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"Electric instruments"
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A microscale soft ionic power source modulates neuronal network activity
Bio-integrated devices need power sources to operate
1
,
2
. Despite widely used technologies that can provide power to large-scale targets, such as wired energy supplies from batteries or wireless energy transduction
3
, a need to efficiently stimulate cells and tissues on the microscale is still pressing. The ideal miniaturized power source should be biocompatible, mechanically flexible and able to generate an ionic current for biological stimulation, instead of using electron flow as in conventional electronic devices
4
–
6
. One approach is to use soft power sources inspired by the electrical eel
7
,
8
; however, power sources that combine the required capabilities have not yet been produced, because it is challenging to obtain miniaturized units that both conserve contained energy before usage and are easily triggered to produce an energy output. Here we develop a miniaturized soft power source by depositing lipid-supported networks of nanolitre hydrogel droplets that use internal ion gradients to generate energy. Compared to the original eel-inspired design
7
, our approach can shrink the volume of a power unit by more than 10
5
-fold and it can store energy for longer than 24 h, enabling operation on-demand with a 680-fold greater power density of about 1,300 W m
−3
. Our droplet device can serve as a biocompatible and biological ionic current source to modulate neuronal network activity in three-dimensional neural microtissues and in ex vivo mouse brain slices. Ultimately, our soft microscale ionotronic device might be integrated into living organisms.
A study describes the development of a miniaturized hydrogel-based soft power source capable of modulating the activity of networks of neuronal cells without the need for metal electrodes.
Journal Article
Play it loud : an epic history of the style, sound, and revolution of the electric guitar
Two veteran music writers give us the story of an American icon: the electric guitar. Features interviews with dozens of players and creators and a foreword by Carlos Santana.
Book
Mormyroidea-inspired electronic skin for active non-contact three-dimensional tracking and sensing
The capacity to discern and locate positions in three-dimensional space is crucial for human-machine interfaces and robotic perception. However, current soft electronics can only obtain two-dimensional spatial locations through physical contact. In this study, we report a non-contact position targeting concept enabled by transparent and thin soft electronic skin (E-skin) with three-dimensional sensing capabilities. Inspired by the active electrosensation of mormyroidea fish, this E-skin actively ascertains the 3D positions of targeted objects in a contactless manner and can wirelessly convey the corresponding positions to other devices in real-time. Consequently, this E-skin readily enables interaction with machines, i.e., manipulating virtual objects, controlling robotic arms, and drones in either virtual or actual 3D space. Additionally, it can be integrated with robots to provide them with 3D situational awareness for perceiving their surroundings, avoiding obstacles, or tracking targets.
Developing electronic skins for sensing the spatial location of objects beyond two-dimensional space is difficult. The authors present a flexible, lightweight, and transparent electronic skin for non-contact accurate 3D motion sensing. This achieves micron-level precision, reducing complexity and power consumption.
Journal Article
Play it loud : instruments of rock & roll
Play It Loud celebrates the musical instruments that gave rock and roll its signature sound-from Louis Jordan's alto saxophone and John Lennon's Rickenbacker to the drum set owned by Metallica's Lars Ulrich, Lady Gaga's keytar, and beyond. Seven engrossing essays by veteran music journalists and scholars discuss the technical developments that fostered rock's seductive riffs and driving rhythms, the thrilling innovations musicians have devised to achieve unique effects, and the visual impact their instruments have had. Abundant photographs depict rock's most iconic instruments-including Jerry Lee Lewis's baby grand piano, Chuck Berry's Gibson ES-350T guitar, Bootsy Collins's star-shaped bass, Keith Moon's drum set, and the white Stratocaster Jimi Hendrix played at Woodstock-as works of art in their own right. Produced in collaboration with the Rock & Roll Hall of Fame, this astounding book goes behind the music to offer a rare and in-depth look at the instruments that inspired the musicians and made possible the songs we know and love. Exhibition: The Metropolitan Museum of Art, New York, USA (01.04-15.09.2019); The Rock & Roll Hall of Fame, Cleveland, USA (20.11.2019-13.09.2020). -- Book jacket.
Book
Gene and Allele-Specific Expression Underlying the Electric Signal Divergence in African Weakly Electric Fish
Abstract
In the African weakly electric fish genus Campylomormyrus, electric organ discharge signals are strikingly different in shape and duration among closely related species, contribute to prezygotic isolation, and may have triggered an adaptive radiation. We performed mRNA sequencing on electric organs and skeletal muscles (from which the electric organs derive) from 3 species with short (0.4 ms), medium (5 ms), and long (40 ms) electric organ discharges and 2 different cross-species hybrids. We identified 1,444 upregulated genes in electric organ shared by all 5 species/hybrid cohorts, rendering them candidate genes for electric organ–specific properties in Campylomormyrus. We further identified several candidate genes, including KCNJ2 and KLF5, and their upregulation may contribute to increased electric organ discharge duration. Hybrids between a short (Campylomormyrus compressirostris) and a long (Campylomormyrus rhynchophorus) discharging species exhibit electric organ discharges of intermediate duration and showed imbalanced expression of KCNJ2 alleles, pointing toward a cis-regulatory difference at this locus, relative to electric organ discharge duration. KLF5 is a transcription factor potentially balancing potassium channel gene expression, a crucial process for the formation of an electric organ discharge. Unraveling the genetic basis of the species-specific modulation of the electric organ discharge in Campylomormyrus is crucial for understanding the adaptive radiation of this emerging model taxon of ecological (perhaps even sympatric) speciation.
Journal Article
The birth of loud : Leo Fender, Les Paul, and the guitar-pioneering rivalry that shaped rock 'n' roll
A riveting saga in the history of rock 'n' roll: the decades-long rivalry between the two men who innovated the electric guitar's amplified sound--Leo Fender and Les Paul--and their intense competition to convince rock stars like the Beatles, Jimi Hendrix, and Eric Clapton to play the instruments they built.
Book
Structural mechanism of muscle nicotinic receptor desensitization and block by curare
Binding of the neurotransmitter acetylcholine to its receptors on muscle fibers depolarizes the membrane and thereby triggers muscle contraction. We sought to understand at the level of three-dimensional structure how agonists and antagonists alter nicotinic acetylcholine receptor conformation. We used the muscle-type receptor from the
Torpedo
ray to first define the structure of the receptor in a resting, activatable state. We then determined the receptor structure bound to the agonist carbachol, which stabilizes an asymmetric, closed channel desensitized state. We find conformational changes in a peripheral membrane helix are tied to recovery from desensitization. To probe mechanisms of antagonism, we obtained receptor structures with the active component of curare, a poison arrow toxin and precursor to modern muscle relaxants.
d
-Tubocurarine stabilizes the receptor in a desensitized-like state in the presence and absence of agonist. These findings define the transitions between resting and desensitized states and reveal divergent means by which antagonists block channel activity of the muscle-type nicotinic receptor.
Here the authors reveal the structural basis of how the nicotinic acetylcholine receptor type found on skeletal muscle and in fish electric organs desensitizes in response to agonist and how the arrow poison curare antagonizes the channel by stabilizing a desensitized state.
Journal Article
Performance of Acoustic, Electro-Acoustic and Optical Sensors in Precise Waveform Analysis of a Plucked and Struck Guitar String
This study presents a comparative performance analysis of three sensor technologies—microphone, magnetic pickup, and laser Doppler vibrometer—for capturing string vibration under varied excitation conditions: striking, plectrum plucking, and wire plucking. Two different magnetic pickups are included in the comparison. Measurements were taken at multiple excitation levels on a simplified electric guitar mounted on a stable platform with repeatable excitation mechanisms. The analysis focuses on each sensor’s capacity to resolve fine-scale waveform features during the initial attack while also taking into account its capability to measure general changes in instrument dynamics and timbre. We evaluate their ability to distinguish vibro-acoustic phenomena resulting from changes in excitation method and strength as well as measurement location. Our findings highlight the significant influence of sensor choice on observable string vibration. While the microphone captures the overall radiated sound, it lacks the required spatial selectivity and offers poor SNR performance 34 dB lower then other methods. Magnetic pickups enable precise string-specific measurements, offering a compelling balance of accuracy and cost-effectiveness. Results show that their low-pass frequency characteristic limits temporal fidelity and must be accounted for when analysing general sound timbre. Laser Doppler vibrometers provide superior micro-temporal fidelity, which can have critical implications for physical modeling, instrument design, and advanced audio signal processing, but have severe practical limitations. Critically, we demonstrate that the required optical target, even when weighing as little as 0.1% of the string’s mass, alters the string’s vibratory characteristics by influencing RMS energy and spectral content.
Journal Article
Change in Acoustic Parameters of Electric Guitar Strings Under Dynamic Loading
The aim of our work was to investigate how electric guitar strings wear out. There are many myths about string wear. We decided to investigate what the wear process looks like in real life. In our work, sound processing methods such as DTFT and spectrogram were used. However, the most important research method is the use of time-frequency analysis to study the sound of the string and its wear process. Another key method used in our work is the application of a phenomenon known from psychoacoustics, pitch. In our work, we have been able to show that the use of pitch in combination with time-frequency analysis makes it possible to demonstrate string wear. This was not achievable for previously known methods. We have also shown that the string yield limit is exceeded immediately when the strings are placed on the guitar neck. This affects the sound equation of the string. In this work, we have proposed a transformation of the classical string equation so that it correctly describes the sound of the string as it is worn. The research method we have developed, combining pitch and time-frequency analysis, could presumably be used in the future to study the wear and tear of other vibrating systems, such as bridges and viaducts.
Journal Article