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"Developmental Neuroscience"
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The future of neuroscience in developmental psychopathology
Developmental psychopathology started as an intersection of fields and is now a field itself. As we contemplate the future of this field, we consider the ways in which a newer, interdisciplinary field – human developmental neuroscience – can inform, and be informed by, developmental psychopathology. To do so, we outline principles of developmental psychopathology and how they are and/or can be implemented in developmental neuroscience. In turn, we highlight how the collaboration between these fields can lead to richer models and more impactful translation. In doing so, we describe the ways in which models from developmental psychopathology can enrich developmental neuroscience and future directions for developmental psychopathology.
Journal Article
Zero to birth : how the human brain is built
\"By the time a baby is born, its brain has nearly 100 billion intricately shaped neurons wired together to comprise a small, soft-matter supercomputer. How is this incredibly complicated organ built in just nine months? This book is a step-by-step guide to what we know about the development of the human brain, from its earliest embryonic origin to birth and a little beyond. Written from an experimental neuroscientist's perspective, this book provides readers with a conceptual understanding of the field of developmental neurobiology, outlining both the biological mechanisms (genetic, environmental, and stochastic) that play significant and interrelated roles in neural development, and how we have come to understand the human brain's construction and function. Highlighting the major questions that have propelled the field forward - including those pushing at the frontiers of the field today - and the stories of major discoveries made by pioneering scientists around the world, the book describes how the structures and mechanisms of the developing brain were discovered. Chapters progress chronologically, tracking the actual growth and development of the human brain from conception to just after birth, as well as the history of how these mechanisms were revealed. Throughout, findings from studies of model organisms, such as nematodes, flies, frogs, fish, birds, mice, and sometimes non-human primates, are woven into the narrative and put into the context of a human embryo or fetus, as there are clear indications that the same processes involving the same genes are found across species. The book concludes with a discussion of what makes individual brains unique and how research on early neural development is helping us better understand the genetic and embryonic origins of many neurological and cognitive traits that only reveal themselves later in life\"-- Provided by publisher.
BOOK
New tools for studying microglia in the mouse and human CNS
The specific function of microglia, the tissue resident macrophages of the brain and spinal cord, has been difficult to ascertain because of a lack of tools to distinguish microglia from other immune cells, thereby limiting specific immunostaining, purification, and manipulation. Because of their unique developmental origins and predicted functions, the distinction of microglia from other myeloid cells is critically important for understanding brain development and disease; better toolswould greatly facilitate studies of microglia function in the developing, adult, and injured CNS. Here, we identify transmembrane protein 119 (Tmem119), a cell-surface protein of unknown function, as a highly expressed microglia-specific marker in both mouse and human. We developed monoclonal antibodies to its intracellular and extracellular domains that enable the immunostaining of microglia in histological sections in healthy and diseased brains, as well as isolation of pure nonactivated microglia by FACS. Using our antibodies, we provide, to our knowledge, the first RNAseq profiles of highly pure mouse microglia during development and after an immune challenge. We used these to demonstrate that mouse microglia mature by the second postnatal week and to predict novel microglial functions. Together, we anticipate these resources will be valuable for the future study and understanding of microglia in health and disease.
Journal Article
The long evolution of brains and minds
On the basis of evolutionary and behavioral biology, neuroscience and anthropology, this book investigates to which extent it is possible to reconstruct the evolution of nervous systems and brains as well as of mental-cognitive abilities, in short \"intelligence\", and to which extent we can correlate the one with the other. One central question is, whether or not abilities exist that make humans truly unique, or whether the evolution of the human mind was a gradual process. Exactly which neural features make animals and humans intelligent and creative? Is it absolute or relative brain size or the size of \"intelligence centers\" inside the brains, the number of nerve cells inside the brain in total or in such \"intelligence centers\" decisive for the degree of intelligence, of mind and eventually consciousness? Which are the driving forces behind these processes? Here, many different answers exist. For some experts the driving force for brains and minds are the conditions for biological survival: the more complex these conditions, the more effective need to be sense organs, nervous systems and brains, and the stronger is the tendency to an increase in learning abilities, behavioral flexibility and innovation power of animals. This is the ecological intelligence hypothesis. Other authors believe that the true driving force is the challenge from social life of an animal: the more complex the social conditions, the more sophisticated are abilities such as social learning, imitation, empathy, knowledge transfer, consciousness and the development of a theory of mind and meta-cognition. This, again, needs progressive changes inside the brains. This is the social intelligence hypothesis. Again other authors distinguish physical intelligence as a third form of cognitive functions mostly related to tool use, tool fabrication and understanding of the principles of how things work. Finally, some experts believe that the decisive factor in the evolution of brains and minds consisted in an increase in the speed and efficacy of information processing in cognitive brain centers. This is the general intelligence or information processing hypothesis. It is discussed, which of these hypotheses is the most convincing one. At its end, the book deals with the eminent question of whether we can arrive at a naturalistic concept of mind and consciousness. Is it possible to explain mind and intelligence within the framework of the natural science, or do mind and intelligence as found in humans, transcend nature? -- Back cover.
Book
The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders
Background
The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD.
Methods
LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability.
Results
Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some ‘lessons learnt’. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted).
Conclusion
We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies.
Journal Article
The neuroscience of adolescence
As scientific inquiry and public interest in the adolescent brain grows, so too does the need for an accessible textbook that communicates the growing research on this topic. 'The Neuroscience of Adolescence' is a comprehensive educational tool for developmental cognitive neuroscience students at all levels as it details the varying elements that shape the adolescent brain. Historical notions of adolescence have focused on the significant hormonal changes that occur as one transitions from childhood to adolescence, but new research has revealed a more nuanced picture that helps inform our understanding of how the brain functions across the lifespan. By emphasizing the biological and neurobiological changes that occur during adolescence, this book gives students a holistic understanding of this developmental window and uniquely discusses the policy implications of neuroscience research on the lives of young people today.
Book
The extraordinary “ordinary magic” of resilience
In this essay, I will briefly sample different instances of the utilization of the concept of resilience, attempting to complement a comprehensive representation of the field in the special issue of Development and Psychopathology inspired by the 42nd Minnesota Symposium on Child Psychology, hosted by the Institute of Child Development at the University of Minnesota and held in October of 2022. Having established the general context of the field, I will zoom in on some of its features, which I consider “low-hanging fruit” and which can be harvested in a systematic way to advance the study of resilience in the context of the future of developmental psychopathology.
Journal Article
Nonverbal learning disabilities
\"Increasing numbers of children and adolescents are being diagnosed with nonverbal learning disabilities (NLD), yet clinicians and educators have few scientific resources to guide assessment and intervention. This book presents up-to-date knowledge on the nature of NLD and how to differentiate it from DSM-5 disorders such as autism spectrum disorder and developmental coordination disorder. Effective strategies for helping K-12 students and their families address the challenges of NLD in and outside of the classroom are illustrated with vivid case material. The authors thoughtfully consider controversies surrounding NLD, discuss why the diagnosis is not included in the current DSM and ICD classification systems, and identify important directions for future research\"-- Provided by publisher.
Book
Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein
INTRODUCTION Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron‐to‐neuron transmission along its projections. The lower integrity of the LC‐EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains limited. METHODS We associated diffusion‐weighted 7T magnetic resonance imaging (MRI) metrics of microstructural integrity within the LC‐EC tract to plasma AD‐related biomarkers in a cohort of 47 cognitively unimpaired adults. RESULTS Worse overall and local LC‐EC integrity, indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), was related to elevated concentrations of plasma phosphorylated tau 181 (p‐tau181), p‐tau217, and glial fibrillary acidic protein (GFAP). A higher orientation dispersion index (ODI) within the LC‐EC tract was linked to elevated plasma p‐tau181 and p‐tau231 levels. DISCUSSION The lower integrity of the LC‐EC pathway may serve as a key indicator of the earliest AD‐related pathophysiological processes to improve detection of at‐risk individuals. Highlights Standard DTI model metrics in the LC‐ EC tract are linked to elevated plasma p‐tau and GFAP. A higher ODI in the voxels containing the LC‐EC tract is related to elevated plasma p‐tau. LC‐EC integrity links to AD‐related biomarkers show topographic specificity. Lower LC‐EC integrity may be a key indicator of the earliest AD‐related pathology.
Journal Article