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Friendship bread : a novel
Still reeling from a personal tragedy that left her estranged from the sister who was once her best friend, Julia Evarts remains at a loss as to how to move on with her life until she receives an anonymous gift of Amish Friendship Bread with instructions on how to make the bread herself, and a request to share it with others.
Book
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
This double-blind, multicenter, randomized trial showed that letrozole, as compared with clomiphene, was associated with higher live-birth and ovulation rates among infertile women with the polycystic ovary syndrome.
The polycystic ovary syndrome, which is diagnosed on the basis of hyperandrogenism, oligo-ovulation with associated oligomenorrhea, and polycystic ovaries on ultrasonography, affects 5 to 10% of reproductive-age women and is the most common cause of anovulatory infertility.
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Although the syndrome is a complex reproductive–metabolic disorder, the hypothalamic–pituitary axis has been the target of first-line ovulation-induction therapy. Clomiphene citrate, a selective estrogen-receptor modulator that antagonizes the negative feedback of estrogen at the hypothalamus with a consequent increase in ovarian stimulation by endogenous gonadotropin, has been used for this indication for decades.
Clomiphene has drawbacks, including its overall poor efficacy (only a . . .
Journal Article
Solstice
The friendship between Monica Jensen, a recently divorced schoolteacher, and Sheila Trask, a charismatic artist, intensifies into a turbulent, reckless relationship as Monica loses sight of her conventional values.
Book
Friends forever : how girls and women forge lasting relationships
From their biological and cultural origins to the varied manifestations of social connections, this book explores the deep bonds forged between women. By sharing stories from girls and women throughout their lives, authors Degges-White and Gainey thoughtfully illustrate the roles that contemporary social relationships play at different stages in our lives while offering insights to deeper self-understanding and for finding, establishing, and sustaining relationships at any age.
Book
Genital Inflammation and the Risk of HIV Acquisition in Women
Background. Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group. Methods. Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial. Results. HIV seroconversion was associated with raised genital inflammatory cytokines (including chemokines MIP-1α, MIP-1β, and IP-10). The risk of HIV acquisition was significantly higher in women with evidence of genital inflammation, defined by at least 5 of 9 inflammatory cytokines being raised (odds ratio, 3.2; 95% confidence interval, 1.3–7.9; P = .014). Genital cytokine concentrations were persistently raised (for about 1 year before infection), with no readily identifiable cause despite extensive investigation of several potential factors, including sexually transmitted infections and systemic cytokines. Conclusions. Elevated genital concentrations of HIV target cell–recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.
Journal Article