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Evaluating clinical and public health interventions : a practical guide to study design and statistics
\"Whether you are evaluating the effectiveness of a drug, a medical device, a behavioral intervention, a community mobilization, or even a new law, this is the book for you. Written in plain language, it simplifies the process of designing interventions, analyzing the data, and publishing the results. Because the choice of research design depends on the nature of the intervention, the book covers randomized and nonrandomized designs, prospective and retrospective studies, planned clinical trials and observational studies. In addition to reviewing standard statistical analysis, the book has easy-to-follow explanations of cutting edge techniques for evaluating interventions, including propensity score analysis, instrumental variable analysis, interrupted time series analysis and sensitivity analysis. All techniques are illustrated with up-to-date examples from medical and public health literature. This will be essential reading for a wide range of healthcare professionals involved in research as well as those more specifically interested in public health issues and epidemiology\"--Provided by publisher.
Book
Area under the ROC Curve has the most consistent evaluation for binary classification
The proper use of model evaluation metrics is important for model evaluation and model selection in binary classification tasks. This study investigates how consistent different metrics are at evaluating models across data of different prevalence while the relationships between different variables and the sample size are kept constant. Analyzing 156 data scenarios, 18 model evaluation metrics and five commonly used machine learning models as well as a naive random guess model, I find that evaluation metrics that are less influenced by prevalence offer more consistent evaluation of individual models and more consistent ranking of a set of models. In particular, Area Under the ROC Curve (AUC) which takes all decision thresholds into account when evaluating models has the smallest variance in evaluating individual models and smallest variance in ranking of a set of models. A close threshold analysis using all possible thresholds for all metrics further supports the hypothesis that considering all decision thresholds helps reduce the variance in model evaluation with respect to prevalence change in data. The results have significant implications for model evaluation and model selection in binary classification tasks.
Journal Article
The measure of all minds : evaluating natural and artificial intelligence
Are psychometric tests valid for a new reality of artificial intelligence systems, technology-enhanced humans, and hybrids yet to come? Are the Turing Test, the ubiquitous CAPTCHAs, and the various animal cognition tests the best alternatives? Josâe Hernâandez-Orallo formulates major scientific questions, integrates the most significant research developments, and offers a vision of the universal evaluation of cognition. By replacing the dominant anthropocentric stance with a universal perspective where living organisms are considered as a special case, long-standing questions in the evaluation of behavior can be addressed in a wider landscape. Can we derive task difficulty intrinsically? Is a universal g factor - a common general component for all abilities - theoretically possible? Using algorithmic information theory as a foundation, the book elaborates on the evaluation of perceptual, developmental, social, verbal and collective features and critically analyzes what the future of intelligence might look like.
Book
No surgical innovation without evaluation: the IDEAL recommendations
Surgery and other invasive therapies are complex interventions, the assessment of which is challenged by factors that depend on operator, team, and setting, such as learning curves, quality variations, and perception of equipoise. We propose recommendations for the assessment of surgery based on a five-stage description of the surgical development process. We also encourage the widespread use of prospective databases and registries. Reports of new techniques should be registered as a professional duty, anonymously if necessary when outcomes are adverse. Case series studies should be replaced by prospective development studies for early technical modifications and by prospective research databases for later pre-trial evaluation. Protocols for these studies should be registered publicly. Statistical process control techniques can be useful in both early and late assessment. Randomised trials should be used whenever possible to investigate efficacy, but adequate pre-trial data are essential to allow power calculations, clarify the definition and indications of the intervention, and develop quality measures. Difficulties in doing randomised clinical trials should be addressed by measures to evaluate learning curves and alleviate equipoise problems. Alternative prospective designs, such as interrupted time series studies, should be used when randomised trials are not feasible. Established procedures should be monitored with prospective databases to analyse outcome variations and to identify late and rare events. Achievement of improved design, conduct, and reporting of surgical research will need concerted action by editors, funders of health care and research, regulatory bodies, and professional societies.
Journal Article
Demystifying Content Analysis
Objective. In the course of daily teaching responsibilities, pharmacy educators collect rich data that can provide valuable insight into student learning. This article describes the qualitative data analysis method of content analysis, which can be useful to pharmacy educators because of its application in the investigation of a wide variety of data sources, including textual, visual, and audio files.
Findings. Both manifest and latent content analysis approaches are described, with several examples used to illustrate the processes. This article also offers insights into the variety of relevant terms and visualizations found in the content analysis literature. Finally, common threats to the reliability and validity of content analysis are discussed, along with suitable strategies to mitigate these risks during analysis.
Summary. This review of content analysis as a qualitative data analysis method will provide clarity and actionable instruction for both novice and experienced pharmacy education researchers.
Journal Article
Quasi-experimental study designs series—paper 5: a checklist for classifying studies evaluating the effects on health interventions—a taxonomy without labels
The aim of the study was to extend a previously published checklist of study design features to include study designs often used by health systems researchers and economists. Our intention is to help review authors in any field to set eligibility criteria for studies to include in a systematic review that relate directly to the intrinsic strength of the studies in inferring causality. We also seek to clarify key equivalences and differences in terminology used by different research communities.
Expert consensus meeting.
The checklist comprises seven questions, each with a list of response items, addressing: clustering of an intervention as an aspect of allocation or due to the intrinsic nature of the delivery of the intervention; for whom, and when, outcome data are available; how the intervention effect was estimated; the principle underlying control for confounding; how groups were formed; the features of a study carried out after it was designed; and the variables measured before intervention.
The checklist clarifies the basis of credible quasi-experimental studies, reconciling different terminology used in different fields of investigation and facilitating communications across research communities. By applying the checklist, review authors' attention is also directed to the assumptions underpinning the methods for inferring causality.
Journal Article