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Purpose:  Research purposes of analyzing the Human Development Index open unemployment rate to Poverty with intervening variables of economic development in Central Java Province in 2015-2020.   Theoretical framework:  Human Development measures human development achievements based on a number of basic components of quality of life. Unemployment is a macroeconomic problem that directly affects human survival. Poverty is the inability to meet the minimum standard of living, where the measurement of poverty is based on consumption. The major theory used relates to the Neo-liberal and Social Democracy paradigms. Economic growth has a correlation with the number of poor people, where high economic growth will have an impact on reducing the number of poor people, with the assumption that economic growth is pro-poor.    Design/methodology/approach:  This research uses a quantitative approach. The analysis uses the website's secondary data published by the Central Statistics Agency. The number of data is 210, processed using AMOS to determine the direct and indirect effects and a Sobel calculator to assess the impact of the intervening variables.   Findings:  The results showed that the Human Development Index did not significantly impact Economic Growth, the Open Unemployment Rate substantially influenced Economic Growth, and the Human Development Index significantly affected Poverty. Open Unemployment Rate has no significant impact on Poverty. Economic growth has no significant effect on Poverty. The Growth of Economic can not mediate impact human development index on Poverty. Economic growth can not mediate result of the open unemployment rate to Poverty    Research, Practical & Social implications: the research can be carried out in different places with a broader objective. Provincial or district/city governments in Central Java Province as policy material and or policy projections in the future   Originality/value: The findings of this study can be generalized to different provinces so that they can be used as material for government policies to increase the human development index, reduce unemployment, increase economic growth so that poverty will decrease.

Background Gastrointestinal (GI) cancers were responsible for 26.3% of cancer cases and 35.4% of deaths worldwide in 2018. This study aimed to analyze the global incidence, mortality, prevalence, and contributing risk factors of the 6 major GI cancer entities [esophageal cancer (EC), gastric cancer (GC), liver cancer (LC), pancreatic cancer (PC), colon cancer, and rectal cancer]. Methods Using the Global Cancer Observatory and the Global Health Observatory databases, we reviewed the current GI cancer incidence, prevalence, and mortality, analyzed the association of GI cancer prevalence with national human development indices (HDIs), identified the contributing risk factors, and estimated developing age‐ and sex‐specific trends in incidence and mortality. Results In 2020, the trend in age‐standardized rate of incidence of GI cancers closely mirrored that of mortality, with the highest rates of LC, EC, and GC in Asia and of colorectal cancer (CRC) and PC mainly in Europe. Incidence and mortality were positively, but the mortality‐to‐incidence ratio (MIR) was inversely correlated with the national HDI levels. High MIRs in developing countries likely reflected the lack of preventive strategies and effective treatments. GI cancer prevalence was highest in Europe and was also positively correlated with HDIs and lifestyle‐associated risk factors, such as alcohol consumption, smoking, obesity, insufficient physical activity, and high blood cholesterol level, but negatively correlated with hypertension and diabetes. Incidences of EC were consistently and those of GC mostly decreasing, whereas incidences of CRC were increasing in most countries/regions, especially in the younger populations. Incidences of LC and PC were also increasing in all age‐gender populations except for younger males. Mortalities were decreasing for EC, GC, and CRC in most countries/regions, and age‐specific trends were observed in PC and LC with a decrease in the younger but an increase in the older population. Conclusions On the global scale, higher GI cancer burden was accompanied, for the most part, by factors associated with the so‐called Western lifestyle reflected by high and very high national HDI levels. In countries/regions with very high HDI levels, patients survived longer, and increasing GI cancer cases were observed with increasing national HDI levels. Optimizing GI cancer prevention and improving therapies, especially for patients with comorbid metabolic diseases, are thus urgently recommended. Prevalence of gastrointestinal cancers was positively correlated with national human development index levels, but negatively with hypertension and diabetes rates. Age‐specific trends were observed in stomach cancer and esophagus cancer for incidence and in liver cancer and pancreatic cancer for mortality, as well as sex‐specific trends for stomach cancer and pancreatic cancer in the elder.These findings suggest that future research has to focus on the specific etiology of gastrointestinal cancers behind these epidemiologic transitions and improve therapeutic strategies for patients with comorbid metabolic diseases.

Unsustainable consumption of biofuels contributes to deforestation and climate change, while household air pollution from burning solid biofuels in homes results in millions of premature deaths globally every year. Honduras, like many low and medium Human Development Index countries, depends on primary solid biofuels for more than 30% of its primary energy supply (as of 2013). We conducted a societal exergy analysis and developed a forest stock model for Honduras for 1971–2013 and used the results to model an energy transition from traditional wood stoves to either improved efficiency wood cookstoves or modern fuel cookstoves (using Electricity or Liquefied petroleum gas) over the period 2013–2050. The exergy analysis and forest model enabled quantification of the environmental tradeoffs between the improved efficiency and fuel switching scenarios. We find that the continued reliance on wood within both the existing and improved wood cookstove scenarios would exhaust forest stocks by 2050, though improved efficiency could reduce national greenhouse gas emissions. Modern fuel cookstoves would reduce household air pollution, emissions, and deforestation. However, the best alternative to successfully reduce household air pollution, GHG emissions, and deforestation is a rapid switch to electric stoves with significant investment in renewable-based electricity.

India, Pakistan, and Bangladesh (IPB) are the largest South Asian countries in terms of land area, gross domestic product (GDP), and population. The growth in these countries is impacted by inadequate renewable energy policy and implementation over the years, resulting in slow progress towards human development and economic sustainability. These developing countries are blessed with huge potential for renewable energy resources; however, they still heavily rely on fossil fuels (93%). IPB is a major contributor to the total energy consumption of the world and its most energy-intensive building sector (India 47%, Pakistan 55% and Bangladesh 55%) displays inadequate energy performance. This paper comprehensively reviews the energy mix and consumption in IPB with special emphasis on current policies and its impact on economic and human development. The main performance indicators have been critically analyzed for the period 1970–2017. The strength of this paper is a broad overview on energy and development of energy integration in major South Asian countries. Furthermore, it presents a broad deepening on the main sector of energy consumption, i.e., the building sector. The paper also particularly analyzes the existing buildings energy efficiency codes and policies, with specific long-term recommendations to improve average energy consumption per person. The study also examines the technical and regulatory barriers and recommends specific measures to adapt renewable technologies, with special attention to policies affecting energy consumption. The analysis and results are general and can be applied to other developing countries of the world.

Vorinostat (SAHA), an inhibitor of class I and II of histone deacetylases, is the first histone deacetylase inhibitor (HDI) approved for the treatment of cutaneous T-cell lymphoma in 2006. HDIs are promising anticancer agents that inhibit the proliferation of many types of cancer cells including breast carcinoma (BC). BC is a heterogeneous disease with variable biological behavior, morphological features, and response to therapy. Although significant progress in the treatment of BC has been made, high toxicity to normal cells, serious side effects, and the occurrence of multi-drug resistance limit the effective therapy of BC patients. Therefore, new active agents which improve the effectiveness of currently used regimens are highly needed. This manuscript analyzes preclinical and clinical trials data of SAHA, applied individually or in combination with other anticancer agents, considering different histological subtypes of BC.

Incidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I–XI, WHO mortality database, and Global Burden of Disease (GBD)-2019. Concentrating on worldwide variations, this thorough analysis offers insights into patterns of incidence and mortality based on gender and age. Our findings encompass significant indicators, including age-standardized rates (ASRs), average annual percentage change (AAPC), and future projections extending up to the year 2040. Liver cancer holds the sixth position in terms of most frequently diagnosed cancers and stands as the sixth leading cause of cancer-related deaths worldwide in 2020, accounting for 905,677 new cases and 782,000 fatalities. Additionally, liver cancer contributed to 12,528,421 age-standardized disability-adjusted life years (DALYs), with an age-standardized DALYs rate of 161.92 in 2019 worldwide. The age-specific incidence rates exhibited significant variations across different regions, showing a fivefold difference in males and females. A significant increase in incidence was observed in North Europe and Asia, while North African countries reported a higher mortality burden (ASR, 10 per 100,000) compared to developed countries. Since last few years, the incidence and mortality rates have increased and attained Annual Average Percentage Change (AAPC) incidence rate of 7.7 (95% CI 3.9–11.6) for men and the highest AAPC mortality rate of 12.2 (95% CI 9.5–15.0) for women. In 2019, Western Europe emerged as the high-risk region for DALYs related to smoking and alcohol consumption, while high-income North America carried a high risk for DALYs associated with a high body-mass index. The projected trend indicates a surge in new liver cancer incident cases, expected to rise from around 905,347 to an estimated 1,392,474 by 2040. This study described the evidence pertinent to higher incidence trends in liver cancer, particularly among both young and older adults, encompassing males and females, as well as those who are HIV-infected and HBsAg positive. A significant rise in the young population poses a significant public health concern that warrants attention from healthcare professionals to prioritize the promotion of health awareness and the development of effective cancer prevention strategies, particularly in many developing countries.

Heterostructured materials have been reported as a new class of materials with superior mechanical properties, which was attributed to the development of back stress. There are numerous reports on back stress theories and measurements with no consensus. Back stress is developed in soft domains to offset the applied stress, making them appear stronger, while forward stress is developed to make hard domains appear weaker. The extra hardening in heterostructured materials is resulted from interactions between back stresses and forward stresses, and should be described as hetero-deformation induced (HDI) hardening and the measured 'back stress' should be renamed HDI stress. The 'back stress' hardening in the literature can be described more accurately as hetero-deformation induced (HDI) hardening and the measured 'back stress' should be renamed HDI stress.

The mixture of hexamethylene diisocyanate (HDI) and butanol (BuOH) with the intercalation compound of 1,4-diazabicyclo[2.2.2]octane (DABCO) with α-zirconium phosphate (α-ZrP) has been evaluated as a latent thermal catalyst at varying temperatures. α-ZrP·DABCO did not show activity at 25 °C, but showed a high level of activity at a higher temperature of 80 °C. To clarify the reaction behavior of HDI-BuOH with α-ZrP·DABCO, a viscosity value of 1200 mPa·s·g/cm2 was reached at 80 °C for 30 min. To investigate the deintercalation behavior of DABCO from the α-ZrP interlayer, it was investigated in BuOH and in HDI, respectively, under heated conditions. Interestingly, XRD patterns showed a reduction in α-ZrP·DABCO for the interlayer distance due to the deintercalation of DABCO in BuOH, while no changes associated with the deintercalation of DABCO were observed in HDI. Butanol was found to be important for the deintercalation of DABCO. To examine the reactivity of bifunctional monomers, the reaction of 1,4-butanediol (1,4-BDO) and HDI with α-ZrP·DABCO were investigated to show good reactivity at 80 °C and stability at 40 °C.

Soybean is the main crop in Brazil, both in scale and in value. Nonetheless, the beginning was very humble. Soybean was a minor crop until the 1960s, when it was restricted to the South Region (subtropical), from where it expanded to the Midwest Region (tropical) in the 1980s. That was possible thanks to the development of cultivars well adapted to low latitude conditions of the Region. In the Midwest Region, home of the Cerrado Biome, the land was plentiful and affordable with flat topography, deep soils, well drained and easy to handle. The challenge was related to soil fertility, originally acidic and poor in nutrients. The role of research was of fundamental importance in overcoming that challenge. In the 1990s, soybean advanced towards the north center and in the 2000s, it expanded farther to the north (latitudes near 0°). Soybean has been the driving force behind Brazil’s recent agricultural development, with significant economic and social impact. Municipalities that grow soybean have achieved Human Development Indexes higher than the ones that do not grow soybean. Second place among the world’s largest producers, Brazil is expected to take the lead in the coming decade. To move forward, Brazil needs to use the assets it already has: technological efficiency for production in tropical lands, availability of arable lands and entrepreneurial farmers. The global demand for soybean and the associated market prices will determine how much Brazilian soybean production will grow in the coming years. Le soja est la principale culture actuellement au Brésil, à la fois en tonnage (hors canne à sucre) et en valeur. Dans les années 1960, sa production se limitait à la région du Sud (subtropicale) ; ensuite, dans les années 1980, il s’est étendu à la région du Centre-Ouest (tropicale). Cette expansion a été rendue possible grâce au développement de cultivars adaptés. Dans le Centre-Ouest, correspondant à la savane du Cerrado, la terre était abondante et abordable, avec une topographie plate, des sols profonds, bien drainés et faciles à travailler. Le défi était lié à l’amélioration de la fertilité des sols, à l’origine acides et pauvres en nutriments. Le rôle de la recherche a été fondamental. Dans les années 1990, le soja a progressé vers le Centre-Nord et dans les années 2000, il s’est étendu plus au Nord. Il est donc le moteur du développement agricole récent du Brésil, avec un impact économique et social important. Les communes où il est cultivé ont atteint des indices de développement humain (IDH) plus élevés que celles où il n’y en a pas. Deuxième producteur mondial, le Brésil devrait accroître encore son hégémonie du fait de son efficacité technologique, de la disponibilité de terres arables et du caractère entreprenant de ses agriculteurs, et sachant que la demande internationale et les prix associés détermineront cette croissance.

Heterostructured materials are an emerging class of materials with superior performances that are unattainable by their conventional homogeneous counterparts. They consist of heterogeneous zones with dramatic (>100%) variations in mechanical and/or physical properties. The interaction in these hetero-zones produces a synergistic effect where the integrated property exceeds the prediction by the rule-of-mixtures. The heterostructured materials field explores heterostructures to control defect distributions, long-range internal stresses, and nonlinear inter-zone interactions for unprecedented performances. This paper is aimed to provide perspectives on this novel field, describe the state-of-the-art of heterostructured materials, and identify and discuss key issues that deserve additional studies. IMPACT STATEMENT This paper delineates heterostructured materials, which are emerging as a new class of materials with unprecedented properties, new materials science and economic industrial production.