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"Eradication"
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Crisis averted : the hidden science of fighting outbreaks
\"A fascinating window into the secret life of epidemiology, weaving together stories of triumph and tragedy, with a boots-on-the-ground perspective on how we can avert the next public health crisis There are few visible markers of the accomplishments of public health. If epidemiologists do their jobs, nothing happens. An outbreak does not grow into an epidemic. A child does not go hungry. A would-be smoker never lights up. These achievements are rarely noticed or celebrated, but Caitlin Rivers lives for such victories. By making sure that things don't happen, she and legions of scientists, practitioners, and policymakers change the course of history. We have many of the tools and experiences needed to prevent the next crisis, but countless challenges remain, including constantly emerging pathogens, the rapid growth of biotechnology, and the inconsistent cycles of funding for government organizations like the CDC. Progress can be slow, even with the next pandemic potentially right around the corner, but the unsung heroes in public health remain focused on their missions. Crisis Averted is their story-from the eradication of smallpox in the 20th century to today's safeguards against extraterrestrial germs. By taking a candid look at how we solve problems in public health, Caitlin Rivers illuminates the role of epidemiology in all our lives and lays out the case for what can be accomplished, given sufficient vision, leadership, and resources. Crisis Averted is an inspiring and galvanizing clarion call for us to work together towards a healthier, more resilient future\"-- Provided by publisher.
BOOK
Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication
Objective Helicobacter pylori is associated with gastric inflammation, precancerous gastric atrophy (GA) and intestinal metaplasia (IM). We aimed to identify microbes that are associated with progressive inflammation, GA and IM 1 year after H. pylori eradication.DesignA total of 587 H. pylori–positive patients were randomised to receive H. pylori eradication therapy (295 patients) or placebo (292 patients). Bacterial taxonomy was analysed on 404 gastric biopsy samples comprising 102 pairs before and after 1 year H. pylori eradication and 100 pairs before and after 1 year placebo by 16S rRNA sequencing.ResultsAnalysis of microbial sequences confirmed the eradication of H. pylori in treated group after 1 year. Principal component analysis revealed distinct microbial clusters reflected by increase in bacterial diversity (p<0.00001) after H. pylori eradication. While microbial interactions remained largely unchanged after placebo treatment, microbial co-occurrence was less in treated group. Acinetobacter lwoffii, Streptococcus anginosus and Ralstonia were enriched while Roseburia and Sphingomonas were depleted in patients with persistent inflammation 1 year after H. pylori eradication. A distinct cluster of oral bacteria comprising Peptostreptococcus, Streptococcus, Parvimonas, Prevotella, Rothia and Granulicatella were associated with emergence and persistence of GA and IM. Probiotic Faecalibacterium praustznii was depleted in subjects who developed GA following H. pylori eradication. Functional pathways including amino acid metabolism and inositol phosphate metabolism were enriched while folate biosynthesis and NOD-like receptor signalling decreased in atrophy/IM-associated gastric microbiota.ConclusionThis study identified that gastric microbes contribute to the progression of gastric carcinogenesis after H. pylori eradication.
Journal Article
Transgenic cotton and sterile insect releases synergize eradication of pink bollworm a century after it invaded the United States
Invasive organisms pose a global threat and are exceptionally difficult to eradicate after they become abundant in their new habitats. We report a successful multitactic strategy for combating the pink bollworm (Pectinophora gossypiella), one of the world’s most invasive pests. A coordinated program in the southwestern United States and northern Mexico included releases of billions of sterile pink bollworm moths from airplanes and planting of cotton engineered to produce insecticidal proteins from the bacterium Bacillus thuringiensis (Bt). An analysis of computer simulations and 21 y of field data from Arizona demonstrate that the transgenic Bt cotton and sterile insect releases interacted synergistically to reduce the pest’s population size. In Arizona, the program started in 2006 and decreased the pest’s estimated statewide population size from over 2 billion in 2005 to zero in 2013. Complementary regional efforts eradicated this pest throughout the cotton-growing areas of the continental United States and northern Mexico a century after it had invaded both countries. The removal of this pest saved farmers in the United States $192 million from 2014 to 2019. It also eliminated the environmental and safety hazards associated with insecticide sprays that had previously targeted the pink bollworm and facilitated an 82% reduction in insecticides used against all cotton pests in Arizona. The economic and social benefits achieved demonstrate the advantages of using agricultural biotechnology in concert with classical pest control tactics.
Journal Article
The end of plagues : the global battle against infectious disease
\"At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio\"--Provided by publisher.
Book
Global Polio Eradication Initiative: Lessons Learned and Legacy
The world is on the verge of achieving global polio eradication. During >25 years of operations, the Global Polio Eradication Initiative (GPEI) has mobilized and trained millions of volunteers, social mobilizers, and health workers; accessed households untouched by other health initiatives; mapped and brought health interventions to chronically neglected and underserved communities; and established a standardized, real-time global surveillance and response capacity. It is important to document the lessons learned from polio eradication, especially because it is one of the largest ever global health initiatives. The health community has an obligation to ensure that these lessons and the knowledge generated are shared and contribute to real, sustained changes in our approach to global health. We have summarized what we believe are 10 leading lessons learned from the polio eradication initiative. We have the opportunity and obligation to build a better future by applying the lessons learned from GPEI and its infrastructure and unique functions to other global health priorities and initiatives. In so doing, we can extend the global public good gained by ending for all time one of the world's most devastating diseases by also ensuring that these investments provide public health dividends and benefits for years to come.
Journal Article
Have bacteria won?
Today, we are far less likely to die from infection than at any other time in history, but still we worry about epidemics, the menace of antibiotic resistance and modern \"plagues\" like Ebola. In this timely new book, eminent bacteriologist Hugh Pennington explores why these fears remain and why they are unfounded. He reports on outright victories (such as smallpox), battles where the enemy is on its last stand (polio), surprise attacks from vegetarian bats (Ebola, SARS) and demented cows (BSE). Qualified optimism, he argues, is the message for the future but the battles will go on forever. -- Provided by publisher.
Book
Eliminating malaria in Nigeria: insights from Egypt’s success and pathways to sustainable eradication
Malaria remains a critical public health challenge in Nigeria, with the country bearing the highest global burden of the disease. Despite ongoing efforts, malaria continues to exact significant health, economic, and social tolls. Inspired by Egypt’s successful malaria elimination strategies, this study explores actionable interventions that Nigeria can adapt to achieve sustainable malaria eradication. Egypt’s achievements were driven by robust surveillance systems, vector control measures, political commitment, community engagement, and international collaboration. These strategies are assessed for scalability and applicability within Nigeria’s unique socio-political and environmental context. Key focus areas include integrating advanced vector control techniques, strengthening healthcare infrastructure, and fostering cross-border partnerships to mitigate transboundary transmission. Additionally, innovative approaches to address drug resistance, enhance public awareness, and promote equitable access to diagnosis and treatment are discussed. The recent rollout of Nigeria’s R21 malaria vaccine underscores the need for complementary strategies, such as environmental management and improved surveillance technologies. By adopting a holistic, multi-sectoral approach informed by Egypt’s success, Nigeria can significantly reduce its malaria burden, enhance health outcomes, and contribute to global malaria eradication efforts. This study emphasizes the importance of sustained political will, resource allocation, and community participation in achieving long-term success in malaria control and elimination.
Journal Article
The World Health Organization : a history
\"According to its Constitution, the mission of the World Health Organization (WHO) was nothing less than the 'attainment by all peoples of the highest possible level of health' without distinction of race, religion, political belief, economic status, or social condition. But how consistently and how well has the WHO pursued this mission since 1946? This comprehensive and engaging new history explores these questions by looking at its origins and its institutional antecedents, while also considering its contemporary and future roles. It examines how the WHO was shaped by the particular environments of the postwar period and the Cold War, the relative influence of the US and other approaches to healthcare, and its place alongside sometimes competing international bodies such as UNICEF, the World Bank, and the Gates Foundation. The authors re-evaluate the relative success and failure of critical WHO campaigns, from early malaria and smallpox eradication programs to struggles with Ebola today.\"--Back cover.
Book
Microenvironment Eradication of Hepatitis C: A Novel Treatment Paradigm
ObjectivesPrisons are major reservoirs of hepatitis C virus (HCV) in which a therapeutic approach has been particularly difficult so far. Our aim was to create a permanent program of HCV elimination in a prison based on a “test and treat” strategy.MethodsThis open-label clinical trial was conducted in the Spanish prison “El Dueso” between May 2016 and July 2017. Viremic patients were treated with a ledipasvir–sofosbuvir regimen (8–12 weeks) according to the 2015 Spanish Guidelines. A teleconsultation program was established to follow-up patients from the hospital. Non-responders were submitted for a phylogenetic analysis and offered retreatment. An evaluation of new cases of HCV infection was performed every 6 months and upon release in all inmates.Results847 (99.5%) inmates accepted to participate. HCV antibodies were present in 110 (13.0%) and 86 (10.2%) had detectable viremia. Most of them were genotype 1 or 3 (82.6%) and had
Journal Article