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Gilbert Simondon's Psychic and collective individuation : a critical introduction and guide
A critical commentary on Simondon's Psychic and collective individuation. This book clarifies Simondon's complex terminology and structure through chapter by chapter commentary. It also invites a dialogue with other thinkers/philosophers and places the work in its historical context. It includes a discussion about Simondon's relevance to current ideas about biopolitics and post-Nietzschean ethics.
Book
Gilbert and Sullivan
Highlights the original cast members—both the well-known and the (until now) wholly unknown—who staged the duo's comic operas in Britain and in America.
In this, the first book to focus on the original cast members of the classic Gilbert and Sullivan comic operas, world-renowned musical theater expert Kurt Gänzl provides a concise history of the writing and production of each opera, vividly colored by the often little-known life stories of these early performers. Meticulously researched and lavishly illustrated with rare photographs, Gilbert and Sullivan: The Players and the Plays delves into the professional and personal lives of the British and American actors and singers who created the celebrated \"famous fourteen\" Gilbert and Sullivan operas.
eBook
Gilbert & George : The general jungle or Carrying on sculpting, late summer 1971 : presented in its entirety, autumn 2017
\"Since 1967, renowned artists Gilbert & George have made themselves into their art, sacrificing their individual identities to devote themselves to a more democratic art practice, which they call 'Art for All.' This catalogue presents their formative early work, The General Jungle or Carrying on Sculpting (1971). Comprised of twenty-three monumental, multi-panel charcoal-on-paper sculptures depicting the artists wandering streets and parks in London and inscribed with philosophical slogans, The General Jungle or Carrying on Sculpting was first exhibited at the Sonnabend Gallery in New York in 1971. Published in conjunction with Lâevy Gorvy's exhibition of the work, this fully illustrated catalogue features a newly commissioned essay by Michael Bracewell based on a recent interview with the artists, an original poem by Kostas Anagnopoulos, newspaper reviews from the inaugural exhibition at the Sonnabend Gallery, and a facsimile of the postal sculpture A Day in the Life of George & Gilbert, the sculptors (1971).\" -- Publisher's description
Book
Magnetic skyrmions on a two-lane racetrack
Magnetic skyrmions are particle-like textures in magnetization, characterized by a topological winding number. Nanometer-scale skyrmions have been observed at room temperature in magnetic multilayer structures. The combination of their small size, topological quantization and their efficient electric manipulation makes them interesting candidates for information carriers in high-performance memory devices. A skyrmion racetrack memory has been suggested, in which information is encoded in the distance between skyrmions moving in a one-dimensional nanostrip. Here, I propose an alternative design where skyrmions move in two (or more) parallel lanes and the information is stored in the lane number of each skyrmion. Such a multilane track can be constructed by controlling the height profile of the nanostrip. Repulsive skyrmion-skyrmion interactions in narrow nanostrips guarantee that skyrmions on different lanes cannot pass each other. Current pulses can be used to induce a lane change, and combining these elements provides a robust, efficient design for skyrmion-based storage devices.
Journal Article
Effect of UDP‐glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome
Variations at the six nucleotides −3279 (T > G), −53 (A[TA]6TAA > A[TA]7TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP‐glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome and in 200 healthy adults. Every subject was classified as a genotype depending on variation status of the six nucleotides in the UGT1A1 gene. The UGT1A1 activity for each genotype was calculated and then those genotypes were divided into 10 subgroups (Q1~Q10) according to their UGT1A1 activities, by using 10% as an interval. There were 24 genotypes observed, with UGT1A1 activity ranged 9%~100% of normal. There were two and six subjects with Gilbert's syndrome and none of healthy controls carrying genotypes in the Q1 and Q2 subgroups, respectively. The odds of developing Gilbert's syndrome were significantly higher for subjects carrying genotypes in the Q3, Q4, and Q5 subgroups than for those with genotype in the Q10 subgroup (odds ratios: 240.22, 59.80, and 14.67, respectively, P < .001 for each). Among the 178 patients of Gilbert's syndrome, serum bilirubin value was inversely correlated with UGT1A1 activity (r = −.306, P < .001). The sensitivity was 72.0% and the specificity was 90.5% by using UGT1A1 activity ≦40% of normal as the cut‐off point to distinguish between healthy subjects and patients of Gilbert's syndrome. Our results demonstrate that UGT1A1 activity is certainly a determinate for serum bilirubin value and UGT1A1 activity ≦40% of normal is a proper risk factor for the development of Gilbert's syndrome.
Journal Article
Case Series: Hyperbilirubinemia under elexacaftor/tezacaftor/ivacaftor in the presence of Gilbert’s syndrome
Liver-related side effects are a known complication of treatment with elexacaftor/tezacaftor/ivacaftor (ETI) for cystic fibrosis (CF). Gilbert’s syndrome is caused by a genetic mutation that reduces activity of the enzyme UDP glucuronosyltransferase 1 polypeptide A1 (UGT1A1), causing elevated levels of unconjugated bilirubin in the blood and duodenal bile. The presence of Gilbert’s syndrome and CF might represent additive risk factors for liver-related adverse events during ETI treatment. This case series describes six people with CF (pwCF) in whom previously unknown Gilbert’s syndrome was unmasked after initiation of treatment with ETI. Although all patients had some level of hepatic dysfunction and/or elevated levels of bilirubin after initiation of ETI, the clinical course varied. Only one patient had to stop ETI therapy altogether, while the others were able to continue treatment (some at a reduced dosage and others at the full recommended daily dosage). All patients, even those using a lower dosage, experienced clinical benefit during ETI therapy. Gilbert’s syndrome is not a contraindication for ETI therapy but may be mistaken for a risk factor for liver-related adverse events in pwCF. This is something that physicians need to be aware of in pwCF who show liver adverse events during ETI therapy.
Journal Article
