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This article reviews the literature related to the performance of fiber reinforced concrete (FRC) in the context of the durability of concrete infrastructures. The durability of a concrete infrastructure is defined by its ability to sustain reliable levels of serviceability and structural integrity in environmental exposure which may be harsh without any major need for repair intervention throughout the design service life. Conventional concrete has relatively low tensile capacity and ductility, and thus is susceptible to cracking. Cracks are considered to be pathways for gases, liquids, and deleterious solutes entering the concrete, which lead to the early onset of deterioration processes in the concrete or reinforcing steel. Chloride aqueous solution may reach the embedded steel quickly after cracked regions are exposed to de-icing salt or spray in coastal regions, which de-passivates the protective film, whereby corrosion initiation occurs decades earlier than when chlorides would have to gradually ingress uncracked concrete covering the steel in the absence of cracks. Appropriate inclusion of steel or non-metallic fibers has been proven to increase both the tensile capacity and ductility of FRC. Many researchers have investigated durability enhancement by use of FRC. This paper reviews substantial evidence that the improved tensile characteristics of FRC used to construct infrastructure, improve its durability through mainly the fiber bridging and control of cracks. The evidence is based on both reported laboratory investigations under controlled conditions and the monitored performance of actual infrastructure constructed of FRC. The paper aims to help design engineers towards considering the use of FRC in real-life concrete infrastructures appropriately and more confidently.

A new methodology for achieving the formation and compressional heating of a field reversed configuration (FRC) plasmoid has been investigated both theoretically and experimentally at the University of Washington and MSNW. This approach, based on previous FRC empirical scaling, is expected to achieve fusion gain as large as 10. For the FRC, the fusion gain, G ∼ ϕp⋅Be2 where ϕp is the FRC poloidal flux and Be the confining axial magnetic field. G is essentially independent of the FRC radial scale making feasible a small, compact reactor. The necessary ϕp (>60 mWb) is achieved by employing a large formation chamber (∼0.8 m radius) combined with the requisite axial magnetic field reversal time (Eθ ∼ 20 kV m−1) for generating a high initial temperature (Ti > 1 keV) FRC. By employing the dynamic formation procedure, the FRC is accelerated to ∼100–150 km s−1. This subsonic velocity is maintained as the FRC is translated through a series of cylindrical coils of decreasing radius but of sufficient length (>LFRC) and number (∼10) to produce essentially an isentropic and adiabatic radial wall-compression of the equilibrium FRC. The final stage is a 12 cm diameter, 3–6 m long confinement and burn chamber with a vacuum field of 7–9 T produced by external solenoidal coils inside the flux conserving cylinder. The vacuum field is compressed by the FRC on insertion to 35 T resulting in fusion gain conditions for the 2–5 ms transit. The large ratio of FRC to inner wall radius (0.85) substantially lowers the FRC edge pressure thereby greatly reducing both particle and thermal losses. The resulting D–T fusion yield for the 3.5 MJ FRC is 20–40 MJ/pulse. The final ejection and expansion of the FRC into a large, low field mirror chamber provides a mechanism for FRC energy recovery. The experimental justification and the physics basis for the entire process from formation through burn of the Compact FRC Fusion Reactor concept is presented.

The tumor-draining lymph nodes (TDLNs) are primary sites for induction of tumor immunity. They are also common sites of metastasis, suggesting that tumor-induced mechanisms can subvert anti-tumor immune responses and promote metastatic seeding. The high endothelial venules (HEVs) together with CCL21-expressing fibroblastic reticular cells (FRCs) are essential for lymphocyte recruitment into the LNs. We established multicolor antibody panels for evaluation of HEVs and FRCs in TDLNs from breast cancer (BC) patients. Our data show that patients with invasive BC display extensive structural and molecular remodeling of the HEVs, including vessel dilation, thinning of the endothelium and discontinuous expression of the HEV-marker PNAd. Remodeling of the HEVs was associated with dysregulation of CCL21 in perivascular FRCs and with accumulation of CCL21-saturated lymphocytes, which we link to loss of CCL21-binding heparan sulfate in FRCs. These changes were rare or absent in LNs from patients with non-invasive BC and cancer-free organ donors and were observed independent of nodal metastasis. Thus, pre-metastatic dysregulation of core stromal and vascular functions within TDLNs reflect the primary tumor invasiveness in BC. This adds to the understanding of cancer-induced perturbation of the immune response and opens for prospects of vascular and stromal changes in TDLNs as potential biomarkers.

Effective damage identification is paramount to evaluating safety conditions and preventing catastrophic failures of concrete structures. Although various methods have been introduced in the literature, developing robust and reliable structural health monitoring (SHM) procedures remains an open research challenge. This study proposes a new approach utilizing a 1-D convolution neural network to identify the formation of cracks from the raw electromechanical impedance (EMI) signature of externally bonded piezoelectric lead zirconate titanate (PZT) transducers. Externally bonded PZT transducers were used to determine the EMI signature of fiber-reinforced concrete specimens subjected to monotonous and repeatable compression loading. A leave-one-specimen-out cross-validation scenario was adopted for the proposed SHM approach for a stricter and more realistic validation procedure. The experimental study and the obtained results clearly demonstrate the capacity of the introduced approach to provide autonomous and reliable damage identification in a PZT-enabled SHM system, with a mean accuracy of 95.24% and a standard deviation of 5.64%.

Real-time structural health monitoring (SHM) and accurate diagnosis of imminent damage are critical to ensure the structural safety of conventional reinforced concrete (RC) and fiber-reinforced concrete (FRC) structures. Implementations of a piezoelectric lead zirconate titanate (PZT) sensor network in the critical areas of structural members can identify the damage level. This study uses a recently developed PZT-enabled Electro-Mechanical Impedance (EMI)-based, real-time, wireless, and portable SHM and damage detection system in prismatic specimens subjected to flexural repeated loading plain concrete (PC) and FRC. Furthermore, this research examined the efficacy of the proposed SHM methodology for FRC cracking identification of the specimens at various loading levels with different sensor layouts. Additionally, damage quantification using values of statistical damage indices is included. For this reason, the well-known conventional static metric of the Root Mean Square Deviation (RMSD) and the Mean Absolute Percentage Deviation (MAPD) were used and compared. This paper addresses a reliable monitoring experimental methodology in FRC to diagnose damage and predict the forthcoming flexural failure at early damage stages, such as at the onset of cracking. Test results indicated that damage assessment is successfully achieved using RMSD and MAPD indices of a strategically placed network of PZT sensors. Furthermore, the Upper Control Limit (UCL) index was adopted as a threshold for further sifting the scalar damage indices. Additionally, the proposed PZT-enable SHM method for prompt damage level is first established, providing the relationship between the voltage frequency response of the 32 PZT sensors and the crack propagation of the FRC prisms due to the step-by-step increased imposed load. In conclusion, damage diagnosis through continuous monitoring of PZTs responses of FRC due to flexural loading is a quantitative, reliable, and promising application.

The use of vegetable fibres as a sustainable alternative to non-natural sources of fibres applied for concrete reinforcement has been studied for over three decades. The main issues about plant-based fibres pointed out by other authors are the variability in their properties and concerns about potential high biodegradability in the alkaline pH of the concrete matrix. Aiming to minimise the variability of flax and hemp fibres, this research compares a range of chemical surface treatments, analysing their effects on the behaviour of the fibres and the effects of their addition to concrete. Corroborating what has been found by other authors, the treatment using NaOH 10% for 24 h was able to enhance the properties of hemp fibre-reinforced concrete and reduce the degradability in alkaline solution. For flax fibres, a novel alternative stood out: treatment using 1% of stearic acid in ethanol for 4 h. Treatment using this solution increased the tensile by 101%, causing a minor effect on the elastic modulus. Concrete mixes reinforced with the treated flax fibres presented reduced thermal conductivity and elastic modulus and increased residual tensile strength and fracture energy.

Antibody-secreting plasma cells (PCs) arise rapidly during adaptive immunity to control infections. The early PCs are retained within the reactive lymphoid organ where their localization and homeostasis rely on extrinsic factors, presumably produced by local niche cells. While myeloid cells have been proposed to form those niches, the contribution by colocalizing stromal cells has remained unclear. Here, we characterized a subset of fibroblastic reticular cells (FRCs) that forms a dense meshwork throughout medullary cords of lymph nodes (LNs) where PCs reside. This medullary FRC type is shown to be anatomically, phenotypically, and functionally distinct from T zone FRCs, both in mice and humans. By using static and dynamic imaging approaches, we provide evidence that medullary FRCs are the main cell type in contact with PCs guiding them in their migration. Medullary FRCs also represent a major local source of the PC survival factors IL-6, BAFF, and CXCL12, besides also producing APRIL. In vitro, medullary FRCs alone or in combination with macrophages promote PC survival while other LN cell types do not have this property. Thus, we propose that this FRC subset, together with medullary macrophages, forms PC survival niches within the LN medulla, and thereby helps in promoting the rapid development of humoral immunity, which is critical in limiting early pathogen spread.

TAE Technologies’ fifth-generation fusion device, C-2W (also called ‘Norman’), is the world’s largest compact-toroid device and has made significant progress in field-reversed configuration (FRC) plasma performance. C-2W produces record breaking, macroscopically stable, high-temperature advanced beam-driven FRC plasmas, dominated by injected fast particles and sustained in steady state, which is primarily limited by neutral-beam (NB) pulse duration. The NB power supply system has recently been upgraded to extend the pulse length from 30 ms to 40 ms, which allows for a longer plasma lifetime and thus better characterization and further enhancement of FRC performance. An active plasma control system is routinely used in C-2W to produce consistent FRC performance as well as for reliable machine operations using magnet coils, edge-biasing electrodes, gas injection and tunable-energy NBs. Google’s machine learning framework for experimental optimization has also been routinely used to enhance plasma performance. Dedicated plasma optimization experimental campaigns, particularly focused on the external magnetic field profile and NB injection (NBI) optimizations, have produced a superior FRC plasma performance; for instance, achieving a total plasma energy of ∼13 kJ, a trapped poloidal magnetic flux of ∼16 mWb (based on the rigid-rotor model) and plasma sustainment in steady state up to ∼40 ms. Furthermore, under some operating conditions, the electron temperature of FRC plasmas at a quiescent phase has successfully reached up to ∼1 keV at the peak inside the FRC separatrix for the first time. The overall FRC performance is well correlated with the NB and edge-biasing systems, where higher total plasma energy is obtained with higher NBI power and applied voltage on biasing electrodes. C-2W operations have now reached a mature level where the machine can produce hot, stable, long-lived, and repeatable plasmas in a well-controlled manner.