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Patients with severe motor and intellectual disability (SMID) experience persistent spastic pain and severe malpositioning of the limbs, exacerbated by the lack of effective treatment for severe spastic palsy. This study (UMIN-CTR, UMIN000048842) aimed to evaluate the efficacy and safety of radial extracorporeal shock wave therapy (rESWT) for spastic palsy in these patients. rESWT was applied to the biceps brachii of 15 elbow joints with flexion pattern spastic palsy of Modified Ashworth Scale (MAS) grade 1+ or greater in 11 patients with SMID. The MAS score, elbow range of motion (ROM) and adverse events were monitored for up to 10 weeks. Electromyography signals at rest were recorded on 8 elbow joints. Following a single rESWT session, the spasticity of the elbow joint immediately decreased, the MAS score significantly decreased from 2 (range, 2–3) to 1 (range, 1–2), and the elbow ROM significantly increased by 10° (range, 0°–15°). Moreover, muscle activity decreased by 24% (range, 11–37%), being clinically meaningful in SMID. rESWT resulted in an immediate and clear improvement in the MAS score for approximately 8 weeks and in the elbow ROM, continuing even at 10 weeks. Our findings highlight rESWT as a non-invasive therapy for spastic palsy in patients with SMID.

ObjectivesTo assess whether radial extracorporeal shock wave therapy (rESWT), sham-rESWT or a standardised exercise programme in combination with advice plus customised foot orthoses is more effective than advice plus customised foot orthoses alone in alleviating heel pain in patients with plantar fasciopathy.Methods200 patients with plantar fasciopathy were included in a four-arm, parallel-group, sham-controlled, observer-blinded, partly patient-blinded trial. At baseline, before randomisation, all patients received advice plus customised foot orthoses. Patients were randomised to rESWT (n=50), sham-rESWT (n=50), exercise (n=50) or advice plus customised foot orthoses alone (n=50). Patients in the rESWT and sham-rESWT groups received three treatments. The exercise programme comprised two exercises performed three times a week for 12 weeks, including eight supervised sessions with a physiotherapist. Patients allocated to advice plus customised foot orthoses did not receive additional treatment. The primary outcome was change in heel pain during activity in the previous week per Numeric Rating Scale (0–10) from baseline to 6-month follow-up. The outcome was collected at baseline, and 3, 6 and 12 months.ResultsThe primary analysis showed no statistically significant between-group differences in mean change in heel pain during activity for rESWT versus advice plus customised foot orthoses (−0.02, 95% CI −1.01 to 0.96), sham-rESWT versus advice plus customised foot orthoses (0.52, 95% CI −0.49 to 1.53) and exercise versus advice plus customised foot orthoses (−0.11, 95% CI −1.11 to 0.89) at 6 months.ConclusionIn patients with plantar fasciopathy, there was no additional benefit of rESWT, sham-rESWT or a standardised exercise programme over advice plus customised foot orthoses in alleviating heel pain.Trial registration number NCT03472989.

Coronary heart disease (CHD) affects a large number of patients, and their survival period with the condition is relatively long. Cardiac shock wave therapy (CSWT) is an anti-myocardial ischemic therapy. This study aims to investigate the rehabilitative effects and underlying mechanisms of CSWT combined with exercise rehabilitation in patients undergoing percutaneous coronary intervention (PCI) for CHD. The study was a prospective randomized controlled trial conducted at Yunnan Fuwai Cardiovascular Hospital from 2020 to 2022, enrolling 74 patients who underwent PCI for CHD. They were randomly assigned to two groups: a control group of 37 patients and a study group of 37 patients. The intervention consisted of CSWT combined with exercise rehabilitation. Following the intervention, patients in the study group demonstrated increases in peak oxygen uptake (peak VO2), high-density lipoprotein cholesterol (HDL-C) and other parameters compared to pre-treatment levels. The combination of CSWT and exercise rehabilitation was found to improve myocardial markers, related anti-inflammatory and anti-atherosclerotic indicators in patients with CHD. Moreover, it alleviated myocardial ischemia while enhancing parameters such as oxygen uptake in cardiopulmonary exercise testing (CPET). These findings may offer novel insights into anti-ischemic treatment and cardiac rehabilitation for patients with CHD in future clinical practice.

Radial extracorporeal shock wave therapy (r-ESWT) is accepted as one of the most effective treatment modalities for plantar fasciitis (PF). Also kinesio taping (KT) applicationis effective for the treatment of PF. However, there is not enough evidence about the effectiveness of the combination of these two modalities in the treatment of PF. This prospective randomized clinical trial was planned to investigate the acute effects of KT application in addition to r-ESWT application on pain, foot function and flexibility. The study was performed on 42 patients with unilateral PF, that were randomly assigned into two groups receiving four sessions of either r-ESWT or r-ESWT+KT treatment once per week. All patients performed home exercises. Patients' pain levels were evaluated via the Visual Analogue Scale (VAS), and foot function via the Foot Function Index (FFI). Flexibility was evaluated through gastro-soleus and plantar fascia flexibility tests. The evaluations were done before and one week after the final treatment. Two Way Analysis of Variance with Repeated Measures and Generalized Estimating Equations (GEE) methods were used in statistical analyses. As a result, rest pain and activity pain decreased in both groups and there is no differences between the groups (respectively p: 0,831; p: 0.331). FFI pain and disability subscores decreased and were also similar between the groups (respectively p: 0.304; p: 0.978). FFI activity limitation subscore decreased in the r-ESWT group more than r-ESWT+KT group (p: 0.002). Night pain, gastro-soleus and plantar fascia flexibility did not change in both goups (respectively p: 0.713; p: 0.413; p: 0.475). Adding KT to r-ESWT application did not create an additional pain relieving effect, on the contrary, resulted in less improvement in activity limitation. This may be related to the fact that KT application to the sole and heel region creates a hard surface on the heel. r-ESWT application may be more beneficial in PF where activity limitation are prominent. The registration number: NCT06516393.

Background. The superiority of focused shockwave therapy (F-SWT) versus radial shockwave therapy (R-SWT) for treating noncalcific rotator cuff tendinopathies remains controversial. This study is aimed at comparing the effectiveness of F-SWT versus R-SWT for the management of noncalcific rotator cuff tendinopathies. Methods. A total of 46 patients affected by noncalcific rotator cuff tendinopathies were randomly divided into 2 groups of 23 individuals. Patients in group A received 4 sessions of F-SWT, while patients in group B were treated by 4 sessions of R-SWT. In each session, mean energy flux density (EFD) for F-SW 3000 shots was 0.09±0.018 mJ/mm2 with 5.1±0.5 Hz, while average pressure for R-SW 3000 shots was 4.0±0.35 bar with 3.2±0.0 Hz. Pain level and shoulder function were assessed with the numerical rating scale (NRS) and Constant-Murley Scale (CMS). The primary endpoint was the change in the mean NRS pain score from baseline to 24 weeks after the intervention. Secondary endpoints were changes in the mean NRS pain scores at all other follow-up points, changes in the mean CMS scores, and radiographic findings. Results. There were no significant differences between the two groups regarding NRS pain score and CMS score within 24 weeks after intervention (all p>0.05). However, F-SWT resulted in significantly lower NRS compared with R-SWT at 24 weeks and 48 weeks after treatment (2.7±1.0 vs. 4.5±1.2 and 1.4±1.0 vs. 3.0±0.8, respectively, all p<0.001). Similar results were found in CMS changes and radiographic findings. Conclusions. Both F-SWT and R-SWT are effective in patients with noncalcific rotator cuff tendinopathy. F-SWT proved to be significantly superior to R-SWT at long-term follow-up (more than 24 weeks). This trial is registered with ChiCTR1900022932.

Persistent symptoms of lateral epicondylitis prompt patients to seek effective conservative treatment. The study aimed to determine the effects of focused shock wave (FSWT) and ultrasound therapies for lateral epicondylitis. Sixty patients with tennis elbow were randomly divided into three equal groups: A, B, and C. Group A received a total of 3 FSWT sessions, with 7 days between treatments; Group B received ultrasound therapy in 10 sessions over 2 weeks, while patients in Group C were treated with placebo ultrasound. All patients were also given deep friction massage. Before the start of therapy, and at 1, 3, 6, and 12 weeks after its completion, pain intensity and function of the affected upper limb were assessed in all patients. Wrist extensor and flexor strength and grip strength were measured in the affected and unaffected limb. Significant reductions in pain and significant improvements in the function of the affected limb compared to baseline values were observed in all study groups at 6 and 12 weeks after the completion of therapy. Analysis of percentage changes in these variables showed significant differences between Groups A and B in favor of Group A. The strength of wrist extensors and grip strength of the affected limb at 6 and 12 weeks after treatment completion was significantly higher in Groups A and B compared to pre-therapy values. However, there were no statistically significant differences between the groups regarding percentage changes in muscle strength in the affected limb. Pain reduction and function improvement in patients with lateral epicondylitis were significantly greater after FSWT (0.2 mJ/mm 2 / 4 Hz / 2000 shocks) than after sonotherapy (3 MHz / 0.5 W/cm 2 / 20%). Increases in wrist extensor strength and grip strength of the affected limb were comparable after both therapies. Given the greater therapeutic effect in the subjective evaluation, we recommend a combination therapy of FSWT with deep friction massage. Trial registration The trial was prospectively registered in the ISRCTN registry (no. ISRCTN11907358 registration date 30.07.2020).

Extracorporeal shockwave therapy (ESWT) is a non-invasive physical therapy intervention that has emerged in the recent past to address the upswing of osteoarthritis (OA). However, insufficient evidence is present to prove the efficacy of ESWT on grade IV knee osteoarthritis (KOA). The present study aimed to examine the effects of ESWT on functional ability in patients suffering from grade IV KOA. Thirty volunteers aged 45–60 years with grade IV primary KOA diagnosed by an orthopaedic surgeon based on the Kellgren-Lawrence score participated in the study. The participants were equally and randomly divided into two groups (i.e. experimental and control), with 15 participants in each group. The participants in the control group performed conventional physiotherapy (CPT) that included ultrasound therapy, isometric quadriceps, SLR and isometric hip adductor strengthening exercises. The participants in the experimental group received ESWT in addition to CPT. Lower extremity functional scale (LEFS) score was measured before and after the four weeks of intervention. In both groups, a statistically significant (p = 0.001) improvement in LEFS was observed. In the experimental groups, it improved by 81.92% and in the control groups by 48.15%. A statistically significant (p < 0.001) difference was observed in LEFS post-intervention values between both groups. As demonstrated by our trial results, the addition of ESWT to the CPT program will yield beneficial results in ameliorating the functional disability in patients with primary KOA (grade IV). Further studies are needed to confirm and apply these findings to a larger cohort.

The study's goal was to compare and evaluate the benefits of deep friction massage and ultrasonic therapy (US) vs extracorporeal shockwave therapy (ESWT) for people with lateral epicondylitis. This double-blind, parallel-arm randomized clinical trial was conducted after ethical approval on a sample of 80 subjects with lateral epicondylitis. Participants were enrolled based on predefined eligibility criteria. They were randomly allocated to groups A and B. Group A received ESWT, while Group B received the US combined with deep friction massage. Data was collected using the Numeric Pain Rating Score (NPRS) and Patient-rated tennis elbow evaluation questionnaire (PRTEE) at baseline, at 3rd, and at 7th week of treatment. On the basis of the normality of the data, a non-parametric test was applied to evaluate between-group and within-group differences. P value ≤ 0.05 was considered significant. There was a significant difference between groups (p < 0.001). Comparisons of PRTEE scores at 3rd week and 7th week of intervention were found significant for both groups (p < 0.001). While considering between-group comparisons based on percentile scores of PRTEE at baseline, 3rd and 7th week of intervention, in group A Median (IQR) at the baseline was 24.00 (5.00), at 3rd week, 10.00 (5.00) and 7th week was 1.50 (2.50) and in group B Median (IQR) at the baseline was 25.00 (4.00), at 3rd week 19.50 (4.50) and at 7th week was 11.50 (2.50). The results were significant in both groups (p = 0.000), but between-group analysis revealed that ESWT is more effective in patients with lateral epicondylitis.

This pilot study primarily aimed to detect the adherence as well as the effect size required to estimate the actual sample size needed for a larger scale study to compare and evaluate the effectiveness of two extracorporeal shock wave therapy (ESWT) protocols along, with a physical therapy program in reducing pain and improving function among patients suffering from plantar fasciitis. The study also aimed to report the effects of the ESWT protocols used on pain and function. A total of 26 participants took part in the study, including 17 females and 9 males. The average age of the participants was 34 years with a body mass index (BMI) of 23 kg/m2. Participants were divided into three equal groups; Group A received ESWT at a frequency of 15 Hz and intensity of 3, Group B received ESWT at a frequency of 10 Hz and intensity of 4, while Group C underwent the selected physical therapy program along with sham shock wave therapy as a control. Pain levels were assessed using the Visual Analog Scale (VAS) while functional improvements were evaluated using the Foot Function Index (FFI). Data was collected prior to treatment, after three sessions and at the end of six weeks (after six sessions). The three groups were well matched, and the results revealed high adherence rates (90%, 90% and 80% respectively). Results also indicated reductions in pain levels and improvements in function for both intervention groups when compared to the control group. Group A demonstrated better outcomes compared to Group B while Group C showed relatively less improvement. The study concluded a high adherence rate for the three groups as well as a small effect size detected of 0.282 that would suggest a total of 123 participants to be required to replicate the study on a larger scale. With regards to the findings of this pilot, the combination of ESWT and a targeted physical therapy program revealed a possible effective therapeutic approach for plantar fasciitis, with a higher frequency potentially yielding more favourable results.

Background Myofascial pain syndrome (MPS) is a common, costly, and often persistent musculoskeletal condition. Radial shockwave therapy (RSWT) is one of the most frequently used treatments for MPS. However, there is limited evidence to support its short-term effectiveness, primarily due to the poor methodological quality of the studies. This study aimed to determine the effectiveness of radial shockwave therapy, compared with placebo treatment, in patients with MPS in the neck and upper back. Method A two-armed, randomized, double-blind, placebo-controlled trial was carried out in an outpatient physical rehabilitation department in a tertiary hospital. The sample comprised 70 adults aged 18 years or above with MPS. The intervention group received six treatment sessions. These consisted of RSWT: 1.5 bars (0.068 mJ/mm 2 ), 2000 pulses, and a frequency of 15 Hz; and standard physical therapy stretches and exercises, including therapeutic home exercises. The control group received an identical treatment regime, except that they received a no-energy shock (nontherapeutic dose) of 0.3 bar (0.01 mJ/mm 2 ). The outcome measures were the numeric pain score (NPS), neck disability index (NDI), pressure pain threshold (PPT) and SF-12 score at the 4-, 8- and 12-week follow-ups. Results The study revealed a significant improvement ( p  < 0.05) in the NPS and PPT at the follow-up assessments (0–4, 0–8, and 0–12 weeks). The placebo group showed a significant difference in NDI scores at all intervals, whereas the shockwave group only showed significant improvement at 0–4 weeks. The shockwave group did not have significant changes in SF-12 scores, whereas the placebo group showed significant improvement in the SF physical score between 0–8 weeks ( p  = 0.01) and 0–12 weeks ( p  = 0.02). No statistically or clinically significant differences were observed between the placebo and shockwave groups across all outcomes at 4, 8, and 12 weeks. Conclusion No significant differences were found between the placebo and shockwave groups at 4, 8, and 12 weeks. However, both groups showed statistically and clinically significant improvements in the NPS and PPT. Both groups showed improvements in the NPS and PPT scores; therefore, we recommend using radial RSWT as an adjunct to standard care, which includes therapeutic home exercises for individuals with MPS. Trial registration The trial was prospectively registered on 19 April 2022 with https://clinicaltrials.gov/study/NCT05381987 and conducted according to Consolidated Standards of Reporting Trials (CONSORT) guidelines.