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"FIBROMYALGIA"
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Correction: Fibromyalgia-associated hyperalgesia is related to psychopathological alterations but not to gut microbiome changes
[This corrects the article DOI: 10.1371/journal.pone.0274026.].
Journal Article
What your doctor may not tell you about fibromyalgia : the revolutionary treatment that can reverse the disease
\"What Your Doctor May Not Tell You About Fibromyalgia is the only protocol that actually treat the condition, reduces drug dependency, and offer an actual cure. Most patients with fibromyalgia are on as astonishing array of medications--sometimes taking over 10 different medications and supplements a day to treat symptoms ranging from muscle pain and fatigue to hypoglycemia, IBS, and chronic candidiasis--and they still can't control their pain ourth edition of the book goes deeper into understanding the disease and the early intervention options that are available.\"-- Provided by publisher.
Book
Effects of Transcutaneous Electrical Acustimulation on Patients with Fibromyalgia Syndrome: Study Protocol of a Randomized, Double-Blind, Sham-Controlled Trial
Background: Fibromyalgia Syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, and localized tenderness. Transcutaneous Electrical Acustimulation (TEA) is a non-invasive therapy that combines Traditional Chinese Medicine with electrical stimulation at specific acupoints. Previous studies have shown that TEA is effective in treating pain-related conditions. This study aims to evaluate the efficacy and mechanisms of TEA treatment for FMS. Design: This is a prospective, randomized, double-blind, and placebo-controlled trial with two parallel groups, conducted at a single center. Forty participants will be randomly assigned to either the TEA group or the sham-TEA group in a 1:1 ratio. Participants will receive 2 weeks of treatment followed by 2 weeks of follow-up. The primary outcome is the change in VAS pain scores before and after treatment. Secondary outcomes include FMS and pain-related questionnaire scales, infrared thermography (IRT), vibration-controlled transient elastography (VCTE), blood neurobiological markers, cytokines, and metabolomics. Trial Registration: Keywords: FMS, traditional Chinese medicine, chronic pain, Hegu (LI4), Taichong (LR3)
Journal Article
Correction: Reduced activity, reactivity and functionality of the sympathetic nervous system in fibromyalgia: An electrodermal study
[This corrects the article DOI: 10.1371/journal.pone.0241154.].
Journal Article
Fibromyalgia Pathogenesis and Treatment Options Update
This review article presents and summarizes up-to-date literature on the clinical manifestations, diagnosis, pathophysiological mechanisms, and treatment options for fibromyalgia patients. First, the most recent diagnostic criteria for fibromyalgia, as put forth by the American College of Rheumatology will be summarized. Clinical features, including chronic widespread pain, hyperalgesia, mood disorders, anxiety, and disturbed sleep patterns will be explored in-depth. The pathogenesis and pathophysiology of fibromyalgia involves alterations in multiple ascending and descending central nervous system pathways, as well as peripheral pathways, leading to heightened pain sensitivity. Risk factors have been studied extensively, and the most recent research focuses on various genetic influences and the contributions of stress and poor sleep. Lastly, the discussion in this article focuses on treatment options for fibromyalgia; some have been mainstay options for many years. Pharmacological agents include tricyclic antidepressants, anti-epileptic drugs, selective serotonin reuptake inhibitors, norepinephrine/serotonin reuptake inhibitors, as well as some investigational agents. The evidence behind non-pharmacologic treatments, including massage therapy, exercise, and acupuncture, are discussed.
Journal Article
Toxic
\"Millions of people are suffering from chronic illnesses that, unbeknownst to them, are the result of exposure to environmental toxins and infectious agents such as mold and Borrelia, which causes Lyme disease. Millions. Because the symptoms of these illnesses are so varied and unusual, many of these individuals have sought medical care only to be dismissed, as if what they are experiencing is \"in their head.\" Many (if not most) have tried to tough it out and continue to function without hope of improvement. Unfortunately, their illnesses are very real. Toxic is a book of hope for these individuals, their loved ones, and the physicians who provide their care. Over many years of helping thousands of patients recover their health (even after their previous doctors had given up on them), Dr. Neil Nathan has come to understand some of the most common causes for these debilitating illnesses, which allows for the utilization of more precise and effective forms of treatment.\"--From publisher.
Book
Evaluation of Choroidal Vascularity Index and Choroidal Thickness in Newly Diagnosed Fibromyalgia Patients
INTRODUCTION: This study aimed to analyze and compare the early choroiad vascularity index (CVI) and choroidal Thickness (CT) values of newly diagnosed fibromyalgia (FM) patients and healthy subjects.METHODS: The participants in this study consisted of 24 female FM patients (study group) and 30 similarly aged female healthy subjects (control group). Only newly diagnosed FM patients were included in the study group. FM was diagnosed according to the American College of Rheumatology (ACR) 2010 classification criteria.Fibromyalgia Impact Questionnaire (FIQ) was used to assess the disease severity. CT values were measured at five points: Subfoveal, 750 μm temporally, 1500 μm temporally, 750 μm nasally to the foveal center, 1500 μm nasally to the foveal center (1500-N). CVI values were measured using the public domain ImageJ software for subfoveal and total choroidal areas.RESULTS: CT values in 1500 μm nasal and temporal were statistically lower in the FM group (p<0.05). While 750 μm nasal and temporal, subfoveal CT values were no statistically significant different (p>0.05). There was no statistically significant difference between the groups in terms of subfoveal-CVI, (p>0.05) but total-CVI values were significantly higher in the FM group (p<0.05).DISCUSSION AND CONCLUSION: The thinner choroidal thickness in the nasal and temporal regions compared to the central area, preserved choroidal vascularity index in the subfoveal area, and overall increased CVI in these patients may indicate that choroidal vascular changes and thinning start from the peripheral choroidal area at early stages of FM.
Journal Article