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Online social networks provide rich information that characterizes the user’s personality, his interests, hobbies, and reflects his current state. Users of social networks publish photos, posts, videos, audio, etc. every day. Online social networks (OSN) open up a wide range of research opportunities for scientists. Much research conducted in recent years using graph neural networks (GNN) has shown their advantages over conventional deep learning. In particular, the use of graph neural networks for online social network analysis seems to be the most suitable. In this article we studied the use of graph convolutional neural networks with different convolution layers (GCNConv, SAGEConv, GraphConv, GATConv, TransformerConv, GINConv) for predicting the user’s professional success in VKontakte online social network, based on data obtained from his profiles. We have used various parameters obtained from users’ personal pages in VKontakte social network (the number of friends, subscribers, interesting pages, etc.) as their features for determining the professional success, as well as networks (graphs) reflecting connections between users (followers/ friends). In this work we performed graph classification by using graph convolutional neural networks (with different types of convolution layers). The best accuracy of the graph convolutional neural network (0.88) was achieved by using the graph isomorphism network (GIN) layer. The results, obtained in this work, will serve for further studies of social success, based on metrics of personal profiles of OSN users and social graphs using neural network methods.

Allostery is considered important in regulating protein’s activity. Drug development depends on the understanding of allosteric mechanisms, especially the identification of allosteric sites, which is a prerequisite in drug discovery and design. Many computational methods have been developed for allosteric site prediction using pocket features and protein dynamics. Here, we present an ensemble learning method, consisting of eXtreme gradient boosting and graph convolutional neural network, to predict allosteric sites. Our model can learn physical properties and topology without any prior information, and shows good performance under multiple indicators. Prediction results showed that 84.9% of allosteric pockets in the test set appeared in the top 3 positions. The PASSer: Protein Allosteric Sites Server ( https://passer.smu.edu ), along with a command line interface ( https://github.com/smutaogroup/passerCLI ) provide insights for further analysis in drug discovery.

Audio features are physical features that reflect single or complex coordinated movements in the vocal organs. Hence, in speech-based automatic depression classification, it is critical to consider the relationship among audio features. Here, we propose a deep learning-based classification model for discriminating depression and its severity using correlation among audio features. This model represents the correlation between audio features as graph structures and learns speech characteristics using a graph convolutional neural network. We conducted classification experiments in which the same subjects were allowed to be included in both the training and test data (Setting 1) and the subjects in the training and test data were completely separated (Setting 2). The results showed that the classification accuracy in Setting 1 significantly outperformed existing state-of-the-art methods, whereas that in Setting 2, which has not been presented in existing studies, was much lower than in Setting 1. We conclude that the proposed model is an effective tool for discriminating recurring patients and their severities, but it is difficult to detect new depressed patients. For practical application of the model, depression-specific speech regions appearing locally rather than the entire speech of depressed patients should be detected and assigned the appropriate class labels.

Graph Convolutional Neural Networks (GCNs) have been widely used in various fields due to their powerful capabilities in processing graph-structured data. However, GCNs encounter significant challenges when applied to scale-free graphs with power-law distributions, resulting in substantial distortions. Moreover, most of the existing GCN models are shallow structures, which restricts their ability to capture dependencies among distant nodes and more refined high-order node features in scale-free graphs with hierarchical structures. To more broadly and precisely apply GCNs to real-world graphs exhibiting scale-free or hierarchical structures and utilize multi-level aggregation of GCNs for capturing high-level information in local representations, we propose the Hyperbolic Deep Graph Convolutional Neural Network (HDGCNN), an end-to-end deep graph representation learning framework that can map scale-free graphs from Euclidean space to hyperbolic space. In HDGCNN, we define the fundamental operations of deep graph convolutional neural networks in hyperbolic space. Additionally, we introduce a hyperbolic feature transformation method based on identity mapping and a dense connection scheme based on a novel non-local message passing framework. In addition, we present a neighborhood aggregation method that combines initial structural features with hyperbolic attention coefficients. Through the above methods, HDGCNN effectively leverages both the structural features and node features of graph data, enabling enhanced exploration of non-local structural features and more refined node features in scale-free or hierarchical graphs. Experimental results demonstrate that HDGCNN achieves remarkable performance improvements over state-of-the-art GCNs in node classification and link prediction tasks, even when utilizing low-dimensional embedding representations. Furthermore, when compared to shallow hyperbolic graph convolutional neural network models, HDGCNN exhibits notable advantages and performance enhancements.

In soccer, quantitatively evaluating the performance of players and teams is essential to improve tactical coaching and players’ decision-making abilities. To achieve this, some methods use predicted probabilities of shoot event occurrences to quantify player performances, but conventional shoot prediction models have not performed well and have failed to consider the reliability of the event probability. This paper proposes a novel method that effectively utilizes players’ spatio-temporal relations and prediction uncertainty to predict shoot event occurrences with greater accuracy and robustness. Specifically, we represent players’ relations as a complete bipartite graph, which effectively incorporates soccer domain knowledge, and capture latent features by applying a graph convolutional recurrent neural network (GCRNN) to the constructed graph. Our model utilizes a Bayesian neural network to predict the probability of shoot event occurrence, considering spatio-temporal relations between players and prediction uncertainty. In our experiments, we confirmed that the proposed method outperformed several other methods in terms of prediction performance, and we found that considering players’ distances significantly affects the prediction accuracy.

Demand prediction plays a critical role in traffic research. The key challenge of traffic demand prediction lies in modeling the complex spatial dependencies and temporal dynamics. However, there is no mature and widely accepted concept to support the solution of the above challenge. Essentially, a prediction model combined with similar objects in temporal and spatial dimensions could obtain better performance. This paper proposes a concept called the Similarity-based Principle (SP), which is applied to improve the prediction performance of deep learning models in complex traffic scenarios. For the temporal components, the long-term temporal dynamics in contemporaneous historical data for ridership are extracted by the Stacked Autoencoder (SAE) method. For the spatial components, the activity-based spatial geographic information (ABG-information) is used to capture the spatial correlation of the traffic network, which is reflected in the daily activities of humans. Specifically, the SP is applied to a Spatio-temporal Graph Convolutional Neural Network (STGCNN) model. In the case study, the Similarity-based Principle Spatio-temporal Graph Convolutional Neural Network (SP-STGCNN) model predicts demand for bicycle sharing in San Francisco. The results show that the SP effectively improves the model's performance. The prediction accuracy is enhanced by up to 10.34% compared with STGCNN. For spatial relationships, the model using the geographic information attribute performs better than that using the road information attribute and the distance attribute. It is proved that the construction of the Spatio-temporal model-based similarity principle can improve the performance.

There is significant interest in the development and application of deep neural networks (DNNs) to neuroimaging data. A growing literature suggests that DNNs outperform their classical counterparts in a variety of neuroimaging applications, yet there are few direct comparisons of relative utility. Here, we compared the performance of three DNN architectures and a classical machine learning algorithm (kernel regression) in predicting individual phenotypes from whole-brain resting-state functional connectivity (RSFC) patterns. One of the DNNs was a generic fully-connected feedforward neural network, while the other two DNNs were recently published approaches specifically designed to exploit the structure of connectome data. By using a combined sample of almost 10,000 participants from the Human Connectome Project (HCP) and UK Biobank, we showed that the three DNNs and kernel regression achieved similar performance across a wide range of behavioral and demographic measures. Furthermore, the generic feedforward neural network exhibited similar performance to the two state-of-the-art connectome-specific DNNs. When predicting fluid intelligence in the UK Biobank, performance of all algorithms dramatically improved when sample size increased from 100 to 1000 subjects. Improvement was smaller, but still significant, when sample size increased from 1000 to 5000 subjects. Importantly, kernel regression was competitive across all sample sizes. Overall, our study suggests that kernel regression is as effective as DNNs for RSFC-based behavioral prediction, while incurring significantly lower computational costs. Therefore, kernel regression might serve as a useful baseline algorithm for future studies.

Functional connectivity of the human brain, representing statistical dependence of information flow between cortical regions, significantly contributes to the study of the intrinsic brain network and its functional mechanism. To fully explore its potential in the early diagnosis of Alzheimer's disease (AD) using electroencephalogram (EEG) recordings, this article introduces a novel dynamical spatial–temporal graph convolutional neural network (ST‐GCN) for better classification performance. Different from existing studies that are based on either topological brain function characteristics or temporal features of EEG, the proposed ST‐GCN considers both the adjacency matrix of functional connectivity from multiple EEG channels and corresponding dynamics of signal EEG channel simultaneously. Different from the traditional graph convolutional neural networks, the proposed ST‐GCN makes full use of the constrained spatial topology of functional connectivity and the discriminative dynamic temporal information represented by the 1D convolution. We conducted extensive experiments on the clinical EEG data set of AD patients and Healthy Controls. The results demonstrate that the proposed method achieves better classification performance (92.3%) than the state‐of‐the‐art methods. This approach can not only help diagnose AD but also better understand the effect of normal ageing on brain network characteristics before we can accurately diagnose the condition based on resting‐state EEG. To fully explore its potential in the early diagnosis of Alzheimer's disease (AD) using electroencephalogram (EEG) recordings, this article introduces a novel dynamical spatial–temporal graph convolutional neural network (ST‐GCN) for better classification performance.

Background Analyzing single-cell RNA sequencing (scRNAseq) data plays an important role in understanding the intrinsic and extrinsic cellular processes in biological and biomedical research. One significant effort in this area is the identification of cell types. With the availability of a huge amount of single cell sequencing data and discovering more and more cell types, classifying cells into known cell types has become a priority nowadays. Several methods have been introduced to classify cells utilizing gene expression data. However, incorporating biological gene interaction networks has been proved valuable in cell classification procedures. Results In this study, we propose a multimodal end-to-end deep learning model, named sigGCN, for cell classification that combines a graph convolutional network (GCN) and a neural network to exploit gene interaction networks. We used standard classification metrics to evaluate the performance of the proposed method on the within-dataset classification and the cross-dataset classification. We compared the performance of the proposed method with those of the existing cell classification tools and traditional machine learning classification methods. Conclusions Results indicate that the proposed method outperforms other commonly used methods in terms of classification accuracy and F1 scores. This study shows that the integration of prior knowledge about gene interactions with gene expressions using GCN methodologies can extract effective features improving the performance of cell classification.

Sign language is the main channel for hearing-impaired people to communicate with others. It is a visual language that conveys highly structured components of manual and non-manual parameters such that it needs a lot of effort to master by hearing people. Sign language recognition aims to facilitate this mastering difficulty and bridge the communication gap between hearing-impaired people and others. This study presents an efficient architecture for sign language recognition based on a convolutional graph neural network (GCN). The presented architecture consists of a few separable 3DGCN layers, which are enhanced by a spatial attention mechanism. The limited number of layers in the proposed architecture enables it to avoid the common over-smoothing problem in deep graph neural networks. Furthermore, the attention mechanism enhances the spatial context representation of the gestures. The proposed architecture is evaluated on different datasets and shows outstanding results.