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Threat of platform-owner entry and complementor responses
Research Summary This paper studies the impact of platform‐owner entry threat on complementors in platform‐based markets. We examine how app developers on the Android mobile platform adjust innovation efforts (rate and direction) and value‐capture strategies in response to the threat of Google's entry into their markets. We find that after Google's entry threat increases, affected developers reduce innovation and raise the prices for the affected apps. However, their incentives to innovate are not completely suppressed; rather, they shift innovation to unaffected and new apps. Given that many apps already offer similar features, Google's entry threat may thus reduce wasteful development efforts. We discuss the implications of these results for platform owners, complementors, and policy makers. Managerial Summary We examine one prevalent source of conflict: platform owners' entry into complementary product spaces. We show that app developers on Google's Android system are strategic and nimble actors. They respond to the threat of Google's entry by adjusting both value‐creation and value‐capture strategies. We also show that platform owners could use direct entry to shape innovation directions and encourage variety of complements. Overall, on the one hand, Google's entry may have pushed complementors into other areas (which might be less lucrative) and strengthened its position in the mobile market. On the other hand, the entry may have reduced wasteful production efforts in the development of redundant applications. The overall welfare implication is thus ambiguous. Video
Journal Article
Tradeoffs in viral fitness driven by alternative entry pathways
Understanding how viruses enter host cells is critical for elucidating key aspects of viral infectivity, transmission, and pathogenesis. Here, we investigate the consequences of two alternative viral entry routes: endocytosis and direct entry at the plasma membrane. To this end, we employed a recombinant virus expressing the SARS-CoV-2 spike protein. This artificial system produced clear and striking phenotypes, enabling us to observe distinct differences between the two entry pathways. Plasma membrane entry promoted rapid viral spread through cell-cell fusion, whereas endocytic entry supported sustained virion production with reduced cell death. Notably, a spike variant that utilized the direct entry route dominated during coinfection, promoting extensive cell fusion and suppressing the phenotype of a variant restricted to endocytic entry. These findings clarify the functional trade-offs between viral entry pathways and introduce a novel framework for studying them through the lens of virus-virus interactions and social evolution.
Journal Article
National Geographic traveler. The Mediterranean : ports of call & beyond
An overview of the best Mediterranean sights to help you plan your visit, whether you're traveling by cruise ship, car, or train.
Book
Correction: The future of digital donation crowdfunding
[This corrects the article DOI: 10.1371/journal.pone.0275898.].
Journal Article
Cruise ports Mediterranean Europe : a guide to perfect days on shore
Part history tour, part beach vacation, part culinary odyssey, this region offers a veritable feast for every traveller, whether in world-class cities or zipping around tiny islands. Lonely Planet is your passport to Cruise Ports Mediterranean Europe, with amazing travel experiences and the best planning advice. Admire Gaudâi's genius in Barcelona, feast on art in Florence, or walk Dubrovnik's historic street; all with your trusted travel companion. Get to the heart of Cruise Ports Mediterranean Europe and begin your journey now!
Book
ACE2-independent entry factors for SARS-CoV-2 infection and immune activation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), remains a major public health threat, particularly in vulnerable populations. SARS-CoV-2 spike proteins interact with the human angiotensin-converting enzyme 2 (ACE2) receptor, together with accessory molecules that facilitate viral entry, through its spike receptor-binding domain (RBD). Although ACE2 is the primary receptor required for viral replication, its expression patterns do not fully correlate with viral distribution or tissue pathology. Moreover, SARS-CoV-2 has been shown to infect cells and tissues lacking detectable ACE2 expression. Viral entry via ACE2-independent pathways may also confer resistance to some monoclonal antibodies (Abs) targeting the spike RBD that block ACE2-mediated binding. These observations highlight the potential significance of ACE2-independent entry factors in SARS-CoV-2 infection, particularly in vaccinated individuals with Abs directed against ACE2-dependent viral entry. In this review, we discuss the emerging roles of ACE2-independent entry factors in SARS-CoV-2 infection and the immune responses. These factors include CD147, AXL, CD169/Siglec-1, CD209L, CD209, CLEC4G, ASGR1, LDLRAD3, TMEM30A, TMEM106B, transferrin receptor 1, GPR78, integrin α5β1, KREMEN1, LFA-1, and CD4. While ACE2 remains central to viral replication, ACE2-independent entry appears sufficient to elicit immune responses. Therefore, future investigations are warranted to elucidate the roles of ACE2-independent mechanisms in immune-mediated pathology and viral evolution, independent of immune pressure targeting ACE2-mediated entry in previously infected or vaccinated individuals.
Journal Article
The Advanced BRain Imaging on ageing and Memory
To understand the neurocognitive mechanisms that underlie heterogeneity in cognitive ageing, recent scientific efforts have led to a growing public availability of imaging cohort data. The Advanced BRain Imaging on ageing and Memory (ABRIM) project aims to add to these existing datasets by taking an adult lifespan approach to provide a cross-sectional, normative database with a particular focus on connectivity, myelinization and iron content of the brain in concurrence with cognitive functioning, mechanisms of reserve, and sleep-wake rhythms. ABRIM freely shares MRI and behavioural data from 295 participants between 18-80 years, stratified by age decade and sex (median age 52, IQR 36-66, 53.20% females). The ABRIM MRI collection consists of both the raw and pre-processed structural and functional MRI data to facilitate data usage among both expert and non-expert users. The ABRIM behavioural collection includes measures of cognitive functioning (i.e., global cognition, processing speed, executive functions, and memory), proxy measures of cognitive reserve (e.g., educational attainment, verbal intelligence, and occupational complexity), and various self-reported questionnaires (e.g., on depressive symptoms, pain, and the use of memory strategies in daily life and during a memory task). In a sub-sample (n = 120), we recorded sleep-wake rhythms using an actigraphy device (Actiwatch 2, Philips Respironics) for a period of 7 consecutive days. Here, we provide an in-depth description of our study protocol, pre-processing pipelines, and data availability. ABRIM provides a cross-sectional database on healthy participants throughout the adult lifespan, including numerous parameters relevant to improve our understanding of cognitive ageing. Therefore, ABRIM enables researchers to model the advanced imaging parameters and cognitive topologies as a function of age, identify the normal range of values of such parameters, and to further investigate the diverse mechanisms of reserve and resilience.
Journal Article