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In endothermic species, heat released as a product of metabolism ensures stable internal temperature throughout the organism, despite varying environmental conditions. Mitochondria are major actors in this thermogenic process. Part of the energy released by the oxidation of respiratory substrates drives ATP synthesis and metabolite transport, but a substantial proportion is released as heat. Using a temperature-sensitive fluorescent probe targeted to mitochondria, we measured mitochondrial temperature in situ under different physiological conditions. At a constant external temperature of 38 °C, mitochondria were more than 10 °C warmer when the respiratory chain (RC) was fully functional, both in human embryonic kidney (HEK) 293 cells and primary skin fibroblasts. This differential was abolished in cells depleted of mitochondrial DNA or treated with respiratory inhibitors but preserved or enhanced by expressing thermogenic enzymes, such as the alternative oxidase or the uncoupling protein 1. The activity of various RC enzymes was maximal at or slightly above 50 °C. In view of their potential consequences, these observations need to be further validated and explored by independent methods. Our study prompts a critical re-examination of the literature on mitochondria.

Delphi technique is a structured process commonly used to developed healthcare quality indicators, but there is a little recommendation for researchers who wish to use it. This study aimed 1) to describe reporting of the Delphi method to develop quality indicators, 2) to discuss specific methodological skills for quality indicators selection 3) to give guidance about this practice. Three electronic data bases were searched over a 30 years period (1978-2009). All articles that used the Delphi method to select quality indicators were identified. A standardized data extraction form was developed. Four domains (questionnaire preparation, expert panel, progress of the survey and Delphi results) were assessed. Of 80 included studies, quality of reporting varied significantly between items (9% for year's number of experience of the experts to 98% for the type of Delphi used). Reporting of methodological aspects needed to evaluate the reliability of the survey was insufficient: only 39% (31/80) of studies reported response rates for all rounds, 60% (48/80) that feedback was given between rounds, 77% (62/80) the method used to achieve consensus and 57% (48/80) listed quality indicators selected at the end of the survey. A modified Delphi procedure was used in 49/78 (63%) with a physical meeting of the panel members, usually between Delphi rounds. Median number of panel members was 17(Q1:11; Q3:31). In 40/70 (57%) studies, the panel included multiple stakeholders, who were healthcare professionals in 95% (38/40) of cases. Among 75 studies describing criteria to select quality indicators, 28 (37%) used validity and 17(23%) feasibility. The use and reporting of the Delphi method for quality indicators selection need to be improved. We provide some guidance to the investigators to improve the using and reporting of the method in future surveys.

Materialism is recognized as an important determinant of consumer behavior. However, studies exploring how materialism influences impulsive buying through the Diderot effect in digital contexts remain scarce. This study analyzes data from 416 adult consumers in Türkiye using Structural Equation Modeling (SEM). Four hypotheses were tested: (i) materialism increases the Diderot effect, (ii) the Diderot effect strengthens impulsive buying, (iii) materialism directly influences impulsive buying, and (iv) materialism indirectly affects impulsive buying through the Diderot effect. The findings support all four hypotheses. Materialism significantly increases both the Diderot effect and impulsive buying in online environments. The Diderot effect partially mediates this relationship and acts as an independent predictor of impulsive tendencies. The study also points out that digital stimuli such as recommendation systems, fast payment options, and social proof may reinforce this mechanism, highlighting the importance of understanding consumer behavior in digital settings. Overall, the results underline that materialistic desires, when combined with the completion motive of the Diderot effect, strongly shape impulsive tendencies. Beyond advancing theory, the study emphasizes that marketing strategies should go beyond promoting higher consumption and instead foster conscious and sustainable shopping practices. This approach not only supports consumer well-being, but also contributes to building ethical and sustainable markets.

The musical education painstakingly planned by the French philosopher Denis Diderot for his daughter Angélique included not only a wide repertoire for the keyboard, but also advanced rudiments of harmony and musical theory. This inusual pedagogical choice, set against the theories of Diderot regarding the deficient education of women as being at the root of their supposed intellectual inferiority, is the starting point of this article. The aim is to analyse the possible influence of Enlightenment ideas on the musical life of women in France during the last third of the eighteenth century. In addition, our analysis to the repertoire for harpsichord interpreted by Angélique, valuable evidence of musical life in the domestic sphere in this period, will give us an insight into an aspect of the history of music often overlooked by the official account, whose protagonists were mostly women.

The other school naturally takes the opposite view. Because I belong to the latter I must defend Diderot. There is no doubt that several crafts were introduced into England from French industry, wigmaking, originally French and adopted by the English, and probably others, could be traced back to French origin. [...]the tools and methods must have been French. Mr. James C. Sorber, of the Board of Directors of the Chester County Historical Society, West Chester, Pennsylvania, had a rather unique nail-making device shown above at the Whatsit session of the Fall Meeting of the EAIA at Williamsburg £1959].

As in human disease, macrophages (MØ) are central players in the development and progression of experimental atherosclerosis. In this study we have evaluated the phenotype of MØ associated with progression of atherosclerosis in the apolipoprotein E (ApoE) knockout (KO) mouse model.We found that bone marrow-derived MØ submitted to M1 and M2 polarization specifically expressed arginase (Arg) II and Arg I, respectively. This distinct arginase expression was used to evaluate the frequency and distribution of M1 and M2 MØ in cross-sections of atherosclerotic plaques of ApoE KO mice. Early lesions were infiltrated by Arg I(+) (M2) MØ. This type of MØ favored the proliferation of smooth muscle cells, in vitro. Arg II(+) (M1) MØ appeared and prevailed in lesions of aged ApoE KO mice and lesion progression was correlated with the dominance of M1 over the M2 MØ phenotype. In order to address whether the M2->M1 switch could be due to a phenotypic switch of the infiltrated cells, we performed in vitro repolarization experiments. We found that fully polarized MØ retained their plasticity since they could revert their phenotype. The analysis of the distribution of Arg I- and Arg II-expressing MØ also argued against a recent recruitment of M1 MØ in the lesion. The combined data therefore suggest that the M2->M1 switch observed in vivo is due to a conversion of cells already present in the lesion. Our study suggests that interventional tools able to revert the MØ infiltrate towards the M2 phenotype may exert an atheroprotective action.

Historians of the Enlightenment are stymied by Denis Diderot's cloven polymathy. An insoluble dilemma arises between, on one hand, the amazing range of interests attested in his roles as both editor and contributor for the Encyclopédie and, on the other hand, his incorrigible dilettantism, in the centrifugal and often inconclusive pursuit of whatever topic came his way. We will do better to relinquish synthesis and highlight instead the multiplicity and versatility of Diderot's productive exuberance as such. We can then see how, rather than build arguments, he metabolized ideas into designs exhibiting a constantly increasing complexity that matched his inexhaustible energy. We can also appreciate his lifelong habit of writing in response to outside, and more or less random, prompts and assignments. An accidental polymath, Diderot preferred the pursuit of a train of thought over disciplined conclusiveness: witness his preference for dialogue over more integrative forms driven by argumentative power. A stranger to disciplinary methodology, he would nowadays be a journalist, not an academic.

In Mercier’s futuristic novel published in 1771, the author’s alter ego wakes up one day as a sevenhundred-year-old man and he rediscovers the city of Paris in the company of a citizen of the 25th century. Memory and forgetting can be interpreted in different ways in the novel: on the one hand, we can see how the elderly man remembers his own time, what memories he keeps from the 18th century, and also how the people of this new Paris are kept in the memory of future generations. On the other hand, we will examine the author’s point of view, especially the influence of the philosophers of his time. During Mercier’s meditations on the tombs and ruins, it is mainly the impact of Diderot’s thoughts that dominates, and these passages show that the notions of memory and forgetting are closely related to those of imagination and dream.

The loss or absence of vision is probably one of the most incapacitating events that can befall a human being. The importance of vision for humans is also reflected in brain anatomy as approximately one third of the human brain is devoted to vision. It is therefore unsurprising that throughout history many attempts have been undertaken to develop devices aiming at substituting for a missing visual capacity. In this review, we present two concepts that have been prevalent over the last two decades. The first concept is sensory substitution, which refers to the use of another sensory modality to perform a task that is normally primarily sub-served by the lost sense. The second concept is cross-modal plasticity, which occurs when loss of input in one sensory modality leads to reorganization in brain representation of other sensory modalities. Both phenomena are training-dependent. We also briefly describe the history of blindness from ancient times to modernity, and then proceed to address the means that have been used to help blind individuals, with an emphasis on modern technologies, invasive (various type of surgical implants) and non-invasive devices. With the advent of brain imaging, it has become possible to peer into the neural substrates of sensory substitution and highlight the magnitude of the plastic processes that lead to a rewired brain. Finally, we will address the important question of the value and practicality of the available technologies and future directions.