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Albizia odoratissima is a valuable drought-tolerant native tree species in the dry and hot river valleys of China, which has important ecological and economic values. Exploring its genetic background and phylogenetic direction will be conducive to its further exploitation and use, and promote the process of vegetation restoration in the dry hot river valley region. A genome assembly of approximately 719.88 Mb was achieved at the contig level, featuring a contig N50 of 53.74 Mb. Of this, 98.58% of gene sequences were organized into 13 pseudochromosomes. The A. odoratissima genome contained 96.96% of conserved genes, including 1,538 intact single-copy genes and 42 intact duplicated genes. It had an angiosperm palaeotripling event and the last whole genome duplication event occurred approximately 62.9 million years ago. A. odoratissima shares 8,936 gene families with five other legume species, while 1,420 gene families are unique to A. odoratissima . Under drought stress, photosynthesis was significantly inhibited to reduce water consumption, osmoregulatory substances were significantly increased to alleviate osmotic stress, and flavonoid accumulation was induced to enhance antioxidant capacity through the up-regulation of AoANS ( Aod07G019900 ) gene expression, thereby improving drought tolerance. High-quality reference genomes generated through molecular studies are advancing research into the molecular mechanisms of A. odoratissima .

Background Genome‐wide association studies (GWAS) have made little progress in identifying variants linked to depression. We hypothesized that examining depressive symptoms and considering gene–environment interaction (GxE) might improve efficiency for gene discovery. We therefore conducted a GWAS and genome‐wide by environment interaction study (GWEIS) of depressive symptoms. Methods Using data from the SHARe cohort of the Women's Health Initiative, comprising African Americans (n = 7,179) and Hispanics/Latinas (n = 3,138), we examined genetic main effects and GxE with stressful life events and social support. We also conducted a heritability analysis using genome‐wide complex trait analysis (GCTA). Replication was attempted in four independent cohorts. Results No SNPs achieved genome‐wide significance for main effects in either discovery sample. The top signals in African Americans were rs73531535 (located 20 kb from GPR139, P = 5.75 × 10−8) and rs75407252 (intronic to CACNA2D3, P = 6.99 × 10−7). In Hispanics/Latinas, the top signals were rs2532087 (located 27 kb from CD38, P = 2.44 × 10−7) and rs4542757 (intronic to DCC, P = 7.31 × 10−7). In the GEWIS with stressful life events, one interaction signal was genome‐wide significant in African Americans (rs4652467; P = 4.10 × 10−10; located 14 kb from CEP350). This interaction was not observed in a smaller replication cohort. Although heritability estimates for depressive symptoms and stressful life events were each less than 10%, they were strongly genetically correlated (rG = 0.95), suggesting that common variation underlying self‐reported depressive symptoms and stressful life event exposure, though modest on their own, were highly overlapping in this sample. Conclusions Our results underscore the need for larger samples, more GEWIS, and greater investigation into genetic and environmental determinants of depressive symptoms in minorities.