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The epilepsy book : a companion for patients : optimizing diagnosis and treatment
This book presents scientific evidence about epilepsy along with straightforward guidance and recommendations. Responses to frequently asked questions and clarification of uncertainties are provided to empower patients to optimize their medical, psychological and social care. This book helps mediate between patients and health care professionals and can assist both sides to understand the condition of epilepsy at all levels. The information provided in the book empowers patients to share decision making with their carers and clinicians and enables them to make informed decisions, by taking into account the best scientific evidence, as well as the patients' values and preferences. The Epilepsy Book: A Companion for Patients is ideal for patients with epilepsy and their carers, and will also be of interest to health care professionals, medical students and teachers. Thalia Valeta's approach to epilepsy facilitates deeper understanding of the unmet needs and expectations of patients.
Book
Correction: Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results
[This corrects the article DOI: 10.1371/journal.pone.0282658.].
Journal Article
Epilepsy : the ultimate teen guide
An updated overview of epilepsy that specifically addresses how this condition can affect teens. Epilepsy: The Ultimate Teen Guide, Second Edition gives positive, factual information and explains how young people can take control of their situations by understanding, managing, treating, and living normal lives with epilepsy. This edition includes updated chapters, resource lists, and statistics.
Book
Identification of epilepsy-associated neuronal subtypes and gene expression underlying epileptogenesis
Epilepsy is one of the most common neurological disorders, yet its pathophysiology is poorly understood due to the high complexity of affected neuronal circuits. To identify dysfunctional neuronal subtypes underlying seizure activity in the human brain, we have performed single-nucleus transcriptomics analysis of >110,000 neuronal transcriptomes derived from temporal cortex samples of multiple temporal lobe epilepsy and non-epileptic subjects. We found that the largest transcriptomic changes occur in distinct neuronal subtypes from several families of principal neurons (L5-6_Fezf2 and L2-3_Cux2) and GABAergic interneurons (Sst and Pvalb), whereas other subtypes in the same families were less affected. Furthermore, the subtypes with the largest epilepsy-related transcriptomic changes may belong to the same circuit, since we observed coordinated transcriptomic shifts across these subtypes. Glutamate signaling exhibited one of the strongest dysregulations in epilepsy, highlighted by layer-wise transcriptional changes in multiple glutamate receptor genes and strong upregulation of genes coding for AMPA receptor auxiliary subunits. Overall, our data reveal a neuronal subtype-specific molecular phenotype of epilepsy.
The pathophysiology of epilepsy is unclear. Here, the authors present single-nuclei transcriptomic profiling of human temporal lobe epilepsy from patients. They identified epilepsy-associated neuronal subtypes, and a panel of dysregulated genes, predicting neuronal circuits contributing to epilepsy.
Journal Article
Navigating life with epilesy
\"Navigating Life with Epilepsy aims to provide clear and reliable information about epilepsy, including \"what\" (definition), \"how\" (pathophysiology), \"who\" (epidemiology), and \"why\" (etiology). The volume guides the reader through current approaches to diagnosis (including a review of diagnostic tests) and treatment, and shares patient experiences and advice on navigating the myriad psychosocial challenges associated with epilepsy. Epilepsy is a heterogeneous disorder with many causes and a wide spectrum of severity. This text will focus on issues relevant to adolescents and adults with epilepsy; there are many guides for parents of children with epilepsy and issues specific to younger children are beyond the scope of this book. The focus is on translation of current medical knowledge to the lay reader. However, because epilepsy can have profound psychosocial consequences, the book aims to extend beyond the bounds of a medical handbook to include discussion of issues that are of high priority to patients, including those surrounding, driving, work, and relationships\"-- Provided by publisher.
BOOK
098 The adult profile of SUDEP using the epilepsy deaths register
IntroductionThere is no ‘standard’ sudden unexpected death in epilepsy (SUDEP). Attention can be focussed on prevention in those thought to be most at risk of SUDEP but every person with epilepsy is at risk. We sought to identify the median profile of the people with a definite SUDEP death.MethodThe voluntary Epilepsy Death Register collects information on the circumstances surrounding the death of a person with epilepsy to identify and improve risk factors that contribute to these deaths. 349 post-mortem confirmed individual entries allowed the production of a profile of the composite, median adult patient at risk of SUDEP.ResultsThe median death would be male (58.5%) aged 19–30 (48.7%) who lives in the family home (73.3%). and currently in work (45.6%). They were diagnosed more than 10 years ago (53.5%), taking antiepileptic medication (90.1%) and under the care of a specialist in epilepsy (76.2%). They were not known to forget medication (56.4%), had not had a recent AED change (58.7%), Their death was unwitnessed (81.0%) and they were found on their back (57.4%). 55.5% of families did not know that epilepsy could kill.DiscussionSUDEP can occur in otherwise well people with epilepsy. SUDEP should be discussed and safety checks embedded for everyone rather than just ‘at risk’ subgroups.
Journal Article
Epilepsy Research Institute Partner Symposium: Radically advancing research into epilepsy
On 28 April 2025, the Epilepsy Research Institute Symposium at BNA2025 brought together four early career researchers to present on their findings in different areas of fundamental epilepsy research. Here, we provide a snapshot of the Symposium and highlights from the researchers’ talks.
Journal Article