Explore the vast range of titles available.

Background: Proper understanding of concepts of physiology forms basis of good clinical practice. To make the lectures of physiology, more interesting and understanding one has to review the teaching methods at regular intervals. Aims and Objectives: This study is designed to get feedback regarding teaching methods in physiology from MBBS students of Government Medical College, Kozhikode, to make teaching more effective. Materials and Methods: Two hundred randomly selected students who successfully completed 1st-year MBBS are included in the study group. The standard questionnaire is shared to study group through Google forms and adequate time is given to record their responses. Descriptive statistics are used. Frequency is expressed in percentage. Results: Most of students prefer interactive teaching methodologies such as group discussion as their preferred mode of learning rather than conventional didactic lectures in whole batch. Students also like to have integration with other subjects and early clinical exposure to understand the concepts precisely. Conclusion: Teaching in small groups with proper integration and alignment with other subjects will make maximum results in rather than the traditional teacher centered medical education. Periodic review of teaching methods is very much essential to make the subject more interesting.

The value principle in organizational economics states that the net market value of the goods that a firm sells is a key determinant of its organizational design. We survey and extend some recent developments in the theoretical literature at the nexus of organizational and industrial economics, focusing on this precept as the unifying theme. Under perfect competition, we study how market price influences the use of scarce professional management and the degree of organizational heterogeneity in an industry. In a more general setting, we show how changes in demand influence not only the use of professional management, but also the size and the market power of firms. And we show how prices can affect the internal control structure of firms, sometimes in highly distorted ways. We discuss applications to comparative industrial organization and to technological diffusion.

This paper details a method for investigating the stability of a layered slope that combines random field theory with horizontal integration. Both the cohesion and friction coefficient are treated as a Gaussian random field. The closed-form solution of the factor of safety and the probability of failure of the layered slope are derived, in which the effects of spatial correlation lengths and spatial correlation parameters on the stability of the layered slope are considered. The derived probability of failure is greatly affected by the input spatial correlation length of the soil parameters. The effectiveness of this proposed method is validated with the results of the Monte Carlo simulation.

Resource decision making is complex and variable when considering the vertical integration problem (VIP) and the horizontal integration problem (HIP) in an enterprise. The VIP involves sharing the enterprise's resource or information with the suppliers and customers as directly as possible to increase all participants' profits. On the other hand, the HIP considers allying with other competitors when the enterprise is short of the needed resources. The challenges associated with the VIP and HIP are usually dependent and inseparable. In this paper, the integral method called dummy goal programming is proposed to deal with the HIP and VIP simultaneously. On the basis of our numerical example, we can conclude that this proposed method can cope with these problems completely and that it provides the overall aspiration level for the enterprise.

This paper examines one of the NHS England Pioneers programmes of Integrated Care, which was implemented in three localities in East London, covering the area served by one of the largest hospital groups in the UK and bringing together commissioners, providers and local authorities. The partners agreed to build a model of integrated care that focused on the whole person. This qualitative and participatory evaluation looked at how an ambitious vision translated into the delivery of integrated care on the ground. The study explored the micro-mechanisms of integrated care relationships based on the experience of health and social care professionals working in acute and community care settings. We employed a participatory approach, the Researcher in Residence model, whereby the researcher was embedded in the organisations she evaluated and worked alongside managers and clinicians to build collaboration across the full range of stakeholders, develop shared learning, and find common ground through competing interests, while trying to address power imbalances. A number of complementary qualitative methods of data generation were used, including documentary analysis, participant observations, semi-structured interviews, and coproduction workshops with frontline health and social care professionals to interpret the data and develop recommendations. Our fieldwork exposed persistent organisational fragmentation, despite the dominant rhetoric of integration and efforts to build a shared vision at senior governance levels. The evaluation identified several important themes, including: a growing barrier between acute and community services; a persisting difficulty experienced by health and social care staff in working together because of professional and cultural differences, as well as conflicting organisational priorities and guidelines; and a lack of capacity and support to deliver a genuine multidisciplinary approach in practice, despite the ethos of multiagency being embraced widely. By focusing on professionals' working routines, we detailed how and why action taken by organisational leaders failed to have tangible impact. The inability to align organisational priorities and guidelines on the ground, as well as a failure to acknowledge the impact of structural incentives for organisations to compete at the expense of cooperation, in a context of limited financial and human resources, acted as barriers to more coordinated working. Within an environment of continuous reconfigurations, staff were often confused about the functions of new services and did not feel they had influence on change processes. Investing in a genuine bottom-up approach could ensure that the range of activities needed to generate system-wide cultural transformation reflect the capacity of the organisations and systems and address genuine local needs. The authors acknowledge several limitations of this study, including the focus on one geographical area, East London, and the timing of the evaluation, with several new interventions and programmes introduced more or less simultaneously. Some of the intermediate care services under evaluation were still at pilot stage and some teams were undergoing new reconfigurations, reflecting the fast-pace of change of the past decade. This created confusion at times, for instance when discussing specific roles and activities with participants. We tried to address some of these challenges by organising several workshops with different teams to co-interpret and discuss the findings.

The development of single-cell multimodal assays provides a powerful tool for investigating multiple dimensions of cellular heterogeneity, enabling new insights into development, tissue homeostasis and disease. A key challenge in the analysis of single-cell multimodal data is to devise appropriate strategies for tying together data across different modalities. The term ‘data integration’ has been used to describe this task, encompassing a broad collection of approaches ranging from batch correction of individual omics datasets to association of chromatin accessibility and genetic variation with transcription. Although existing integration strategies exploit similar mathematical ideas, they typically have distinct goals and rely on different principles and assumptions. Consequently, new definitions and concepts are needed to contextualize existing methods and to enable development of new methods. As the number of single-cell experiments with multiple data modalities increases, Argelaguet and colleagues review the concepts and challenges of data integration.

Spatial transcriptomics technologies generate gene expression profiles with spatial context, requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample integration, and cell-type deconvolution. We present GraphST, a graph self-supervised contrastive learning method that fully exploits spatial transcriptomics data to outperform existing methods. It combines graph neural networks with self-supervised contrastive learning to learn informative and discriminative spot representations by minimizing the embedding distance between spatially adjacent spots and vice versa. We demonstrated GraphST on multiple tissue types and technology platforms. GraphST achieved 10% higher clustering accuracy and better delineated fine-grained tissue structures in brain and embryo tissues. GraphST is also the only method that can jointly analyze multiple tissue slices in vertical or horizontal integration while correcting batch effects. Lastly, GraphST demonstrated superior cell-type deconvolution to capture spatial niches like lymph node germinal centers and exhausted tumor infiltrating T cells in breast tumor tissue. Advances in spatial transcriptomics technologies have enabled the gene expression profiling of tissues while retaining spatial context. Here the authors present GraphST, a graph self-supervised contrastive learning method that learns informative and discriminative spot representations from spatial transcriptomics data.

Empires of Entertainmentintegrates legal, regulatory, industrial, and political histories to chronicle the dramatic transformation within the media between 1980 and 1996. As film, broadcast, and cable grew from fundamentally separate industries to interconnected, synergistic components of global media conglomerates, the concepts of vertical and horizontal integration were redesigned. The parameters and boundaries of market concentration, consolidation, and government scrutiny began to shift as America's politics changed under the Reagan administration. Through the use of case studies that highlight key moments in this transformation, Jennifer Holt explores the politics of deregulation, the reinterpretation of antitrust law, and lasting modifications in the media landscape. Holt skillfully expands the conventional models and boundaries of media history. A fundamental part of her argument is that these media industries have been intertwined for decades and, as such, cannot be considered separately. Instead, film, cable and broadcast must be understood in relation to one another, as critical components of a common history.Empires of Entertainmentis a unique account of deregulation and its impact on political economy, industrial strategies, and media culture at the end of the twentieth century.

Background: Allied health science (AHS) courses in India include degree, diploma, and certificate courses in various disciplines that support the practice of medicine to make the health-care team function efficiently as they provide assistance in the laboratory, technical, and other support services. Many of the AHS courses have basic medical sciences that are taught in a compartmentalized manner as traditional method. However, horizontal integration module is not included for AHS. Aims and Objectives: The objective of this study was to analyze the performance of the 1st year AHS students to the application of horizontal integration as a small module within traditional teaching in physiology. Materials and Methods: Thirty-three students underwent 12 lectures in physiology in the topic of \"The Gastrointestinal Tract (GIT)\" in a traditional teaching method of didactic lectures. The students then had an interactive 2-h horizontally integrated modular session on \"Biochemical principles of diet-nutrition.\" The interrelated topic from biochemistry and physiology was incorporated as horizontal integration. The students' performance was assessed with a pre-test and post-test, structured viva voce in diet-nutrition and a traditional viva voce in the traditionally taught GIT topic. Results: The results showed that the post-test mark was higher than the pre-test mark; the performance of students who scored<60% termed as average and below-average students with 50%: Being cutoff for passing in health professions education in India improved in the structured viva voce in diet-nutrition when compared to traditional viva voce in GIT. Conclusion: We conclude this integrated module demonstrated enhanced learning performance of students with high scores in post-test, the better performance in the structured viva voce showing improved understanding and learning ability.

Several high-tech manufacturing technologies are emerging to meet the demand for mass customized products. These technologies include configurable robots, augmented reality and the Internet-of-Things. Manufacturing enterprises can leverage these new technologies to pursue increased flexibility, i.e., the ability to perform a larger variety of activities within a shorter time. However, the flexibility offered by these new technologies is not fully exploited, because current operations management techniques are not dynamic enough to support high variability and frequent change. The HORSE Project investigated several of the new technologies to find novel ways to improve flexibility, as part of the Horizon 2020 research and innovation program. The purpose of the project was to develop a system, integrating these new technologies, to support efficient and flexible manufacturing. This article presents the core result of the project: a reference architecture for a manufacturing operations management system. It is based on the application and extension of business process management (BPM) to manage dynamic manufacturing processes. It is argued that BPM can complement current operations management techniques by acting as an orchestrator in manufacturing processes augmented by smart technologies. Building on well-known information systems’ architecting frameworks, design science research is performed to determine how BPM can be applied and adapted in smart manufacturing operations. The resulting reference architecture is realized in a concrete HORSE system and deployed and evaluated in ten practical cases, of which one is discussed in detail. It is shown that the developed system can flexibly orchestrate the manufacturing process through vertical control of all agents, and dynamic allocation of agents in the manufacturing process. Based on that, we conclude that BPM can be applied to overcome some of the obstacles toward increased flexibility and smart manufacturing.