.

We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was implemented with BioStudio, an open-source framework developed for eukaryotic genome design, which coordinates design modifications from nucleotide to genome scales and enforces version control to systematically track edits. To achieve complete Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams around the world will be consolidated into a single strain by “endoreduplication intercross.” Chemically synthesized genomes like Sc2.0 are fully customizable and allow experimentalists to ask otherwise intractable questions about chromosome structure, function, and evolution with a bottom-up design strategy.

Efficient n = O bond activation is crucial for the catalytic reduction of nitrogen compounds, which is highly affected by the construction of active centers. In this study, n = O bond activation was achieved by a single-atom catalyst (SAC) with phosphorus anchored on a Co active center to form intermediate N-species for further hydrogenation and reduction. Unique phosphorus-doped discontinuous active sites exhibit better n = O activation performance than conventional N-cooperated single-atom sites, with a high Faradic efficiency of 92.0% and a maximum ammonia yield rate of 433.3 μg NH4·h−1 cm−2. This approach of constructing environmental sites through heteroatom modification significantly improves atom efficiency and will guide the design of future functional SACs with wide-ranging applications.

Immunotherapy holds the potential to induce durable responses, but only a minority of patients currently respond. The etiologies of primary and secondary resistance to immunotherapy are multifaceted, deriving not only from tumor intrinsic factors, but also from the complex interplay between cancer and its microenvironment. In addressing frontiers in clinical immunotherapy, we describe two categories of approaches to the design of novel drugs and combination therapies: the first involves direct modification of the tumor, while the second indirectly enhances immunogenicity through alteration of the microenvironment. By systematically addressing the factors that mediate resistance, we are able to identify mechanistically-driven novel approaches to improve immunotherapy outcomes.