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Accurately assessing pain severity is essential for effective pain treatment and desirable patient outcomes. In clinical settings, pain intensity assessment relies on self-reporting methods, which are subjective to individuals and impractical for noncommunicative or critically ill patients. Previous studies have attempted to measure pain objectively using physiological responses to an external pain stimulus, assuming that the participant is free of internal body pain. However, this approach does not reflect the situation in a clinical setting, where a patient subjected to an external pain stimulus may already be experiencing internal body pain. This study investigates the hypothesis that an individual's physiological response to external pain varies in the presence of preexisting pain. We recruited 39 healthy participants aged 22-37 years, including 23 female and 16 male participants. Physiological signals, electrodermal activity, and electromyography were recorded while participants were subject to a combination of preexisting heat pain and cold pain stimuli. Feature engineering methods were applied to extract time-series features, and statistical analysis using ANOVA was conducted to assess significance. We found that the preexisting pain influences the body's physiological responses to an external pain stimulus. Several features-particularly those related to temporal statistics, successive differences, and distributions-showed statistically significant variation across varying preexisting pain conditions, with P values <.05 depending on the feature and stimulus. Our findings suggest that preexisting pain alters the body's physiological response to new pain stimuli, highlighting the importance of considering pain history in objective pain assessment models.

Important levels of pain are reported upon discharge from major surgery, with a risk of becoming chronic. Further, individuals express the need for support in managing pain after discharge. However, very few studies address pain management interventions in the postdischarge phase after surgery, including for individuals undergoing total joint arthroplasty (TJA). We have conducted a pilot randomized controlled trial testing a brief mindfulness intervention targeting people at risk for chronic postsurgical pain 2 weeks after surgery. Although the intervention we proposed was judged acceptable based on ratings obtained through a questionnaire, the nuanced perceptions of why and how it is considered acceptable are critical in refining the intervention. Moreover, the acceptability of mindfulness interventions in the perioperative context remains generally unknown and even more so in the postdischarge setting. The purpose of this study was to use qualitative data to explore the individual perception of acceptability of a brief 4-week, Web- and mindfulness-based intervention for pain following discharge after a TJA. A qualitative description was used to assess patients' perception of the preliminary version of the intervention for pain management following discharge after surgery. The qualitative assessment was done at the end of the 4-week intervention (6 weeks after surgery). Semistructured interviews with open-ended questions were used to encourage free expression from participants (n=16) before proceeding to content analysis. When reflecting on the benefits of the intervention, the main themes that emerged were mindfulness, pain acceptance, and supplementary relief. Overall, the intervention was perceived as relevant and suitable during recovery, although participants experienced a few challenges related to the novelty of mindfulness practice. Engagement and readiness were discussed in relation to adherence to the intervention. Addressing expectations and personal beliefs before the intervention could improve participants' adherence. Offering additional support when spikes of pain occur could help overcome some challenges related to mindfulness practice during postoperative recovery. Given the increasing number of TJA surgeries performed annually and the effectiveness of nonpharmacological interventions, such as mindfulness-based approaches, in supporting recovery and well-being, efforts should be made to increase patient access to these promising adjunctive treatments. Combining nonpharmacological interventions before and after surgery may be an interesting avenue to optimize pain relief and recovery, as well as prevent complications. Finally, the use of technology could improve the accessibility, scalability, and adoption of these promising approaches for individuals with limited resources and mobility.

Spinal pain, one of the most common musculoskeletal disorders (MSDs), significantly impacts the quality of life due to chronic pain and disability. Physical activity has shown promise in managing spinal pain, although optimizing adherence to exercise remains a challenge. The digital development of artificial intelligence (AI)-driven applications offers a possibility for guiding and supporting patients with MSDs in their daily lives. The trial aimed to investigate the effect of an 8-week AI-composed exercise program on pain intensity and well-being in patients with spinal pain. It also examined the relationship between exercise frequency, pain intensity, and well-being. In addition, app usage frequency was examined as a proxy for app engagement. Data from users who met the inclusion criteria were collected retrospectively from the medicalmotion app between January 1, 2020, and June 30, 2023. The intervention involved the use of the medicalmotion app, which provides 3-5 personalized exercises for each session based on individual user data. The primary outcomes assessed pain intensity and well-being using the numeric rating scale (NRS) and the Likert scale. Data were collected at baseline (t0), 4 weeks (t1), and 8 weeks (t2). The correlation between exercise frequency, pain intensity, and well-being was analyzed as a secondary outcome. In addition, average session length and frequency were measured to determine app engagement. Statistical analysis included ANOVA and Spearman correlation analysis. The study included 379 participants with a mean age of 50.96 (SD 12.22) years. At t2, there was a significant reduction of 1.78 points on the NRS (P<.001). The score on the Likert scale for well-being improved by 3.11 points after 8 weeks. Pain intensity showed a negative correlation with the number of daily exercises performed at t1 and t2. Well-being had a small negative correlation with the average number of exercises performed per day. The average number of exercises performed per day was 3.58. The average session length was approximately 10 minutes, and the average interaction with the app was 49.2% (n=27.6 days) of the 56 available days. Overall, the study demonstrates that an app-based intervention program can substantially reduce pain intensity and increase well-being in patients with spinal pain. This retrospective study showed that an app that digitizes multidisciplinary rehabilitation for the self-management of spinal pain significantly reduced user-reported pain intensity in a preselected population of app users.

Low back pain (LBP) is a leading cause of work absence globally. Digital interventions have the potential to increase access to self-management support for individuals with persistent LBP. This study aims to evaluate the feasibility, usability, and acceptability of a digital educational program (MyRelief) designed to support self-management strategies for people with persistent LBP. A prospective uncontrolled feasibility study was conducted across 4 countries (Italy, Portugal, Sweden, and the United Kingdom) between 2020 and 2021. Adults in employment with nonspecific persistent LBP (>3 mo) with access to the internet were eligible to participate. Participants were given access to MyRelief, an 8-unit evidence-based educational self-management program. The feasibility of the MyRelief program was assessed using recruitment rates, an a priori success threshold of >70% of the target sample (50 participants), and a retention <35% dropout rate. Pre- and postintervention measures of functional disability were assessed using the Oswestry Disability Index (ODI), and health-related quality of life using the 5-level EuroQol questionnaire. Additional postintervention measures included the Patient Enablement Instrument and the System Usability Scale. Quantitative data were analyzed descriptively, and qualitative feedback was analyzed using a reflexive analytical approach. The recruitment feasibility threshold was met, and 40/50 (80%) participants (19 male and 21 female; mean age 57 years) were enrolled in the study. A total of 17 participants (11 male and 6 female) completed both the baseline and 12-week follow-up questionnaires. This represented a retention rate of 42.5% (17/40) and a dropout rate of 57.5%, which did not meet the a priori criteria of <35% dropouts. Approximately half of the participants presented with low baseline disability scores (mean ODI 24.0; 95% CI 18-31) with no significant change at follow-up (mean ODI 23.9; 95% CI 16-31). The 5-level EuroQol questionnaire scores improved from 0.68 (95% CI 0.608-0.76) to 0.72 (95% CI 0.66-0.79), indicating a clinically significant change. Patient Enablement Instrument scores postintervention were high (mean 5.31), indicating good perceived enablement. The mean System Usability Scale score was 72.4 (95% CI 67.5-73.3), indicating a good level of perceived ease-of-use. Overall, the quality of outcome measure completion was high (100%). Qualitative feedback indicated areas for improvement relating to challenges around access and navigation within the website. The MyRelief study demonstrated feasibility in terms of recruitment but not retention. However, low baseline disability levels are not representative of the wider persistent LBP population. Future studies should broaden recruitment strategies, in particular, by recruiting from health care settings to improve representativeness. Although usability met industry standards, qualitative feedback suggests that navigation and accessibility require further optimization to better align with end user preferences for digital health interventions.

Mobile health (mHealth) technologies, such as smartphones and wearables, enable continuous assessments of individual health information. In chronic musculoskeletal conditions, pain flares, defined as periods of increased pain severity, often coincide with worsening disease activity and cause significant impacts on physical and emotional well-being. Using mHealth technologies can provide insights into individual pain patterns and associated factors. This study aims to characterize pain flares and identify associated factors in rheumatoid arthritis (RA) by (1) describing the frequency and duration of pain flares using progressively stringent definitions based on pain severity, and (2) exploring associations between pain flares and temporal changes in symptoms across emotional, cognitive, and behavioral domains. Our 30-day mHealth study collected daily pain severity and related symptoms (scores 1-5, higher are worse) via a smartphone app and passively recorded sleep and physical activity via a wrist-worn accelerometer. Pain flares were defined using a 5-point scale: (1) above average (AA): pain severity > personal median, (2) above threshold (AT): pain severity > 3, and (3) move above threshold (MAT): pain severity moves from 1, 2, 3 to 4 or 5. A case-crossover analysis compared within-person variations of daily symptoms across hazard (3 days before a pain flare) and control (3 days not preceding a pain flare) periods using mean and intraindividual standard deviation. Conditional logistic regression estimated the odds ratio (OR) for pain flare occurrence. A total of 195 participants (160/195, 82.1% females; mean age 57.2 years; average years with RA: 11.3) contributed 5290 days of data. Of these, 88.7% (173/195) experienced at least 1 AA flare (median monthly rate 4, IQR 2.1-5). Nearly half experienced at least 1 AT or MAT flare (median monthly rate 2, IQR 1-4). These pain flares lasted 2 days (IQR 2-3) on average across definitions, with some extending up to 12 days. Worsening mood over 3 days was associated with a 2-fold increase in the likelihood of AT flares the following day (OR 2.04, IQR 1.06-3.94; P<.05). Greater variability in anxiety over 3 days increased the likelihood of both AT (OR 1.67, IQR 1.01-2.78; P<.05) and MAT flares (OR 1.82, IQR 1.08-3.07; P<.05). Similarly, greater variability in sleepiness (OR 1.89, IQR 1.03-3.47; P<.05) also increased the likelihood of AT flares. Sedentary time (%) consistently showed almost no influence across all definitions. Similarly, the simplest definition of AA demonstrated no significant associations across all symptoms. Pain flares were commonly observed in RA. Changes in sleep patterns and emotional distress were associated with pain flare occurrences. This analysis demonstrates the potential of daily mHealth data to identify pain flares, opening opportunities for timely monitoring and personalized management.

Arts engagement using virtual reality and serious games represent promising nonpharmacological self-management treatment approaches to chronic pain. This study is the first randomized controlled trial to explore the impact of a web-based serious game that simulated a visit to an art museum on pain and social disconnection among individuals living with chronic pain and loneliness. This study aimed to test the joint and separate effects of exposure to digital art and attachment figure priming on pain and social disconnection among individuals living with chronic pain and loneliness. This randomized controlled trial used a 2 (digital artwork present and absent) × 2 (secure attachment and avoidant attachment prime) repeated measures factorial web-based experimental design with a hanging control condition. Mediation and moderation analyses examined how feelings about the social world triggered by the artwork and frequency of museum visits impacted the effects of the interventions on pain and social disconnection. The results are based on 308 participants. Mean age of the participants was 42.78 (SD 13.11; range 18-76) years, and 60.2% (n=186) were women. Posttest pain was lower than pretest pain for the artwork present (P=.001) and absent (P=.001) conditions. Similarly, posttest pain was lower than pretest pain for the secure (P=.001) and avoidant (P=.001) attachment priming conditions. Relative to the control group, artwork present (P=.001) and absent (P=.01) conditions had decreased posttest pain. The secure (P=.001) and avoidant (P=.001) attachment priming conditions also had lower posttest pain scores relative to the control group. Moreover, social disconnection decreased from pre- to posttest for both the artwork present (P=.04) and the secure attachment priming (P=.002) conditions. Relative to the control group, posttest social disconnection was lower for the artwork present (P=.02) and secure attachment priming condition (P=.03). The artwork-secure attachment (P=.001) and artwork-avoidant attachment (P=.006) conditions had lower posttest pain scores compared with the control group. Social disconnection decreased from pre- to posttest for the artwork-secure attachment (P=.01) and no artwork-secure attachment (P=.05) conditions. Posttest social disconnection was lower for the artwork-secure attachment condition compared with the control group (P=.04). Positive feelings about the social world triggered by artwork exposure and frequency of museum visits in the last year played a mediating and moderating role in these effects. Positive feelings about the social world were associated with decreased pain (B=-.53) and social disconnection (B=-.25), and these effects operated on individuals exposed to digital artwork at low, medium, and high frequency of physical museum visits. Relative to a control group, visiting a web-based art museum reliably decreased pain and social disconnection among individuals living with chronic pain and loneliness. Engaging with digital artwork that triggers positive feelings about the social world may mitigate the burden of chronic pain.

Best practice guidelines recommend educating surgical patients about non-pharmacological pain care (NPPC) techniques that can be used in addition to pain medication for perioperative pain management, given the risks for opioid misuse following surgery. As part of the parent non-pharmacologic options in postoperative hospital-based and rehabilitation pain management (NOHARM) clinical trial, we implemented the Healing After Surgery initiative, which leveraged the Epic electronic health record (EHR) to provide patients with education on NPPC techniques perioperatively. We disseminated educational materials directly to patients via the EHR patient portal and prompted patients to select the techniques they were most interested in using, which auto-populated the EHR so that their care team could view their preferences. We also built clinical decision support elements in the EHR to prompt and support inpatient nurses in providing patients with education and reinforcement for using their preferred NPPC techniques. Print materials, a website, a DVD, videos on hospital televisions, a toll-free number, and Zoom-based group calls provided additional education on NPPC techniques. This study evaluated nurses' perceptions of barriers and facilitators to implementing the EHR-based Healing After Surgery initiative. We invited inpatient nursing leaders and bedside nurses to participate in a semistructured interview. Inpatient nursing leaders were invited to complete a brief survey that asked them to rate their agreement with 7 items using a numeric rating scale (1=not at all, 10=a great deal). Interview findings from 29 nurses revealed: (1) nurses gravitated towards providing NPPC techniques they were familiar with, (2) the initiative was patient-centric with opportunities to better engage patients, and (3) nurses experienced challenges implementing and prioritizing the intervention in the inpatient setting due to competing demands in a pandemic and postpandemic environment. Interviews revealed mixed effectiveness of implementation strategies. We received survey responses from 47 nursing leaders who indicated that their staff knew about the Healing After Surgery initiative (mean=7.53, SD=1.77) and what they were expected to do (mean=7, SD=1.88). They thought the Healing After Surgery initiative supported patients' pain management needs (mean=6.76, SD=2.24), endorsed it as a priority (mean=7.02, SD=2.56), and encouraged staff to support it (mean=5.98, SD=2.78). They indicated staff experienced some burden supporting the initiative (mean=3.93, SD=2.47), but supported some variation of the initiative continuing once the parent trial ended (mean=7.72, SD=2.62). Nurses understood the intervention's benefit but struggled to implement unfamiliar NPPC techniques and prioritize the initiative due to other clinical demands. Additional implementation strategies may be needed to better engage patients and facilitate intervention delivery.

Older adults may experience chronic pain as they age, which can affect their physical and psychological well-being. Virtual reality (VR) is emerging as a novel and nonpharmacological intervention that offers pain relief and mood enhancement through immersive experiences. However, the feasibility and effectiveness of using nonlocalized and commercial VR applications for chronic pain relief and mood enhancement among community-dwelling older adults remain underexplored. The main objectives of this study were to (1) evaluate the feasibility of using commercial-off-the-shelf VR applications for managing chronic pain among older adults, (2) assess the efficacy of VR in alleviating chronic pain, and (3) examine its impact on the well-being of older adults in a community setting. The study was a single-arm mixed methods pilot study. It was divided into two stages, including preparation and implementation. A total of 13 older adults (8 with chronic pain and 5 without) were recruited to participate in a 3-week VR intervention. Participants engaged in VR sessions that followed a step-by-step adaptation process. Each session included 360-degree relaxation videos and VR-based boxing exercises via Les Mills BODYCOMBAT, lasting 15 minutes. Pain intensity, pain self-efficacy, well-being, and mood were measured pre- and post-intervention using the Numeric Pain Rating Scale (NPRS), a pain self-efficacy question, the World Health Organization-Five Well-Being Index (WHO-5), and the Mood Assessment Scale (Mood). VR feasibility was evaluated based on completion rates, adverse outcomes, and qualitative feedback from semistructured interviews. Of the 13 participants recruited, 11 completed the intervention (84.6% completion rate). The mean age was 79.2 (SD 9.2) years. The study found a statistically significant 16.32% improvement in the mean mood score, with a mean increase of 2.64 (SD 1.45) points and a large effect size (P<.001; Cohen d=1.82). The median pain self-efficacy score decreased from 3.0 (IQR 1.5-3.0) to 1.0 (IQR 1.0-2.0) (z=-2.236; P=.03). However, no significant changes were observed in pain intensity or overall well-being. The study demonstrated the high feasibility of commercial-off-the-shelf VR technology for older adults. Minor adverse effects were reported, including back pain and headset discomfort. In addition, 90.9% of participants enjoyed the VR experience, and all were willing to join future sessions. The pilot study demonstrated that commercial-off-the-shelf VR applications can effectively enhance mood and pain self-efficacy. Additional procedures, such as prebriefing, real-time interpretation, and a gradual adaptation process, were essential to overcoming barriers such as language, cultural nuances, and the digital literacy of older adults. Despite the lack of significant changes in pain intensity or overall well-being, the psychological benefits suggest that VR could be a valuable adjunct tool in chronic pain management. Future research should focus on larger sample sizes, longer intervention durations, randomized controlled trials, and the development of localized commercial VR applications to further explore their efficacy.

Consumer-grade wearables, such as Fitbits, are a promising, cost-effective methodology for objectively assessing sleep and physical activity in youth with pain. This study investigated the acceptability and feasibility of implementing Fitbits for youth with acute and chronic pain in and out of hospital settings while maintaining data security and patient confidentiality. We investigated participant experience of Fitbit use over 3 to 4 weeks for a sample of youth with acute pain undergoing either orthopedic or cardiac surgical procedures (N=34, mean age 14.46, SD 3.70 years, 47.06% [n=36] female) and a sample of youth with chronic pain enrolled in an intensive interdisciplinary pain treatment program (N=28, mean age 15.00, SD 2.33 years, 82.14% [n=23] female). We assessed the acceptability of Fitbit use through survey items probing comfort (0=extremely uncomfortable to 10=extremely comfortable), perceived burdensomeness (0=not burdensome at all to 10=extremely burdensome), and open-ended issues or concerns. Feasibility was assessed by tracking the daily compliant wear of the Fitbit device, which was operationalized as more than 600 minutes of daily wear time. We tested for group differences in acceptability and feasibility between orthopedic and cardiac patients within the acute pain sample and between the acute pain and chronic pain samples. We created an automated data pipeline to ensure data security, patient confidentiality, and quality. Acceptability findings revealed high levels of reported comfort (acute pain: mean 8.56, SD 1.43; chronic pain: mean 8.27, SD 1.69) and low levels of perceived burdensomeness (acute: mean 0.68, SD 1.17; chronic: mean 1.15, SD 1.38) related to Fitbit wearing in both samples. No significant differences in these acceptability outcomes emerged between orthopedic and cardiac patients or between the acute pain and chronic pain groups (P values>.10). Transient concerns of mild wrist irritation and sleep discomfort were occasionally reported across both samples (15.79% [n=9] of participants). Feasibility findings indicated high feasibility (acute: median compliance rate of 86.67%; chronic: median compliance rate of 96.65%) for the study duration in both samples. Mann-Whitney U tests indicated significantly higher median compliance rates per participant among orthopedic as compared with cardiac patients (U=146.5, P=.04) and significantly higher median compliance rates per participant among the chronic pain group as compared with the acute pain group (U=186, P<.001), including significantly higher median compliant days (U=162, P<.001) and study days (U=234.5, P<.001) per participant. These findings support the use of Fitbits as an acceptable and feasible method for collecting objective data on sleep and physical activity for youth experiencing pain. Findings also highlight the logistics of implementing consumer-grade wearable devices throughout all stages of the clinical research process.

Neck pain is a common musculoskeletal disorder, often linked to forward head posture (FHP). Studies have shown that exercise interventions can improve pain, craniovertebral angle (CVA), range of motion, and function in individuals with FHP. While telerehabilitation exercise has proven effective for other musculoskeletal conditions, its effectiveness in addressing neck pain and FHP is still being investigated. This study aimed to evaluate and compare the effectiveness of an internet-based telerehabilitation therapeutic exercise program with an in-person supervised program in improving clinical outcomes among young adult females with chronic nonspecific neck pain and FHP. The study hypothesized that there would be no significant differences in outcomes between the 2 groups. A randomized controlled trial was conducted with 50 participants experiencing chronic neck pain and FHP, recruited through public announcement and voluntary sign-up. Participants were randomly assigned to either a telerehabilitation group or an in-person supervision group. Both groups completed the same 6-week, physiotherapist-supervised therapeutic exercise program, delivered via Zoom (Zoom Video Communications) or in the physiotherapy department laboratory, respectively. Outcome assessments were conducted face-to-face by blinded assessors at baseline, after 4 and 6 weeks of intervention, and at a 2-week follow-up. Outcome measures included pain intensity (assessed using the Visual Analog Scale [VAS]), CVA, neck disability (assessed using the Neck Disability Index [NDI]), and cervical range of motion (CROM). Adherence was monitored using attendance logs. Of the 50 participants, 48 completed the intervention with 1 dropout from each group. Adherence among completers was 100 percent in both groups. All 50 participants were included in the analysis using the intention-to-treat principle. No differences in effectiveness were found between the telerehabilitation and in-person groups, as no significant interaction effect between group and time was observed across all outcome measures including VAS, CVA, NDI, and CROM (P values ranged .07-.61). However, improvements were observed in all outcomes across time, including a 2.2- to 4.1-cm reduction in VAS, 5°-8.8° increase in CVA, 3.3- to 7.1-point reduction in NDI (P<.001 for all), and 3.5°-22.7° increase in CROM (P<.001 to P=.04). Both telerehabilitation and in-person supervision were similarly effective in improving pain, posture, neck disability, and CROM in young adult females with chronic neck pain and FHP. These findings suggest that telerehabilitation may be a feasible and accessible alternative to conventional in-person therapeutic exercise programs for managing chronic neck pain with FHP.