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"Genetic enhancement"
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The ethics of ability and enhancement
This book explores our ethical responsibilities regarding health in general and disabilities in particular. Disability studies and human enhancement stand out as two emerging areas of research in medical ethics, prompting debates into ethical questions of identity, embodiment, discrimination, and accommodation, as well as questions concerning distributive justice and limitations on people's medical rights. Edited by two ethicist philosophers, this book combines their mastery of the theoretical debates surrounding disability and human enhancement with attention to real world questions that health workers and patients may face. By including a wide range of high-quality voices and perspectives, the book provides an invaluable resource for scholars who are working on this important and emerging area of leadership and health care ethics.
Book
Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean
Resequencing of 302 soybean accessions and GWAS provide a comprehensive resource for soybean geneticists and breeders.
Understanding soybean (
Glycine max
) domestication and improvement at a genetic level is important to inform future efforts to further improve a crop that provides the world's main source of oilseed. We detect 230 selective sweeps and 162 selected copy number variants by analysis of 302 resequenced wild, landrace and improved soybean accessions at >11× depth. A genome-wide association study using these new sequences reveals associations between 10 selected regions and 9 domestication or improvement traits, and identifies 13 previously uncharacterized loci for agronomic traits including oil content, plant height and pubescence form. Combined with previous quantitative trait loci (QTL) information, we find that, of the 230 selected regions, 96 correlate with reported oil QTLs and 21 contain fatty acid biosynthesis genes. Moreover, we observe that some traits and loci are associated with geographical regions, which shows that soybean populations are structured geographically. This study provides resources for genomics-enabled improvements in soybean breeding.
Journal Article
Caveats on human cognitive enhancement technologies based on the sociocultural context of Singapore
A survey study by Haining et al reported significantly higher percentages of Singaporeans approving of human cognitive enhancement via reprogenetic technologies, as compared with American respondents in a similar previous survey study conducted in the USA. Some caveats on human cognitive enhancement with reprogenetic technologies, such as polygenic embryo screening and germline gene editing, are thus discussed based on the local sociocultural context of Singapore. First, within a hypercompetitive shame-based Confucian society such as Singapore, the autonomy of the cognitively enhanced offspring would likely be curtailed by the heavy-handed ‘tiger-parenting’ approach of their parents, who, after investing so much money in enhancing their cognitive ability, would have ‘heightened’ expectations of their academic performance. Second, cognitive enhancement may not improve the personal happiness, sense of fulfilment and overall well-being of the offspring, particularly if their unique motivations and aspirations do not align with the idealised visions and expectations of their parents, and if they are unable to fulfil the unrealistic and unreasonable expectations imposed by their parents and broader society. Third, cognitive enhancement may not necessarily improve the future prospects and life success of the offspring if this further exacerbates an unbalanced job market with an oversupply of university graduates. Fourth, cognitive enhancement is anticipated to be very expensive and hence be afforded only by the affluent, thereby further aggravating existing socioeconomic disparities. Last, the high costs of such technologies could further accelerate demographic decline due to the heavy financial burden on prospective parents. Hence, Singapore must carefully consider these caveats before permitting such cognitive-enhancing technologies.
Journal Article
Comprehensive metabolic profiling and phenotyping of interspecific introgression lines for tomato improvement
Tomato represents an important source of fiber and nutrients in the human diet and is a central model for the study of fruit biology. To identify components of fruit metabolic composition, here we have phenotyped tomato introgression lines (ILs) containing chromosome segments of a wild species in the genetic background of a cultivated variety. Using this high-diversity population, we identify 889 quantitative fruit metabolic loci and 326 loci that modify yield-associated traits. The mapping analysis indicates that at least 50% of the metabolic loci are associated with quantitative trait loci (QTLs) that modify whole-plant yield-associated traits. We generate a cartographic network based on correlation analysis that reveals whole-plant phenotype associated and independent metabolic associations, including links with metabolites of nutritional and organoleptic importance. The results of our genomic survey illustrate the power of genome-wide metabolic profiling and detailed morphological analysis for uncovering traits with potential for crop breeding.
Journal Article
Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice
New cultivars with very erect leaves, which increase light capture for photosynthesis and nitrogen storage for grain filling, may have increased grain yields
1
. Here we show that the erect leaf phenotype of a rice brassinosteroid–deficient mutant,
osdwarf4-1
, is associated with enhanced grain yields under conditions of dense planting, even without extra fertilizer. Molecular and biochemical studies reveal that two different cytochrome P450s, CYP90B2/OsDWARF4 and CYP724B1/D11, function redundantly in C-22 hydroxylation, the rate-limiting step of brassinosteroid biosynthesis. Therefore, despite the central role of brassinosteroids in plant growth and development, mutation of
OsDWARF4
alone causes only limited defects in brassinosteroid biosynthesis and plant morphology. These results suggest that regulated genetic modulation of brassinosteroid biosynthesis can improve crops without the negative environmental effects of fertilizers.
Journal Article
Arsenic hazards: strategies for tolerance and remediation by plants
Arsenic toxicity has become a global concern owing to the ever-increasing contamination of water, soil and crops in many regions of the world. To limit the detrimental impact of arsenic compounds, efficient strategies such as phytoremediation are required. Suitable plants include arsenic hyperaccumulating ferns and aquatic plants that are capable of completing their life cycle in the presence of high levels of arsenic through the concerted action of arsenate reduction to arsenite, arsenite complexation, and vacuolar compartmentalization of complexed or inorganic arsenic. Tolerance can also be conferred by lowering arsenic uptake by suppression of phosphate transport activity, a major pathway for arsenate entry. In many unicellular organisms, arsenic tolerance is based on the active removal of cytosolic arsenite while limiting the uptake of arsenate. Recent molecular studies have revealed many of the gene products involved in these processes, providing the tools to improve crop species and to optimize phytoremediation; however, so far only single genes have been manipulated, which has limited progress. We will discuss recent advances and their potential applications, particularly in the context of multigenic engineering approaches.
Journal Article
Metabolic engineering of carotenoid biosynthesis in plants
Carotenoids are one of the most diverse classes of natural compounds. Plant carotenoids are composed of a C40 isoprenoid skeleton with or without epoxy, hydroxy and keto groups. They have fundamental roles in human nutrition as antioxidants and vitamin A precursors and their consumption is increasingly associated with protection from a range of diseases. They are also used commercially as safe food, feed and cosmetic colorants and they protect plants from photooxidative stress. In the past six years many metabolic engineering efforts have been undertaken in plants aiming to improve the nutritional value of staple crops, to enable the use of plants as ‘cell factories’ for producing specialty carotenoids and to improve plant resistance to abiotic stress.
Journal Article
Genetic enhancement from the perspective of transhumanism: exploring a new paradigm of transhuman evolution
Transhumanism is a movement that advocates for the enhancement of human capabilities through the use of advanced technologies such as genetic enhancement. This article explores the definition, history, and development of transhumanism. Then, it compares the stance on genetic enhancement from the perspectives of bio-conservatism, bio-liberalism, and transhumanism. This article posits that transhuman evolution has twofold implications, allowing for the integration of transhumanist research and evolutionary biology. First, it offers a compelling scientific framework for understanding genetic enhancement, avoiding technological progressivism, and incorporating concepts of evolutionary biology. Second, it represents a new evolutionary paradigm distinct from traditional Lamarckism and Darwinism. It marks the third synthesis of evolutionary biology, offering fresh perspectives on established concepts such as artificial selection and gene-culture co-evolution. In recent decades, human enhancement has captivated not only evolutionary biologists, neurobiologists, psychologists, and philosophers, but also those in fields such as cybernetics and artificial intelligence. In addition to genetic enhancement, other human enhancement technologies, including brain-computer interfaces and brain uploading, are currently under development, which the paradigm of transhuman evolution can better integrate into its framework.
Journal Article
scorpion neurotoxin increases the potency of a fungal insecticide
The low virulence of the insecticidal fungus
Metarhizium anisopliae
has stymied its widespread use in controlling insect pests. We show that high-level expression of an insect-specific neurotoxin from the scorpion
Androctonus australis
in hemolymph by
M. anisopliae
increases fungal toxicity 22-fold against tobacco hornworm (
Manduca sexta
) caterpillars and ninefold against adult yellow fever mosquitoes (
Aedes aegypti
) without compromising host specificity. Prelethal effects include reduced mobility and feeding of the insects targeted.
Journal Article