Explore the vast range of titles available.

Background Clear guidance for successive antidepressant pharmacological treatments for non-responders in major depression is not well established. Method Based on the RAND/UCLA Appropriateness Method, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of treatment-resistant depression. The expert guidelines combine scientific evidence and expert clinicians’ opinions to produce recommendations for treatment-resistant depression. A written survey comprising 118 questions related to highly-detailed clinical presentations was completed on a risk-benefit scale ranging from 0 to 9 by 36 psychiatrist experts in the field of major depression and its treatments. Key-recommendations are provided by the scientific committee after data analysis and interpretation of the results of the survey. Results The scope of these guidelines encompasses the assessment of pharmacological resistance and situations at risk of resistance, as well as the pharmacological and psychological strategies in major depression. Conclusion The expert consensus guidelines will contribute to facilitate treatment decisions for clinicians involved in the daily assessment and management of treatment-resistant depression across a number of common and complex clinical situations.

Over the past decade, researchers have shifted their focus from documenting health care disparities to identifying solutions to close the gap in care. Finding Answers: Disparities Research for Change, a national program of the Robert Wood Johnson Foundation, is charged with identifying promising interventions to reduce disparities. Based on our work conducting systematic reviews of the literature, evaluating promising practices, and providing technical assistance to health care organizations, we present a roadmap for reducing racial and ethnic disparities in care. The roadmap outlines a dynamic process in which individual interventions are just one part. It highlights that organizations and providers need to take responsibility for reducing disparities, establish a general infrastructure and culture to improve quality, and integrate targeted disparities interventions into quality improvement efforts. Additionally, we summarize the major lessons learned through the Finding Answers program. We share best practices for implementing disparities interventions and synthesize cross-cutting themes from 12 systematic reviews of the literature. Our research shows that promising interventions frequently are culturally tailored to meet patients’ needs, employ multidisciplinary teams of care providers, and target multiple leverage points along a patient’s pathway of care. Health education that uses interactive techniques to deliver skills training appears to be more effective than traditional didactic approaches. Furthermore, patient navigation and engaging family and community members in the health care process may improve outcomes for minority patients. We anticipate that the roadmap and best practices will be useful for organizations, policymakers, and researchers striving to provide high-quality equitable care.

Purpose This paper aims to critically examine the conceptualisation of the principle of materiality, which is one of the most divisive concepts in current regulatory work on standard setting for sustainability reporting. This paper pays particular attention to the current agenda for standard setting for sustainability reporting and the related discourse, including the International Sustainability Standard Board (ISSB) Exposure Draft IFRS S1 General Requirements for Disclosure of Sustainability-related Financial Information. A new conceptualisation of materiality is proposed based on the critique. Design/methodology/approach The academic and grey literature relating to current regulatory work on sustainability reporting, responses to the ISSB General Requirement Exposure Draft and sustainability reporting frameworks and standards are reviewed. This review also includes the papers in this journal’s special issue on standard setting for sustainability reporting. This review is used to develop original views on how materiality could be conceptualised and interpreted for sustainability reporting. This paper’s viewpoint is built on the criticisms of various definitions of materiality found in the literature and the author’s original critique of the materiality definitions provided in various reports and standards/frameworks on sustainability reporting. Findings Both financial materiality and double materiality approaches have drawbacks. A single materiality approach underpinned by accountability for financial and non-financial capitals instead of decision usefulness for any stakeholder is proposed. The proposed conceptualisation is also underpinned by the need to recognise dependencies between the environment, society and organisations when creating long-term enterprise value. The proposed approach is expected to trigger real changes in organisational practices to pursue a purpose beyond profit. Practical implications The proposed approach to defining materiality for sustainability reporting bridges the divide between financial materiality and social and environmental materiality concepts underpinning different standards and regulations. Social implications The approach to materiality proposed in this paper is aimed at enabling organisations to pursue United Nations Sustainable Development Goals to make the planet and societies more sustainable. Originality/value This paper proposes a new conceptualisation of and approach to materiality determination for sustainability reporting.

Background Recommendations for pharmacological treatments of major depression with specific comorbid psychiatric conditions are lacking. Method The French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental developed expert consensus guidelines for the management of depression based on the RAND/UCLA Appropriatneness Method. Recommendations for lines of treatment are provided by the scientific committee after data analysis and interpretation of the results of a survey of 36 psychiatrist experts in the field of major depression and its treatments. Results The expert guidelines combine scientific evidence and expert clinician’s opinion to produce recommendations for major depression with comorbid anxiety disorders, personality disorders or substance use disorders and in geriatric depression. Conclusion These guidelines provide direction addressing common clinical dilemmas that arise in the pharmacologic treatment of major depression with comorbid psychiatric conditions.

Panel rocked by investigations into surgeon — but its credibility stays intact.

Key Points Provides an understanding of the selection process for dental foundation training. Suggests there should be a greater appreciation of the ethical concerns that underpin professional attributes. Situational judgement tests (SJTs) are multiple-choice psychological assessments that claim to measure professional attributes such as empathy, integrity, team involvement and resilience. One of their attractions is the ability to rank large numbers of candidates. Last year SJTs formed a major component (50% of the assessment marks) of the selection process for dental foundation training (DFT). However, it is not clear what SJTs are actually assessing. There is also the concern that applicants who have developed ethical reasoning skills may be disadvantaged by such tests. The DFT selection process needs to explicitly recognise the importance of ethical reasoning.

GSTS Pathology was set up as a partnership between Serco and Guy's and St Thomas's NHS Foundation Trust in 2009 after a review of pathology services carried out in 2006 by the Labour peer Patrick Carter had recommended that savings could be made if pathology services were delivered by specialised service providers. 1 King's College Hospital joined in 2010. A report by the campaigning group Corporate Watch that was based on published documents and requests made under freedom of information legislation claimed that the joint venture was an organisation \"in turmoil,\" with demoralised staff, a failing IT system, and a high level of clinical incidents such as losing or mislabelling patients' blood and cell samples. 2 GSTS Pathology is bidding to win contracts to provide pathology services in the east of England and south London, which it says have the potential to deliver major growth to the business in 2013. A new management team, headed by Richard Jones, formerly with the health insurer Bupa and the private hospital group Spire Healthcare, was appointed early in 2011 to turn the business round.

Editor's note This well circulated but heretofore unpublished report is the summary statement of an interdisciplinary meeting of scholars convened by the National Science Foundation in Arlington, Virginia on June 28, 2010. The workshop, which was funded by the NSF's Political Science Program (Social, Behavioral & Economic Sciences Grant #1037831), was convened to answer two compelling questions: Are studies of social behavior that build from discoveries about genes and/or cognition of greater social and scientific value than studies of the same topics that ignore such factors? And, how can fundable research on genes, cognition, and politics generate transformative scientific practices, infrastructure, and findings of high social value? Assembled for the workshop were a group of scholars representing diverse yet increasingly connected research areas, including genetics, cognitive science and neuroscience, decision making and risk analysis, economics, political science, and sociology. The resulting report outlines the substantial challenges facing interdisciplinary research but also describes the considerable contributions to knowledge that could result from sustained collaborations between biologists, geneticists, and brain scientists on the one hand and social scientists on the other. Following this main report are three white papers by Jeremy Freese. Elizabeth Hammock, and Rose McDermott, which address importmant considerations related to the discussion. For a download of the full report, see http://www.isr.umich.edu.cps/workshop.Welcome.html.